A W Munro

Summary

Affiliation: University of Strathclyde
Country: UK

Publications

  1. ncbi Determination of the redox properties of human NADPH-cytochrome P450 reductase
    A W Munro
    Department of Pure and Applied Chemistry, University of Strathclyde, The Royal College, 204 George Street, Glasgow, G1 1XL, UK
    Biochemistry 40:1956-63. 2001
  2. ncbi Resonance Raman scattering of cytochrome P450 BM3 and effect of imidazole inhibitors
    S J Smith
    Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom
    Biopolymers 70:620-7. 2003
  3. ncbi Biodiversity of cytochrome P450 redox systems
    K J McLean
    Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, UK
    Biochem Soc Trans 33:796-801. 2005
  4. pmc Effects of environment on flavin reactivity in morphinone reductase: analysis of enzymes displaying differential charge near the N-1 atom and C-2 carbonyl region of the active-site flavin
    D H Craig
    Department of Biochemistry and Centre for Chemical Biology, University of Leicester, University Road, Leicester LE1 7RH, UK
    Biochem J 359:315-23. 2001
  5. ncbi Electron transfer in human cytochrome P450 reductase
    A Gutierrez
    Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK
    Biochem Soc Trans 31:497-501. 2003
  6. ncbi Flavoenzyme catalysed oxidation of amines: roles for flavin and protein-based radicals
    S E Rigby
    Department of Biological Sciences, Queen Mary College, University of London, London E1 4NS, UK
    Biochem Soc Trans 33:754-7. 2005
  7. ncbi CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen
    K J McLean
    Manchester Interdisciplinary Biocentre, School of Chemical Engineering and Analytical Science, University of Manchester, 131 Princess Street, Manchester M1 7ND, UK
    Biochem Soc Trans 34:1178-82. 2006

Collaborators

  • S K Chapman
  • K J McLean
  • N S Scrutton
  • S E Rigby
  • S J Smith
  • A Gutierrez
  • D H Craig
  • H Toogood
  • D Leys
  • J P Combe
  • M J Sutcliffe
  • J Basran
  • A van Thiel
  • A W Mohsen
  • C R Wolf
  • G C K Roberts
  • A Grunau
  • W E Smith
  • M Paine
  • N C Bruce
  • T Barna
  • P C Moody

Detail Information

Publications7

  1. ncbi Determination of the redox properties of human NADPH-cytochrome P450 reductase
    A W Munro
    Department of Pure and Applied Chemistry, University of Strathclyde, The Royal College, 204 George Street, Glasgow, G1 1XL, UK
    Biochemistry 40:1956-63. 2001
    ..However, they differ markedly from those of yeast and bacterial CPRs, pointing to an important evolutionary difference in electronic regulation of these enzymes...
  2. ncbi Resonance Raman scattering of cytochrome P450 BM3 and effect of imidazole inhibitors
    S J Smith
    Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow G1 1XL, United Kingdom
    Biopolymers 70:620-7. 2003
    ..The effect of both inhibitors is similar but there is a subtle difference in the extent of the reduction in the intensity of nu(11), which suggests that steric effects within the pocket are having some effect...
  3. ncbi Biodiversity of cytochrome P450 redox systems
    K J McLean
    Department of Biochemistry, University of Leicester, The Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, UK
    Biochem Soc Trans 33:796-801. 2005
    ..This paper examines some of the recent advances in our understanding of the biodiversity of the P450 redox apparatus, with a particular emphasis on the redox systems in the pathogen Mycobacterium tuberculosis...
  4. pmc Effects of environment on flavin reactivity in morphinone reductase: analysis of enzymes displaying differential charge near the N-1 atom and C-2 carbonyl region of the active-site flavin
    D H Craig
    Department of Biochemistry and Centre for Chemical Biology, University of Leicester, University Road, Leicester LE1 7RH, UK
    Biochem J 359:315-23. 2001
    ..This finding may have general implications for flavoenzyme catalysis, since it has generally been assumed that positive charge in this region has a stabilizing effect on the reduced form of flavin...
  5. ncbi Electron transfer in human cytochrome P450 reductase
    A Gutierrez
    Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK
    Biochem Soc Trans 31:497-501. 2003
    ..These studies and the mechanism of electron transfer in CPR are reported herein...
  6. ncbi Flavoenzyme catalysed oxidation of amines: roles for flavin and protein-based radicals
    S E Rigby
    Department of Biological Sciences, Queen Mary College, University of London, London E1 4NS, UK
    Biochem Soc Trans 33:754-7. 2005
    ..Oxidation of amines by flavoenzymes is less well understood. The role of protein-based radicals and flavin semiquinone radicals in the oxidation of amines is discussed...
  7. ncbi CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen
    K J McLean
    Manchester Interdisciplinary Biocentre, School of Chemical Engineering and Analytical Science, University of Manchester, 131 Princess Street, Manchester M1 7ND, UK
    Biochem Soc Trans 34:1178-82. 2006
    ..The accessory flavoprotein and iron-sulfur proteins required to drive P450 catalysis are also discussed, providing an overview of the current state of knowledge of Mtb P450 redox systems...