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Genomes and Genes | Lubna NasirSummaryAffiliation: University of Glasgow Country: UK Publications
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Publications
Papillomavirus E5: the smallest oncoprotein with many functionsAldo Venuti
Department of Pathology and Animal Health, University of Naples Federico II, Naples, Italy
Mol Cancer 10:140. 2011..This review will highlight the differences between HPV-16 E5 (16E5) and E5 from other PVs, primarily from BPV. It will discuss the targeting of E5 as a possible therapeutic agent...
Telomeres and telomerase: Biological and clinical importance in dogsLubna Nasir
Institute of Comparative Medicine, University of Glasgow, Faculty of Veterinary Medicine, Bearsden Road, Glasgow G61 1QH, UK
Vet J 175:155-63. 2008....- Identification and functional analysis of sequence variants in the long control region and the E2 open reading frame of bovine papillomavirus type 1 isolated from equine sarcoidsL Nasir
Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow Faculty of Veterinary Medicine, Bearsden Road, Glasgow, Scotland, UK
Virology 364:355-61. 2007..These data suggest the viral BPV variants commonly detected in sarcoids have an enhanced function in equine cells compared to their function in bovine cells... - Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT)Lubna Nasir
Department Veterinary Clinical Studies, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, UK
Gene 336:105-13. 2004..This data will allow for further investigation of telomerase in canine malignancies as well as the development of the dog as a model system for human telomerase investigations... - Bovine papillomaviruses: their role in the aetiology of cutaneous tumours of bovids and equidsLubna Nasir
Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow, Garscube Estate, Glasgow G61 1QH
Vet Dermatol 19:243-54. 2008..Only limited information on the clinical or pathological aspects of either bovine or equine tumours will be provided as this subject has been extensively addressed previously... 
Small interfering RNA targeting bovine papillomavirus type 1 E2 induces apoptosis in equine sarcoid transformed fibroblastsPhilipe A M Gobeil
Institute of Comparative Medicine, University of Glasgow Faculty of Veterinary Medicine, Garscube Campus, Scotland, UK
Virus Res 145:162-5. 2009..siRNA treated cells showed significantly higher apoptosis rates than control cells. Thus sequence specific targeting of E2 provides a powerful strategy to eliminate BPV-1 genomes and induce cell death in BPV-1 transformed cells...- Equine sarcoid fibroblasts over-express matrix metalloproteinases and are invasiveZhengqiang Yuan
Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
Virology 396:143-51. 2010..This demonstrates that BPV-1 induces over-expression of MMPs contributing to invasiveness of sarcoid fibroblasts. Inhibition of E2 by siRNA leads to abrogation of invasion suggesting that E2 is a good target for sarcoid treatment... - Bovine papillomavirus infection in equine sarcoids and in bovine bladder cancersZhengqiang Yuan
Division of Pathological Sciences, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK
Vet J 174:599-604. 2007..The BPV-1 E5 ORF showed sequence variation but BPV-2 ORF did not. The presence of BPV-1 E5 variations or their absence in the BPV-2 E5 ORF does not appear to have an effect on viral DNA load in either tumour type... - p38 mitogen-activated protein kinase is crucial for bovine papillomavirus type-1 transformation of equine fibroblastsZhengqiang Yuan
College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK
J Gen Virol 92:1778-86. 2011..These findings provide new insights into the pathogenesis of equine sarcoids and suggest that p38 could be a potential target for equine sarcoid therapy... - Detection of bovine papillomavirus type 1 genomes and viral gene expression in equine inflammatory skin conditionsZhengqiang Yuan
Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, UK
Virus Res 124:245-9. 2007..We conclude that some cases of equine dermatitis are associated with the presence of circular, episomally maintained BPV-1 genomes that express viral transcripts... - Bovine papillomavirus type 1 oncoprotein E5 inhibits equine MHC class I and interacts with equine MHC I heavy chainBarbara Marchetti
Institute of Comparative Medicine, University of Glasgow, Glasgow G61 1QH, Scotland, UK
J Gen Virol 90:2865-70. 2009..We conclude that, as in bovine cells and tumours, E5 is a player in the transformation of equine cells and the induction of sarcoids, and a potential major cause of MHC I downregulation and hence poor immune clearance of tumour cells... - Telomere dynamics rather than age predict life expectancy in the wildPierre Bize
Division of Ecology and Evolutionary Biology, University of Glasgow, Glasgow G12 8QQ, UK
Proc Biol Sci 276:1679-83. 2009.... - The detection of Bovine Papillomavirus type 1 DNA in fliesMargaret Finlay
Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK
Virus Res 144:315-7. 2009..Sequence analysis of the BPV-1 LCR from flies indicates that flies harbour BPV-1 LCR sequence variants II and IV which are commonly detected in equine sarcoids. These data suggest that flies may be able to transmit BPV-1 between equids... - A novel two-step transcriptional activation system for gene therapy directed toward epithelial cellsMaja L Arendt
Institute of Comparative Medicine, Division of Pathological Sciences, University of Glasgow Faculty of Veterinary Medicine, Bearsden Road, Glasgow G61 1QH, United Kingdom
Mol Cancer Ther 8:3244-54. 2009..We propose that our new system should be considered in future TSTA, particularly when targeting epithelial-derived cells... - Expression of cell cycle associated proteins cyclin A, CDK-2, p27kip1 and p53 in equine sarcoidsColin Nixon
Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, UK
Cancer Lett 221:237-45. 2005..Our analysis of p53 shows that a subset of sarcoids are associated with abnormal cytoplasmic and nuclear expression of p53 and that the transactivation function of p53 is compromised in cells with cytoplasmic p53... - Upregulation of equine matrix metalloproteinase 1 by bovine papillomavirus type 1 is through the transcription factor activator protein-1Zhengqiang Yuan
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK
J Gen Virol 92:2608-19. 2011..These findings shed light on the mechanism of BPV-1-mediated equine fibroblast infiltration and indicate that both BPV-1 oncoproteins and AP-1 could be potential targets for equine sarcoid therapy... - Different contribution of bovine papillomavirus type 1 oncoproteins to the transformation of equine fibroblastsZhengqiang Yuan
School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK
J Gen Virol 92:773-83. 2011..Together, these observations strongly suggest that BPV-1 proteins play indispensable roles in the transformation of equine fibroblasts. These data also suggest that BPV-1 proteins are potential drug targets for equine sarcoid therapy... - The cloning and functional analysis of canine matrix metalloproteinase-13 gene promoterSarah E Campbell
Molecular Therapeutics Research Group, Department of Clinical Studies, Faculty of Veterinary Medicine, Department of Clinical Studies, University of Glasgow, Glasgow, UK
Gene 286:233-40. 2002..The canine MMP-13 promoter activity has also been compared to the basal and induced activity of the canine MMP-9, gelatinase B promoter in these cell types... - Human telomerase reverse transcriptase (hTERT) extends the lifespan of canine chondrocytes in vitro without inducing neoplastic transformationIain P Nicholson
Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Garscube Estate, Bearsden Road, Glasgow, UK G61 1QH, UK
Vet J 174:570-6. 2007..This suggests that hTERT may represent a tool for the generation of tissue engineered chondrocytes suitable for autologous re-implantation into the affected areas of osteoarthritic joints... - Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERalpha and p53Joanna S Morris
Division of Pathological Sciences, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
Vet J 175:218-26. 2008..TopBP1 is expressed in feline mammary tumours and its expression is correlated with histological grade. Many neoplasms which over-express p53 or are ERalpha negative show TopBP1 immunoreactivity... - A cohort study of telomere and telomerase biology in catsTom P McKevitt
Institute of Comparative Medicine, Department of Veterinary Clinical Studies, Glasgow University Veterinary School, Glasgow University, Glasgow, UK G61 1QH
Am J Vet Res 64:1496-9. 2003..Hence, as well as developing our understanding of aging in cats, these data may be usefully extrapolated to aging in humans... - Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53Margaret Finlay
MRC University of Glasgow Centre for Virus Research, Institute of Infection, Inflammation and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow, Scotland, G61 1QH, United Kingdom
Vet Res 43:81. 2012..Furthermore we show that BPV-1 increases p53 expression in sarcoid cell lines and p53 expression can be either nuclear or cytoplasmic. The mechanism and clinical significance of increase/abnormal p53 expression remains to be established... - Telomere loss in relation to age and early environment in long-lived birdsMargaret E Hall
Environmental and Evolutionary Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
Proc Biol Sci 271:1571-6. 2004..Early conditions, possibly through their effects on oxidative stress, appear to play an important role in telomere attrition and thus potentially in the longevity of individuals... - Evaluation of student attitudes to cooperative learning in undergraduate veterinary medicineVicki H M Dale
Educational Technologist at the Faculty of Veterinary Medicine, University of Glasgow, Glasgow, G61 1QH, UK
J Vet Med Educ 32:511-6. 2005..An evaluation was carried out as a basis for optimizing subsequent CL activities in the undergraduate course... - Exploring student attitudes to directed self-learning online through evaluation of an Internet-based biomolecular sciences resourceVicki H M Dale
Faculty of Veterinary Medicine, University of Glasgow, Glasgow, G61 1QH, UK
J Vet Med Educ 32:129-37. 2005..Evaluations were carried out to gauge students' experiences of using the resource as a basis for exploring students' attitudes toward online, independent learning... - Telomere lengths in dogs decrease with increasing donor ageTom P McKevitt
Department of Small Animal Clinical Studies, University of Glasgow Veterinary School, Glasgow, UK
J Nutr 132:1604S-6S. 2002..006). These results warrant further investigation of possible interbreed differences, given that shorter telomeres may contribute to differing life expectancy between breeds... - Early nutrition and phenotypic development: 'catch-up' growth leads to elevated metabolic rate in adulthoodFrancois Criscuolo
Ornithology Group, Division of Environmental and Evolutionary Biology, Institute of Biomedical and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow G12 8QQ, UK
Proc Biol Sci 275:1565-70. 2008..It suggests that modification of metabolic efficiency may be one of the mechanisms mediating the observed long-term costs of accelerated growth, and indicates links between early nutrition and the metabolic syndrome...