A M Mowat

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. doi Simultaneous presentation and cross-presentation of immune-stimulating complex-associated cognate antigen by antigen-specific B cells
    Neil C Robson
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Eur J Immunol 38:1238-46. 2008
  2. ncbi Coeliac disease--a meeting point for genetics, immunology, and protein chemistry
    Allan McI Mowat
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Scotland G11 6NT, Glasgow, UK
    Lancet 361:1290-2. 2003
  3. ncbi Dendritic cells and immune responses to orally administered antigens
    Allan McI Mowat
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, Scotland G11 6NT, UK
    Vaccine 23:1797-9. 2005
  4. ncbi Oral tolerance: overview and historical perspectives
    Allan McI Mowat
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, Scotland, UK
    Ann N Y Acad Sci 1029:1-8. 2004
  5. ncbi Anatomical basis of tolerance and immunity to intestinal antigens
    Allan McI Mowat
    Department of Immunology and Bacteriology, Western Infirmary, Glasgow G11 6NT, UK
    Nat Rev Immunol 3:331-41. 2003
  6. ncbi Anatomical and cellular basis of immunity and tolerance in the intestine
    Allan McI Mowat
    Department of Immunology and Bacteriology, Division of Immunology, Inflammation and Infection, University of Glasgow, Western Infirmary, Glasgow, Scotland
    J Pediatr Gastroenterol Nutr 39:S723-4. 2004
  7. ncbi CTA1-DD-immune stimulating complexes: a novel, rationally designed combined mucosal vaccine adjuvant effective with nanogram doses of antigen
    A M Mowat
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, Scotland
    J Immunol 167:3398-405. 2001
  8. ncbi Normal induction of oral tolerance in the absence of a functional IL-12-dependent IFN-gamma signaling pathway
    A M Mowat
    Department of Immunology, University of Glasgow, Western Infirmary, United Kingdom
    J Immunol 163:4728-36. 1999
  9. ncbi Oral vaccination with immune stimulating complexes
    A M Mowat
    Department of Immunology, University of Glasgow, Western Infirmary, Scotland, UK
    Immunol Lett 65:133-40. 1999
  10. doi Does TLR2 regulate intestinal inflammation?
    Allan McI Mowat
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Scotland, UK
    Eur J Immunol 40:318-20. 2010

Collaborators

Detail Information

Publications31

  1. doi Simultaneous presentation and cross-presentation of immune-stimulating complex-associated cognate antigen by antigen-specific B cells
    Neil C Robson
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Eur J Immunol 38:1238-46. 2008
    ....
  2. ncbi Coeliac disease--a meeting point for genetics, immunology, and protein chemistry
    Allan McI Mowat
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Scotland G11 6NT, Glasgow, UK
    Lancet 361:1290-2. 2003
    ..However, it had not previously been shown that candidate epitope peptides could be generated from gluten in vivo, or that these epitopes were selective products of physiological digestion of gluten by tissue transglutaminase...
  3. ncbi Dendritic cells and immune responses to orally administered antigens
    Allan McI Mowat
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, Scotland G11 6NT, UK
    Vaccine 23:1797-9. 2005
    ..ISCOMS or saponins such as Quil A may prove useful adjuvants to incorporate in plant derived, mucosally active vaccines...
  4. ncbi Oral tolerance: overview and historical perspectives
    Allan McI Mowat
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, Scotland, UK
    Ann N Y Acad Sci 1029:1-8. 2004
    ..Dendritic cells in the Peyer's patches or mucosal lamina propria are the most likely APCs involved, but it remains to be determined exactly where these interactions occur and what the precise nature of the relevant dendritic cells is...
  5. ncbi Anatomical basis of tolerance and immunity to intestinal antigens
    Allan McI Mowat
    Department of Immunology and Bacteriology, Western Infirmary, Glasgow G11 6NT, UK
    Nat Rev Immunol 3:331-41. 2003
    ..This article reviews the unique aspects of the local microenvironment of the intestinal immune system and discuss how these promote the development of regulatory responses that ensure the maintenance of homeostasis in the gut...
  6. ncbi Anatomical and cellular basis of immunity and tolerance in the intestine
    Allan McI Mowat
    Department of Immunology and Bacteriology, Division of Immunology, Inflammation and Infection, University of Glasgow, Western Infirmary, Glasgow, Scotland
    J Pediatr Gastroenterol Nutr 39:S723-4. 2004
  7. ncbi CTA1-DD-immune stimulating complexes: a novel, rationally designed combined mucosal vaccine adjuvant effective with nanogram doses of antigen
    A M Mowat
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, Scotland
    J Immunol 167:3398-405. 2001
    ..We conclude that rationally designed vectors consisting of CTA1-DD and ISCOMS may provide a novel strategy for the generation of potent and safe mucosal vaccines...
  8. ncbi Normal induction of oral tolerance in the absence of a functional IL-12-dependent IFN-gamma signaling pathway
    A M Mowat
    Department of Immunology, University of Glasgow, Western Infirmary, United Kingdom
    J Immunol 163:4728-36. 1999
    ..We conclude that IL-12-dependent IFN-gamma-mediated regulation does not play an essential role in oral tolerance...
  9. ncbi Oral vaccination with immune stimulating complexes
    A M Mowat
    Department of Immunology, University of Glasgow, Western Infirmary, Scotland, UK
    Immunol Lett 65:133-40. 1999
    ..This pathway may be amenable to exploitation for vaccine development, especially if combined with another vector with a different mucosal adjuvant profile, such as cholera toxin...
  10. doi Does TLR2 regulate intestinal inflammation?
    Allan McI Mowat
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Scotland, UK
    Eur J Immunol 40:318-20. 2010
    ....
  11. ncbi Oral tolerance
    P Garside
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow G11 6NT, UK
    Semin Immunol 13:177-85. 2001
    ..e. 'the journey' of orally administered antigen may promote these mechanisms...
  12. ncbi IL-12 is a central mediator of acute graft-versus-host disease in mice
    E Williamson
    Department of Immunology, Western Infirmary, University of Glasgow, Scotland
    J Immunol 157:689-99. 1996
    ....
  13. ncbi Induction of local innate immune responses and modulation of antigen uptake as mechanisms underlying the mucosal adjuvant properties of immune stimulating complexes (ISCOMS)
    Elizabeth Furrie
    Immunobiology Unit, Institute of Child Health, London, UK
    Vaccine 20:2254-62. 2002
    ..Thus, ISCOMS may increase the immunogenicity of intestinal antigen via a combination of effects on antigen uptake and on local accessory cells...
  14. pmc Dendritic cell maturation enhances CD8+ T-cell responses to exogenous antigen via a proteasome-independent mechanism of major histocompatibility complex class I loading
    Neil C Robson
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, UK
    Immunology 109:374-83. 2003
    ....
  15. pmc The influence of follicular migration on T-cell differentiation
    Karen M Smith
    Division of Immunology, Infection and Inflammation, Western Infirmary, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    Immunology 111:248-51. 2004
    ....
  16. ncbi Induction of protective and mucosal immunity against diphtheria by a immune stimulating complex (ISCOMS) based vaccine
    Antonio Aguila
    Division of Immunology, Infection and Inflammation, University of Glasgow, Biomedical Research Centre, 120 University Place, Glasgow, Scotland G12 8TA, United Kingdom
    Vaccine 24:5201-10. 2006
    ..ISCOMS based vaccines may provide a novel strategy for mucosal and systemic immunisation against diphtheria...
  17. ncbi Inverse Rap1 and phospho-ERK expression discriminate the maintenance phase of tolerance and priming of antigen-specific CD4+ T cells in vitro and in vivo
    Angela M Morton
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 179:8026-34. 2007
    ....
  18. ncbi Immunomodulatory dendritic cells in intestinal lamina propria
    Fernando G Chirdo
    Division of Immunology, Infection and Inflammation, Western Infirmary, Glasgow, Scotland
    Eur J Immunol 35:1831-40. 2005
    ..LP DC also expressed significant levels of mRNA for IL-10 and type I IFN, but not IL-12, suggesting they may play a central and unique role in immune homeostasis in the gut...
  19. doi Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells
    V Cerovic
    Institute for Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Mucosal Immunol 6:104-13. 2013
    ..Therefore, these cells may prove to be valuable targets for the treatment of intestinal inflammation or in the development of effective oral vaccines...
  20. pmc Priming of systemic and local delayed-type hypersensitivity responses by feeding low doses of ovalbumin to mice
    A G Lamont
    Department of Bacteriology and Immunology, Western Infirmary, Glasgow, U K
    Immunology 66:595-9. 1989
    ..The development of clinical food hypersensitivities may be highly dependent on the dose of dietary antigen at the time of first encounter...
  21. ncbi Direct quantitation of T cell signaling by laser scanning cytometry
    Angela M Grierson
    Division of Immunology, Infection and Inflammation, Western Infirmary, University of Glasgow, Glasgow, G11 6NT, UK
    J Immunol Methods 301:140-53. 2005
    ..The purpose of this protocol is to describe in vitro and ex vivo methods for quantifying cell signaling molecule expression and activation within antigen-specific T cells by laser scanning cytometry...
  22. pmc IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function
    Ivan Monteleone
    Division of Immunology Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, Scotland, UK
    Eur J Immunol 38:1533-47. 2008
    ..Thus, IL-10 may maintain LP DC in a partially unresponsive state to TLR ligation, allowing them to have a critical role in immune homeostasis in the gut...
  23. pmc The role of antigen-presenting cells and interleukin-12 in the priming of antigen-specific CD4+ T cells by immune stimulating complexes
    Neil C Robson
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, UK
    Immunology 110:95-104. 2003
    ..We suggest that DC are the principal APC responsible for the priming of CD4+ T cells by ISCOMs in vivo and that directed targeting of these vectors to DC may enhance their efficancy as vaccine adjuvants...
  24. ncbi Induction of bystander suppression by feeding antigen occurs despite normal clonal expansion of the bystander T cell population
    Owain R Millington
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Glasgow G11 6NT, Scotland, United Kingdom
    J Immunol 173:6059-64. 2004
    ..Thus, bystander suppression does not reflect clonal deletion or reduced clonal expansion of the bystander T cells, but may act by altering the functional differentiation of bystander T cells...
  25. ncbi Oral tolerance and allergic responses to food proteins
    Stephan Strobel
    Peninsula Postgraduate Health Institute, Peninsula Medical School, Plymouth, UK
    Curr Opin Allergy Clin Immunol 6:207-13. 2006
    ..This paper addresses the mechanisms at the interface of innate and adaptive immunity that determine how the body responds to orally administered proteins and how local bacteria modify these...
  26. ncbi The role of dendritic cells in regulating mucosal immunity and tolerance
    Allan McI Mowat
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow G11 6NT, UK
    Novartis Found Symp 252:291-302; discussion 302-5. 2003
    ..In addition, we will discuss evidence that adjuvant vectors such as ISCOMS may be effective mucosal vaccines due to an ability to activate intestinal DCs...
  27. ncbi Preparation of immune stimulating complexes (ISCOMs) as adjuvants
    A M Mowat
    University of Glasgow, Glasgow, Scotland
    Curr Protoc Immunol . 2001
    ..In the first, hydrophobic groups are revealed by acid treatment of the protein. The second describes preparation of ISCOMs containing integral membrane proteins that therefore possess a hydrophobic transmembrane domain...
  28. pmc Differential cytokine production associated with distinct phases of murine graft-versus-host reaction
    P Garside
    Department of Immunology, University of Glasgow, Western Infirmary
    Immunology 82:211-4. 1994
    ..These studies may assist in the development of specific immunotherapies aimed at individual aspects of immunologically mediated disease...
  29. doi Mucosal macrophages and the regulation of immune responses in the intestine
    Andrew M Platt
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow, Scotland G12 8TA, UK
    Immunol Lett 119:22-31. 2008
    ....
  30. pmc The atypical chemokine receptor D6 contributes to the development of experimental colitis
    Yvonne Bordon
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Glasgow, United Kingdom
    J Immunol 182:5032-40. 2009
    ..Thus, D6 can contribute to the development of colitis by regulating IL-17A secretion by gammadelta T cells in the inflamed colon...
  31. doi An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation
    Andrew M Platt
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom
    J Immunol 184:6843-54. 2010
    ..The balance between proinflammatory and resident Ms in the colon is controlled by CCR2-dependent recruitment mechanisms, which could prove useful as targets for therapy in inflammatory bowel disease...