Adele Murrell

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer
    Adele Murrell
    Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Cambridge, United Kingdom
    PLoS ONE 3:e1849. 2008
  2. pmc Quantitative analysis of DNA methylation at all human imprinted regions reveals preservation of epigenetic stability in adult somatic tissue
    Kathryn Woodfine
    Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, Cambridge, UK
    Epigenetics Chromatin 4:1. 2011
  3. doi Setting up and maintaining differential insulators and boundaries for genomic imprinting
    Adele Murrell
    Cancer Research UK, London, England
    Biochem Cell Biol 89:469-78. 2011
  4. pmc Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA
    Malwina Niemczyk
    Cancer Research UK, Robinson Way, Cambridge CB2 0RE, UK
    Am J Hum Genet 93:224-35. 2013
  5. pmc Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus
    Raffaella Nativio
    Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, Cambridge, United Kingdom
    PLoS Genet 5:e1000739. 2009
  6. pmc Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome
    Raffaella Nativio
    Department of Oncology, Cancer Research UK Cambridge Research Institute, University of Cambridge, LiKaShing Centre, Cambridge, UK
    Hum Mol Genet 20:1363-74. 2011
  7. pmc Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus
    Yoko Ito
    Department of Oncology, University of Cambridge, CRUK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK
    Nucleic Acids Res 41:5290-302. 2013
  8. doi Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression
    Ashraf E K Ibrahim
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Gut 60:499-508. 2011
  9. pmc Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer
    Yoko Ito
    Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Hum Mol Genet 17:2633-43. 2008
  10. doi Quantitative chromosome conformation capture
    Raffaella Nativio
    Department of Oncology, CRUK Cambridge Research Institute, University of Cambridge, Cambridge, UK
    Methods Mol Biol 925:173-85. 2012

Collaborators

Detail Information

Publications25

  1. pmc Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer
    Adele Murrell
    Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Cambridge, United Kingdom
    PLoS ONE 3:e1849. 2008
    ..This DMR, known as DMR0, has been shown to be methylated on the silent maternal IGF2 allele presumably with a role in repression. The effect of IGF2 DMR0 methylation changes in the aetiology of BWS or SRS is unknown...
  2. pmc Quantitative analysis of DNA methylation at all human imprinted regions reveals preservation of epigenetic stability in adult somatic tissue
    Kathryn Woodfine
    Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, Cambridge, UK
    Epigenetics Chromatin 4:1. 2011
    ..abstract:..
  3. doi Setting up and maintaining differential insulators and boundaries for genomic imprinting
    Adele Murrell
    Cancer Research UK, London, England
    Biochem Cell Biol 89:469-78. 2011
    ....
  4. pmc Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA
    Malwina Niemczyk
    Cancer Research UK, Robinson Way, Cambridge CB2 0RE, UK
    Am J Hum Genet 93:224-35. 2013
    ....
  5. pmc Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus
    Raffaella Nativio
    Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, Cambridge, United Kingdom
    PLoS Genet 5:e1000739. 2009
    ....
  6. pmc Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome
    Raffaella Nativio
    Department of Oncology, Cancer Research UK Cambridge Research Institute, University of Cambridge, LiKaShing Centre, Cambridge, UK
    Hum Mol Genet 20:1363-74. 2011
    ..The two alternative chromatin conformations are differently favoured in BWS and SRS likely predisposing the locus to the activation of IGF2 or H19, respectively...
  7. pmc Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus
    Yoko Ito
    Department of Oncology, University of Cambridge, CRUK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK
    Nucleic Acids Res 41:5290-302. 2013
    ..Together, these data provide new insights into the responsiveness of chromatin topography to DNA methylation changes...
  8. doi Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression
    Ashraf E K Ibrahim
    Department of Pathology, Division of Molecular Histopathology, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Gut 60:499-508. 2011
    ....
  9. pmc Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer
    Yoko Ito
    Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Hum Mol Genet 17:2633-43. 2008
    ..These results indicate that IGF2 DMR0 hypomethylation has diagnostic potential for colon cancer rather than value as a surrogate biomarker for constitutive LOI...
  10. doi Quantitative chromosome conformation capture
    Raffaella Nativio
    Department of Oncology, CRUK Cambridge Research Institute, University of Cambridge, Cambridge, UK
    Methods Mol Biol 925:173-85. 2012
    ..Here we describe the 3C methodology, its power, and limitations, together with the controls and normalization steps required for an accurate analysis...
  11. doi Diverse epigenetic strategies interact to control epidermal differentiation
    Klaas W Mulder
    Epithelial Cell Biology Group, Cancer Research UK Cambridge Research Institute, Robinson Way, Cambridge CB2 0RE, UK
    Nat Cell Biol 14:753-63. 2012
    ..Thus, regulation of distinct gene expression programs through the interplay between diverse epigenetic strategies protects epidermal stem cells from differentiation...
  12. doi Molecular mechanisms of genomic imprinting and clinical implications for cancer
    Santiago Uribe-Lewis
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, UK
    Expert Rev Mol Med 13:e2. 2011
    ..Finally, we speculate on the clinical applications of epigenetic drugs in cancer...
  13. ncbi Genomic imprinting: CTCF protects the boundaries
    Annabelle Lewis
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge, CB2 4AT, UK
    Curr Biol 14:R284-6. 2004
    ..It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline...
  14. doi Status of genomic imprinting in epigenetically distinct pluripotent stem cells
    Bowen Sun
    The Anne McLaren Laboratory for Regenerative Medicine, Department of Surgery, University of Cambridge, Cambridge, United Kingdom
    Stem Cells 30:161-8. 2012
    ..Our results also reinforce the view that hESCs and EpiSCs are in vitro counterparts, sharing an epigenetic status distinct from ESCs and iPSCs...
  15. pmc Evaluation of allelic expression of imprinted genes in adult human blood
    Jennifer M Frost
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London, United Kingdom
    PLoS ONE 5:e13556. 2010
    ..In general, the expression profiles of imprinted genes are well characterised during human and mouse fetal development, but not in human adults...
  16. ncbi From genome to epigenome
    Adele Murrell
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Hum Mol Genet 14:R3-R10. 2005
    ..Here, we review the current thinking and progress on how to get from the genome to the epigenome(s) and discuss some potential applications...
  17. doi Epigenetic mechanisms in development and disease
    Adele Murrell
    Epigenetics and Imprinting Laboratory, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Biochem Soc Trans 41:697-9. 2013
    ....
  18. pmc Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets
    Ionel Sandovici
    Metabolic Research Laboratories, Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge CB2 0SW, United Kingdom
    Proc Natl Acad Sci U S A 108:5449-54. 2011
    ..We therefore propose that environmentally induced changes in promoter-enhancer interactions represent a fundamental epigenetic mechanism by which nutrition and aging can influence long-term health...
  19. ncbi Genomic imprinting and cancer: from primordial germ cells to somatic cells
    Adele Murrell
    Department of Oncology, University of Cambridge, MRC Hutchison Centre, Hills Road Cambridge CB2 2XZ, UK
    ScientificWorldJournal 6:1888-910. 2006
    ..This review summarises what we know about imprinting in stem cells and how loss of imprinting may contribute to neoplasia...
  20. ncbi Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiation
    Fiona A Lovett
    The Babraham Institute, Babraham Research Campus, Cambridge, CB2 4AT, UK
    J Cell Sci 119:4828-40. 2006
    ..We thus define a regulatory mechanism for p38 activation that relates cell-cell-derived adhesion signalling to the synthesis of the major fetal growth factor, IGF-II...
  21. ncbi An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype
    Adele Murrell
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Hum Mol Genet 13:247-55. 2004
    ..This indicates either a genetic predisposition to LOM or interactions between genotype and epigenotype that impinge on the disease phenotype...
  22. ncbi Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops
    Adele Murrell
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nat Genet 36:889-93. 2004
    ..These interactions are epigenetically regulated and partition maternal and paternal chromatin into distinct loops. This generates a simple epigenetic switch for Igf2 through which it moves between an active and a silent chromatin domain...
  23. pmc Genomic imprinting controls matrix attachment regions in the Igf2 gene
    Michael Weber
    Institut de Genetique Moleculaire, UMR 5535 CNRS, Universite Montpellier II, IFR 122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Mol Cell Biol 23:8953-9. 2003
    ..Our work clearly demonstrates that genomic imprinting controls matrix attachment regions in the Igf2 gene...
  24. pmc CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2
    Sreenivasulu Kurukuti
    Department of Development and Genetics, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Proc Natl Acad Sci U S A 103:10684-9. 2006
    ....
  25. ncbi Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions
    Susana Lopes
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Hum Mol Genet 12:295-305. 2003
    ..These observations are likely to be relevant to other gene clusters in which epigenetic regulation plays a role, and in pathological situations in which epigenetic regulation is disrupted...