Research Topics
Species | Graham K MurraySummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Psychotic symptoms in young people without psychotic illness: mechanisms and meaningGraham K Murray
Department of Psychiatry, University of Cambridge, Box 189 Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Br J Psychiatry 201:4-6. 2012..Clinicians should be aware that psychotic symptoms in young people are more often associated with common mental disorders such as depression and anxiety than with severe psychotic illness...
Reinforcement and reversal learning in first-episode psychosisG K Murray
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Schizophr Bull 34:848-55. 2008..Abnormalities in reinforcement learning and reversal learning have been reported in psychosis, possibly secondary to subcortical dopamine abnormalities...- Substantia nigra/ventral tegmental reward prediction error disruption in psychosisG K Murray
Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
Mol Psychiatry 13:239, 267-76. 2008..This study provides the first evidence linking abnormal mesolimbic activity, reward learning and psychosis... - Infant motor development and adult cognitive functions in schizophreniaG K Murray
Department of Psychiatry, University of Cambridge, UK
Schizophr Res 81:65-74. 2006..Childhood neuromotor dysfunction is a risk factor for schizophrenia, a disorder in which cognitive deficits are prominent. The relationship between early neurodevelopment and adult cognition in schizophrenia remains unclear... - Infant motor development is associated with adult cognitive categorisation in a longitudinal birth cohort studyG K Murray
Department of Psychiatry, University of Cambridge, UK, and Muurola Hospital, Hospital District of Lapland, Finland
J Child Psychol Psychiatry 47:25-9. 2006..We hypothesised that the age of learning to stand in infancy would be associated with adult executive function and that the association would be apparent throughout the range of abilities, rather than confined to extremes... - The neural underpinnings of associative learning in health and psychosis: how can performance be preserved when brain responses are abnormal?Graham K Murray
Brain Mapping Unit, University of Cambridge, Box 189, Cambridge CB2 0QQ, UK
Schizophr Bull 36:465-71. 2010..The findings suggest that a combination of these factors may resolve the question of why performance is sometimes preserved when brain patterns are disrupted... - Infant developmental milestones and subsequent cognitive functionGraham K Murray
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
Ann Neurol 62:128-36. 2007..We hypothesized that earlier attainment of developmental milestones would be associated with better subsequent intellectual performance throughout the range of abilities, rather than confined to extremes... - Incentive motivation in first-episode psychosis: a behavioural studyGraham K Murray
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
BMC Psychiatry 8:34. 2008..It has been proposed that there are abnormalities in incentive motivational processing in psychosis, possibly secondary to subcortical dopamine abnormalities, but few empirical studies have addressed this issue... - Different vulnerability indicators for psychosis and their neuropsychological characteristics in the Northern Finland 1986 Birth CohortSari Mukkala
Department of Psychiatry, Institute of Clinical Medicine, University of Oulu, Oulu, Finland
J Clin Exp Neuropsychol 33:385-94. 2011..The two risk groups did not differ significantly from controls, but differed from the psychosis group in fine motor function. Neuropsychological impairments were not evident in a non-help-seeking high-risk sample... 
Schizophrenia in the offspring of antenatally depressed mothers in the northern Finland 1966 birth cohort: relationship to family history of psychosisPirjo Maki
Department of Psychiatry, Institute of Clinical Medicine, University of Oulu, P O Box 5000, FIN 90014 Oulu, Finland
Am J Psychiatry 167:70-7. 2010..The authors examined whether maternal antenatal depressed mood increased the risk of schizophrenia and other psychoses among offspring with and without a familial history of psychosis...- No association of COMT (Val158Met) genotype with brain structure differences between men and womenAnna Barnes
Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
PLoS ONE 7:e33964. 2012.... - Neuregulin-1 genotype is associated with structural differences in the normal human brainAnna Barnes
Department of Psychiatry, University of Cambridge, Box 189 Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Neuroimage 59:2057-61. 2012..These results suggest that this genetic variant may mediate risk for schizophrenia, in part, through its effect on brain structure in these regions... - Association between duration of untreated psychosis and brain morphology in schizophrenia within the Northern Finland 1966 Birth CohortMatti Penttilä
University of Oulu, Institute of Clinical Medicine, Department of Psychiatry, P O Box 5000, FIN 90014 Oulu, Finland
Schizophr Res 123:145-52. 2010..Our aim was to analyze the relation between DUP and the brain structure in schizophrenia in the general population, after several years of illness... - Fronto-cerebellar systems are associated with infant motor and adult executive functions in healthy adults but not in schizophreniaKhanum Ridler
Brain Mapping Unit, Department of Psychiatry, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
Proc Natl Acad Sci U S A 103:15651-6. 2006..Disruption of this anatomical system may underlie both the early developmental and adult cognitive abnormalities in schizophrenia... - Individual differences in psychotic effects of ketamine are predicted by brain function measured under placeboGarry D Honey
Department of Psychiatry, Brain Mapping Unit and Behavioural and Clinical Neurosciences Institute, University of Cambridge, School of Clinical Medicine, Cambridge CB2 2QQ, United Kingdom
J Neurosci 28:6295-303. 2008..These results demonstrate precise and predictive brain markers for individual profiles of vulnerability to drug-induced psychosis... - Associations between early development and outcome in schizophrenia--A 35-year follow-up of the Northern Finland 1966 Birth CohortErika Jaaskelainen
Department of Psychiatry, University of Oulu, Finland, P O Box 5000, 90014 University of Oulu, Finland
Schizophr Res 99:29-37. 2008..We conclude that risk factors for schizophrenia are not necessarily prognostic factors... - Young people at risk for psychosis: case finding and sample characteristics of the Oulu Brain and Mind StudyJuha Veijola
Departments of Psychiatry Child Psychiatry, Institute of Clinical Medicine, Institute of Health Sciences, University of Oulu, and Departments of Psychiatry Diagnostic Radiology Unit of General Practice, Oulu University Hospital, Oulu, Department of Psychiatry, University of Turku, Turku, Finland Department of Psychiatry Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge Cognition Ltd, Cambridge, UK
Early Interv Psychiatry 7:146-54. 2013..Combining methods from familial, clinical and psychometric high-risk approaches provides a tractable method for studying risk of psychosis in the general population... - The brain structural disposition to social interactionMaël Lebreton
Brain Mapping Unit, University of Cambridge, Cambridge, UK
Eur J Neurosci 29:2247-52. 2009..These findings provide evidence for a brain structural disposition to social interaction, and that sensitivity to social reward shares a common neural basis with systems for processing primary reward information... - Effects of modafinil on emotional processing in first episode psychosisLinda Scoriels
Department of Psychiatry, University of Cambridge, Robinson Way, Cambridge, UK
Biol Psychiatry 69:457-64. 2011..We aimed to establish whether modafinil might have a role in the adjuvant treatment of emotional impairments in the first episode of psychosis, when therapeutic endeavor is arguably most vital... - Learning and cognitive flexibility: frontostriatal function and monoaminergic modulationAngie A Kehagia
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Curr Opin Neurobiol 20:199-204. 2010..The role of prefrontal noradrenaline (NA) in higher order flexibility indexed through attentional set-shifting has recently received significant empirical support, and similar avenues appear promising in the field of task switching... - Predictors of schizophrenia: evidence from the Northern Finland 1966 Birth Cohort and other sourcesMatti Isohanni
Department of Psychiatry, University of Oulu, PO Box 5000, Finland
Br J Psychiatry Suppl 48:s4-7. 2005..Subtle motor, emotional, cognitive and behavioural abnormalities are often present in apparently healthy individuals who later develop schizophrenia, suggesting that some aspects of causation are established before overt psychosis... - Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosisPhilip R Corlett
Brain Mapping Unit, Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, England
Arch Gen Psychiatry 63:611-21. 2006..They are consistent with a model of delusion formation positing disruptions in error-dependent learning... - The relevance of reward pathways for schizophreniaHisham Ziauddeen
Department of Psychiatry, University of Cambridge, UK
Curr Opin Psychiatry 23:91-6. 2010..We examine how disturbances in reward-related processes relate to the pathophysiology and symptomatology of this disorder... - Association of cannabis use with prodromal symptoms of psychosis in adolescenceJouko Miettunen
Department of Psychiatry, University of Oulu, PO Box 5000, 90014 University of Oulu, Finland
Br J Psychiatry 192:470-1. 2008..23; 95% CI 1.70-2.94). A dose-response effect was seen. We conclude that cannabis use is associated with prodromal symptoms of psychosis in adolescence... - Default mode network in young people with familial risk for psychosis - the Oulu Brain and Mind studyTuomas Jukuri
Department of Psychiatry, Institute of Clinical Medicine, University of Oulu, Finland
Schizophr Res 143:239-45. 2013..We compared the activity of the DMN between FR participants and controls... - Predictors of schizophrenia--a reviewPirjo Maki
Department of Psychiatry, University of Oulu, PO Box 5000, FIN 90014 University of Oulu, Finland
Br Med Bull 73:1-15. 2005.... - The persistence of developmental markers in childhood and adolescence and risk for schizophrenic psychoses in adult life. A 34-year follow-up of the Northern Finland 1966 birth cohortMatti Isohanni
Department of Psychiatry, University of Oulu, P O Box 5000, 90014 Oulu, Finland
Schizophr Res 71:213-25. 2004..These findings are in line with the hypothesis that a neural diathesis is present during postnatal brain development before schizophrenia. This supports the longitudinal dimension and life span models of schizophrenia... - Substance use in a population-based clinic sample of people with first-episode psychosisJennifer H Barnett
Department of Psychiatry, Box 189, University of Cambridge, UK
Br J Psychiatry 190:515-20. 2007..Substance use is implicated in the cause and course of psychosis...