Heath Murray

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc Molecular basis for the exploitation of spore formation as survival mechanism by virulent phage phi29
    Wilfried J J Meijer
    Instituto de Biología Molecular Eladio Viñuela CSIC, Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma, Canto Blanco, Madrid, Spain
    EMBO J 24:3647-57. 2005
  2. doi request reprint Dynamic control of the DNA replication initiation protein DnaA by Soj/ParA
    Heath Murray
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Cell 135:74-84. 2008
  3. pmc Soj/ParA stalls DNA replication by inhibiting helix formation of the initiator protein DnaA
    Graham Scholefield
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    EMBO J 31:1542-55. 2012
  4. pmc A mechanism for cell cycle regulation of sporulation initiation in Bacillus subtilis
    Jan Willem Veening
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    Genes Dev 23:1959-70. 2009
  5. doi request reprint DnaA and ORC: more than DNA replication initiators
    Graham Scholefield
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK
    Trends Cell Biol 21:188-94. 2011
  6. doi request reprint YabA and DnaD inhibit helix assembly of the DNA replication initiation protein DnaA
    Graham Scholefield
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK
    Mol Microbiol 90:147-59. 2013
  7. doi request reprint Spo0J regulates the oligomeric state of Soj to trigger its switch from an activator to an inhibitor of DNA replication initiation
    Graham Scholefield
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4AX, UK
    Mol Microbiol 79:1089-100. 2011
  8. pmc Diversity and redundancy in bacterial chromosome segregation mechanisms
    Jeff Errington
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Philos Trans R Soc Lond B Biol Sci 360:497-505. 2005
  9. ncbi request reprint The bacterial chromosome segregation protein Spo0J spreads along DNA from parS nucleation sites
    Heath Murray
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Mol Microbiol 61:1352-61. 2006

Collaborators

Detail Information

Publications9

  1. pmc Molecular basis for the exploitation of spore formation as survival mechanism by virulent phage phi29
    Wilfried J J Meijer
    Instituto de Biología Molecular Eladio Viñuela CSIC, Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma, Canto Blanco, Madrid, Spain
    EMBO J 24:3647-57. 2005
    ....
  2. doi request reprint Dynamic control of the DNA replication initiation protein DnaA by Soj/ParA
    Heath Murray
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Cell 135:74-84. 2008
    ..These results suggest that the pleiotropy manifested by chromosomal parABS mutations could be the indirect effects of a primary activity regulating DNA replication initiation...
  3. pmc Soj/ParA stalls DNA replication by inhibiting helix formation of the initiator protein DnaA
    Graham Scholefield
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    EMBO J 31:1542-55. 2012
    ..This work defines a significant new regulatory mechanism for the control of DNA replication initiation in bacteria...
  4. pmc A mechanism for cell cycle regulation of sporulation initiation in Bacillus subtilis
    Jan Willem Veening
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    Genes Dev 23:1959-70. 2009
    ..This regulation avoids the generation of spore formers with replicating chromosomes, which would result in diploid or polyploid spores that we show have reduced viability...
  5. doi request reprint DnaA and ORC: more than DNA replication initiators
    Graham Scholefield
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK
    Trends Cell Biol 21:188-94. 2011
    ..The aim of this review is to highlight these new findings, focusing on the pathways and mechanisms utilized by DNA replication initiator proteins to carry out a diverse array of cellular functions...
  6. doi request reprint YabA and DnaD inhibit helix assembly of the DNA replication initiation protein DnaA
    Graham Scholefield
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4AX, UK
    Mol Microbiol 90:147-59. 2013
    ..subtilis, in contrast to the prevailing model of bacterial DNA replication based on Escherichia coli DnaA where ATP binding appears to be the targeted activity. ..
  7. doi request reprint Spo0J regulates the oligomeric state of Soj to trigger its switch from an activator to an inhibitor of DNA replication initiation
    Graham Scholefield
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4AX, UK
    Mol Microbiol 79:1089-100. 2011
    ..We discuss how the regulation of Soj ATPase activity by Spo0J could be utilized to control the initiation of DNA replication during the cell cycle...
  8. pmc Diversity and redundancy in bacterial chromosome segregation mechanisms
    Jeff Errington
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Philos Trans R Soc Lond B Biol Sci 360:497-505. 2005
    ..The key components of this system have been identified, and their functions are understood, in outline. Although this system appears to be specialized, most of the functions are conserved widely throughout the bacteria...
  9. ncbi request reprint The bacterial chromosome segregation protein Spo0J spreads along DNA from parS nucleation sites
    Heath Murray
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Mol Microbiol 61:1352-61. 2006
    ..These 'Spo0J domains' provide large structures near oriC that could potentially demark, organize or localize the origin region of the chromosome...