Sean Munro


Affiliation: University of Cambridge
Country: UK


  1. Rosa Ferreira C, Sweeney S, Munro S. The small G protein Arl8 contributes to lysosomal function and long-range axonal transport in Drosophila. Biol Open. 2018;7: pubmed publisher
    ..Thus Drosophila Arl8 controls late endocytic function and transport via at least two distinct effectors.This article has an associated First Person interview with the first author of the paper. ..
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    Munro S. The Arf-like GTPase Arl1 and its role in membrane traffic. Biochem Soc Trans. 2005;33:601-5 pubmed
    ..Genetic analysis in a number of species has shown that Arl1 is not essential for exocytosis, but rather suggest that it is required for traffic from endosomes to the Golgi. ..
  3. Wong M, Munro S. Membrane trafficking. The specificity of vesicle traffic to the Golgi is encoded in the golgin coiled-coil proteins. Science. 2014;346:1256898 pubmed publisher
    ..These findings demonstrate that golgins act as tethers in vivo, and hence the specificity we find to be encoded in this tethering is likely to make a major contribution to the organization of membrane traffic at the Golgi apparatus. ..
  4. Muschalik N, Munro S. Golgins. Curr Biol. 2018;28:R374-R376 pubmed publisher
    ..Muschalik and Munro introduce golgins and their roles as vesicle tethers and scaffolds at the Golgi. ..
  5. Munro S. What is the Golgi apparatus, and why are we asking?. BMC Biol. 2011;9:63 pubmed publisher
  6. Munro S. Open questions: what is there left for cell biologists to do?. BMC Biol. 2013;11:16 pubmed publisher
  7. Riedel F, Gillingham A, Rosa Ferreira C, Galindo A, Munro S. An antibody toolkit for the study of membrane traffic in Drosophila melanogaster. Biol Open. 2016;5:987-92 pubmed publisher
    ..We anticipate that these antibodies will provide a useful tool kit to facilitate the investigation of how the endomembrane system functions and varies in the diverse tissue types of metazoans. ..
  8. Wong M, Gillingham A, Munro S. The golgin coiled-coil proteins capture different types of transport carriers via distinct N-terminal motifs. BMC Biol. 2017;15:3 pubmed publisher
    ..There appear to be at least four different types of motif, consistent with specific golgins capturing specific classes of carrier and implying the existence of distinct receptors present on each of these different carrier classes. ..
  9. Munro S. The golgin coiled-coil proteins of the Golgi apparatus. Cold Spring Harb Perspect Biol. 2011;3: pubmed publisher
    ..Such a collective role might explain the lack of cell lethality seen following loss of some of the genes in human familial conditions or mouse models. ..

More Information


  1. Torres I, Rosa Ferreira C, Munro S. The Arf family G protein Arl1 is required for secretory granule biogenesis in Drosophila. J Cell Sci. 2014;127:2151-60 pubmed publisher
    ..Arl1 does not appear to be required for AP-1 recruitment in all tissues, suggesting that it is crucially required to enhance Arf1 activation at the trans-Golgi in particular tissues. ..
  2. Gillingham A, Sinka R, Torres I, Lilley K, Munro S. Toward a comprehensive map of the effectors of rab GTPases. Dev Cell. 2014;31:358-73 pubmed publisher
    ..These include tethering complexes, coiled-coiled proteins, motor linkers, Rab regulators, and several proteins linked to human disease. ..
  3. Rosa Ferreira C, Christis C, Torres I, Munro S. The small G protein Arl5 contributes to endosome-to-Golgi traffic by aiding the recruitment of the GARP complex to the Golgi. Biol Open. 2015;4:474-81 pubmed publisher
    ..Thus it appears that Arl5 is one of the factors that directs the recruitment of the GARP complex to the trans-Golgi, and this function is conserved in both flies and humans. ..
  4. Riedel F, Galindo A, Muschalik N, Munro S. The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases. J Cell Biol. 2018;217:601-617 pubmed publisher
    ..Thus, in metazoans, Rab1 activation requires TRAPP subunits not found in yeast, and Rab11 activation is shared by TRAPPII and an unrelated GEF that is metazoan specific. ..
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    Munro S, Freeman M. The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD. Curr Biol. 2000;10:813-20 pubmed
    ..They suggest that alteration in receptor glycosylation can regulate the relative efficiency of different ligands. ..
  6. Galindo A, Soler N, McLaughlin S, Yu M, Williams R, Munro S. Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi. Cell Rep. 2016;16:839-50 pubmed publisher
    ..The findings provide structural insight into how Arf1 GEFs, and hence active Arf1, achieve their correct subcellular distribution. ..