G I Murray

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. ncbi request reprint The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression
    Brian Carpenter
    Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Biochim Biophys Acta 1765:85-100. 2006
  2. pmc Liver fatty acid binding protein expression in colorectal neoplasia
    L C Lawrie
    Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen, Foresterhill AB25 2ZD, UK
    Br J Cancer 90:1955-60. 2004
  3. pmc Characterisation and protein expression profiling of annexins in colorectal cancer
    R Duncan
    Department of Pathology, University of Aberdeen, Aberdeen, UK
    Br J Cancer 98:426-33. 2008
  4. pmc The proteomics of colorectal cancer: identification of a protein signature associated with prognosis
    Donna O'Dwyer
    Department of Pathology, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 6:e27718. 2011
  5. pmc The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer
    Gordon T Brown
    Pathology, Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 9:e90776. 2014
  6. pmc Lack of association between the rs2294008 polymorphism in the prostate stem cell antigen gene and colorectal neoplasia: a case-control and immunohistochemical study
    Christopher Smith
    Gastrointestinal Research Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland
    BMC Res Notes 5:371. 2012
  7. pmc Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability
    Blair H Smith
    University of Aberdeen, Department of General Practice and Primary Care, Foresterhill Health Centre, Westburn Road, Aberdeen, UK
    BMC Med Genet 7:74. 2006
  8. pmc APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling
    Russell D Petty
    University of Aberdeen, UK
    BMC Cancer 9:434. 2009
  9. ncbi request reprint The role of cytochrome P450 in tumour development and progression and its potential in therapy
    G I Murray
    Department of Pathology, University of Aberdeen, Aberdeen, UK
    J Pathol 192:419-26. 2000
  10. ncbi request reprint Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1
    G I Murray
    Department of Pathology, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom
    Annu Rev Pharmacol Toxicol 41:297-316. 2001

Collaborators

Detail Information

Publications74

  1. ncbi request reprint The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression
    Brian Carpenter
    Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Biochim Biophys Acta 1765:85-100. 2006
    ..The different stages of tumour development that are potentially regulated by the hnRNPs along with their aberrant expression profiles in tumour tissues will also be discussed...
  2. pmc Liver fatty acid binding protein expression in colorectal neoplasia
    L C Lawrie
    Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen, Foresterhill AB25 2ZD, UK
    Br J Cancer 90:1955-60. 2004
    ..This study demonstrates that loss of L-FABP occurs at the adenoma stage of colorectal tumour development and also indicates that L-FABP is a marker of colorectal cancer differentiation...
  3. pmc Characterisation and protein expression profiling of annexins in colorectal cancer
    R Duncan
    Department of Pathology, University of Aberdeen, Aberdeen, UK
    Br J Cancer 98:426-33. 2008
    ..In conclusion, this study has shown that individual annexins are present in colorectal cancer, specific annexins are overexpressed in colorectal cancer and the annexin expression profile is associated with survival...
  4. pmc The proteomics of colorectal cancer: identification of a protein signature associated with prognosis
    Donna O'Dwyer
    Department of Pathology, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 6:e27718. 2011
    ..306, p = 0.007, HR = 0.504, 95%CI 0.303-0.838) and that remained independently prognostic (p = 0.01, HR = 0.416, 95%CI 0.208-0.829) in a multivariate model...
  5. pmc The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer
    Gordon T Brown
    Pathology, Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 9:e90776. 2014
    ..CYP26B1 was independently prognostic in a multivariate model both in the whole patient cohort (HR = 1.177, 95%CI = 1.020-1.216, p = 0.026) and in mismatch repair proficient tumours (HR = 1.255, 95%CI = 1.073-1.467, p = 0.004)...
  6. pmc Lack of association between the rs2294008 polymorphism in the prostate stem cell antigen gene and colorectal neoplasia: a case-control and immunohistochemical study
    Christopher Smith
    Gastrointestinal Research Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland
    BMC Res Notes 5:371. 2012
    ..In addition, we performed immunohistochemical staining for PSCA in colonic tissue representing all stages of the adenoma-carcinoma sequence...
  7. pmc Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability
    Blair H Smith
    University of Aberdeen, Department of General Practice and Primary Care, Foresterhill Health Centre, Westburn Road, Aberdeen, UK
    BMC Med Genet 7:74. 2006
    ....
  8. pmc APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling
    Russell D Petty
    University of Aberdeen, UK
    BMC Cancer 9:434. 2009
    ..The aim was to identify novel 5FU resistance mechanisms and qualify these as candidate biomarkers and therapeutic targets...
  9. ncbi request reprint The role of cytochrome P450 in tumour development and progression and its potential in therapy
    G I Murray
    Department of Pathology, University of Aberdeen, Aberdeen, UK
    J Pathol 192:419-26. 2000
    ..The tumour-specific expression of P450 provides the basis for the development of novel diagnostic and therapeutic strategies...
  10. ncbi request reprint Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1
    G I Murray
    Department of Pathology, University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom
    Annu Rev Pharmacol Toxicol 41:297-316. 2001
    ..In humans CYP1B1 is overexpressed in tumor cells, and this has important implications for tumor development and progression and the development of anticancer drugs specifically activated by CYP1B1...
  11. ncbi request reprint Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer
    G I Murray
    Department of Pathology, University of Aberdeen, U K
    J Pathol 185:256-61. 1998
    ..02). The identification of individual MMPs in oesophageal cancer provides a rational basis for use in the treatment of oesophageal cancer of MMP inhibitors which are currently undergoing clinical trial...
  12. ncbi request reprint An overview of laser microdissection technologies
    Graeme I Murray
    Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Acta Histochem 109:171-6. 2007
    ..Through their appropriate application they have provided significant new insights into cell biology and pathology...
  13. doi request reprint Profiling the expression of cytochrome P450 in breast cancer
    Graeme I Murray
    Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK
    Histopathology 57:202-11. 2010
    ..The aim was to define the P450 expression profile in breast cancer and establish the significance of P450 expression in this tumour type...
  14. ncbi request reprint Tumor-specific expression of cytochrome P450 CYP1B1
    G I Murray
    Department of Pathology, University of Aberdeen, Foresterhill, United Kingdom
    Cancer Res 57:3026-31. 1997
    ..These results provide the basis for the development of novel methods of cancer diagnosis based on the identification of CYP1B1 in tumor cells and the development of anticancer drugs that are selectively activated in tumors by CYP1B1...
  15. ncbi request reprint Characterization and over-expression of chaperonin t-complex proteins in colorectal cancer
    C Coghlin
    Department of Pathology, University of Aberdeen, Aberdeen, UK
    J Pathol 210:351-7. 2006
    ..05). These results show that both TCP1 beta and TCP1 epsilon are over-expressed in colorectal cancer and indicate a role for TCP1 beta and TCP1 epsilon in colorectal cancer progression...
  16. ncbi request reprint Evaluation of the epidermal growth factor receptor (EGFR) in colorectal tumours and lymph node metastases
    J A McKay
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, AB25 2ZD, Aberdeen, UK
    Eur J Cancer 38:2258-64. 2002
    ..05). These results indicate that while EGFR overexpression is a common event in colorectal carcinogenesis, it does not influence patient prognosis...
  17. ncbi request reprint Expression of matrix metalloproteinases 1, 2, 9 and their tissue inhibitors in stage II non-small cell lung cancer: implications for MMP inhibition therapy
    S C Pritchard
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Oncol Rep 8:421-4. 2001
    ..These results suggest that a broad spectrum MMP inhibitor is worthy of evaluation as a therapeutic method of reducing tumor invasion and metastasis in stage II NSCLC...
  18. pmc Colorectal cancer genomics: evidence for multiple genotypes which influence survival
    P H Rooney
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, AB25 2ZD, Aberdeen
    Br J Cancer 85:1492-8. 2001
    ..Although genomic change in CRC is relevant to the survival of patients with Dukes' C CRC, careful analysis is required to identify cell lines which are representative models of CRC genomics...
  19. pmc Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer
    B Carpenter
    Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Br J Cancer 95:921-7. 2006
    ..There was no correlation between hnRNP K and p53 expression, however, patients who presented tumours that were positive for hnRNP K and p53 had a poorer survival outcome (P=0.045)...
  20. pmc Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression: a marker of malignant potential?
    M H McLean
    Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Br J Cancer 108:2537-41. 2013
    ..Expression has been linked to malignant disease development and progression...
  21. pmc Matrix metalloproteinases and their inhibitors in gastric cancer
    G I Murray
    Department of Pathology, University of Aberdeen, UK
    Gut 43:791-7. 1998
    ..The matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) are strongly implicated in tumour invasion and metastasis...
  22. pmc Cytochrome P450 CYP3A in human renal cell cancer
    G I Murray
    Department of Pathology, University of Aberdeen, Foresterhill, UK
    Br J Cancer 79:1836-42. 1999
    ..The presence of CYP3A in renal cell cancer might be important in the metabolic potentiation as well as the detoxification of chemotherapeutic agents used to renal cancer...
  23. pmc Enhanced expression of cytochrome P450 in stomach cancer
    G I Murray
    Department of Pathology, University of Aberdeen, Foresterhill, UK
    Br J Cancer 77:1040-4. 1998
    ....
  24. ncbi request reprint Expression of cell cycle control proteins in primary colorectal tumors does not always predict expression in lymph node metastases
    J A McKay
    Department of Medicine and Therapeutics, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland, United Kingdom
    Clin Cancer Res 6:1113-8. 2000
    ..In addition, PCNA-labeling indices between paired samples were neither consistently higher nor lower, suggesting that the proliferative capacity of tumor cells is not directly related to their ability to metastasize...
  25. pmc c-erbB-2 is not a major factor in the development of colorectal cancer
    J A McKay
    Department of Medicine and Therapeutics, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2Z, UK
    Br J Cancer 86:568-73. 2002
    ..05 in each case), suggesting that c-erbB-2 is not a prognostic marker in colorectal cancer...
  26. pmc Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer
    M C McFadyen
    Departments of Pathology, Obstetrics and Gynaecology, Medicine and Therapeutics, Molecular and Cell Biology, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Br J Cancer 85:242-6. 2001
    ..005 Spearman's rank correlation test). In contrast no detectable CYP1B1 was found in normal ovary...
  27. pmc CYP3A4 and VDR gene polymorphisms and the risk of prostate cancer in men with benign prostate hyperplasia
    M T Tayeb
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresthill, UK
    Br J Cancer 88:928-32. 2003
    ..43; 95% CI=0.99-11.77). While independent confirmation is required in further studies, these results provide a potential tool to assist prediction strategies for this important disease...
  28. pmc Application of laser capture microdissection and proteomics in colon cancer
    L C Lawrie
    Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Mol Pathol 54:253-8. 2001
    ..CONCLUSION: A method for performing two dimensional gel electrophoresis and mass spectrometry using laser capture microdissected tissue has been developed...
  29. ncbi request reprint Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance
    M C McFadyen
    Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Biochem Pharmacol 62:207-12. 2001
    ..This study is the first to indicate that the presence of CYP1B1 in cells decreases their sensitivity to the cytotoxic effects of a specific anticancer drug...
  30. ncbi request reprint Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation?
    B Rochat
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, Scotland, UK
    J Pharmacol Exp Ther 296:537-41. 2001
    ..The results obtained indicate that several anticancer agents inhibit CYP1B1 activity. Drug inactivation by CYP1B1 may represent a novel mechanism of resistance, influencing the clinical outcome of chemotherapy...
  31. doi request reprint COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics
    M H McLean
    GI Research Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK
    Histopathology 52:806-15. 2008
    ..To assess cyclooxygenase-2 (COX-2) expression in sporadic colonic adenomas and to explore the association of COX-2 positivity with adenoma characteristics linked to increased risk of malignant transformation...
  32. ncbi request reprint Spot the differences: proteomics in cancer research
    L C Lawrie
    University of Aberdeen, Foresterhill, UK
    Lancet Oncol 2:270-7. 2001
    ..This new technology will give much-needed insight into the molecular mechanisms of tumour development and progression...
  33. ncbi request reprint Analysis of uracil DNA glycosylase in human colorectal cancer
    C Dusseau
    Department of Medicine and Therapeutics, Aberdeen Royal Infirmary, University of Aberdeen, UK
    Int J Oncol 18:393-9. 2001
    ..The high tumor:normal tissue ratio supports further interest in base excision repair, through UDG, as a potential source of fluoropyrimidine resistance in colorectal cancer...
  34. ncbi request reprint p53 protein expression in a population-based series of primary vulval squamous cell carcinoma and immediate adjacent field change
    D T McConnell
    Department of Pathology, University of Aberdeen, Scotland
    Gynecol Oncol 67:248-54. 1997
    ..Our aim was to study correlations between survival, disease recurrence, and p53 protein expression in a well defined population-based series of vulval squamous cell carcinoma and immediate adjacent epithelial skin changes...
  35. doi request reprint The role of annexins in tumour development and progression
    S Mussunoor
    Department of Pathology, University of Aberdeen, UK
    J Pathol 216:131-40. 2008
    ..Changes in the expression of individual annexins are associated with particular types of tumour and hence the annexins may also be useful biomarkers in the clinic...
  36. pmc Matrix metalloproteinase 13 activity is associated with poor prognosis in colorectal cancer
    M F Leeman
    Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    J Clin Pathol 55:758-62. 2002
    ..MMP-13 (collagenase 3) has a central role in the MMP activation cascade. The purpose of this study was to investigate the presence and activity of MMP-13 in colorectal cancer and relate these to clinicopathological features...
  37. ncbi request reprint Analysis of key cell-cycle checkpoint proteins in colorectal tumours
    Judith A McKay
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    J Pathol 196:386-93. 2002
    ..0266), but it was not an independent predictor of survival. These results suggest that loss of control of cell-cycle checkpoints is a common occurrence in colorectal tumours and may be an important therapeutic target...
  38. ncbi request reprint The role of cytochrome P450 in cytotoxic bioactivation: future therapeutic directions
    P H Rooney
    Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Curr Cancer Drug Targets 4:257-65. 2004
    ..Specific activation of pro-drugs by isoforms whose expression or particular catalytic activity is limited to cancer cells offers the possibility of truly targeted chemotherapy with minimized systemic toxicity...
  39. pmc Immunohistochemistry of neurone specific enolase with gamma subunit specific anti-peptide monoclonal antibodies
    G I Murray
    Department of Pathology, University of Aberdeen
    J Clin Pathol 46:993-6. 1993
    ....
  40. pmc Human papillomavirus 16 infection in adenocarcinoma of the cervix
    G K Chew
    Department of Gynaecology Oncology, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK
    Br J Cancer 93:1301-4. 2005
    ..014). Women with ACC also had significantly higher HPV DNA copy number per cell compared to the control group (P=0.00007). Higher HPV DNA copy number is associated with risk of developing ACC...
  41. pmc Amplification of fluorescent in situ hybridisation signals in formalin fixed paraffin wax embedded sections of colon tumour using biotinylated tyramide
    J A McKay
    Department of Medicine and Therapeutics, University of Aberdeen, Institute of Medical Sciences, Foresterhill, UK
    Mol Pathol 50:322-5. 1997
    ....
  42. pmc Characterization of dihydropyrimidine dehydrogenase in human colorectal tumours
    H L McLeod
    Department of Medicine, University of Aberdeen, Foresterhill, UK
    Br J Cancer 77:461-5. 1998
    ..As a large degree of the variation in tumour DPD activity is not explained by PMNC activity, more accurate alternatives are needed before DPD activity can be used for targeting 5-FU therapy...
  43. ncbi request reprint Thymidine phosphorylase and dihydropyrimidine dehydrogenase protein expression in colorectal cancer
    E S Collie-Duguid
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, Scotland
    Int J Cancer 94:297-301. 2001
    ..This suggests the presence of co-ordinated regulation of these pyrimidine metabolic enzymes and offers a strategy for optimising the use of pyrimidine-based chemotherapy...
  44. ncbi request reprint Gene expression profiling in non-small cell lung cancer: from molecular mechanisms to clinical application
    Russell D Petty
    Department of Oncology, Aberdeen and Oncology Research Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
    Clin Cancer Res 10:3237-48. 2004
    ..Taken together, these advances hold the promise of an improved understanding of the molecular biology of NSCLC and its treatment, which in turn will lead to improved outcomes for this deadly disease...
  45. ncbi request reprint Cytochrome P450 1B1: a novel anticancer therapeutic target
    Morag C E McFadyen
    Robert Gordon University, School of Pharmacy, Schoolhill, Aberdeen, AB10 1FR, UK
    Future Oncol 1:259-63. 2005
    ..The therapeutic strategy, which is at the most advanced stage of development, is a CYP1B1-based vaccine which has already successfully completed a Phase I clinical trial...
  46. ncbi request reprint Quantitative analysis of the Ah receptor/cytochrome P450 CYP1B1/CYP1A1 signalling pathway
    Morag C E McFadyen
    Department of Pathology, University of Aberdeen, Aberdeen, AB25 2ZD, UK
    Biochem Pharmacol 65:1663-74. 2003
    ..In addition, the expression pattern of CYP1B1 mRNA and protein in the MOG-G-CCM cells highlights this cell line as a potential model for studying CYP1B1 expression in human tissue...
  47. ncbi request reprint Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers
    Stephanie Curran
    Department of Pathology, University of Aberdeen, Aberdeen, United Kingdom
    Clin Cancer Res 10:8229-34. 2004
    ..Therefore, to understand their role in tumor invasion, it is necessary to evaluate them collectively...
  48. ncbi request reprint Cytochrome P450 enzymes: novel options for cancer therapeutics
    Morag C E McFadyen
    Department of Pathology, University of Aberdeen, Aberdeen, United Kingdom
    Mol Cancer Ther 3:363-71. 2004
    ..The purpose of this review is to outline the novel therapeutic options and opportunities arising from both enhanced endogenous expression of cytochrome P450 in tumors and cytochrome P450-mediated gene therapy...
  49. ncbi request reprint Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis
    Meera Kumarakulasingham
    Department of Pathology, University of Aberdeen and Auvation, Ltd, Aberdeen, United Kingdom
    Clin Cancer Res 11:3758-65. 2005
    ..The purpose of this study was to define the P450 profile of colorectal cancer and establish the prognostic significance of expression of individual P450s in colorectal cancer...
  50. ncbi request reprint Expression of Fhit, cell adhesion molecules and matrix metalloproteinases in atypical adenomatous hyperplasia and pulmonary adenocarcinoma
    Keith M Kerr
    Department of Pathology, Aberdeen University Medical School, Aberdeen, UK
    J Pathol 203:638-44. 2004
    ..Loss of MMP-2 and TIMP-2 in stromally invasive tumour may reflect a particular role for MMP-2 at the BAC stage, with later down-regulation of this particular enzyme...
  51. ncbi request reprint The candidate oncogene ZNF217 is frequently amplified in colon cancer
    Patrick H Rooney
    Department of Pathology, University of Aberdeen, UK
    J Pathol 204:282-8. 2004
    ..There was a trend toward poorer survival in patients whose cancers had either gain or loss of ZNF217...
  52. ncbi request reprint Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival
    Sinclair R Dundas
    Department of Pathology, University of Aberdeen, Aberdeen, UK
    J Pathol 205:74-81. 2005
    ..Our experimental approach emphasises the analytical power of combining proteomics with tissue microarray analysis in the context of a well-defined tumour database...
  53. ncbi request reprint Genomic instability at the BUB1 locus in colorectal cancer, but not in non-small cell lung cancer
    R G Jaffrey
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Scotland
    Cancer Res 60:4349-52. 2000
    ..Additional investigations may shed light on the mechanistic impact of the mitotic spindle checkpoint pathway in colorectal tumor initiation and progression...
  54. ncbi request reprint Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain
    M C McFayden
    Department of Pathology, University of Aberdeen, Foresterhill, UK
    Biochem Pharmacol 55:825-30. 1998
    ..The distribution of individual P450s in different regions of human brain is likely to be highly important in determining the response of the brain to toxic foreign compounds...
  55. ncbi request reprint Cytochrome P450 CYP3A5 in the human anterior pituitary gland
    G I Murray
    Department of Pathology, University of Aberdeen, UK
    FEBS Lett 364:79-82. 1995
    ..This is the first direct identification of an individual P450 subfamily in the pituitary gland and the presence of CYP3A in the pituitary gland may play a role in regulating growth hormone secretion...
  56. pmc Cytochrome P450 CYP1B1 activity in renal cell carcinoma
    M C E McFadyen
    Department of Pathology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Br J Cancer 91:966-71. 2004
    ..The presence of detectable CYP1B1, which is capable of metabolising anticancer drugs in tumour cells, highlights a novel target for therapeutic intervention...
  57. ncbi request reprint The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers
    Natalie Jeffery
    Department of Pathology, University of Aberdeen, Aberdeen, UK
    Histopathology 54:820-8. 2009
    ..Roles in pathways involved in early tumour development are also being identified for this system, and the aim of this study was to define the expression profile of the major MMPs and TIMPs in colorectal polyp cancers...
  58. ncbi request reprint Topoisomerase I protein expression in primary colorectal cancer and lymph node metastases
    Attasit Boonsong
    Department of Medicine and Therapeutics and Pathology, University of Aberdeen Institute of Medical Sciences, Aberdeen, Scotland, UK
    Hum Pathol 33:1114-9. 2002
    ..Topo I expression now needs to be evaluated in patients undergoing topo I-inhibitor therapy, to better define the role of this protein as a predictive marker...
  59. ncbi request reprint Tumor transcriptome reveals the predictive and prognostic impact of lysosomal protease inhibitors in non-small-cell lung cancer
    Russell D Petty
    Oncology Research Group, Department of Medicine and Therapeutics, Institute of Medical Sciences, School of Medicine, University of Aberdeen, Aberdeen, nited Kingdom
    J Clin Oncol 24:1729-44. 2006
    ..Insight into clinical response to platinum-based chemotherapy (PBC) in non-small-cell lung cancer (NSCLC)...
  60. ncbi request reprint Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis
    Sharon Marsh
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Oncol Rep 9:231-4. 2002
    ..05 in all cases). Discordance in TS protein levels between primary and secondary tumours demonstrates the danger of predicting outcome after chemotherapy in metastatic colorectal cancer from the primary tumour...
  61. ncbi request reprint An introduction to laser-based tissue microdissection techniques
    Stephanie Curran
    Department of Pathology, University of Aberdeen, UK
    Methods Mol Biol 293:3-8. 2005
    ..This chapter provides an overview of the different laser-based microdissection systems and an introduction to the principles involved in the function and applications of these individual systems...
  62. ncbi request reprint Laser capture microdissection and PCR for analysis of human papilloma virus infection
    Kheng Chew
    Department of Obstetrics and Gynaecology, University of Aberdeen, UK
    Methods Mol Biol 293:295-300. 2005
    ..Our results show that HPV type 16 is present in endocervical adenocarcinoma cells...
  63. ncbi request reprint Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers
    Diane Downie
    Department of Pathology, University of Aberdee, UK
    Clin Cancer Res 11:7369-75. 2005
    ..The purpose of this study was to define the cytochrome P450 profile of ovarian cancer and identify novel therapeutic targets and establish the prognostic significance of expression of individual cytochrome P450s in this type of cancer...
  64. ncbi request reprint New insights into the roles of matrix metalloproteinases in colorectal cancer development and progression
    Matthew F Leeman
    Department of Pathology, University of Aberdeen, Aberdeen, UK
    J Pathol 201:528-34. 2003
    ....
  65. ncbi request reprint Profiling markers of prognosis in colorectal cancer
    Matthew S Lyall
    Department of Pathology, University of Aberdeen, Aberdeen, UK
    Clin Cancer Res 12:1184-91. 2006
    ..There is a need to further stratify prognostically distinct groups of colorectal cancer, and the purpose of this study was to identify prognostically significant immunohistochemical marker profiles in colorectal cancer...
  66. doi request reprint Loss of sensory and noradrenergic innervation in benign colorectal adenomatous polyps--a putative role of semaphorins 3F and 3A
    N Graf
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Neurogastroenterol Motil 24:120-8, e83. 2012
    ..Nerve fibers can exert trophic/anti-trophic effects on epithelial cells. Substance P (SP) is a pro-proliferative neuropeptide, whereas sympathetic noradrenaline is anti-proliferative at high concentrations...
  67. ncbi request reprint Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats
    M C Wright
    Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland
    Gastroenterology 121:685-98. 2001
    ..Hepatic stellate cells (HSCs) play a pivotal role in liver fibrosis and stimulating their apoptosis could be an effective treatment for liver fibrosis...
  68. ncbi request reprint CYP3A4 promoter variant is associated with prostate cancer risk in men with benign prostate hyperplasia
    Mohammed T Tayeb
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen, UK
    Oncol Rep 9:653-5. 2002
    ..The CYP3A4 variant allele identified men with BPH who are at increased risk of progressing to PRCa (odds ratio 6.3, 95% CI 2.3-17.3), providing a potential tool to assist prediction strategies for this disease...
  69. ncbi request reprint The structure, regulation, and function of human matrix metalloproteinase-13
    Matthew F Leeman
    Department of Pathology, University of Aberdeen, Foresterhill, UK
    Crit Rev Biochem Mol Biol 37:149-66. 2002
    ..This commentary provides a detailed overview of the regulatory mechanisms, structure, and function of human MMP-13 and highlights the key factors involved in the biology of this important molecule...
  70. ncbi request reprint Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue
    Dawn M Carnell
    Marie Curie Research Wing, Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, United Kingdom
    Int J Radiat Oncol Biol Phys 58:500-9. 2004
    ..To validate CYP1B1 as a molecular target for the development of selective cancer therapeutics for use in combination with radiation...
  71. ncbi request reprint Cytochrome P450 1B1 expression in glial cell tumors: an immunotherapeutic target
    Julia A Barnett
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:3559-67. 2007
    ..To evaluate the viability of further research efforts targeting this antigen, we examined the expression of CYP1B1 in glial cell malignancies...
  72. ncbi request reprint Vitamin D receptor, HER-2 polymorphisms and risk of prostate cancer in men with benign prostate hyperplasia
    Mohammed T Tayeb
    Department of Medical Sciences, Faculty of Medicine and Medical Sciences, Umm Al Qura University, Makkah, Kingdom of Saudi Arabia
    Saudi Med J 25:447-51. 2004
    ..This study used a case-control design to assess the predictive value of 3 polymorphisms in VDR (TaqI and FokI) and HER-2 (Val655Ile) to determine the risk of developing PRCa in patients with BPH...
  73. ncbi request reprint Cytochrome P450 enzymes and tumor therapy
    Matthias Lohr
    Mol Cancer Ther 3:1503; author reply 1503-4. 2004
  74. ncbi request reprint Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients
    Fahd Al-Mulla
    Kuwait University, Faculty of Medicine, Safat, Kuwait
    J Clin Oncol 24:5672-9. 2006
    ..We examined whether RKIP expression in primary colorectal cancers (CRCs) correlates with the risk of metastasis and overall survival...