Sylke Muller

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi Thioredoxin reductase and glutathione synthesis in Plasmodium falciparum
    Sylke Muller
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, UK
    Redox Rep 8:251-5. 2003
  2. ncbi Redox and antioxidant systems of the malaria parasite Plasmodium falciparum
    Sylke Muller
    School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, UK
    Mol Microbiol 53:1291-305. 2004
  3. ncbi Thiol-based redox metabolism of protozoan parasites
    Sylke Muller
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, DD1 5EH, Dundee, UK
    Trends Parasitol 19:320-8. 2003
  4. ncbi Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis
    Sasala R Wickramasinghe
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 393:447-57. 2006

Collaborators

Detail Information

Publications4

  1. ncbi Thioredoxin reductase and glutathione synthesis in Plasmodium falciparum
    Sylke Muller
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, UK
    Redox Rep 8:251-5. 2003
    ..falciparum. In addition to this antioxidant function, glutathione is important for detoxification processes and is possibly involved in the development of resistance against drugs such as chloroquine...
  2. ncbi Redox and antioxidant systems of the malaria parasite Plasmodium falciparum
    Sylke Muller
    School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, UK
    Mol Microbiol 53:1291-305. 2004
    ....
  3. ncbi Thiol-based redox metabolism of protozoan parasites
    Sylke Muller
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, DD1 5EH, Dundee, UK
    Trends Parasitol 19:320-8. 2003
    ..In Plasmodium falciparum, the crystal structures of glutathione reductase and glutamate dehydrogenase are now available; another drug target, thioredoxin reductase, has been demonstrated to be essential for the malarial parasite...
  4. ncbi Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis
    Sasala R Wickramasinghe
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 393:447-57. 2006
    ..Hexachlorophene (EC50 6.2 microM) and analogues such as bithionol also have antimalarial activity in vitro, suggesting they might be useful leads for further development...