A G Murzin

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Structural classification of proteins: new superfamilies
    A G Murzin
    Centre for Protein Engineering, Medical Research Council Centre, Cambridge, UK
    Curr Opin Struct Biol 6:386-94. 1996
  2. ncbi request reprint Biochemistry. DNA building block reinvented
    Alexey G Murzin
    MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK
    Science 297:61-2. 2002
  3. pmc SCOP2 prototype: a new approach to protein structure mining
    Antonina Andreeva
    MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK and European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK
    Nucleic Acids Res 42:D310-4. 2014
  4. pmc Structural classification of proteins and structural genomics: new insights into protein folding and evolution
    Antonina Andreeva
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:1190-7. 2010
  5. doi request reprint Biochemistry. Metamorphic proteins
    Alexey G Murzin
    MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, UK
    Science 320:1725-6. 2008
  6. ncbi request reprint CASP2 knowledge-based approach to distant homology recognition and fold prediction in CASP4
    A G Murzin
    Centre for Protein Engineering, MRC Centre, Cambridge, United Kingdom
    Proteins . 2001
  7. ncbi request reprint Structure classification-based assessment of CASP3 predictions for the fold recognition targets
    A G Murzin
    Centre for Protein Engineering, MRC Centre, Cambridge, United Kingdom
    Proteins . 1999
  8. ncbi request reprint How far divergent evolution goes in proteins
    A G Murzin
    Centre for Protein Engineering, MRC Centre, Cambridge, UK
    Curr Opin Struct Biol 8:380-7. 1998
  9. ncbi request reprint Distant homology recognition using structural classification of proteins
    A G Murzin
    Center for Protein Engineering, MRC Center, Cambridge, United Kingdom
    Proteins . 1997
  10. pmc SCOP database in 2002: refinements accommodate structural genomics
    Loredana Lo Conte
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nucleic Acids Res 30:264-7. 2002

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Structural classification of proteins: new superfamilies
    A G Murzin
    Centre for Protein Engineering, Medical Research Council Centre, Cambridge, UK
    Curr Opin Struct Biol 6:386-94. 1996
    ....
  2. ncbi request reprint Biochemistry. DNA building block reinvented
    Alexey G Murzin
    MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK
    Science 297:61-2. 2002
  3. pmc SCOP2 prototype: a new approach to protein structure mining
    Antonina Andreeva
    MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK and European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, UK
    Nucleic Acids Res 42:D310-4. 2014
    ..The new classification project is expected to ensure new advances in the field and open new areas of research. ..
  4. pmc Structural classification of proteins and structural genomics: new insights into protein folding and evolution
    Antonina Andreeva
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, England
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:1190-7. 2010
    ....
  5. doi request reprint Biochemistry. Metamorphic proteins
    Alexey G Murzin
    MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, UK
    Science 320:1725-6. 2008
  6. ncbi request reprint CASP2 knowledge-based approach to distant homology recognition and fold prediction in CASP4
    A G Murzin
    Centre for Protein Engineering, MRC Centre, Cambridge, United Kingdom
    Proteins . 2001
    ....
  7. ncbi request reprint Structure classification-based assessment of CASP3 predictions for the fold recognition targets
    A G Murzin
    Centre for Protein Engineering, MRC Centre, Cambridge, United Kingdom
    Proteins . 1999
    ..The total number of the selected 'correct' predictions and the quality of these predictions were used to compare the performance of different predictor teams and different prediction methods in the fold prediction/recognition category...
  8. ncbi request reprint How far divergent evolution goes in proteins
    A G Murzin
    Centre for Protein Engineering, MRC Centre, Cambridge, UK
    Curr Opin Struct Biol 8:380-7. 1998
    ..There is strong evidence for their distant homology with proteins of known structure despite significant functional or structural differences...
  9. ncbi request reprint Distant homology recognition using structural classification of proteins
    A G Murzin
    Center for Protein Engineering, MRC Center, Cambridge, United Kingdom
    Proteins . 1997
    ..Our global alignments, extended manually from these local alignments, also appeared to be rather accurate...
  10. pmc SCOP database in 2002: refinements accommodate structural genomics
    Loredana Lo Conte
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nucleic Acids Res 30:264-7. 2002
    ..The SCOP search engine has also been updated, and a set of links to external resources added at the level of domain entries. SCOP can be accessed at http://scop.mrc-lmb.cam.ac.uk/scop...
  11. pmc SISYPHUS--structural alignments for proteins with non-trivial relationships
    Antonina Andreeva
    MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK
    Nucleic Acids Res 35:D253-9. 2007
    ..The SISYPHUS multiple alignments are displayed with SPICE, a browser that provides an integrated view of protein sequences, structures and their annotations. The database is available from http://sisyphus.mrc-cpe.cam.ac.uk...
  12. pmc Data growth and its impact on the SCOP database: new developments
    Antonina Andreeva
    MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 0QH, UK
    Nucleic Acids Res 36:D419-25. 2008
    ..SCOP can be accessed at http://scop.mrc-lmb.cam.ac.uk/scop...
  13. ncbi request reprint Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2)
    Aruna Sathyamurthy
    Medical Research Council Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Biol Chem 278:46968-73. 2003
    ..There are significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT repeats and these domains...
  14. pmc Structure and distribution of pentapeptide repeats in bacteria
    A Bateman
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Protein Sci 7:1477-80. 1998
    ..A structural model of the pentapeptide repeats is presented...
  15. pmc SCOP database in 2004: refinements integrate structure and sequence family data
    Antonina Andreeva
    MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK
    Nucleic Acids Res 32:D226-9. 2004
    ..SCOP can be accessed at http://scop.mrc-lmb.cam.ac.uk/scop...
  16. pmc SCOP: a structural classification of proteins database
    L Lo Conte
    MRC Laboratory of Molecular Biology, Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK
    Nucleic Acids Res 28:257-9. 2000
    ..The database and its associated files are freely accessible from a number of WWW sites mirrored from URL http://scop.mrc-lmb.cam.ac.uk/scop/..
  17. ncbi request reprint Evolution of protein fold in the presence of functional constraints
    Antonina Andreeva
    MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK
    Curr Opin Struct Biol 16:399-408. 2006
    ..Gene duplication breaks down homo-oligomeric symmetry and relieves the pressure to maintain the local architecture of redundant active sites; this can lead to further structural changes...
  18. pmc Biochemical and structural characterization of a novel family of cystathionine beta-synthase domain proteins fused to a Zn ribbon-like domain
    Michael Proudfoot
    Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Room 72, Toronto, ON, Canada
    J Mol Biol 375:301-15. 2008
    ..We suggest that, in vivo, some Zn ribbon domains might also bind iron and therefore possess an electron carrier activity, adding another physiological role to this large family of important proteins...
  19. ncbi request reprint Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins
    Benjamin G Bobay
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, 27695, USA
    FEBS Lett 579:5669-74. 2005
    ..This strongly suggests that MraZ also binds DNA and allows for a consensus model of DNA recognition by the members of this novel protein superfamily...
  20. ncbi request reprint Structure of the chromo barrel domain from the MOF acetyltransferase
    Peter R Nielsen
    Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, UK
    J Biol Chem 280:32326-31. 2005
    ..This structural similarity suggests a probable evolutionary pathway from these other modules to the canonical chromo domains (or vice versa) with the chromo barrel domain representing an intermediate structure...
  21. ncbi request reprint The crystal structure of YdcE, a 4-oxalocrotonate tautomerase homologue from Escherichia coli, confirms the structural basis for oligomer diversity
    Jeffrey J Almrud
    Department of Chemistry and Biochemistry, Division of Medicinal Chemistry, College of Pharmacy, The University of Texas, Austin, TX 78712 1071, USA
    Biochemistry 41:12010-24. 2002
    ..The dimeric arrangement of YdcE represents a new structure in the 4-OT family and demonstrates structural diversity within the 4-OT family not previously reported...
  22. ncbi request reprint The HI0073/HI0074 protein pair from Haemophilus influenzae is a member of a new nucleotidyltransferase family: structure, sequence analyses, and solution studies
    Christopher Lehmann
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    Proteins 50:249-60. 2003
    ..Double- and single-stranded DNA binding assays showed no evidence of DNA binding to HI0074 or to HI0073/HI0074 complex despite the suggestive shape of the putative binding cleft formed by the HI0074 dimer...
  23. ncbi request reprint House cleaning, a part of good housekeeping
    Michael Y Galperin
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Mol Microbiol 59:5-19. 2006
    ..We discuss the structural diversity of these enzymes, their phylogenetic distribution, substrate specificity and the problem of identifying their true substrates...
  24. ncbi request reprint Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9
    Peter R Nielsen
    Cambridge Centre for Molecular Recognition, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Nature 416:103-7. 2002
    ..These findings predict which other chromodomains will bind methylated proteins and suggest a motif that they recognize...
  25. ncbi request reprint 4-Oxalocrotonate tautomerase, its homologue YwhB, and active vinylpyruvate hydratase: synthesis and evaluation of 2-fluoro substrate analogues
    William H Johnson
    Division of Medicinal Chemistry, College of Pharmacy, The University of Texas, Austin, Texas 78712 1071, USA
    Biochemistry 43:10490-501. 2004
    ..The combined results set the stage for crystallographic studies of 4-OT, YwhB, and VPH using these inhibitors as ligands...
  26. ncbi request reprint Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions
    Olga V Moroz
    York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, UK
    J Mol Biol 347:243-55. 2005
    ..We outline probable tertiary and quaternary structures of the all-alpha NTP pyrophosphatase superfamily members...
  27. pmc NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins
    Benjamin G Bobay
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, 27695, USA
    J Biol Chem 281:21399-409. 2006
    ..The results of accompanying in vitro DNA-binding studies serve to highlight binding differences between the two proteins...
  28. ncbi request reprint Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation
    Galina V Mukamolova
    Institute of Biological Sciences, University of Wales, Aberystwyth, Ceredigion SY23 3DD, UK
    Mol Microbiol 59:84-98. 2006
    ....
  29. ncbi request reprint Cloning, expression, and characterization of a cis-3-chloroacrylic acid dehalogenase: insights into the mechanistic, structural, and evolutionary relationship between isomer-specific 3-chloroacrylic acid dehalogenases
    Gerrit J Poelarends
    Division of Medicinal Chemistry, College of Pharmacy, The University of Texas, Austin, Texas 78712 1074, USA
    Biochemistry 43:759-72. 2004
    ..The discovery of a fifth family of enzymes within this superfamily further demonstrates the diversity of activities and structures that can be created from 4-OT-like sequences...