R Mott

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc GLIDERS--a web-based search engine for genome-wide linkage disequilibrium between HapMap SNPs
    Robert Lawrence
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    BMC Bioinformatics 10:367. 2009
  2. doi request reprint Genetic control of differential acetylation in diabetic rats
    Pamela J Kaisaki
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, United Kingdom
    PLoS ONE 9:e94555. 2014
  3. doi request reprint The architecture of parent-of-origin effects in mice
    Richard Mott
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK Electronic address
    Cell 156:332-42. 2014
  4. doi request reprint Dissecting quantitative traits in mice
    Richard Mott
    Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom email
    Annu Rev Genomics Hum Genet 14:421-39. 2013
  5. pmc Genotype is an important determinant factor of host susceptibility to periodontitis in the Collaborative Cross and inbred mouse populations
    Ariel Shusterman
    Department of Prosthodontics, Faculty of Dental Medicine, Hadassah Medical Centers and The Hebrew University, Jerusalem, Israel
    BMC Genet 14:68. 2013
  6. pmc An integrated system for genetic analysis
    Simon Fiddy
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    BMC Bioinformatics 7:210. 2006
  7. pmc Finding the molecular basis of complex genetic variation in humans and mice
    Richard Mott
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Philos Trans R Soc Lond B Biol Sci 361:393-401. 2006
  8. pmc Prospects for complex trait analysis in the mouse
    Richard Mott
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 9JN, UK
    Mamm Genome 19:306-8. 2008
  9. ncbi request reprint Accurate formula for P-values of gapped local sequence and profile alignments
    R Mott
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK
    J Mol Biol 300:649-59. 2000
  10. ncbi request reprint Local sequence alignments with monotonic gap penalties
    R Mott
    SmithKline Beecham Pharmaceuticals R and D, New Frontiers Science Park North, 3rd Avenue, Harlow CM19 5AW, UK
    Bioinformatics 15:455-62. 1999

Detail Information

Publications60

  1. pmc GLIDERS--a web-based search engine for genome-wide linkage disequilibrium between HapMap SNPs
    Robert Lawrence
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    BMC Bioinformatics 10:367. 2009
    ..3 across the human genome for any SNP genotyped within HapMap phase 2 and 3, regardless of distance between the markers...
  2. doi request reprint Genetic control of differential acetylation in diabetic rats
    Pamela J Kaisaki
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, United Kingdom
    PLoS ONE 9:e94555. 2014
    ..We conclude that physiological differences between GK and BN rats are mediated by a combination of differential protein acetylation and gene transcription and that genetic variation can modulate acetylation independently of expression. ..
  3. doi request reprint The architecture of parent-of-origin effects in mice
    Richard Mott
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK Electronic address
    Cell 156:332-42. 2014
    ..We propose that this gene network effect may account for some of the missing heritability seen when comparing sibling-based to population-based studies of the phenotypic effects of genetic variants. ..
  4. doi request reprint Dissecting quantitative traits in mice
    Richard Mott
    Wellcome Trust Center for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom email
    Annu Rev Genomics Hum Genet 14:421-39. 2013
    ..In combination with new rapid methods for producing transgenic mice that make it efficient to test candidate genes and variants, these advances significantly enhance the mouse genetics toolbox for dissecting quantitative traits. ..
  5. pmc Genotype is an important determinant factor of host susceptibility to periodontitis in the Collaborative Cross and inbred mouse populations
    Ariel Shusterman
    Department of Prosthodontics, Faculty of Dental Medicine, Hadassah Medical Centers and The Hebrew University, Jerusalem, Israel
    BMC Genet 14:68. 2013
    ....
  6. pmc An integrated system for genetic analysis
    Simon Fiddy
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    BMC Bioinformatics 7:210. 2006
    ..Large-scale genetic mapping projects require data management systems that can handle complex phenotypes and detect and correct high-throughput genotyping errors, yet are easy to use...
  7. pmc Finding the molecular basis of complex genetic variation in humans and mice
    Richard Mott
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Philos Trans R Soc Lond B Biol Sci 361:393-401. 2006
    ..I also discuss how the prospects of rodent model systems compare with association mapping in humans...
  8. pmc Prospects for complex trait analysis in the mouse
    Richard Mott
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 9JN, UK
    Mamm Genome 19:306-8. 2008
  9. ncbi request reprint Accurate formula for P-values of gapped local sequence and profile alignments
    R Mott
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK
    J Mol Biol 300:649-59. 2000
    ..Consequently, it may not be practicable to find a general formula that is significantly more accurate until the sub-asymptotic behaviour of alignments is better understood...
  10. ncbi request reprint Local sequence alignments with monotonic gap penalties
    R Mott
    SmithKline Beecham Pharmaceuticals R and D, New Frontiers Science Park North, 3rd Avenue, Harlow CM19 5AW, UK
    Bioinformatics 15:455-62. 1999
    ..There is a need for an efficient algorithm which can find local alignments using non-linear gap penalties...
  11. ncbi request reprint Approximate statistics of gapped alignments
    R Mott
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    J Comput Biol 6:91-112. 1999
    ..The approximation is tested by simulation and shown to be accurate over a range of commonly used substitution matrices and gap-penalties...
  12. pmc High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues
    Guo Jen Huang
    Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
    Genome Res 19:1133-40. 2009
    ..Approximately one third of cis-acting eQTLs and one half of trans-acting eQTLs are tissue specific. We have created an important systems biology resource for the genetic analysis of complex traits in a key model organism...
  13. pmc Using progenitor strain information to identify quantitative trait nucleotides in outbred mice
    B Yalcin
    Wellcome Trust Centre for Human Genetics, Oxford University, UK
    Genetics 171:673-81. 2005
    ....
  14. ncbi request reprint Automatic analysis of agarose gel images
    P S Adiga
    Psychiatric Genetics Group, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Bioinformatics 17:1084-9. 2001
    ..AVAILABILITY: The IDL source code of the software is available on request from jonathan.flint@well.ox.ac.uk..
  15. ncbi request reprint LD mapping of maternally and non-maternally derived alleles and atopy in FcepsilonRI-beta
    James A Traherne
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK
    Hum Mol Genet 12:2577-85. 2003
    ..Two regions of increased CpG concentration were identified in Fc epsilon RI-beta. One of these approximated a SNP cluster that showed strong association and maternal effects, providing a potential substrate for epigenetic effects...
  16. ncbi request reprint Management, presentation and interpretation of genome scans using GSCANDB
    Martin Taylor
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Bioinformatics 23:1545-9. 2007
    ..In order to achieve a successful outcome, it may be necessary to analyse the data in different ways and compare the results with genome annotations and other genome scans...
  17. ncbi request reprint A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice
    Leah C Solberg
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford Roosevelt Drive, Oxford, OX3 7BN, UK
    Mamm Genome 17:129-46. 2006
    ....
  18. ncbi request reprint Genome-wide genetic association of complex traits in heterogeneous stock mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 38:879-87. 2006
    ..Our data set, freely available at http://gscan.well.ox.ac.uk, provides an entry point to the functional characterization of genes involved in many complex traits...
  19. pmc Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT
    Gabrielle Barnby
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 76:950-66. 2005
    ..0001). Logistic regression analysis of SNP data across GRIN2A and ABAT showed a trend toward haplotypic differences between cases and controls...
  20. pmc A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock
    Martina Johannesson
    Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
    Genome Res 19:150-8. 2009
    ....
  21. ncbi request reprint Finding the molecular basis of quantitative traits: successes and pitfalls
    J Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Rev Genet 2:437-45. 2001
    ..Here, we discuss why this is and how new experimental strategies and analytical techniques, combined with the fruits of the genome projects, are beginning to identify candidate genes for QTL studies in several model organisms...
  22. pmc Genetic and environmental effects on complex traits in mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Genetics 174:959-84. 2006
    ..Our results indicate that assays of gene function using mouse models should take into account interactions between gene and environment...
  23. ncbi request reprint QTL fine-mapping with recombinant-inbred heterogeneous stocks and in vitro heterogeneous stocks
    William S J Valdar
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX4 7AD, UK
    Mamm Genome 14:830-8. 2003
    ..We found that quite modest generation times of 10-20 generations were optimal. Microsatellites were superior to SNPs only when the generation time was 30 or more and when the markers were widely spaced...
  24. pmc Differential sensitivity of mouse strains to an N-alkylated imino sugar: glycosphingolipid metabolism and acrosome formation
    Aarnoud C van der Spoel
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Pharmacogenomics 9:717-31. 2008
    ....
  25. doi request reprint Applying mouse complex-trait resources to behavioural genetics
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 456:724-7. 2008
    ..Using these resources, scientists will be able to analyse mouse behaviour at an unprecedented level of detail. Interpreting the new data, however, will require a shift in focus from gene-based approaches to network-based approaches...
  26. pmc Quantitative prediction of NF-kappa B DNA-protein interactions
    Irina A Udalova
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Proc Natl Acad Sci U S A 99:8167-72. 2002
    ..We propose that this approach may be valuable, either on its own or in combination with other methods, when standard profile models are disadvantaged by complex internucleotide interactions...
  27. pmc Mapping in structured populations by resample model averaging
    William Valdar
    Wellcome Trust Centre for Human Genetics, Roosevelt Dr, Oxford OX3 7BN, United Kingdom
    Genetics 182:1263-77. 2009
    ..The generality of our approach means it can potentially be applied to any population of unknown structure...
  28. pmc Bayesian quantitative trait locus mapping using inferred haplotypes
    Caroline Durrant
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    Genetics 184:839-52. 2010
    ..We apply the method to data from a panel of recombinant inbred lines of Arabidopsis thaliana, descended from 19 inbred founders...
  29. pmc Elusive copy number variation in the mouse genome
    Avigail Agam
    Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    PLoS ONE 5:e12839. 2010
    ..Yet there are large discrepancies between studies, so that the extent of the genome affected by CNVs is unknown. We combined molecular and aCGH analyses of CNVs in inbred mouse strains to investigate this question...
  30. pmc Simultaneous detection and fine mapping of quantitative trait loci in mice using heterogeneous stocks
    Richard Mott
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, OX3 7BN, United Kingdom
    Genetics 160:1609-18. 2002
    ..We show by simulation that a QTL accounting for 5% of the total variance can be detected and fine mapped with >50% probability to within 3 cM by genotyping approximately 1500 animals...
  31. pmc Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Genetics 172:1783-97. 2006
    ..However, even with a very large panel of RILs, mapping resolution may not be sufficient to identify single genes unambiguously. Our results are generally applicable to the design of RILs in other species...
  32. ncbi request reprint Strategies for mapping and cloning quantitative trait genes in rodents
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Nat Rev Genet 6:271-86. 2005
    ..We review the potential of these strategies to identify genes that underlie QTLs in rodents...
  33. ncbi request reprint Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus
    Janice M Fullerton
    Wellcome Trust Centre for Human Genetics, Headington, Oxford, United Kingdom
    Biol Psychiatry 63:874-83. 2008
    ..This locus is syntenic with a human region that has been consistently implicated in the genetic aetiology of neuroticism...
  34. ncbi request reprint Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice
    Binnaz Yalcin
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 36:1197-202. 2004
    ..We then use quantitative complementation to show that Rgs2 is a quantitative trait gene. This combined genetic and functional approach should be applicable to the analysis of any quantitative trait...
  35. ncbi request reprint Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution
    C P Ponting
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
    Genome Res 11:1996-2008. 2001
    ..These findings demonstrate how completely sequenced genomes can be exploited to further understand the relationships between molecular structure, function, and evolution...
  36. pmc Haplotypic analysis of the TNF locus by association efficiency and entropy
    Hans Ackerman
    Wellcome Trust for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Genome Biol 4:R24. 2003
    ..3 kilobases in 296 healthy, unrelated Gambian and Malawian adults. We generated 592 high-quality haplotypes by integrating family- and population-based reconstruction methods...
  37. pmc Comparing the fine specificity of DNA binding by NF-kappaB p50 and p52 using principal coordinates analysis
    Anastasia Nijnik
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nucleic Acids Res 31:1497-501. 2003
    ..These findings are compatible with crystallographic data showing that p52 has greater ability than p50 to form water molecule-mediated hydrogen bonds with inner nucleotide positions of the binding site...
  38. pmc Predicting protein cellular localization using a domain projection method
    Richard Mott
    Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
    Genome Res 12:1168-74. 2002
    ..This method is complementary to approaches that use amino-acid composition or identify sorting sequences; these methods may be combined to further enhance prediction accuracy...
  39. pmc SW-ARRAY: a dynamic programming solution for the identification of copy-number changes in genomic DNA using array comparative genome hybridization data
    Thomas S Price
    The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Churchill Hospital Headington, Oxford OX3 7BN, UK
    Nucleic Acids Res 33:3455-64. 2005
    ..It is scalable and well-suited to high resolution whole genome array CGH studies that use array probes derived from large insert clones as well as PCR products and oligonucleotides...
  40. pmc A high-resolution single nucleotide polymorphism genetic map of the mouse genome
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Biol 4:e395. 2006
    ..Genetic maps are available from http://gscan.well.ox.ac.uk/#genetic_map and as supporting information to this publication...
  41. pmc Screening for recently selected alleles by analysis of human haplotype similarity
    Neil A Hanchard
    Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    Am J Hum Genet 78:153-9. 2006
    ..Using this method, we also evaluated >4,000 SNPs on chromosome 20, indicating the applicability of the method to regional data sets...
  42. pmc Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism
    Jan Fullerton
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Hum Genet 72:879-90. 2003
    ..One locus, on chromosome 1, is syntenic with that reported from QTL mapping of rodent emotionality, an animal model of neuroticism, suggesting that some animal and human QTLs influencing emotional stability may be homologous...
  43. ncbi request reprint Population-specific patterns of linkage disequilibrium in the human 5q31 region
    G Luoni
    University Department of Paediatrics, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, Oxon OX3 7BN, UK
    Genes Immun 6:723-7. 2005
    ..Much of this effect is due to SNPs that are absent in Europeans, possibly reflecting recent positive selection in the West African population...
  44. pmc Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice
    B Yalcin
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 101:9734-9. 2004
    ..We show that the definition of haplotype blocks is not robust and that methods for QTL mapping may fail if they assume a simple block-like structure...
  45. pmc Quantitative high-throughput analysis of transcription factor binding specificities
    Jane Linnell
    Wellcome Trust Centre for Human Genetics, University of Oxford, 7 Roosevelt Drive, Oxford OX3 7BN, UK
    Nucleic Acids Res 32:e44. 2004
    ..This approach offers the potential for high-throughput determination of TF binding profiles and predicting the effects of single nucleotide polymorphisms on TF binding affinity. New DNA binding data for OCT-1 are presented...
  46. ncbi request reprint Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma
    Youming Zhang
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 34:181-6. 2003
    ..We also found association with these variants to severe clinical asthma. The gene product (PHF11) contains two PHD zinc fingers and probably regulates transcription. Distinctive splice variants were expressed in immune tissues and cells...
  47. ncbi request reprint Genomewide analysis of the host response to malaria in Kenyan children
    Michael J Griffiths
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
    J Infect Dis 191:1599-611. 2005
    ..The delineation of subjects on the basis of patterns of gene expression provides a molecular perspective of the host response to malaria and further functional insight into the underlying processes of pathogenesis...
  48. pmc Replication profile of PCDH11X and PCDH11Y, a gene pair located in the non-pseudoautosomal homologous region Xq21.3/Yp11.2
    N D Wilson
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    Chromosome Res 15:485-98. 2007
    ..Our data are relevant to the complex relationship between X-inactivation, as a chromosome-wide phenomenon, and asynchrony of replication and expression status of single genes on chromosome X...
  49. ncbi request reprint Genetic variants in major depression
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Novartis Found Symp 289:23-32; discussion 33-42, 87-93. 2008
    ..Larger sample sizes and more sophisticated analytical approaches will be needed than have hitherto been applied...
  50. pmc Dynamic and physical clustering of gene expression during epidermal barrier formation in differentiating keratinocytes
    Jennifer M Taylor
    Wellcome Trust Centre for Human Genetics, Oxford, England
    PLoS ONE 4:e7651. 2009
    ..The findings provide a reference for subsequent understanding of how the barrier functions in health and disease...
  51. ncbi request reprint The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...
  52. pmc A quantitative trait locus influencing anxiety in the laboratory rat
    Alberto Fernandez-Teruel
    Medical Psychological Unit, School of Medicine, Universitat Autonoma de Barcelona, Barcelona E 08143, Spain
    Genome Res 12:618-26. 2002
    ..As the neural basis of fear is conserved across species, we suggest that the QTL may have relevance to trait anxiety in humans...
  53. ncbi request reprint A first-generation linkage disequilibrium map of human chromosome 22
    Elisabeth Dawson
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 418:544-8. 2002
    ..This study demonstrates the feasibility of developing genome-wide maps of LD...
  54. ncbi request reprint Initial sequencing and comparative analysis of the mouse genome
    Robert H Waterston
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 420:520-62. 2002
    ....
  55. doi request reprint SNP and haplotype mapping for genetic analysis in the rat
    Kathrin Saar
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strae 10, 13125 Berlin, Germany
    Nat Genet 40:560-6. 2008
    ..We provide a detailed SNP map and demonstrate its utility for mapping of quantitative trait loci. This community resource is openly available and augments the genetic tools for this workhorse of physiological studies...
  56. ncbi request reprint A haplotype map for the laboratory mouse
    Richard Mott
    Nat Genet 39:1054-6. 2007
  57. ncbi request reprint Recognizing the fold of a protein structure
    Andrew Harrison
    Biomolecular Structure and Modelling Unit, Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Bioinformatics 19:1748-59. 2003
    ....
  58. pmc Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum
    Delia O'Rourke
    Genetics Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Genome Res 16:1005-16. 2006
    ..The genes induced during infection by M. nematophilum appear largely distinct from genes induced by other pathogens, suggesting that C. elegans mounts pathogen-specific responses to infection...
  59. pmc Recent improvements to the SMART domain-based sequence annotation resource
    Ivica Letunic
    EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Nucleic Acids Res 30:242-4. 2002
    ..SMART output can now be easily included in users' documents. A SMART mirror has been created at http://smart.ox.ac.uk...
  60. ncbi request reprint Quantifying the similarities within fold space
    Andrew Harrison
    Biomolecular Structure and Modelling Unit, Department of Biochemistry and Molecular Biology, University College London, Gower Street, UK
    J Mol Biol 323:909-26. 2002
    ..g. alpha-beta sandwiches), in that super-secondary motifs can be used to link neighbouring fold groups. However, in other regions of fold space much more discrete topologies are observed with little similarity between folds...