Research Topics
Genomes and GenesSpecies | Ulrich MullerSummaryAffiliation: University of Cambridge Country: UK Publications
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Detail Information
Publications
The identification and management of ADHD offenders within the criminal justice system: a consensus statement from the UK Adult ADHD Network and criminal justice agenciesSusan J Young
King s College London, Institute of Psychiatry, UK
BMC Psychiatry 11:32. 2011..In time this will provide better justice for both offenders and society...- Directed forgetting in schizophrenia: prefrontal memory and inhibition deficitsUlrich Muller
Dept of Psychiatry, University of Leipzig, Leipzig, Germany
Eur Arch Psychiatry Clin Neurosci 255:251-7. 2005..The DF effect was associated with disease duration but not with symptom severity. Memory-related inhibition problems are difficult to assess in patients with schizophrenia and might be related to fronto-temporal disconnection... - Reduced daytime activity in patients with acquired brain damage and apathy: a study with ambulatory actigraphyUlrich Muller
Department of Psychiatry, University of Leipzig, Germany
Brain Inj 20:157-60. 2006..Apathy is difficult to assess in clinical practice. Ambulatory actigraphy was used with the aim to measure locomotor activity during the daytime as a correlate of self-initiated action in brain-damaged patients with apathy... - Plasma level-dependent effects of methylphenidate on task-related functional magnetic resonance imaging signal changesUlrich Muller
MRC Behavioural and Clinical Neuroscience Centre, University of Cambridge, Cambridge, UK
Psychopharmacology (Berl) 180:624-33. 2005..Understanding of its cognition-enhancing effects and the neurobiological mechanisms involved, especially in elderly people, is currently incomplete... - Noradrenergic blockade and numeric working memory in humansUlrich Muller
Department of Psychiatry, University of Leipzig, Germany
J Psychopharmacol 19:21-8. 2005..Because both beta-blockers induced a comparable decrease of blood pressure and pulse, the propranolol effect on the 'working component' of working memory is considered to be a central, presumably prefrontal one... - Prefrontal cognitive deficits in patients with schizophrenia treated with atypical or conventional antipsychoticsU Muller
Department of Psychiatry, University of Leipzig, Leipzig, Germany
Eur Psychiatry 20:70-3. 2005..Manipulation tasks might be useful for neurocognitive follow-up and intervention studies... - Lack of effects of guanfacine on executive and memory functions in healthy male volunteersUlrich Muller
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
Psychopharmacology (Berl) 182:205-13. 2005..Guanfacine is an alpha2-adrenergic receptor agonist that has been shown to have beneficial effects on working memory and attentional functions in monkeys and in patients with attention deficit hyperactivity disorder... - Effects of modafinil on working memory processes in humansUlrich Muller
Department of Psychiatry, University of Leipzig, Leipzig, Germany
Psychopharmacology (Berl) 177:161-9. 2004..So far, understanding of the cognitive enhancing effects of modafinil and the relevant neurobiological mechanisms are incomplete... - [A systematic comparison of national and international dementia guidelines]U Muller
Klinik und Poliklinik fur Psychiatrie, Universitat Leipzig
Fortschr Neurol Psychiatr 71:285-95. 2003..g. routine EEG, FDG PET, cognitive training). A discussion of the prevalent guideline pluralism and a pleading for regionally adapted international guidelines conclude this article... - The origin of pharmacopsychology: Emil Kraepelin's experiments in Leipzig, Dorpat and Heidelberg (1882-1892)Ulrich Muller
Department of Experimental Psychology, University of Cambridge, Downing Site, CB2 3EB, Cambridge, UK
Psychopharmacology (Berl) 184:131-8. 2006..Kraepelin's contributions to psychopharmacology and clinical neuropsychology were far ahead of his time and his conceptual achievements have been largely neglected by modern psychiatry and cognitive neuroscience... - Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorderSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
Biol Psychiatry 62:977-84. 2007..Compared with psychostimulants, atomoxetine has a distinct mode of brain action and potentially lower addictive potential. Studies have yet to assess whether atomoxetine improves cognition following a single oral dose in ADHD... - Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonistKaren D Ersche
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
Biol Psychiatry 70:754-62. 2011..The aim of this study was to measure behavioral and neural markers of compulsivity in stimulant-dependent individuals and to test whether these markers could be modulated by treatment with drugs targeting the dopamine system... - Translational approaches to frontostriatal dysfunction in attention-deficit/hyperactivity disorder using a computerized neuropsychological batterySamuel R Chamberlain
Department of Psychiatry and Medical Research Council Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom
Biol Psychiatry 69:1192-203. 2011..The findings suggest overlapping but also distinct early cognitive effects of ADHD medications and have important implications for understanding the pathophysiology of ADHD and for future trials... - Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependenceKaren D Ersche
University of Cambridge, Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, Cambridge, England
Arch Gen Psychiatry 67:632-44. 2010..We hypothesized that dopamine-related targets are relevant for treatment of stimulant dependence, and there will likely be individual differences in response to dopaminergic challenges... - The dopamine D2 receptor antagonist sulpiride modulates striatal BOLD signal during the manipulation of information in working memoryChris M Dodds
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Psychopharmacology (Berl) 207:35-45. 2009..Dopamine (DA) plays an important role in working memory. However, the precise functions supported by different DA receptor subtypes in different neural regions remain unclear... - The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attentionJonathan P Roiser
Department of Psychiatry, Box 189, Addenbrooke s Hospital, Cambridge, UKInstitute of Neurology, Queen Square House, London, UK
Int J Neuropsychopharmacol 10:449-61. 2007.... - Effects of psychostimulants on alertness and spatial bias in healthy participantsChris Dodds
Department of Experimental Psychology, University of Cambridge, UK
J Cogn Neurosci 21:529-37. 2009.... - Atomoxetine increases salivary cortisol in healthy volunteersSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
J Psychopharmacol 21:545-9. 2007..Furthermore, the effects of atomoxetine on HPA axis function may have clinical implications given the use of this agent in the treatment of ADHD... - Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging studySamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
Biol Psychiatry 65:550-5. 2009..However, the mechanisms by which atomoxetine improves inhibitory control have yet to be determined... - Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging studySamuel R Chamberlain
Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
Br J Psychiatry 193:216-21. 2008..Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking... - Effects of acute modafinil on cognition in trichotillomaniaSamuel R Chamberlain
Department of Psychiatry and MRC Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
Psychopharmacology (Berl) 212:597-601. 2010..Individuals with trichotillomania often report significant difficulty resisting the urges and drive to pull hair... - Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependenceKaren D Ersche
Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Am J Psychiatry 169:926-36. 2012.... - Neuropharmacological modulation of cognitionSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, UK
Curr Opin Neurol 19:607-12. 2006..The purpose of this article is to review recent neuropharmacological manipulation studies in humans relating to these domains... - Lack of deleterious effects of buspirone on cognition in healthy male volunteersSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK
J Psychopharmacol 21:210-5. 2007..Future research directions are discussed in relation to acute and chronic studies in neuropsychiatric populations... - Relationship between SLC6A3 genotype and striatal dopamine transporter availability: a meta-analysis of human single photon emission computed tomography studiesAnna Costa
Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
Synapse 65:998-1005. 2011..Further work is needed to clarify the molecular mechanisms by which this polymorphism may affect cognition and psychiatric disorders, if not through altered expression as measured by molecular imaging... - Functional connectivity and brain networks in schizophreniaMary Ellen Lynall
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
J Neurosci 30:9477-87. 2010.... - Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulationSharon Morein-Zamir
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Box 189, CB2 2QQ, Cambridge, UK
Psychopharmacology (Berl) 212:357-67. 2010..Patients with obsessive compulsive disorder (OCD) demonstrate impaired cognition in some selected domains. Although serotoninergic dysfunction has been implicated in OCD, recent evidence suggests that dopamine may play a role as well... - Amisulpride-induced acute akathisia in OCD: an example of dysfunctional dopamine-serotonin interactions?Karen D Ersche
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
J Psychopharmacol 26:887-90. 2012..We further speculate about the neuropathology possibly underlying this clinical observation and outline a testable hypothesis for future molecular imaging studies... - Neurochemical modulation of response inhibition and probabilistic learning in humansSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 189, Cambridge CB2 2QQ, UK
Science 311:861-3. 2006.... - Noradrenergic modulation of working memory and emotional memory in humansSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
Psychopharmacology (Berl) 188:397-407. 2006..NA dysfunction and abnormalities in arousal-dependent memory functions are evident in a variety of neuropsychiatric illnesses... - Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interestNatalia Del Campo
Department of Psychiatry, University of Cambridge, Cambridge, UK
Neuroimage 55:101-12. 2011.... - Methylphenidate has differential effects on blood oxygenation level-dependent signal related to cognitive subprocesses of reversal learningChris M Dodds
Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 28:5976-82. 2008..The results show that the precise neural site of modulation by methylphenidate depends on the nature of the cognitive subprocess recruited... - Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controlsJ H Barnett
Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Mol Psychiatry 12:502-9. 2007..There was no evidence of publication bias. We conclude that there is small but significant relationship between Val(158)Met genotype and executive function in healthy individuals but not in schizophrenia... - Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteersS E Winder-Rhodes
Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
J Psychopharmacol 24:1649-57. 2010..Our findings support the hypothesised involvement of α1-adrenoceptors in some of the cognitive-enhancing effects of modafinil and warrant further investigation... - Neural and behavioral endophenotypes in ADHDNatalia Del Campo
Department of Psychiatry, and Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Curr Top Behav Neurosci 11:65-91. 2012..To this end, recent evidence drawn from molecular and structural neuroimaging studies are discussed in the light of widely accepted neuropsychological and pharmacological models of ADHD... - Effects of pallidal deep brain stimulation and levodopa treatment on reaction-time performance in Parkinson's diseaseT Schubert
Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
Exp Brain Res 144:8-16. 2002..Furthermore, our data show a way to uncover the subcortical-cortical circuitry serving human sensorimotor behavior... - Serotonin transporter imaging with [123I]beta-CIT SPECT before and after one year of citalopram treatment of obsessive-compulsive disorderKatarina Stengler-Wenzke
Department of Psychiatry, University of Leipzig, Leipzig, Germany
Neuropsychobiology 53:40-5. 2006..The neurobiological mechanisms of SSRI action and failure to respond to SSRI treatment remain to be elucidated... - Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorderSwen Hesse
Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, D 04103 Leipzig, Germany
Psychiatry Res 140:63-72. 2005..Our data provide evidence for imbalanced monoaminergic neurotransmitter modulation in OCD. Further studies with more selective DAT and SERT radiotracers are needed... - Manipulation of working memory information is impaired in Parkinson's disease and related to working memory capacityP Bublak
Department of Neurology, Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
Neuropsychology 16:577-90. 2002..Increasing complexity may either affect their manipulation ability directly or impede the management of inhibitory control requirements inherent to the task... - Is correction for age necessary in neuroimaging studies of the central serotonin transporter?Swen Hesse
Department of Nuclear Medicine, University of Leipzig, Germany
Eur J Nucl Med Mol Imaging 30:427-30. 2003..From these results we conclude that age-related changes in SERT density need to be considered in future clinical studies... - Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disordersSwen Hesse
Department of Nuclear Medicine, University Hospital, University of Leipzig, Leipzig, Germany
Neurosci Biobehav Rev 28:547-63. 2004..We furthermore elucidate the potential of SERT imaging techniques in estimating the effect of selective serotonin reuptake-inhibitors... - Paroxetine versus citalopram treatment of pathological crying after brain injuryU Muller
Department of Neurology, Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
Brain Inj 13:805-11. 1999..The only adverse effect after paroxetine was nausea, which was reversible, in two patients, and nausea with vomiting in another two patients, who were switched to citalopram. Citalopram was tolerated without adverse effects...