P Mullany

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Comparison of Tn5397 from Clostridium difficile, Tn916 from Enterococcus faecalis and the CW459tet(M) element from Clostridium perfringens shows that they have similar conjugation regions but different insertion and excision modules
    A P Roberts
    Department of Microbiology, Eastman Dental Institute for Oral Health Care Sciences, University College London, University of London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Microbiology 147:1243-51. 2001
  2. pmc Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers
    Michael S M Brouwer
    Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Nat Commun 4:2601. 2013
  3. doi request reprint Tetracycline resistance genes and mobile genetic elements from the oral metagenome
    P Mullany
    University College Eastman Dental Institute, 256 Gray s Inn Road University College, London WC1X 8LD, UK
    Clin Microbiol Infect 18:58-61. 2012
  4. pmc Behavior and target site selection of conjugative transposon Tn916 in two different strains of toxigenic Clostridium difficile
    Peter Mullany
    Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK
    Appl Environ Microbiol 78:2147-53. 2012
  5. pmc Determination of the genetic support for tet(W) in oral bacteria
    A Villedieu
    Division of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray s Inn Road, University College London, London WC1X 8LD, United Kingdom
    Antimicrob Agents Chemother 51:2195-7. 2007
  6. pmc Potential role of Veillonella spp. as a reservoir of transferable tetracycline resistance in the oral cavity
    D Ready
    Microbiology, Eastman Dental Hospital, UCLH NHS Foundation Trust, London WC1X 8LD, UK
    Antimicrob Agents Chemother 50:2866-8. 2006
  7. pmc The large resolvase TndX is required and sufficient for integration and excision of derivatives of the novel conjugative transposon Tn5397
    H Wang
    Department of Microbiology, Eastman Dental Institute for Oral Health Care Sciences, University College London, London WC1X 8LD, United Kingdom
    J Bacteriol 182:6577-83. 2000
  8. pmc Transfer of TN916-like elements in microcosm dental plaques
    A P Roberts
    Department of Microbiology, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
    Antimicrob Agents Chemother 45:2943-6. 2001
  9. ncbi request reprint Antibiotic resistance in the cultivable plaque microbiota of children from different ethnic groups
    D Ready
    Eastman Dental Hospital, UCLH NHS Foundation Trust, 256 Gray s Inn Road, London WC1X 8LD, UK
    Int J Antimicrob Agents 27:376-82. 2006
  10. ncbi request reprint Genes encoding homologues of three consecutive enzymes in the butyrate/butanol-producing pathway of Clostridium acetobutylicum are clustered on the Clostridium difficile chromosome
    P Mullany
    Department of Medical Microbiology, St Bartholomew s Hospital Medical College, West Smithfield, London, UK
    FEMS Microbiol Lett 124:61-7. 1994

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Comparison of Tn5397 from Clostridium difficile, Tn916 from Enterococcus faecalis and the CW459tet(M) element from Clostridium perfringens shows that they have similar conjugation regions but different insertion and excision modules
    A P Roberts
    Department of Microbiology, Eastman Dental Institute for Oral Health Care Sciences, University College London, University of London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Microbiology 147:1243-51. 2001
    ..Based on these studies it is concluded that the clostridial elements have a modular genetic organization and were derived independently from distinct mobile genetic elements...
  2. pmc Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers
    Michael S M Brouwer
    Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Nat Commun 4:2601. 2013
    ..This has implications for the treatment of C. difficile infections, as non-toxigenic strains are being tested as treatments in clinical trials. ..
  3. doi request reprint Tetracycline resistance genes and mobile genetic elements from the oral metagenome
    P Mullany
    University College Eastman Dental Institute, 256 Gray s Inn Road University College, London WC1X 8LD, UK
    Clin Microbiol Infect 18:58-61. 2012
    ..To do this, metagenomic approaches have been applied and this has allowed the isolation of novel tetracycline resistance genes and mobile genetic elements...
  4. pmc Behavior and target site selection of conjugative transposon Tn916 in two different strains of toxigenic Clostridium difficile
    Peter Mullany
    Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK
    Appl Environ Microbiol 78:2147-53. 2012
    ..To test the usefulness of Tn916 as a mutagen, a functional screen allowed the isolation of a mutant. This mutant contained Tn916 inserted into a gene involved in flagellar biosynthesis...
  5. pmc Determination of the genetic support for tet(W) in oral bacteria
    A Villedieu
    Division of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray s Inn Road, University College London, London WC1X 8LD, United Kingdom
    Antimicrob Agents Chemother 51:2195-7. 2007
    ..was determined. The gene was linked to two different transposases, and these were flanked by two almost identical mef (macrolide efflux) genes. This structure was found in 4 out of 20 tet(W)-containing oral bacteria investigated...
  6. pmc Potential role of Veillonella spp. as a reservoir of transferable tetracycline resistance in the oral cavity
    D Ready
    Microbiology, Eastman Dental Hospital, UCLH NHS Foundation Trust, London WC1X 8LD, UK
    Antimicrob Agents Chemother 50:2866-8. 2006
    ..The most common resistance gene was tet(M). A tet(M)-positive Veillonella dispar strain was shown to transfer a Tn916-like element to four Streptococcus spp. by conjugation at a frequency of 5.2 x 10(-6) to 4.5 x 10(-5) per recipient...
  7. pmc The large resolvase TndX is required and sufficient for integration and excision of derivatives of the novel conjugative transposon Tn5397
    H Wang
    Department of Microbiology, Eastman Dental Institute for Oral Health Care Sciences, University College London, London WC1X 8LD, United Kingdom
    J Bacteriol 182:6577-83. 2000
    ..Analysis of the target site choices showed that the cloned Tn5397 targets from C. difficile and B. subtilis were still hot spots for the minitransposon insertion in E. coli...
  8. pmc Transfer of TN916-like elements in microcosm dental plaques
    A P Roberts
    Department of Microbiology, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
    Antimicrob Agents Chemother 45:2943-6. 2001
    ..This element was shown to transfer to other streptococci both in filter-mating experiments and within the biofilms in the fermentor...
  9. ncbi request reprint Antibiotic resistance in the cultivable plaque microbiota of children from different ethnic groups
    D Ready
    Eastman Dental Hospital, UCLH NHS Foundation Trust, 256 Gray s Inn Road, London WC1X 8LD, UK
    Int J Antimicrob Agents 27:376-82. 2006
    ..This study has demonstrated that antibiotic-resistant bacteria can be readily isolated from the plaque microbiota of children from different ethnic groups...
  10. ncbi request reprint Genes encoding homologues of three consecutive enzymes in the butyrate/butanol-producing pathway of Clostridium acetobutylicum are clustered on the Clostridium difficile chromosome
    P Mullany
    Department of Medical Microbiology, St Bartholomew s Hospital Medical College, West Smithfield, London, UK
    FEMS Microbiol Lett 124:61-7. 1994
    ....
  11. pmc Genetic basis of erythromycin resistance in oral bacteria
    A Villedieu
    Division of Infection and Immunity, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray s Inn Rd, London WC1X 8LD, United Kingdom
    Antimicrob Agents Chemother 48:2298-301. 2004
    ..In addition, we demonstrate the genetic linkage, on various Tn1545-like conjugative transposons, between erythromycin and tetracycline resistance in a number of isolates...
  12. ncbi request reprint Isolation of silver- and antibiotic-resistant Enterobacter cloacae from teeth
    I J Davis
    Eastman Dental Hospital, University College London Hospitals NHS Trust, London, UK
    Oral Microbiol Immunol 20:191-4. 2005
    ..The silE gene, which is encoded on the silver resistance operon, has been sequenced from both isolates. Results suggest that the silver resistance operon is encoded on plasmid DNA...