Sergey Nejentsev

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK
    Science 324:387-9. 2009
  2. doi request reprint Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes
    Sarah F Field
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 57:1753-6. 2008
  3. pmc Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    John A Todd
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Nat Genet 39:857-64. 2007
  4. pmc Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK
    Nature 450:887-92. 2007
  5. ncbi request reprint Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust DiabetesInflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, WT MRC building, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Diabetes 53:2709-12. 2004
  6. pmc Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes
    Rebecca Bailey
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetes 56:2616-21. 2007
  7. ncbi request reprint No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility
    Rebecca Pask
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 2XY UK
    Diabetes Metab Res Rev 22:356-60. 2006
  8. pmc Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    BMC Genet 8:24. 2007
  9. ncbi request reprint Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK
    Hum Mol Genet 13:1633-9. 2004
  10. pmc Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects
    JAMES CURTIS
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom, Level 5, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom
    Tuberculosis (Edinb) 91:22-5. 2011

Collaborators

Detail Information

Publications14

  1. pmc Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK
    Science 324:387-9. 2009
    ..This finding firmly establishes the role of IFIH1 in T1D and demonstrates that resequencing studies can pinpoint disease-causing genes in genomic regions initially identified by GWASs...
  2. doi request reprint Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes
    Sarah F Field
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 57:1753-6. 2008
    ....
  3. pmc Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    John A Todd
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Nat Genet 39:857-64. 2007
    ..Several regions, including 18q22 and 18p11, showed association with autoimmune thyroid disease. This study increases the number of T1D loci with compelling evidence from six to at least ten...
  4. pmc Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK
    Nature 450:887-92. 2007
    ..Taken together with previous studies, we conclude that MHC-class-I-mediated events, principally involving HLA-B*39, contribute to the aetiology of type 1 diabetes...
  5. ncbi request reprint Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust DiabetesInflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, WT MRC building, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Diabetes 53:2709-12. 2004
    ..K. and found no evidence of association. Overall, our results indicate that common sequence variation in the VDR gene has no major effect in type 1 diabetes in the populations tested...
  6. pmc Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes
    Rebecca Bailey
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetes 56:2616-21. 2007
    ..Our aim was to study the association between the CYP27B1 and CYP24A1 gene polymorphisms and type 1 diabetes...
  7. ncbi request reprint No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility
    Rebecca Pask
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 2XY UK
    Diabetes Metab Res Rev 22:356-60. 2006
    ..Replication of association in independent, large-sample studies is essential to further identify the genes involved in T1D. Two single nucleotide polymorphisms (SNPs) in the catalase gene have been reported to be associated with T1D...
  8. pmc Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    BMC Genet 8:24. 2007
    ..Here, we studied sequence polymorphisms in 23 Mb on chromosome 10p12-q11, including the putative IDDM10 region, to identify genes associated with T1D...
  9. ncbi request reprint Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK
    Hum Mol Genet 13:1633-9. 2004
    ..Direct comparison indicates that the tag SNPs selected in one European population effectively predict the non-tag SNPs in the other Europeans, but not in the Gambians, for this region...
  10. pmc Association analysis of the LTA4H gene polymorphisms and pulmonary tuberculosis in 9115 subjects
    JAMES CURTIS
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom, Level 5, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom
    Tuberculosis (Edinb) 91:22-5. 2011
    ..49) and no association of the alleles of any of the six polymorphisms (P = 0.13-0.81). These results suggest that common polymorphisms in the LTA4H gene do not play any major role in susceptibility to clinical pulmonary tuberculosis...
  11. ncbi request reprint Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis
    Sergey Nejentsev
    Department of Virology, University of Turku, Finland
    Hum Immunol 64:345-9. 2003
    ..Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002)...
  12. pmc Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage
    Ivan Angulo
    Department of Medicine, University of Cambridge, Cambridge, UK
    Science 342:866-71. 2013
    ..Selective p110δ inhibitors IC87114 and GS-1101 reduced the activity of the mutant enzyme in vitro, which suggested a therapeutic approach for patients with APDS. ..
  13. ncbi request reprint Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis
    Jeffrey S Szeszko
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Department of Medical Genetics, University of Cambridge, WT MRC building, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Hum Genet 121:155-60. 2007
    ..Our results indicate that common polymorphisms of the SP110 gene have no major effect on susceptibility to tuberculosis in this population...
  14. ncbi request reprint Association of intercellular adhesion molecule-1 gene with type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, CB2 2XY, Cambridge, UK
    Lancet 362:1723-4. 2003
    ..91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments...