Khalid M Naseem

Summary

Affiliation: University of Bradford
Country: UK

Publications

  1. ncbi request reprint The nitration of platelet cytosolic proteins during agonist-induced activation of platelets
    K M Naseem
    Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
    FEBS Lett 473:119-22. 2000
  2. ncbi request reprint The nitration of proteins in platelets: significance in platelet function
    Mojhgan Sabetkar
    Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School, University College London, London, UK
    Free Radic Biol Med 33:728-36. 2002
  3. ncbi request reprint Regulation of platelet guanylyl cyclase by collagen: evidence that Glycoprotein VI mediates platelet nitric oxide synthesis in response to collagen
    Rocio Riba
    Department of Biomedical Sciences, University of Bradford, UK
    Thromb Haemost 94:395-403. 2005
  4. ncbi request reprint Unresolved roles of platelet nitric oxide synthase
    K M Naseem
    Medical Biosciences, University of Bradford, Bradford, West Yorkshire, UK
    J Thromb Haemost 6:10-9. 2008
  5. ncbi request reprint The role of nitric oxide in cardiovascular diseases
    Khalid M Naseem
    Department of Biomedical Sciences, University of Bradford, Great Horton Road, Bradford BD7 1DP, United Kingdom
    Mol Aspects Med 26:33-65. 2005
  6. ncbi request reprint cGMP-independent inhibition of integrin alphaIIbbeta3-mediated platelet adhesion and outside-in signalling by nitric oxide
    Nikolaus G Oberprieler
    Centre for Atherothrombosis Research, Department of Medical Biosciences, University of Bradford, Richmond Building, Richmond Road, Bradford, West Yorkshire BD7 1DP, UK
    FEBS Lett 581:1529-34. 2007
  7. doi request reprint Nitric oxide inhibits platelet adhesion to collagen through cGMP-dependent and independent mechanisms: the potential role for S-nitrosylation
    Catherine Irwin
    Centre for Atherothrombosis Research, University of Bradford, Bradford, UK
    Platelets 20:478-86. 2009
  8. ncbi request reprint Inhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: evidence for cGMP-independent mechanisms
    Nikolaus G Oberprieler
    Department of Medical Biosciences, University of Bradford, Richmond Building, Richmond Road, Bradford, West Yorkshire, UK
    Biochem Pharmacol 73:1593-601. 2007
  9. ncbi request reprint Evaluation of nitrotyrosine-containing proteins in blood platelets
    Khalid M Naseem
    Department of Biomedical Sciences, University of Bradford, UK
    Methods Mol Biol 273:301-12. 2004
  10. ncbi request reprint Sodium orthovanadate induced tyrosine phosphorylation of platelet nitric oxide synthase negatively regulates enzyme activity
    Andrew D Milward
    Department of Medical Biosciences, University of Bradford, Great Horton Road, Bradford, UK
    Biochim Biophys Acta 1760:1411-7. 2006

Collaborators

  • Richard W Farndale
  • S Y Low
  • K Richard Bruckdorfer
  • Anna Nicolaou
  • Rocio Riba
  • Nikolaus G Oberprieler
  • Mojhgan Sabetkar
  • Wayne Roberts
  • Shervanthi Homer-Vanniasinkam
  • Catherine Irwin
  • Maqsood M Elahi
  • Richard S Young
  • Anne M Graham
  • Andrew D Milward
  • K Richard Bruckdorfer
  • Michael Jacobs
  • Nickolas J Bradley
  • Sasithara Ahilathirunayagam
  • Ram P C Chaparala
  • Shanker Pasupathy
  • Bashir M Matata
  • Bilal Patel
  • Marzieh Sharifi
  • Max Troxler
  • Shervanthi Homer-Vaniasinkam

Detail Information

Publications15

  1. ncbi request reprint The nitration of platelet cytosolic proteins during agonist-induced activation of platelets
    K M Naseem
    Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
    FEBS Lett 473:119-22. 2000
    ..The nitration was mimicked by addition of peroxynitrite to unstimulated platelets, although the level of nitrotyrosine formation was greater and its distribution among the proteins was less specific...
  2. ncbi request reprint The nitration of proteins in platelets: significance in platelet function
    Mojhgan Sabetkar
    Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School, University College London, London, UK
    Free Radic Biol Med 33:728-36. 2002
    ..Furthermore, this nitration appears to be transient. The implications of these findings are discussed in terms of platelet biology and cell signaling processes...
  3. ncbi request reprint Regulation of platelet guanylyl cyclase by collagen: evidence that Glycoprotein VI mediates platelet nitric oxide synthesis in response to collagen
    Rocio Riba
    Department of Biomedical Sciences, University of Bradford, UK
    Thromb Haemost 94:395-403. 2005
    ....
  4. ncbi request reprint Unresolved roles of platelet nitric oxide synthase
    K M Naseem
    Medical Biosciences, University of Bradford, Bradford, West Yorkshire, UK
    J Thromb Haemost 6:10-9. 2008
    ..In the present article, we discuss the current understanding of the biochemical and molecular regulation of platelet NO synthesis and outline the potential physiological and clinical significance of this molecule...
  5. ncbi request reprint The role of nitric oxide in cardiovascular diseases
    Khalid M Naseem
    Department of Biomedical Sciences, University of Bradford, Great Horton Road, Bradford BD7 1DP, United Kingdom
    Mol Aspects Med 26:33-65. 2005
    ..In this chapter the cellular and biochemical mechanisms leading to reduced NO bioavailability are discussed and evidence for the prevalence of these mechanisms in cardiovascular disease evaluated...
  6. ncbi request reprint cGMP-independent inhibition of integrin alphaIIbbeta3-mediated platelet adhesion and outside-in signalling by nitric oxide
    Nikolaus G Oberprieler
    Centre for Atherothrombosis Research, Department of Medical Biosciences, University of Bradford, Richmond Building, Richmond Road, Bradford, West Yorkshire BD7 1DP, UK
    FEBS Lett 581:1529-34. 2007
    ..Similar results were observed in suspended platelets indicating that NO-induced effects were independent of spreading-induced signalling. This is the first demonstration that NO directly regulates integrin beta(3) phosphorylation...
  7. doi request reprint Nitric oxide inhibits platelet adhesion to collagen through cGMP-dependent and independent mechanisms: the potential role for S-nitrosylation
    Catherine Irwin
    Centre for Atherothrombosis Research, University of Bradford, Bradford, UK
    Platelets 20:478-86. 2009
    ..Our data demonstrate that S-nitrosylation of platelet proteins in response to exogenous NO may act as a potentially important cGMP-independent signaling mechanism for controlling platelet adhesion...
  8. ncbi request reprint Inhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: evidence for cGMP-independent mechanisms
    Nikolaus G Oberprieler
    Department of Medical Biosciences, University of Bradford, Richmond Building, Richmond Road, Bradford, West Yorkshire, UK
    Biochem Pharmacol 73:1593-601. 2007
    ..Thus, we demonstrate that NO inhibits alpha(IIb)beta(3)-mediated adhesion, by targeting both Ca(2+) and PI3kinase pathways in a cGMP-independent manner...
  9. ncbi request reprint Evaluation of nitrotyrosine-containing proteins in blood platelets
    Khalid M Naseem
    Department of Biomedical Sciences, University of Bradford, UK
    Methods Mol Biol 273:301-12. 2004
  10. ncbi request reprint Sodium orthovanadate induced tyrosine phosphorylation of platelet nitric oxide synthase negatively regulates enzyme activity
    Andrew D Milward
    Department of Medical Biosciences, University of Bradford, Great Horton Road, Bradford, UK
    Biochim Biophys Acta 1760:1411-7. 2006
    ..Our data indicate that tyrosine phosphorylation may act to repress NOS activity. Furthermore, VO4 induces a Src-dependent, and to a lesser degree PKC-dependent, inhibition of platelet NOS...
  11. ncbi request reprint Altered platelet reactivity in peripheral vascular disease complicated with elevated plasma homocysteine levels
    Rocio Riba
    Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
    Atherosclerosis 175:69-75. 2004
    ..The overall effect would be an increased propensity for platelet activation. The presence of even mildly elevated plasma Hcy could dramatically increase thrombotic risk...
  12. ncbi request reprint Nitric oxide in blood. The nitrosative-oxidative disequilibrium hypothesis on the pathogenesis of cardiovascular disease
    Maqsood M Elahi
    The Cardiothoracic Centre, Liverpool NHS Trust, UK
    FEBS J 274:906-23. 2007
    ..In this review, we highlight the possible roles of altered production and/or spatio-temporal distribution of reactive oxidant species and reactive nitrosative species in blood on the pathogenesis of the failing cardiovascular system...
  13. ncbi request reprint The role of protein nitration in the inhibition of platelet activation by peroxynitrite
    Sylvia Y Low
    Departments of Biochemistry and Molecular Biology, Royal Free and University College Medical School University College London, London, UK
    FEBS Lett 511:59-64. 2002
    ..We suggest that low concentrations of peroxynitrite reversibly inhibit platelet aggregation by preventing the phosphorylation of key signalling proteins...
  14. doi request reprint The nitration of platelet vasodilator stimulated phosphoprotein following exposure to low concentrations of hydrogen peroxide
    Mojhgan Sabetkar
    Hampstead Campus University College London, London NW32PF, UK
    Platelets 19:282-92. 2008
    ....
  15. ncbi request reprint Platelet membrane CD154 and sCD154 in progressive peripheral arterial disease: a pilot study
    Richard S Young
    University of Leeds Medical School, UK
    Atherosclerosis 190:452-8. 2007
    ..The expression and potential role of platelet membrane CD154 and sCD154 in atherosclerosis was investigated in patients with peripheral arterial disease...