Navarro P, Moffat M, Mullin N, Chambers I. The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells. Hum Genet. 2011;130:255-64 pubmed publisher
..We conclude that in mouse ES cells the pluripotency-associated machinery exerts an exhaustive control of X-inactivation by taking over the regulation of all three major regulators of X-inactivation: Xist, Tsix, and Rnf12. ..
Navarro P, Festuccia N, Colby D, Gagliardi A, Mullin N, Zhang W, et al. OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells. EMBO J. 2012;31:4547-62 pubmed publisher
..Therefore, cellular variability in self-renewal efficiency is an emergent property of the pluripotency gene regulatory network. ..
Navarro P, Oldfield A, Legoupi J, Festuccia N, Dubois A, Attia M, et al. Molecular coupling of Tsix regulation and pluripotency. Nature. 2010;468:457-60 pubmed publisher
..The holistic pattern of Xist/Tsix regulation by pluripotent factors that we have identified suggests a general direct governance of complex epigenetic processes by the machinery dedicated to pluripotency. ..