Sylke Muller

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi request reprint Thioredoxin reductase and glutathione synthesis in Plasmodium falciparum
    Sylke Muller
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, UK
    Redox Rep 8:251-5. 2003
  2. ncbi request reprint Redox and antioxidant systems of the malaria parasite Plasmodium falciparum
    Sylke Muller
    School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, UK
    Mol Microbiol 53:1291-305. 2004
  3. ncbi request reprint 2-Cys peroxiredoxin PfTrx-Px1 is involved in the antioxidant defence of Plasmodium falciparum
    Susan E Akerman
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Mol Biochem Parasitol 130:75-81. 2003
  4. ncbi request reprint Peroxiredoxin-linked detoxification of hydroperoxides in Toxoplasma gondii
    Susan E Akerman
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Biol Chem 280:564-70. 2005
  5. pmc Glutathione synthetase from Plasmodium falciparum
    Svenja Meierjohann
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 363:833-8. 2002
  6. ncbi request reprint Isocitrate dehydrogenase of Plasmodium falciparum
    Carsten Wrenger
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, UK
    Eur J Biochem 270:1775-83. 2003
  7. ncbi request reprint Identification of a mitochondrial superoxide dismutase with an unusual targeting sequence in Plasmodium falciparum
    Natasha Sienkiewicz
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, WTB MSI Complex, DD15EH, UK
    Mol Biochem Parasitol 137:121-32. 2004
  8. ncbi request reprint The human malaria parasite Plasmodium falciparum has distinct organelle-specific lipoylation pathways
    Carsten Wrenger
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, WTB MSI Complex, Dundee DD1 5EH, UK
    Mol Microbiol 53:103-13. 2004
  9. ncbi request reprint Thiol-based redox metabolism of protozoan parasites
    Sylke Muller
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, DD1 5EH, Dundee, UK
    Trends Parasitol 19:320-8. 2003
  10. pmc Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis
    Sasala R Wickramasinghe
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 393:447-57. 2006

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Thioredoxin reductase and glutathione synthesis in Plasmodium falciparum
    Sylke Muller
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, UK
    Redox Rep 8:251-5. 2003
    ..falciparum. In addition to this antioxidant function, glutathione is important for detoxification processes and is possibly involved in the development of resistance against drugs such as chloroquine...
  2. ncbi request reprint Redox and antioxidant systems of the malaria parasite Plasmodium falciparum
    Sylke Muller
    School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, UK
    Mol Microbiol 53:1291-305. 2004
    ....
  3. ncbi request reprint 2-Cys peroxiredoxin PfTrx-Px1 is involved in the antioxidant defence of Plasmodium falciparum
    Susan E Akerman
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Mol Biochem Parasitol 130:75-81. 2003
    ..No dimeric forms of the protein were detectable after gel filtration suggesting that PfTrx-Px1 predominantly exists as an oligomer...
  4. ncbi request reprint Peroxiredoxin-linked detoxification of hydroperoxides in Toxoplasma gondii
    Susan E Akerman
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Biol Chem 280:564-70. 2005
    ..6 microm depending on the concentration of the non-inhibitory substrate thioredoxin. TgTrx-Px2 protected glutamine synthetase from inactivation by Fe(3+)/DTT, showing that it is an active peroxiredoxin...
  5. pmc Glutathione synthetase from Plasmodium falciparum
    Svenja Meierjohann
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 363:833-8. 2002
    ..This may be due to the alteration of several amino acids in the gamma-glutamylcysteine-binding site...
  6. ncbi request reprint Isocitrate dehydrogenase of Plasmodium falciparum
    Carsten Wrenger
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, UK
    Eur J Biochem 270:1775-83. 2003
    ..falciparum under exogenous oxidative stress resulted in an up-regulation of ICDH mRNA and protein levels indicating that the enzyme is involved in mitochondrial redox control rather than energy metabolism of the parasites...
  7. ncbi request reprint Identification of a mitochondrial superoxide dismutase with an unusual targeting sequence in Plasmodium falciparum
    Natasha Sienkiewicz
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, WTB MSI Complex, DD15EH, UK
    Mol Biochem Parasitol 137:121-32. 2004
    ..Northern blots demonstrated that the mRNA levels of both SOD genes are up-regulated upon exposure to oxidative stress...
  8. ncbi request reprint The human malaria parasite Plasmodium falciparum has distinct organelle-specific lipoylation pathways
    Carsten Wrenger
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, WTB MSI Complex, Dundee DD1 5EH, UK
    Mol Microbiol 53:103-13. 2004
    ..falciparum might be attractive therapeutic targets against malaria...
  9. ncbi request reprint Thiol-based redox metabolism of protozoan parasites
    Sylke Muller
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, DD1 5EH, Dundee, UK
    Trends Parasitol 19:320-8. 2003
    ..In Plasmodium falciparum, the crystal structures of glutathione reductase and glutamate dehydrogenase are now available; another drug target, thioredoxin reductase, has been demonstrated to be essential for the malarial parasite...
  10. pmc Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis
    Sasala R Wickramasinghe
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 393:447-57. 2006
    ..Hexachlorophene (EC50 6.2 microM) and analogues such as bithionol also have antimalarial activity in vitro, suggesting they might be useful leads for further development...