G D Murray

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Does intermittent pneumatic compression reduce the risk of post stroke deep vein thrombosis? The CLOTS 3 trial: statistical analysis plan
    Martin Dennis
    Division of Clinical Neurosciences, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 14:66. 2013
  2. pmc Update on the Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II): statistical analysis plan
    Barbara A Gregson
    STICH Office, Neurosurgical Trials Unit, Newcastle University, 3 4 Claremont Terrace, Newcastle upon Tyne, NE2 4AE, UK
    Trials 13:222. 2012
  3. pmc Protocol for a systematic review and individual patient data meta-analysis of prognostic factors of foot ulceration in people with diabetes: the international research collaboration for the prediction of diabetic foot ulcerations (PODUS)
    Fay Crawford
    Department of Vascular Surgery, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, High Heaton, Newcastle NE7 7DN, UK
    BMC Med Res Methodol 13:22. 2013
  4. pmc Recruiting South Asians to a lifestyle intervention trial: experiences and lessons from PODOSA (Prevention of Diabetes & Obesity in South Asians)
    Anne Douglas
    Centre for Population Health Sciences, The University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Trials 12:220. 2011
  5. pmc Surgical trial in lobar intracerebral haemorrhage (STICH II) protocol
    A David Mendelow
    STICH Office, Neurosurgical Trials Unit, Newcastle University, 3 4 Claremont Terrace, Newcastle upon Tyne, NE2 4AE, UK
    Trials 12:124. 2011
  6. pmc European society of intensive care medicine study of therapeutic hypothermia (32-35 °C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial)
    Peter J D Andrews
    Department of Anaesthesia, Critical Care and Pain Management, University of Edinburgh, UK
    Trials 12:8. 2011
  7. pmc The added value of ordinal analysis in clinical trials: an example in traumatic brain injury
    Bob Roozenbeek
    Department of Neurosurgery, Antwerp University Hospital, Wilrijkstraat 10, Edegem, Belgium
    Crit Care 15:R127. 2011
  8. pmc The effectiveness of extra corporeal shock wave therapy for plantar heel pain: a systematic review and meta-analysis
    Colin E Thomson
    School of Health Sciences, Queen Margaret University College, Edinburgh, EH6 8HF, UK
    BMC Musculoskelet Disord 6:19. 2005
  9. ncbi request reprint Multivariable prognostic analysis in traumatic brain injury: results from the IMPACT study
    Gordon D Murray
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:329-37. 2007
  10. ncbi request reprint Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy
    Gordon D Murray
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 22:511-7. 2005

Detail Information

Publications62

  1. pmc Does intermittent pneumatic compression reduce the risk of post stroke deep vein thrombosis? The CLOTS 3 trial: statistical analysis plan
    Martin Dennis
    Division of Clinical Neurosciences, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 14:66. 2013
    ..The CLOTS 3 trial aims to determine whether, compared with best medical care, best medical care plus intermittent pneumatic compression (IPC) in immobile stroke patients reduces the risk of proximal deep vein thrombosis (DVT)...
  2. pmc Update on the Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II): statistical analysis plan
    Barbara A Gregson
    STICH Office, Neurosurgical Trials Unit, Newcastle University, 3 4 Claremont Terrace, Newcastle upon Tyne, NE2 4AE, UK
    Trials 13:222. 2012
    ..It is an international, multi-centre, prospective randomised parallel group trial of early surgery in patients with spontaneous lobar ICH. Outcome is measured at six months via a postal questionnaire...
  3. pmc Protocol for a systematic review and individual patient data meta-analysis of prognostic factors of foot ulceration in people with diabetes: the international research collaboration for the prediction of diabetic foot ulcerations (PODUS)
    Fay Crawford
    Department of Vascular Surgery, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, High Heaton, Newcastle NE7 7DN, UK
    BMC Med Res Methodol 13:22. 2013
    ..Can the data from each study be adjusted for a consistent set of adjustment factors?3. Does the model accuracy change when patient populations are stratified according to demographic and/or clinical characteristics?..
  4. pmc Recruiting South Asians to a lifestyle intervention trial: experiences and lessons from PODOSA (Prevention of Diabetes & Obesity in South Asians)
    Anne Douglas
    Centre for Population Health Sciences, The University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Trials 12:220. 2011
    ..Despite the growing emphasis on the inclusion of ethnic minority patients in research, there is little published on the recruitment of these populations especially to randomised, community based, lifestyle intervention trials in the UK...
  5. pmc Surgical trial in lobar intracerebral haemorrhage (STICH II) protocol
    A David Mendelow
    STICH Office, Neurosurgical Trials Unit, Newcastle University, 3 4 Claremont Terrace, Newcastle upon Tyne, NE2 4AE, UK
    Trials 12:124. 2011
    ..The STICH II study will establish whether a policy of earlier surgical evacuation of the haematoma in selected patients will improve outcome compared to a policy of initial conservative treatment...
  6. pmc European society of intensive care medicine study of therapeutic hypothermia (32-35 °C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial)
    Peter J D Andrews
    Department of Anaesthesia, Critical Care and Pain Management, University of Edinburgh, UK
    Trials 12:8. 2011
    ..Previous experience with cooling also appears to be important if complications, which may outweigh the benefits of hypothermia, are to be avoided...
  7. pmc The added value of ordinal analysis in clinical trials: an example in traumatic brain injury
    Bob Roozenbeek
    Department of Neurosurgery, Antwerp University Hospital, Wilrijkstraat 10, Edegem, Belgium
    Crit Care 15:R127. 2011
    ..The objective of this study is to quantify the benefits of ordinal analysis in the real-life situation of a large TBI trial...
  8. pmc The effectiveness of extra corporeal shock wave therapy for plantar heel pain: a systematic review and meta-analysis
    Colin E Thomson
    School of Health Sciences, Queen Margaret University College, Edinburgh, EH6 8HF, UK
    BMC Musculoskelet Disord 6:19. 2005
    ..Our aim was to conduct a systematic review of randomised controlled trials to investigate the effectiveness of extracorporeal shock wave therapy and to produce a precise estimate of the likely benefits of this therapy...
  9. ncbi request reprint Multivariable prognostic analysis in traumatic brain injury: results from the IMPACT study
    Gordon D Murray
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:329-37. 2007
    ....
  10. ncbi request reprint Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy
    Gordon D Murray
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 22:511-7. 2005
    ..The approach raises issues of clinical, statistical, and regulatory importance, and we initiate what we believe needs to become a widespread debate amongst the community involved in clinical research in head injury and stroke...
  11. ncbi request reprint Promoting good research practice
    G D Murray
    Department of Community Health Sciences, University of Edinburgh Medical School, UK
    Stat Methods Med Res 9:17-24. 2000
    ..Poor study design, inappropriate analysis and selective reporting are commonplace. In my opinion the most important challenge currently facing our profession is the task of bridging this chasm...
  12. doi request reprint Forced convective head cooling device reduces human cross-sectional brain temperature measured by magnetic resonance: a non-randomized healthy volunteer pilot study
    B A Harris
    School of Clinical Sciences and Community Health, University of Edinburgh, Edinburgh, UK
    Br J Anaesth 100:365-72. 2008
    ..This pilot study in five healthy adult humans forms the pre-clinical assessment of the effect of a forced convective head cooling device on intracranial temperature, measured non-invasively by magnetic resonance spectroscopy (MRS)...
  13. ncbi request reprint Enhanced upper respiratory tract airflow and head fanning reduce brain temperature in brain-injured, mechanically ventilated patients: a randomized, crossover, factorial trial
    B A Harris
    Intensive Care Unit Ward 20, University of Edinburgh Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK
    Br J Anaesth 98:93-9. 2007
    ..Heat loss from the upper airways and through the skull are physiological mechanisms of brain cooling which have not been fully explored clinically...
  14. pmc Selectivity of NSAIDs for COX-2 and cardiovascular outcome
    S R J Maxwell
    University of Edinburgh, Queen s Medical Research Institute, Royal Infirmary of Edinburgh and Public Health Sciences, University of Edinburgh Medical School, Edinburgh, UK
    Br J Clin Pharmacol 62:243-5. 2006
    ..Nonsteroidal anti-inflammatory drugs (NSAIDs) with increased selectivity for the cyclooxygenase-2 (COX-2) isoform reduce gastrotoxicity but may increase adverse cardiovascular events...
  15. pmc Low dose aspirin and cognitive function in middle aged to elderly adults: randomised controlled trial
    Jackie F Price
    Division of Community Health Sciences and Centre for Public Health and Primary Care Research, University of Edinburgh, Edinburgh
    BMJ 337:a1198. 2008
    ..To determine the effects of low dose aspirin on cognitive function in middle aged to elderly men and women at moderately increased cardiovascular risk...
  16. doi request reprint Associations between polymorphisms in five inflammation-related genes and cognitive ability in older persons
    R E Marioni
    Centre for Population Health Sciences, University of Edinburgh, Scotland, UK
    Genes Brain Behav 9:348-52. 2010
    ..048). There is little evidence to suggest an association between SNPs in the inflammation-related genes IL-1alpha, IL-1beta, IL-6, TCF-1 and F13A1 and cognition in an elderly population of community-dwelling Scottish citizens...
  17. doi request reprint Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trial
    F Gerald R Fowkes
    Centre for Population Health Sciences, University of Edinburgh, Scotland
    JAMA 303:841-8. 2010
    ..Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to preventive treatments...
  18. ncbi request reprint Increased augmentation index and systolic stress in type 1 diabetes mellitus
    I B Wilkinson
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    QJM 93:441-8. 2000
    ..Such haemodynamic effects may contribute to the increased left ventricular mass and risk of cardiovascular disease associated with type 1 diabetes mellitus...
  19. ncbi request reprint Randomized controlled trial of effects of the airflow through the upper respiratory tract of intubated brain-injured patients on brain temperature and selective brain cooling
    P J D Andrews
    Department of Anaesthesia, Intensive Care and Pain Management, University of Edinburgh, UK
    Br J Anaesth 94:330-5. 2005
    ..The normal physiological mechanisms of brain cooling are heat loss from the upper airways and through the skull, and these can produce selective brain cooling...
  20. pmc Genetic polymorphisms of cytochrome p4502E1 and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a white population: a study and literature review, including meta-analysis
    N A Wong
    Department of Pathology, University of Edinburgh Medical School, Scotland, UK
    Mol Pathol 53:88-93. 2000
    ..To investigate the associations between the Rsa I, Dra I, and Taq I genetic polymorphisms of cytochrome p4502E1 and susceptibility to alcoholic liver disease or to hepatocellular carcinoma...
  21. pmc Association between raised inflammatory markers and cognitive decline in elderly people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    Riccardo E Marioni
    Centre for Population Health Sciences, University of Edinburgh, Scotland, UK
    Diabetes 59:710-3. 2010
    ....
  22. ncbi request reprint Prognostic value of cause of injury in traumatic brain injury: results from the IMPACT study
    Isabella Butcher
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:281-6. 2007
    ..Falls were found to be associated with an older age and with a higher incidence of mass lesions. Following adjustment for age in the analysis, the relationship between cause of injury and outcome was lost...
  23. ncbi request reprint Prognostic value of secondary insults in traumatic brain injury: results from the IMPACT study
    Gillian S McHugh
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:287-93. 2007
    ..The occurrence of secondary insults prior to or on admission to hospital in TBI patients is strongly related to poorer outcome and should therefore be a priority for emergency department personnel...
  24. ncbi request reprint Prognostic value of admission blood pressure in traumatic brain injury: results from the IMPACT study
    Isabella Butcher
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:294-302. 2007
    ..Our finding of a smooth relationship with improving outcome as SBP increases up to 135 mm Hg, while not supporting a strong causal inference, does suggest that current guidelines need to be reconsidered...
  25. ncbi request reprint Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Circulation 115:2119-27. 2007
    ....
  26. pmc Peripheral levels of fibrinogen, C-reactive protein, and plasma viscosity predict future cognitive decline in individuals without dementia
    Riccardo E Marioni
    Centre for Population Health Sciences, Public Health Sciences Section, University of Edinburgh, Edinburgh, EH8 9AG, Scotland, UK
    Psychosom Med 71:901-6. 2009
    ..To determine whether circulating levels of the biomarkers C-reactive protein (CRP), fibrinogen, plasma viscosity, and hematocrit were associated with cognitive decline in middle-aged to elderly people...
  27. doi request reprint Frequency of a low ankle brachial index in the general population by age, sex and deprivation: cross-sectional survey of 28,980 men and women
    Jackie F Price
    Division of Community Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland
    Eur J Cardiovasc Prev Rehabil 15:370-5. 2008
    ..The aim of this study was to provide information on the distribution of ABI in a large healthy population, essential for planning implementation of ABI measurement in preventive strategies in the general population...
  28. doi request reprint Association between polymorphisms of the dopamine receptor D2 and catechol-o-methyl transferase genes and cognitive function
    Jennifer L Bolton
    Public Health Sciences, University of Edinburgh, Medical School, Edinburgh EH9 1NN, UK
    Behav Genet 40:630-8. 2010
    ..003), and DRD2 rs1800497 heterozygotes had lowest mean general cognitive ability 'g' (p = 0.007). There was an indication of a potential interaction between the DRD2 SNPs...
  29. doi request reprint Association of KIBRA and memory
    Timothy C Bates
    Department of Psychology, University of Edinburgh, 7 George Square, EH89JZ, Scotland, UK
    Neurosci Lett 458:140-3. 2009
    ....
  30. doi request reprint Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples
    Riccardo E Marioni
    Public Health Sciences Section, Division of Community Health Sciences, Centre for Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, EH8 9AG Edinburgh, Scotland, UK
    Behav Genet 40:3-11. 2010
    ..038). After correction for multiple testing and adjustment for age and sex, no statistically significant associations were found between the SNPs and cognition. CRP is unlikely to be a causal determinant of late-life cognitive ability...
  31. doi request reprint Cancer pain and its relationship to systemic inflammation: an exploratory study
    Barry J A Laird
    University of Edinburgh, UK
    Pain 152:460-3. 2011
    ..This is in keeping with work showing this relationship in nonmalignant pain. Studies targeting inflammation and assessing its effect on pain in cancer would be an important step in the research agenda...
  32. ncbi request reprint Hemostatic factors, inflammatory markers, and progressive peripheral atherosclerosis: the Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, School of Medicine and Veterinary Medicine, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Am J Epidemiol 163:334-41. 2006
    ..Since D-dimer and fibrinogen are acute phase reactants, these data support the hypothesis that inflammation is more related to atherosclerosis than is hypercoagulation...
  33. ncbi request reprint Statistical approaches to the univariate prognostic analysis of the IMPACT database on traumatic brain injury
    Gillian S McHugh
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:251-8. 2007
    ..Many of our approaches are based on simple graphical displays of the data, but, where appropriate, we have also used methods that although established in the statistical literature are relatively novel in their application to TBI...
  34. ncbi request reprint C-reactive protein, interleukin-6, and soluble adhesion molecules as predictors of progressive peripheral atherosclerosis in the general population: Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Edinburgh, EH8 9AG, Scotland
    Circulation 112:976-83. 2005
    ..We therefore studied inflammatory markers as predictors of peripheral atherosclerotic progression, measured by the ankle-brachial index (ABI) at 3 consecutive time points over 12 years...
  35. ncbi request reprint Inflammatory, haemostatic, and rheological markers for incident peripheral arterial disease: Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Eur Heart J 28:354-62. 2007
    ..However, their role in peripheral arterial disease (PAD) is not well established and some of them, including the pro-inflammatory cytokine interleukin-6 (IL-6), have not been examined before in prospective epidemiological studies...
  36. ncbi request reprint Menorrhagia I: measured blood loss, clinical features, and outcome in women with heavy periods: a survey with follow-up data
    Pamela E Warner
    Division of Community Health Sciences, University of Edinburgh Medical School, Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, Edinburgh, Scotland, United Kingdom
    Am J Obstet Gynecol 190:1216-23. 2004
    ..Menorrhagia is defined as blood loss of >80 mL, but in routine clinical practice measurement is seldom undertaken. Our aim was to identify the features of the clinical history that best predict menorrhagic blood loss...
  37. ncbi request reprint Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia
    Kenneth C H Fearon
    Department of Clinical and Surgical Sciences Surgery, The Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    J Clin Oncol 24:3401-7. 2006
    ..Eicosapentaenoic acid (EPA) has been proposed to have specific anticachectic effects. This trial compared EPA diethyl ester with placebo in cachectic cancer patients for effects on weight and lean body mass...
  38. ncbi request reprint Menorrhagia II: is the 80-mL blood loss criterion useful in management of complaint of menorrhagia?
    Pamela E Warner
    Division of Community Health Sciences, University of Edinburgh Medical School, Edinburgh, Scotland, UK
    Am J Obstet Gynecol 190:1224-9. 2004
    ..Menorrhagia is defined in terms of statistical"abnormality"as blood loss of >80 mL. We examined the usefulness of this definition in women who were referred to gynecology clinics with heavy periods...
  39. ncbi request reprint Risk of mortality and cardiovascular disease associated with the ankle-brachial index: Systematic review
    C L Heald
    Public Health Sciences, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, United Kingdom
    Atherosclerosis 189:61-9. 2006
    ..To determine the strength and consistency with which a low ankle brachial pressure index (ABI), measured in the general population, is associated with an increased risk of subsequent death and/or cardiovascular events...
  40. doi request reprint A simulation study evaluating approaches to the analysis of ordinal outcome data in randomized controlled trials in traumatic brain injury: results from the IMPACT Project
    Gillian S McHugh
    Public Health Sciences, Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, UK
    Clin Trials 7:44-57. 2010
    ..One contributor to this lack of success is almost certainly the low efficiency of the conventional approach to the analysis, which discards information by dichotomizing an ordinal outcome scale...
  41. ncbi request reprint Randomized clinical trial comparing self-expanding metallic stents with plastic endoprostheses in the palliation of oesophageal cancer
    C A O'Donnell
    Department of General Practice, University of Glasgow, and Departments of Surgery and Interventional Radiology, Gartnavel General Hospital, Glasgow, and Public Health Sciences, University of Edinburgh, Edinburgh, UK
    Br J Surg 89:985-92. 2002
    ....
  42. ncbi request reprint Predicting outcome after traumatic brain injury: development and validation of a prognostic score based on admission characteristics
    Chantal W P M Hukkelhoven
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    J Neurotrauma 22:1025-39. 2005
    ..The high discriminative ability indicates the potential of this model for classifying patients according to prognostic risk...
  43. ncbi request reprint Adjustment for strong predictors of outcome in traumatic brain injury trials: 25% reduction in sample size requirements in the IMPACT study
    Adrian V Hernandez
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Neurotrauma 23:1295-303. 2006
    ..A major reduction in sample size can be obtained with covariate adjustment in TBI trials. Covariate adjustment for strong predictors should be incorporated in the analysis of future TBI trials...
  44. ncbi request reprint Use and adherence to beta-blockers for secondary prevention of myocardial infarction: who is not getting the treatment?
    Li Wei
    Medicines Monitoring Unit, Department of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Pharmacoepidemiol Drug Saf 13:761-6. 2004
    ..To characterise those who receive beta-blocker therapy after MI and to estimate the effect of adherence to beta-blocker use on subsequent mortality and recurrent MI...
  45. ncbi request reprint Patient age and outcome following severe traumatic brain injury: an analysis of 5600 patients
    Chantal W P M Hukkelhoven
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurosurg 99:666-73. 2003
    ..The authors studied the shape and strength of the relationship between age and outcome, that is, the 6-month mortality rate and unfavorable outcome based on the Glasgow Outcome Scale...
  46. ncbi request reprint IMPACT database of traumatic brain injury: design and description
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical School, Richmond, Virginia 23219, USA
    J Neurotrauma 24:239-50. 2007
    ....
  47. ncbi request reprint Subgroup analyses in therapeutic cardiovascular clinical trials: are most of them misleading?
    Adrian V Hernandez
    Center for Clinical Decision Sciences, Department of Public Health, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am Heart J 151:257-64. 2006
    ..Treatment decisions in clinical cardiology are directed by results from randomized clinical trials (RCTs). We studied the appropriateness of the use and interpretation of subgroup analysis in current therapeutic cardiovascular RCTs...
  48. ncbi request reprint Traumatic subarachnoid hemorrhage: demographic and clinical study of 750 patients from the European brain injury consortium survey of head injuries
    Franco Servadei
    Divisione di Neurochirurgia per la Traumatologia, Ospedale Maurizio Bufalini, Cesena, Italy
    Neurosurgery 50:261-7; discussion 267-9. 2002
    ..The mechanism underlying the link between tSAH and prognosis has not been clarified. The aim of this study was to investigate the association between CT evidence of tSAH and outcomes after moderate or severe head injuries...
  49. ncbi request reprint Prognostic value of demographic characteristics in traumatic brain injury: results from the IMPACT study
    Nino A Mushkudiani
    Center for Medical Decision Making, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:259-69. 2007
    ..We conclude that outcome following TBI is dependent on age, race, to a lesser extent on education, but not on gender...
  50. ncbi request reprint Prognostic value of the Glasgow Coma Scale and pupil reactivity in traumatic brain injury assessed pre-hospital and on enrollment: an IMPACT analysis
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23219, USA
    J Neurotrauma 24:270-80. 2007
    ..0001). Pupil reactivity was more robust between these time points. It is recommended that the study hospital enrollment GCS and pupil reactivity be used for prognostic analysis...
  51. ncbi request reprint Prognosis and clinical trial design in traumatic brain injury: the IMPACT study
    Andrew I R Maas
    Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:232-8. 2007
    ....
  52. ncbi request reprint Prognostic value of computerized tomography scan characteristics in traumatic brain injury: results from the IMPACT study
    Andrew I R Maas
    Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:303-14. 2007
    ..We conclude that both the CT classification and individual CT characteristics are important predictors of outcome in TBI. For clinical trials, a central review process is advocated to minimize observer variability in CT assessment...
  53. ncbi request reprint Prognostic value of admission laboratory parameters in traumatic brain injury: results from the IMPACT study
    Jackelien G M Van Beek
    Center for Clinical Decision Making, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:315-28. 2007
    ..60-0.78). Higher glucose values were associated with increasing age, but on adjusted analysis, the strength of the association with outcome remained. Whether treatment of abnormal values may improve outcome needs further rigorous study...
  54. doi request reprint A systematic review finds methodological improvements necessary for prognostic models in determining traumatic brain injury outcomes
    Nino A Mushkudiani
    Center for Medical Decision Making, Department of Public Health, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Epidemiol 61:331-43. 2008
    ..To describe the modeling techniques used for early prediction of outcome in traumatic brain injury (TBI) and to identify aspects for potential improvements...
  55. pmc Effects of Glasgow Outcome Scale misclassification on traumatic brain injury clinical trials
    Juan Lu
    Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA
    J Neurotrauma 25:641-51. 2008
    ..An awareness of this procedural error and methods to reduce misclassification should be incorporated in TBI clinical trials...
  56. ncbi request reprint Magnesium for neuroprotection after traumatic brain injury
    Andrew I R Maas
    Lancet Neurol 6:20-1. 2007
  57. ncbi request reprint Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
    John A Dormandy
    Department of Clinical Vascular Research, Ingelby House, St Georges Hospital, Blackshaw Road, London SW17 0QT, UK
    Lancet 366:1279-89. 2005
    ..Our aim, therefore, was to ascertain whether pioglitazone reduces macrovascular morbidity and mortality in high-risk patients with type 2 diabetes...
  58. ncbi request reprint Uterine-artery embolization versus surgery for symptomatic uterine fibroids
    Richard D Edwards
    N Engl J Med 356:360-70. 2007
    ..The efficacy and safety of uterine-artery embolization, as compared with standard surgical methods, for the treatment of symptomatic uterine fibroids remain uncertain...
  59. ncbi request reprint New European directive on clinical trials: implications for traumatic head injury research
    Nino Stocchetti
    Intensive Care Med 30:517-8. 2004
  60. ncbi request reprint The management of patients with intradural post-traumatic mass lesions: a multicenter survey of current approaches to surgical management in 729 patients coordinated by the European Brain Injury Consortium
    Christian Compagnone
    World Health Organization Neurotrauma Collaborating Centre and Department of Neurosurgery, M Bufalini Hospital, Cesena, Italy
    Neurosurgery 57:1183-92; discussion 1183-92. 2005
    ..The aim of this study was to survey contemporary approaches to the treatment of head injured patients with an intradural lesion, placing a particular focus on the utilization of decompressive craniectomy...
  61. ncbi request reprint The relationship between volume and health outcomes--a review
    Gordon D Murray
    University of Edinburgh
    Scott Med J 51:17-22. 2006
  62. ncbi request reprint Some prognostic models for traumatic brain injury were not valid
    Chantal W P M Hukkelhoven
    Center for Medical Decision Making Sciences, Department of Public Health, Erasmus MC University Medical Center Rotterdam, P O Box 1739, 3000 DR Rotterdam, The Netherlands
    J Clin Epidemiol 59:132-43. 2006
    ..We aimed to determine the validity of six models that used baseline clinical and computed tomographic characteristics to predict mortality or unfavorable outcome at 6 months or later after severe or moderate TBI...