Fritz A Muhlschlegel

Summary

Affiliation: University of Kent
Country: UK

Publications

  1. pmc The bZIP transcription factor Rca1p is a central regulator of a novel CO₂ sensing pathway in yeast
    Fabien Cottier
    School of Biosciences, University of Kent, Canterbury, United Kingdom
    PLoS Pathog 8:e1002485. 2012
  2. pmc Communication in fungi
    Fabien Cottier
    School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Int J Microbiol 2012:351832. 2012
  3. pmc CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans
    Rebecca A Hall
    School of Biosciences, University of Kent, Canterbury, Kent, UK
    PLoS Pathog 6:e1001193. 2010
  4. pmc The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans
    Rebecca A Hall
    School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Eukaryot Cell 10:1034-42. 2011
  5. pmc Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence
    Torsten Klengel
    Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Curr Biol 15:2021-6. 2005
  6. doi request reprint Candida albicans HSP12 is co-regulated by physiological CO2 and pH
    Chirag C Sheth
    Biomedical Science Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Fungal Genet Biol 45:1075-80. 2008
  7. pmc Functional characterization of the small heat shock protein Hsp12p from Candida albicans
    Man Shun Fu
    School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom
    PLoS ONE 7:e42894. 2012
  8. doi request reprint Carbonic anhydrase regulation and CO(2) sensing in the fungal pathogen Candida glabrata involves a novel Rca1p ortholog
    Fabien Cottier
    School of Biosciences, University of Kent, Canterbury, United Kingdom
    Bioorg Med Chem 21:1549-54. 2013
  9. ncbi request reprint Molecular networks in the fungal pathogen Candida albicans
    Rebecca A Hall
    Department of Biosciences, University of Kent, Canterbury T2 7NJ, UK
    Adv Appl Microbiol 67:191-212. 2009
  10. ncbi request reprint External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans
    Rebecca A Hall
    Department of Biosciences, University of Kent, Canterbury, UK
    Mol Biochem Parasitol 161:140-9. 2008

Collaborators

Detail Information

Publications17

  1. pmc The bZIP transcription factor Rca1p is a central regulator of a novel CO₂ sensing pathway in yeast
    Fabien Cottier
    School of Biosciences, University of Kent, Canterbury, United Kingdom
    PLoS Pathog 8:e1002485. 2012
    ..Rca1p appears to regulate cellular metabolism in response to CO(2) availability in environments as diverse as the phagosome, yeast communities or liquid culture...
  2. pmc Communication in fungi
    Fabien Cottier
    School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Int J Microbiol 2012:351832. 2012
    ..A better understanding of the molecular mechanisms underlying microbial communication will promote our understanding of the "fungal communicome."..
  3. pmc CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans
    Rebecca A Hall
    School of Biosciences, University of Kent, Canterbury, Kent, UK
    PLoS Pathog 6:e1001193. 2010
    ..Our results reveal the existence of a gaseous Candida signalling pathway and its molecular mechanism and provide insights into an evolutionary conserved CO(2)-signalling system...
  4. pmc The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans
    Rebecca A Hall
    School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Eukaryot Cell 10:1034-42. 2011
    ....
  5. pmc Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence
    Torsten Klengel
    Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Curr Biol 15:2021-6. 2005
    ..Novel therapeutic agents could target this pathway at several levels to control fungal infections...
  6. doi request reprint Candida albicans HSP12 is co-regulated by physiological CO2 and pH
    Chirag C Sheth
    Biomedical Science Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Fungal Genet Biol 45:1075-80. 2008
    ..Additionally, Northern analyses and gel mobility shift assays demonstrate the co-regulation of HSP12 by environmental pH via a Rim101-dependent mechanism...
  7. pmc Functional characterization of the small heat shock protein Hsp12p from Candida albicans
    Man Shun Fu
    School of Biosciences, University of Kent, Canterbury, Kent, United Kingdom
    PLoS ONE 7:e42894. 2012
    ..However, when overexpressed, CaHSP12 significantly enhanced cell-cell adhesion, germ tube formation and susceptibility to azole antifungal agents whilst desensitizing C. albicans to the quorum sensing molecule farnesol...
  8. doi request reprint Carbonic anhydrase regulation and CO(2) sensing in the fungal pathogen Candida glabrata involves a novel Rca1p ortholog
    Fabien Cottier
    School of Biosciences, University of Kent, Canterbury, United Kingdom
    Bioorg Med Chem 21:1549-54. 2013
    ..Although our results suggest a high level of similarity between the CO2 sensing pathways from C. glabrata, S. cerevisiae and C. albicans, they also point out significant intrinsic differences...
  9. ncbi request reprint Molecular networks in the fungal pathogen Candida albicans
    Rebecca A Hall
    Department of Biosciences, University of Kent, Canterbury T2 7NJ, UK
    Adv Appl Microbiol 67:191-212. 2009
    ....
  10. ncbi request reprint External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans
    Rebecca A Hall
    Department of Biosciences, University of Kent, Canterbury, UK
    Mol Biochem Parasitol 161:140-9. 2008
    ..Stopped-flow analysis of CAH-4b using 35 different carbonic anhydrase inhibitors identified complex benzenesulfonamide compounds as the most potent inhibitors (K(i) 35-89nM)...
  11. ncbi request reprint Phenotypic identification of Candida albicans by growth on chocolate agar
    Chirag C Sheth
    Department of Biosciences, University of Kent, Canterbury, UK
    Med Mycol 43:735-8. 2005
    ..Implementation of the proposed method is applicable across a range of specimen types, thus allowing the direct identification of C. albicans in clinical samples. This simple method may allow a quicker entry into directed treatment...
  12. doi request reprint A multi-protein complex controls cAMP signalling and filamentation in the fungal pathogen Candida albicans
    Rebecca A Hall
    Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
    Mol Microbiol 75:534-7. 2010
    ..The formation of such a complex highlights the importance of precise regulation of Cyr1p activity in response to host environmental cues...
  13. ncbi request reprint Zeocin resistance as a dominant selective marker for transformation and targeted gene deletions in Candida glabrata
    Alex J Alderton
    Department of Biosciences, University of Kent, Canterbury, Kent, UK
    Mycoses 49:445-51. 2006
    ..glabrata was confirmed by constructing deletions of the ADE2 in both a laboratory and a clinical strain of C. glabrata, using both short (90 bp) and long (400 bp) homology cassettes...
  14. ncbi request reprint PGA4, a GAS homologue from Candida albicans, is up-regulated early in infection processes
    Sabine E Eckert
    Department of Biosciences, University of Kent, Canterbury CT2 7NY, UK
    Fungal Genet Biol 44:368-77. 2007
    ..Our data suggest that PGA4, and potentially PHR3 and PGA5, are expressed under distinct conditions, which differ from those of PHR1 and PHR2...
  15. pmc Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1
    Estelle Geweiss Mogensen
    Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Eukaryot Cell 5:103-11. 2006
    ..neoformans growth. Bicarbonate directly activates the C. neoformans Cac1 adenylyl cyclase required for capsule synthesis. We show that this specific activation is optimal at physiological pH...
  16. doi request reprint Sensing the environment: response of Candida albicans to the X factor
    Fabien Cottier
    Department of Biosciences, University of Kent, Canterbury, UK
    FEMS Microbiol Lett 295:1-9. 2009
    ..This will underline the convergence of several environmental signals onto the mitogen-activated protein kinase and protein kinase A pathways...
  17. ncbi request reprint Quorum sensing and fungal-bacterial interactions in Candida albicans: a communicative network regulating microbial coexistence and virulence
    Luisa De Sordi
    Department of Biosciences, University of Kent, Canterbury, UK
    FEMS Yeast Res 9:990-9. 2009
    ..albicans. Further investigations need to concentrate on the molecular mechanisms and the genetic regulation of these phenomena in order to identify putative novel therapeutic options...