Simon Morton

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun
    Simon Morton
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 22:3876-86. 2003
  2. ncbi Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage
    Iva V Klevernic
    MRC Protein Phosphorylation Unit, The Sir James Black Centre, University of Dundee, Dundee, Scotland, U K
    Biochem J 418:625-34. 2009
  3. ncbi Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2
    Simon Morton
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    FEBS Lett 572:177-83. 2004
  4. ncbi The role of TBK1 and IKKε in the expression and activation of Pellino 1
    Hilary Smith
    MRC Protein Phosphorylation Unit, The Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee, UK
    Biochem J 434:537-48. 2011
  5. ncbi Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ
    Simon Morton
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, CIR Building, Dow Street, Dundee DD1 5EH, UK
    Biochem J 399:265-73. 2006
  6. ncbi Characterization of the reversible phosphorylation and activation of ERK8
    Iva V Klevernic
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 394:365-73. 2006
  7. ncbi Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma
    Simon Morton
    MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    FEBS Lett 582:997-1002. 2008
  8. ncbi Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways
    Edward M Rosser
    MRC Protein Phosphorylation Unit, Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee, UKDD1 5EH
    Org Biomol Chem 2:142-9. 2004

Collaborators

Detail Information

Publications8

  1. ncbi A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun
    Simon Morton
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 22:3876-86. 2003
    ..The agonist-induced dephosphorylation of Thr239 may involve a conformational change that exposes Thr239 to dephosphorylation and/or the activation of a Thr239 phosphatase...
  2. ncbi Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage
    Iva V Klevernic
    MRC Protein Phosphorylation Unit, The Sir James Black Centre, University of Dundee, Dundee, Scotland, U K
    Biochem J 418:625-34. 2009
    ..In contrast, the phosphorylation of EWS-Fli1 induced by MMS was largely mediated by p38alpha/p38beta MAPKs. MMS induced a much stronger phosphorylation of EWS-Fli1 than EWS in heterodimers comprising both proteins...
  3. ncbi Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2
    Simon Morton
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    FEBS Lett 572:177-83. 2004
    ..In JNK-deficient cells, p38 MAPK substituted for JNK partially in the phosphorylation of Thr69 and p38 MAPK or ERK1/2 in the phosphorylation of Thr71. JNK was the only MAP kinase that phosphorylated Ser90 under the conditions examined...
  4. ncbi The role of TBK1 and IKKε in the expression and activation of Pellino 1
    Hilary Smith
    MRC Protein Phosphorylation Unit, The Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee, UK
    Biochem J 434:537-48. 2011
    ..Thus IKKε/TBK1 mediate the activation of Pellino 1's E3 ligase activity, as well as inducing the transcription of its gene and protein expression in response to TLR3 and TLR4 agonists...
  5. ncbi Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ
    Simon Morton
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, CIR Building, Dow Street, Dundee DD1 5EH, UK
    Biochem J 399:265-73. 2006
    ....
  6. ncbi Characterization of the reversible phosphorylation and activation of ERK8
    Iva V Klevernic
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 394:365-73. 2006
    ....
  7. ncbi Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma
    Simon Morton
    MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    FEBS Lett 582:997-1002. 2008
    ..The OPTN[E50K] mutant associated with Primary Open Angle Glaucoma (POAG) displayed strikingly enhanced binding to TBK1, suggesting that this interaction may contribute to familial POAG caused by this mutation...
  8. ncbi Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways
    Edward M Rosser
    MRC Protein Phosphorylation Unit, Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee, UKDD1 5EH
    Org Biomol Chem 2:142-9. 2004
    ..These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways...