Ulrich Muller

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc The identification and management of ADHD offenders within the criminal justice system: a consensus statement from the UK Adult ADHD Network and criminal justice agencies
    Susan J Young
    King s College London, Institute of Psychiatry, UK
    BMC Psychiatry 11:32. 2011
  2. ncbi request reprint Lack of effects of guanfacine on executive and memory functions in healthy male volunteers
    Ulrich Muller
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 182:205-13. 2005
  3. ncbi request reprint Plasma level-dependent effects of methylphenidate on task-related functional magnetic resonance imaging signal changes
    Ulrich Muller
    MRC Behavioural and Clinical Neuroscience Centre, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 180:624-33. 2005
  4. ncbi request reprint Noradrenergic blockade and numeric working memory in humans
    Ulrich Muller
    Department of Psychiatry, University of Leipzig, Germany
    J Psychopharmacol 19:21-8. 2005
  5. ncbi request reprint Prefrontal cognitive deficits in patients with schizophrenia treated with atypical or conventional antipsychotics
    U Muller
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Eur Psychiatry 20:70-3. 2005
  6. ncbi request reprint The origin of pharmacopsychology: Emil Kraepelin's experiments in Leipzig, Dorpat and Heidelberg (1882-1892)
    Ulrich Muller
    Department of Experimental Psychology, University of Cambridge, Downing Site, CB2 3EB, Cambridge, UK
    Psychopharmacology (Berl) 184:131-8. 2006
  7. ncbi request reprint Reduced daytime activity in patients with acquired brain damage and apathy: a study with ambulatory actigraphy
    Ulrich Muller
    Department of Psychiatry, University of Leipzig, Germany
    Brain Inj 20:157-60. 2006
  8. ncbi request reprint Effects of modafinil on working memory processes in humans
    Ulrich Muller
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Psychopharmacology (Berl) 177:161-9. 2004
  9. ncbi request reprint [A systematic comparison of national and international dementia guidelines]
    U Muller
    Klinik und Poliklinik fur Psychiatrie, Universitat Leipzig
    Fortschr Neurol Psychiatr 71:285-95. 2003
  10. ncbi request reprint Directed forgetting in schizophrenia: prefrontal memory and inhibition deficits
    Ulrich Muller
    Dept of Psychiatry, University of Leipzig, Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 255:251-7. 2005

Collaborators

Detail Information

Publications49

  1. pmc The identification and management of ADHD offenders within the criminal justice system: a consensus statement from the UK Adult ADHD Network and criminal justice agencies
    Susan J Young
    King s College London, Institute of Psychiatry, UK
    BMC Psychiatry 11:32. 2011
    ..In time this will provide better justice for both offenders and society...
  2. ncbi request reprint Lack of effects of guanfacine on executive and memory functions in healthy male volunteers
    Ulrich Muller
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 182:205-13. 2005
    ..Guanfacine is an alpha2-adrenergic receptor agonist that has been shown to have beneficial effects on working memory and attentional functions in monkeys and in patients with attention deficit hyperactivity disorder...
  3. ncbi request reprint Plasma level-dependent effects of methylphenidate on task-related functional magnetic resonance imaging signal changes
    Ulrich Muller
    MRC Behavioural and Clinical Neuroscience Centre, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 180:624-33. 2005
    ..Understanding of its cognition-enhancing effects and the neurobiological mechanisms involved, especially in elderly people, is currently incomplete...
  4. ncbi request reprint Noradrenergic blockade and numeric working memory in humans
    Ulrich Muller
    Department of Psychiatry, University of Leipzig, Germany
    J Psychopharmacol 19:21-8. 2005
    ..Because both beta-blockers induced a comparable decrease of blood pressure and pulse, the propranolol effect on the 'working component' of working memory is considered to be a central, presumably prefrontal one...
  5. ncbi request reprint Prefrontal cognitive deficits in patients with schizophrenia treated with atypical or conventional antipsychotics
    U Muller
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Eur Psychiatry 20:70-3. 2005
    ..Manipulation tasks might be useful for neurocognitive follow-up and intervention studies...
  6. ncbi request reprint The origin of pharmacopsychology: Emil Kraepelin's experiments in Leipzig, Dorpat and Heidelberg (1882-1892)
    Ulrich Muller
    Department of Experimental Psychology, University of Cambridge, Downing Site, CB2 3EB, Cambridge, UK
    Psychopharmacology (Berl) 184:131-8. 2006
    ..Kraepelin's contributions to psychopharmacology and clinical neuropsychology were far ahead of his time and his conceptual achievements have been largely neglected by modern psychiatry and cognitive neuroscience...
  7. ncbi request reprint Reduced daytime activity in patients with acquired brain damage and apathy: a study with ambulatory actigraphy
    Ulrich Muller
    Department of Psychiatry, University of Leipzig, Germany
    Brain Inj 20:157-60. 2006
    ..Apathy is difficult to assess in clinical practice. Ambulatory actigraphy was used with the aim to measure locomotor activity during the daytime as a correlate of self-initiated action in brain-damaged patients with apathy...
  8. ncbi request reprint Effects of modafinil on working memory processes in humans
    Ulrich Muller
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Psychopharmacology (Berl) 177:161-9. 2004
    ..So far, understanding of the cognitive enhancing effects of modafinil and the relevant neurobiological mechanisms are incomplete...
  9. ncbi request reprint [A systematic comparison of national and international dementia guidelines]
    U Muller
    Klinik und Poliklinik fur Psychiatrie, Universitat Leipzig
    Fortschr Neurol Psychiatr 71:285-95. 2003
    ..g. routine EEG, FDG PET, cognitive training). A discussion of the prevalent guideline pluralism and a pleading for regionally adapted international guidelines conclude this article...
  10. ncbi request reprint Directed forgetting in schizophrenia: prefrontal memory and inhibition deficits
    Ulrich Muller
    Dept of Psychiatry, University of Leipzig, Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 255:251-7. 2005
    ..The DF effect was associated with disease duration but not with symptom severity. Memory-related inhibition problems are difficult to assess in patients with schizophrenia and might be related to fronto-temporal disconnection...
  11. ncbi request reprint Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Biol Psychiatry 62:977-84. 2007
    ..Compared with psychostimulants, atomoxetine has a distinct mode of brain action and potentially lower addictive potential. Studies have yet to assess whether atomoxetine improves cognition following a single oral dose in ADHD...
  12. ncbi request reprint Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 70:754-62. 2011
    ..The aim of this study was to measure behavioral and neural markers of compulsivity in stimulant-dependent individuals and to test whether these markers could be modulated by treatment with drugs targeting the dopamine system...
  13. doi request reprint Translational approaches to frontostriatal dysfunction in attention-deficit/hyperactivity disorder using a computerized neuropsychological battery
    Samuel R Chamberlain
    Department of Psychiatry and Medical Research Council Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 69:1192-203. 2011
    ..The findings suggest overlapping but also distinct early cognitive effects of ADHD medications and have important implications for understanding the pathophysiology of ADHD and for future trials...
  14. pmc Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence
    Karen D Ersche
    University of Cambridge, Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, Cambridge, England
    Arch Gen Psychiatry 67:632-44. 2010
    ..We hypothesized that dopamine-related targets are relevant for treatment of stimulant dependence, and there will likely be individual differences in response to dopaminergic challenges...
  15. doi request reprint A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment
    Natalia Del Campo
    1 Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Brain 136:3252-70. 2013
    ..This conclusion is reinforced by evidence of neuroanatomical changes in the same set of patients with attention deficit/hyperactivity disorder. ..
  16. pmc The dopamine D2 receptor antagonist sulpiride modulates striatal BOLD signal during the manipulation of information in working memory
    Chris M Dodds
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 207:35-45. 2009
    ..Dopamine (DA) plays an important role in working memory. However, the precise functions supported by different DA receptor subtypes in different neural regions remain unclear...
  17. pmc The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attention
    Jonathan P Roiser
    Department of Psychiatry, Box 189, Addenbrooke s Hospital, Cambridge, UKInstitute of Neurology, Queen Square House, London, UK
    Int J Neuropsychopharmacol 10:449-61. 2007
    ....
  18. pmc Amisulpride-induced acute akathisia in OCD: an example of dysfunctional dopamine-serotonin interactions?
    Karen D Ersche
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    J Psychopharmacol 26:887-90. 2012
    ..We further speculate about the neuropathology possibly underlying this clinical observation and outline a testable hypothesis for future molecular imaging studies...
  19. ncbi request reprint Effects of psychostimulants on alertness and spatial bias in healthy participants
    Chris Dodds
    Department of Experimental Psychology, University of Cambridge, UK
    J Cogn Neurosci 21:529-37. 2009
    ....
  20. ncbi request reprint Atomoxetine increases salivary cortisol in healthy volunteers
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    J Psychopharmacol 21:545-9. 2007
    ..Furthermore, the effects of atomoxetine on HPA axis function may have clinical implications given the use of this agent in the treatment of ADHD...
  21. doi request reprint Effects of acute modafinil on cognition in trichotillomania
    Samuel R Chamberlain
    Department of Psychiatry and MRC Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 212:597-601. 2010
    ..Individuals with trichotillomania often report significant difficulty resisting the urges and drive to pull hair...
  22. doi request reprint Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Biol Psychiatry 65:550-5. 2009
    ..However, the mechanisms by which atomoxetine improves inhibitory control have yet to be determined...
  23. pmc Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Br J Psychiatry 193:216-21. 2008
    ..Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking...
  24. pmc Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence
    Karen D Ersche
    Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Am J Psychiatry 169:926-36. 2012
    ....
  25. ncbi request reprint Neuropharmacological modulation of cognition
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, UK
    Curr Opin Neurol 19:607-12. 2006
    ..The purpose of this article is to review recent neuropharmacological manipulation studies in humans relating to these domains...
  26. ncbi request reprint Lack of deleterious effects of buspirone on cognition in healthy male volunteers
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK
    J Psychopharmacol 21:210-5. 2007
    ..Future research directions are discussed in relation to acute and chronic studies in neuropsychiatric populations...
  27. pmc Serotonin modulates striatal responses to fairness and retaliation in humans
    Molly J Crockett
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 1TN, United Kingdom
    J Neurosci 33:3505-13. 2013
    ..Our findings demonstrate that serotonin modulates social value processing in the striatum, producing context-dependent effects on social behavior...
  28. doi request reprint Relationship between SLC6A3 genotype and striatal dopamine transporter availability: a meta-analysis of human single photon emission computed tomography studies
    Anna Costa
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Synapse 65:998-1005. 2011
    ..Further work is needed to clarify the molecular mechanisms by which this polymorphism may affect cognition and psychiatric disorders, if not through altered expression as measured by molecular imaging...
  29. doi request reprint Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation
    Sharon Morein-Zamir
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Box 189, CB2 2QQ, Cambridge, UK
    Psychopharmacology (Berl) 212:357-67. 2010
    ..Patients with obsessive compulsive disorder (OCD) demonstrate impaired cognition in some selected domains. Although serotoninergic dysfunction has been implicated in OCD, recent evidence suggests that dopamine may play a role as well...
  30. pmc Functional connectivity and brain networks in schizophrenia
    Mary Ellen Lynall
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
    J Neurosci 30:9477-87. 2010
    ....
  31. ncbi request reprint Noradrenergic modulation of working memory and emotional memory in humans
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 188:397-407. 2006
    ..NA dysfunction and abnormalities in arousal-dependent memory functions are evident in a variety of neuropsychiatric illnesses...
  32. pmc Neurochemical modulation of response inhibition and probabilistic learning in humans
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 189, Cambridge CB2 2QQ, UK
    Science 311:861-3. 2006
    ....
  33. ncbi request reprint Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest
    Natalia Del Campo
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuroimage 55:101-12. 2011
    ....
  34. ncbi request reprint [Compulsive-obsessive disorder after severe head trauma: diagnosis and treatment]
    Katarina Stengler-Wenzke
    Klinik und Poliklinik fur Psychiatrie, Universitat Leipzig
    Psychiatr Prax 30:37-9. 2003
    ..The represented connections of the frontal brain lesions and OCD-symptoms with interventions in the serotonin system support the neurobiological hypotheses of the obsessive-compulsive disorder...
  35. doi request reprint Methylphenidate has differential effects on blood oxygenation level-dependent signal related to cognitive subprocesses of reversal learning
    Chris M Dodds
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:5976-82. 2008
    ..The results show that the precise neural site of modulation by methylphenidate depends on the nature of the cognitive subprocess recruited...
  36. ncbi request reprint Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls
    J H Barnett
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Mol Psychiatry 12:502-9. 2007
    ..There was no evidence of publication bias. We conclude that there is small but significant relationship between Val(158)Met genotype and executive function in healthy individuals but not in schizophrenia...
  37. ncbi request reprint Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers
    S E Winder-Rhodes
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Psychopharmacol 24:1649-57. 2010
    ..Our findings support the hypothesised involvement of α1-adrenoceptors in some of the cognitive-enhancing effects of modafinil and warrant further investigation...
  38. doi request reprint Neural and behavioral endophenotypes in ADHD
    Natalia Del Campo
    Department of Psychiatry, and Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Curr Top Behav Neurosci 11:65-91. 2012
    ..To this end, recent evidence drawn from molecular and structural neuroimaging studies are discussed in the light of widely accepted neuropsychological and pharmacological models of ADHD...
  39. ncbi request reprint Effects of pallidal deep brain stimulation and levodopa treatment on reaction-time performance in Parkinson's disease
    T Schubert
    Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
    Exp Brain Res 144:8-16. 2002
    ..Furthermore, our data show a way to uncover the subcortical-cortical circuitry serving human sensorimotor behavior...
  40. doi request reprint The effects of oxytocin on social reward learning in humans
    Rebecca Clark-Elford
    Department of Psychiatry, University of Cambridge, UK
    Int J Neuropsychopharmacol 17:199-209. 2014
    ..We conclude that oxytocin detrimentally affects learning rewards from happy faces in certain contexts. ..
  41. pmc Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia
    Muzaffer Kaser
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom Bahcesehir University, Istanbul, Turkey Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 8:e83255. 2013
    ..Time-frequency power and phase analyses can provide more detailed measures of brain dynamics of MMN deficits in schizophrenia...
  42. ncbi request reprint Reduced serotonin transporter-availability in obsessive-compulsive disorder (OCD)
    Katarina Stengler-Wenzke
    Dept of Psychiatry, University of Leipzig, Johannisallee 20, 04317 Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 254:252-5. 2004
    ..76 (OCD patients) and 3.53 +/- 1.01 (controls). This in vivo finding of significant reduced serotonin transporter availability in midbrain/brainstem using [(123)I] beta-CIT SPECT further supports the serotonin deficit hypothesis of OCD...
  43. doi request reprint Systematic review of national and international guidelines on attention-deficit hyperactivity disorder
    Miguel Seixas
    Adult ADHD Research Clinic, Cambridge, UK
    J Psychopharmacol 26:753-65. 2012
    ..Diagnosis throughout the lifespan is based on a detailed clinical history. There is greater agreement on evidence-based pharmacological treatment than on psychosocial interventions, reflecting the strength of evidence...
  44. ncbi request reprint Serotonin transporter imaging with [123I]beta-CIT SPECT before and after one year of citalopram treatment of obsessive-compulsive disorder
    Katarina Stengler-Wenzke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Neuropsychobiology 53:40-5. 2006
    ..The neurobiological mechanisms of SSRI action and failure to respond to SSRI treatment remain to be elucidated...
  45. ncbi request reprint Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, D 04103 Leipzig, Germany
    Psychiatry Res 140:63-72. 2005
    ..Our data provide evidence for imbalanced monoaminergic neurotransmitter modulation in OCD. Further studies with more selective DAT and SERT radiotracers are needed...
  46. ncbi request reprint Manipulation of working memory information is impaired in Parkinson's disease and related to working memory capacity
    P Bublak
    Department of Neurology, Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
    Neuropsychology 16:577-90. 2002
    ..Increasing complexity may either affect their manipulation ability directly or impede the management of inhibitory control requirements inherent to the task...
  47. ncbi request reprint Is correction for age necessary in neuroimaging studies of the central serotonin transporter?
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Germany
    Eur J Nucl Med Mol Imaging 30:427-30. 2003
    ..From these results we conclude that age-related changes in SERT density need to be considered in future clinical studies...
  48. ncbi request reprint Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders
    Swen Hesse
    Department of Nuclear Medicine, University Hospital, University of Leipzig, Leipzig, Germany
    Neurosci Biobehav Rev 28:547-63. 2004
    ..We furthermore elucidate the potential of SERT imaging techniques in estimating the effect of selective serotonin reuptake-inhibitors...
  49. ncbi request reprint Paroxetine versus citalopram treatment of pathological crying after brain injury
    U Muller
    Department of Neurology, Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
    Brain Inj 13:805-11. 1999
    ..The only adverse effect after paroxetine was nausea, which was reversible, in two patients, and nausea with vomiting in another two patients, who were switched to citalopram. Citalopram was tolerated without adverse effects...