Research Topics
Genomes and Genes | D E NealSummaryAffiliation: University of Newcastle Country: UK Publications
| Collaborators
|
Detail Information
Publications
Prostate cancer: to screen or not to screen?D E Neal
School of Surgical Sciences, Medical School, University of Newcastle upon Tyne, UK
Lancet Oncol 1:17-24. 2000....- Unanswered questions in screening for prostate cancerD E Neal
School of Surgical Sciences, Medical School, University of NE2 4HH, Newcastle upon Tyne, UK
Eur J Cancer 36:1316-21. 2000..New treatments and early chemoprevention or dietary strategies will again shift the ground on which these arguments are being rehearsed. The most urgent evidence required concerns the effectiveness of treatment strategies... - Keratinocyte growth factor activates p38 MAPK to induce stress fibre formation in human prostate DU145 cellsP B Mehta
School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Oncogene 20:5359-65. 2001..As multiple FGFs are over-expressed in human prostate cancer, characterization of the distinct signalling pathway by FGFs may reveal new specific targets for therapy... - MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasionP B Mehta
Prostate Research Group, Department of Surgery, The Medical School, University of Newcastle upon Tyne, Framlington Place, UK
Oncogene 22:1381-9. 2003..Taken together, our results establish MEK5 as a key signalling molecule associated with prostate carcinogenesis. As the MEK5/ERK5 interaction is highly specific, it represents a potential target of therapy... 
Alterations in expression of the multidrug resistance-associated protein (MRP) gene in high-grade transitional cell carcinoma of the bladderS C Clifford
Cancer Research Unit, Medical School, University of Newcastle upon Tyne, UK
Br J Cancer 73:659-66. 1996....- Increased mdr1 gene transcript levels in high-grade carcinoma of the bladder determined by quantitative PCR-based assayS C Clifford
Cancer Research Unit, Medical School, University of Newcastle upon Tyne, UK
Br J Cancer 69:680-6. 1994.... - Cell adhesion molecules in bladder cancer: soluble serum E-cadherin correlates with predictors of recurrenceT R Griffiths
Department of Urology, Freeman Hospital, Newcastle upon Tyne, UK
Br J Cancer 74:579-84. 1996..077). Elevated levels of sE-cadherin are found in sera of patients with bladder cancer and correlate with known prognostic factors... - bcl-2 overexpression combined with p53 protein accumulation correlates with hormone-refractory prostate cancerI Apakama
University Urology Unit, Newcastle upon Tyne, UK
Br J Cancer 74:1258-62. 1996..By deregulating programmed cell death, alteration in these genes may prevent patients from responding to androgen ablation, or allow them to escape hormonal control of the disease... - Bone morphogenetic protein 6 in skeletal metastases from prostate cancer and other common human malignanciesP Autzen
School of Surgical Sciences, The Medical School, University of Newcastle upon Tyne, UK
Br J Cancer 78:1219-23. 1998..Our findings suggest that BMP-6 may hold potential as an attractive marker and possible mediator of skeletal metastases, particularly in prostate carcinoma... - Keratinocyte growth factor expression in hormone insensitive prostate cancerH Y Leung
Department of Surgery, The Medical School, University of Newcastle upon Tyne, UK
Oncogene 15:1115-20. 1997..Functional assessment of recombinant KGF in a proliferation assay demonstrated a mitogenic effect of up to 100% on cultured prostatic epithelial cells... - Identification and isolation of human prostate epithelial stem cells based on alpha(2)beta(1)-integrin expressionA T Collins
Prostate Research Group, Department of Surgery, The Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK
J Cell Sci 114:3865-72. 2001..These properties are consistent with a stem cell origin. Furthermore, the presence of surface integrins on prostate stem cells suggests that these cells share common pathways with stem cells in other tissues... - An open-label phase II study of low-dose thalidomide in androgen-independent prostate cancerM J Drake
Department of Surgery, School of Surgical Sciences, The Medical School, University of Newcastle upon Tyne, UK
Br J Cancer 88:822-7. 2003..The findings indicate that thalidomide may be an option for patients who have failed other forms of therapy, provided close follow-up is maintained for development of peripheral neuropathy... - Alterations of TP53 in microdissected transitional cell carcinoma of the human urinary bladder: high frequency of TP53 accumulation in the absence of detected mutations is associated with poor prognosisR Abdel Fattah
Cancer Research Unit, The Medical School, University of Newcastle upon Tyne, UK
Br J Cancer 77:2230-8. 1998.... - Nuclear accumulation of histone deacetylase 4 (HDAC4) coincides with the loss of androgen sensitivity in hormone refractory cancer of the prostateK Halkidou
School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
Eur Urol 45:382-9; author reply 389. 2004..e. LNCaP, CWR22) reflecting earlier phase disease. CONCLUSIONS: HDAC4 may contribute to the development of HR CaP and, therefore, constitute a potential therapeutic target, particularly in the most lethal phase of androgen independence... - Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancerV J Gnanapragasam
Prostate Research Group, School of Surgical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Br J Cancer 85:1928-36. 2001..03). We conclude that RAC 3 is an important co-activator of the AR in the prostate and may have an important role in the progression of prostate cancer... - Bladder cancer immunogenicity: expression of CD80 and CD86 is insufficient to allow primary CD4+ T cell activation in vitroS J Pettit
Department of Surgery, Medical School, University of Newcastle upon Tyne, UK
Clin Exp Immunol 116:48-56. 1999..This inhibitory effect was associated with increased cell death in the responding lymphocyte population and is concordant with surface expression of CD95L by the J82 cell line... - Neural network analysis of combined conventional and experimental prognostic markers in prostate cancer: a pilot studyR N Naguib
Department of Electrical and Electronic Engineering, University of Newcastle upon Tyne, UK
Br J Cancer 78:246-50. 1998..In addition, the potential for using this technology to evaluate novel markers is highlighted. Further large-scale analyses are required to incorporate this methodology into routine clinical practice... - Cyclin D1 expression in transitional cell carcinoma of the bladder: correlation with p53, waf1, pRb and Ki67V M Tut
Department of Surgery, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
Br J Cancer 84:270-5. 2001..In a multivariate analysis, cyclin D1 expression is an independent prognostic indicator of survival in those patients with muscle-invasive disease... - Distribution of lymphocytes of the alpha(E)beta(7) phenotype and E-cadherin in normal human urothelium and bladder carcinomasJ Cresswell
Department of Surgery, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
Clin Exp Immunol 126:397-402. 2001..Rather than infiltrating into carcinomas, these cells predominate in the surrounding stroma which could suggest a failure of immune function... - Transforming growth factor alpha and epidermal growth factor levels in bladder cancer and their relationship to epidermal growth factor receptorJ K Mellon
Department of Urology, Freeman Hospital, Newcastle upon Tyne, UK
Br J Cancer 73:654-8. 1996..These data suggest that TGF-alpha is the likely ligand for EGFR in bladder tumours... - Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladderC Wright
University Department of Pathology, Newcastle upon Tyne, UK
Br J Cancer 63:967-70. 1991..Alterations in the expression of p53, c-erbB-1 and c-erbB-2 were found frequently in human transitional cell carcinoma of the urinary bladder and may be of clinical use in defining patient sub-groups of differing prognosis... - Reducing mucus production after urinary reconstruction: a prospective randomized trialC N Robson
Departments of Surgery, Physiological Sciences and Statistics, University of Newcastle upon Tyne, Newcastle upon Tyne, England
J Urol 165:1433-40. 2001..CONCLUSIONS: The use of N-acetylcysteine, aspirin and ranitidine did not result in a reduction in mucin production, urine viscosity or improvement in quality of life... - Fibroblast growth factor receptor-2 mutation analysis in human prostate cancerP Mehta
School of Surgical Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
BJU Int 86:681-5. 2000..The human prostate cell lines, LNCaP, PC3, DU145, PNT1A and PNT1B were also examined. In addition, 10 foci of invasive cancer from three patients who underwent radical prostatectomy were also assessed... - Lower urinary tract symptoms and benign prostatic hyperplasiaA Skolarikos
Second Department of Urology, University of Athens, Sismanoglio Hospital, Athens, Greece
Minerva Urol Nefrol 56:109-22. 2004..We review the patho-physiology of the disease, and current approaches and management of this common problem... - Immunolocalization and messenger RNA expression of bone morphogenetic protein-6 in human benign and malignant prostatic tissueF C Hamdy
Department of Surgery, University of Newcastle, The Medical School, Newcastle upon Tyne, United Kingdom
Cancer Res 57:4427-31. 1997..BMP-6 may be responsible, in part, for the osteoblastic changes in metastatic lesions secondary to prostate cancer... - Correlation of vascular endothelial growth factor expression with fibroblast growth factor-8 expression and clinico-pathologic parameters in human prostate cancerA F West
Prostate Research Group, Department of Surgery, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
Br J Cancer 85:576-83. 2001..In conclusion, we report for the first time a correlation of both tumour and stromal VEGF expression in prostate cancer with clinical parameters as well as its correlation to FGF-8 expression... - Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancerT J Dudderidge
Department of Pathology and Royal Free and University College Medical School, University College London, Rockefeller Building, University Street, London, WC1E 6JJ, UK
Br J Cancer 96:1384-93. 2007.... - Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinomaM J Wallard
Department of Oncology, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
Br J Cancer 94:569-77. 2006..This work forms the basis for further functional studies, which will help to confirm the MMPs as potential diagnostic and therapeutic targets in early bladder cancer... - Prostate cancer: screening approachesJ L Donovan
Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR
Br J Hosp Med (Lond) 66:623-6. 2005..Current evidence about the impact and natural history of prostate cancer, screening and diagnostic tests, and the effectiveness of treatments is reviewed below... - Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancerI Sigalas
Cancer Research Unit, The Medical School, University of Newcastle upon Tyne, Framlington Place, UK
Nat Med 2:912-7. 1996..These observations suggest a reassessment of the transforming mechanisms of mdm2 and its relation to p53... - Treatment of carcinoma in situ with intravesical bacillus Calmette-Guerin without maintenanceT R L Griffiths
University Urology Unit, Freeman Hospital, Newcastle upon Tyne, United Kingdom
J Urol 167:2408-12. 2002..Better outcomes in each of the 3 groups may have occurred with maintenance BCG... - Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged menD Gunnell
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, UK
Br J Cancer 88:1682-6. 2003..These patterns support the possibility that IGFs may mediate some diet-cancer associations... - Prognostic significance of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in voided urine samples from patients with transitional cell carcinoma of the bladderG C Durkan
Department of Surgery, Cancer Research Unit, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
Clin Cancer Res 7:3450-6. 2001..To study the role of urinary matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in bladder cancer and their relationship to tumor progression... - Recent trends in the use of radical prostatectomy in England: the epidemiology of diffusionS E Oliver
Department of Health Sciences, University of York, York, UK
BJU Int 91:331-6; discussion 336. 2003.... - MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3K Saeb-Parsy
Department of Uro Oncology, CRUK Cambridge Research Institute, Cambridge CB2 0RE, UK
Br J Cancer 99:663-9. 2008..We show for the first time that the effects of MT1-MMP on cell invasion are mediated in part through changes in DKK3 gene transcription...