Lubna Nasir

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. pmc Papillomavirus E5: the smallest oncoprotein with many functions
    Aldo Venuti
    Department of Pathology and Animal Health, University of Naples Federico II, Naples, Italy
    Mol Cancer 10:140. 2011
  2. ncbi request reprint Bovine papillomaviruses: their role in the aetiology of cutaneous tumours of bovids and equids
    Lubna Nasir
    Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow, Garscube Estate, Glasgow G61 1QH
    Vet Dermatol 19:243-54. 2008
  3. ncbi request reprint Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT)
    Lubna Nasir
    Department Veterinary Clinical Studies, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Gene 336:105-13. 2004
  4. ncbi request reprint Identification and functional analysis of sequence variants in the long control region and the E2 open reading frame of bovine papillomavirus type 1 isolated from equine sarcoids
    L Nasir
    Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow Faculty of Veterinary Medicine, Bearsden Road, Glasgow, Scotland, UK
    Virology 364:355-61. 2007
  5. ncbi request reprint Telomeres and telomerase: Biological and clinical importance in dogs
    Lubna Nasir
    Institute of Comparative Medicine, University of Glasgow, Faculty of Veterinary Medicine, Bearsden Road, Glasgow G61 1QH, UK
    Vet J 175:155-63. 2008
  6. doi request reprint Small interfering RNA targeting bovine papillomavirus type 1 E2 induces apoptosis in equine sarcoid transformed fibroblasts
    Philipe A M Gobeil
    Institute of Comparative Medicine, University of Glasgow Faculty of Veterinary Medicine, Garscube Campus, Scotland, UK
    Virus Res 145:162-5. 2009
  7. doi request reprint Equine sarcoid fibroblasts over-express matrix metalloproteinases and are invasive
    Zhengqiang Yuan
    Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
    Virology 396:143-51. 2010
  8. ncbi request reprint Bovine papillomavirus infection in equine sarcoids and in bovine bladder cancers
    Zhengqiang Yuan
    Division of Pathological Sciences, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Vet J 174:599-604. 2007
  9. pmc Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53
    Margaret Finlay
    MRC University of Glasgow Centre for Virus Research, Institute of Infection, Inflammation and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow, Scotland, G61 1QH, United Kingdom
    Vet Res 43:81. 2012
  10. ncbi request reprint Detection of bovine papillomavirus type 1 genomes and viral gene expression in equine inflammatory skin conditions
    Zhengqiang Yuan
    Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Virus Res 124:245-9. 2007

Collaborators

Detail Information

Publications28

  1. pmc Papillomavirus E5: the smallest oncoprotein with many functions
    Aldo Venuti
    Department of Pathology and Animal Health, University of Naples Federico II, Naples, Italy
    Mol Cancer 10:140. 2011
    ..This review will highlight the differences between HPV-16 E5 (16E5) and E5 from other PVs, primarily from BPV. It will discuss the targeting of E5 as a possible therapeutic agent...
  2. ncbi request reprint Bovine papillomaviruses: their role in the aetiology of cutaneous tumours of bovids and equids
    Lubna Nasir
    Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow, Garscube Estate, Glasgow G61 1QH
    Vet Dermatol 19:243-54. 2008
    ..Only limited information on the clinical or pathological aspects of either bovine or equine tumours will be provided as this subject has been extensively addressed previously...
  3. ncbi request reprint Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT)
    Lubna Nasir
    Department Veterinary Clinical Studies, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Gene 336:105-13. 2004
    ..This data will allow for further investigation of telomerase in canine malignancies as well as the development of the dog as a model system for human telomerase investigations...
  4. ncbi request reprint Identification and functional analysis of sequence variants in the long control region and the E2 open reading frame of bovine papillomavirus type 1 isolated from equine sarcoids
    L Nasir
    Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow Faculty of Veterinary Medicine, Bearsden Road, Glasgow, Scotland, UK
    Virology 364:355-61. 2007
    ..These data suggest the viral BPV variants commonly detected in sarcoids have an enhanced function in equine cells compared to their function in bovine cells...
  5. ncbi request reprint Telomeres and telomerase: Biological and clinical importance in dogs
    Lubna Nasir
    Institute of Comparative Medicine, University of Glasgow, Faculty of Veterinary Medicine, Bearsden Road, Glasgow G61 1QH, UK
    Vet J 175:155-63. 2008
    ....
  6. doi request reprint Small interfering RNA targeting bovine papillomavirus type 1 E2 induces apoptosis in equine sarcoid transformed fibroblasts
    Philipe A M Gobeil
    Institute of Comparative Medicine, University of Glasgow Faculty of Veterinary Medicine, Garscube Campus, Scotland, UK
    Virus Res 145:162-5. 2009
    ..siRNA treated cells showed significantly higher apoptosis rates than control cells. Thus sequence specific targeting of E2 provides a powerful strategy to eliminate BPV-1 genomes and induce cell death in BPV-1 transformed cells...
  7. doi request reprint Equine sarcoid fibroblasts over-express matrix metalloproteinases and are invasive
    Zhengqiang Yuan
    Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
    Virology 396:143-51. 2010
    ..This demonstrates that BPV-1 induces over-expression of MMPs contributing to invasiveness of sarcoid fibroblasts. Inhibition of E2 by siRNA leads to abrogation of invasion suggesting that E2 is a good target for sarcoid treatment...
  8. ncbi request reprint Bovine papillomavirus infection in equine sarcoids and in bovine bladder cancers
    Zhengqiang Yuan
    Division of Pathological Sciences, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Vet J 174:599-604. 2007
    ..The BPV-1 E5 ORF showed sequence variation but BPV-2 ORF did not. The presence of BPV-1 E5 variations or their absence in the BPV-2 E5 ORF does not appear to have an effect on viral DNA load in either tumour type...
  9. pmc Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53
    Margaret Finlay
    MRC University of Glasgow Centre for Virus Research, Institute of Infection, Inflammation and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow, Scotland, G61 1QH, United Kingdom
    Vet Res 43:81. 2012
    ..Furthermore we show that BPV-1 increases p53 expression in sarcoid cell lines and p53 expression can be either nuclear or cytoplasmic. The mechanism and clinical significance of increase/abnormal p53 expression remains to be established...
  10. ncbi request reprint Detection of bovine papillomavirus type 1 genomes and viral gene expression in equine inflammatory skin conditions
    Zhengqiang Yuan
    Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Virus Res 124:245-9. 2007
    ..We conclude that some cases of equine dermatitis are associated with the presence of circular, episomally maintained BPV-1 genomes that express viral transcripts...
  11. doi request reprint p38 mitogen-activated protein kinase is crucial for bovine papillomavirus type-1 transformation of equine fibroblasts
    Zhengqiang Yuan
    College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G61 1QH, UK
    J Gen Virol 92:1778-86. 2011
    ..These findings provide new insights into the pathogenesis of equine sarcoids and suggest that p38 could be a potential target for equine sarcoid therapy...
  12. doi request reprint The detection of Bovine Papillomavirus type 1 DNA in flies
    Margaret Finlay
    Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Virus Res 144:315-7. 2009
    ..Sequence analysis of the BPV-1 LCR from flies indicates that flies harbour BPV-1 LCR sequence variants II and IV which are commonly detected in equine sarcoids. These data suggest that flies may be able to transmit BPV-1 between equids...
  13. doi request reprint A novel two-step transcriptional activation system for gene therapy directed toward epithelial cells
    Maja L Arendt
    Institute of Comparative Medicine, Division of Pathological Sciences, University of Glasgow Faculty of Veterinary Medicine, Bearsden Road, Glasgow G61 1QH, United Kingdom
    Mol Cancer Ther 8:3244-54. 2009
    ..We propose that our new system should be considered in future TSTA, particularly when targeting epithelial-derived cells...
  14. ncbi request reprint Expression of cell cycle associated proteins cyclin A, CDK-2, p27kip1 and p53 in equine sarcoids
    Colin Nixon
    Division of Pathological Sciences, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Cancer Lett 221:237-45. 2005
    ..Our analysis of p53 shows that a subset of sarcoids are associated with abnormal cytoplasmic and nuclear expression of p53 and that the transactivation function of p53 is compromised in cells with cytoplasmic p53...
  15. pmc Telomere dynamics rather than age predict life expectancy in the wild
    Pierre Bize
    Division of Ecology and Evolutionary Biology, University of Glasgow, Glasgow G12 8QQ, UK
    Proc Biol Sci 276:1679-83. 2009
    ....
  16. doi request reprint Bovine papillomavirus type 1 oncoprotein E5 inhibits equine MHC class I and interacts with equine MHC I heavy chain
    Barbara Marchetti
    Institute of Comparative Medicine, University of Glasgow, Glasgow G61 1QH, Scotland, UK
    J Gen Virol 90:2865-70. 2009
    ..We conclude that, as in bovine cells and tumours, E5 is a player in the transformation of equine cells and the induction of sarcoids, and a potential major cause of MHC I downregulation and hence poor immune clearance of tumour cells...
  17. ncbi request reprint Papillomavirus associated diseases of the horse
    Lubna Nasir
    MRC University of Glasgow Centre for Virus Research, College of Medical, Veterinary and Life Sciences, Garscube Estate, Bearsden Road, Glasgow G61 1QH, Scotland, UK Electronic address
    Vet Microbiol 167:159-67. 2013
    ..We then discuss the role of BPV types 1 and 2 in the pathogenesis of equine sarcoids and present recent evidence implicating a novel equine papillomavirus (EcPV-2) in the pathogenesis of equine genital cancers. ..
  18. doi request reprint Upregulation of equine matrix metalloproteinase 1 by bovine papillomavirus type 1 is through the transcription factor activator protein-1
    Zhengqiang Yuan
    Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK
    J Gen Virol 92:2608-19. 2011
    ..These findings shed light on the mechanism of BPV-1-mediated equine fibroblast infiltration and indicate that both BPV-1 oncoproteins and AP-1 could be potential targets for equine sarcoid therapy...
  19. doi request reprint Different contribution of bovine papillomavirus type 1 oncoproteins to the transformation of equine fibroblasts
    Zhengqiang Yuan
    School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK
    J Gen Virol 92:773-83. 2011
    ..Together, these observations strongly suggest that BPV-1 proteins play indispensable roles in the transformation of equine fibroblasts. These data also suggest that BPV-1 proteins are potential drug targets for equine sarcoid therapy...
  20. ncbi request reprint The cloning and functional analysis of canine matrix metalloproteinase-13 gene promoter
    Sarah E Campbell
    Molecular Therapeutics Research Group, Department of Clinical Studies, Faculty of Veterinary Medicine, Department of Clinical Studies, University of Glasgow, Glasgow, UK
    Gene 286:233-40. 2002
    ..The canine MMP-13 promoter activity has also been compared to the basal and induced activity of the canine MMP-9, gelatinase B promoter in these cell types...
  21. ncbi request reprint Human telomerase reverse transcriptase (hTERT) extends the lifespan of canine chondrocytes in vitro without inducing neoplastic transformation
    Iain P Nicholson
    Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Garscube Estate, Bearsden Road, Glasgow, UK G61 1QH, UK
    Vet J 174:570-6. 2007
    ..This suggests that hTERT may represent a tool for the generation of tissue engineered chondrocytes suitable for autologous re-implantation into the affected areas of osteoarthritic joints...
  22. ncbi request reprint Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERalpha and p53
    Joanna S Morris
    Division of Pathological Sciences, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
    Vet J 175:218-26. 2008
    ..TopBP1 is expressed in feline mammary tumours and its expression is correlated with histological grade. Many neoplasms which over-express p53 or are ERalpha negative show TopBP1 immunoreactivity...
  23. ncbi request reprint A cohort study of telomere and telomerase biology in cats
    Tom P McKevitt
    Institute of Comparative Medicine, Department of Veterinary Clinical Studies, Glasgow University Veterinary School, Glasgow University, Glasgow, UK G61 1QH
    Am J Vet Res 64:1496-9. 2003
    ..To investigate telomere lengths in tissues of domestic shorthair (DSH) cats of various ages, evaluate the relationship between telomere length and age of cats, and investigate telomerase activity in the somatic tissues of cats...
  24. pmc Telomere loss in relation to age and early environment in long-lived birds
    Margaret E Hall
    Environmental and Evolutionary Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Proc Biol Sci 271:1571-6. 2004
    ..Early conditions, possibly through their effects on oxidative stress, appear to play an important role in telomere attrition and thus potentially in the longevity of individuals...
  25. ncbi request reprint Evaluation of student attitudes to cooperative learning in undergraduate veterinary medicine
    Vicki H M Dale
    Educational Technologist at the Faculty of Veterinary Medicine, University of Glasgow, Glasgow, G61 1QH, UK
    J Vet Med Educ 32:511-6. 2005
    ..An evaluation was carried out as a basis for optimizing subsequent CL activities in the undergraduate course...
  26. ncbi request reprint Exploring student attitudes to directed self-learning online through evaluation of an Internet-based biomolecular sciences resource
    Vicki H M Dale
    Faculty of Veterinary Medicine, University of Glasgow, Glasgow, G61 1QH, UK
    J Vet Med Educ 32:129-37. 2005
    ..Evaluations were carried out to gauge students' experiences of using the resource as a basis for exploring students' attitudes toward online, independent learning...
  27. ncbi request reprint Telomere lengths in dogs decrease with increasing donor age
    Tom P McKevitt
    Department of Small Animal Clinical Studies, University of Glasgow Veterinary School, Glasgow, UK
    J Nutr 132:1604S-6S. 2002
    ..006). These results warrant further investigation of possible interbreed differences, given that shorter telomeres may contribute to differing life expectancy between breeds...
  28. pmc Early nutrition and phenotypic development: 'catch-up' growth leads to elevated metabolic rate in adulthood
    Francois Criscuolo
    Ornithology Group, Division of Environmental and Evolutionary Biology, Institute of Biomedical and Life Sciences, Graham Kerr Building, University of Glasgow, Glasgow G12 8QQ, UK
    Proc Biol Sci 275:1565-70. 2008
    ..It suggests that modification of metabolic efficiency may be one of the mechanisms mediating the observed long-term costs of accelerated growth, and indicates links between early nutrition and the metabolic syndrome...