Newton E Morton

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Fifty years of genetic epidemiology, with special reference to Japan
    Newton E Morton
    Human Genetics Division, Southampton General Hospital, School of Medicine, University of Southampton, Duthie Building MP 808, SO16 6YD, Southampton, UK
    J Hum Genet 51:269-77. 2006
  2. pmc The optimal measure of allelic association
    N E Morton
    Human Genetics Research Division, Duthie Building Mailpoint 808, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 98:5217-21. 2001
  3. pmc Genetic epidemiology, genetic maps and positional cloning
    Newton E Morton
    University of Southampton, Human Genetics Division, Duthie Building, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Philos Trans R Soc Lond B Biol Sci 358:1701-8. 2003
  4. ncbi request reprint Recollections of James Neel
    Newton E Morton
    Human Genetics Division, Duthie Building Mailpoint 808, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Mutat Res 543:97-104. 2003
  5. ncbi request reprint Toward positional cloning with SNPs
    Newton E Morton
    Human Genetics, Southampton General Hospital, UK
    Curr Opin Mol Ther 4:259-64. 2002
  6. ncbi request reprint Darkness in El Dorado: human genetics on trial
    N E Morton
    Human Genetics Research Division, University of Southampton, Southampton SO16 6YD, UK
    J Genet 80:45-52. 2001
  7. pmc Linkage disequilibrium maps and association mapping
    Newton E Morton
    Human Genetics Division, Southampton General Hospital, Southampton, United Kingdom
    J Clin Invest 115:1425-30. 2005
  8. pmc Genome scanning by composite likelihood
    Newton Morton
    Human Genetics Division, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Am J Hum Genet 80:19-28. 2007
  9. doi request reprint Commentary: Growth of beanbag genetics
    Newton E Morton
    Genetic Epidemiology, Human Genetics Division, School of Medicine, University of Southampton Mailpoint 808, SO16 6YD, UK
    Int J Epidemiol 37:445-6. 2008
  10. pmc Significance levels in complex inheritance
    N E Morton
    Human Genetics, University of Southampton, Anne Hospital, Southampton, United Kingdom
    Am J Hum Genet 62:690-7. 1998

Research Grants

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Fifty years of genetic epidemiology, with special reference to Japan
    Newton E Morton
    Human Genetics Division, Southampton General Hospital, School of Medicine, University of Southampton, Duthie Building MP 808, SO16 6YD, Southampton, UK
    J Hum Genet 51:269-77. 2006
    ..The generation now entering human genetics will have collaborative opportunities undreamed of a few years ago, without the independence that led to great advances during the past half-century...
  2. pmc The optimal measure of allelic association
    N E Morton
    Human Genetics Research Division, Duthie Building Mailpoint 808, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 98:5217-21. 2001
    ....
  3. pmc Genetic epidemiology, genetic maps and positional cloning
    Newton E Morton
    University of Southampton, Human Genetics Division, Duthie Building, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Philos Trans R Soc Lond B Biol Sci 358:1701-8. 2003
    ..This has led to large international programmes, some promising and others alarming, with laws about DNA patenting and ethical guidelines for responsible research still struggling to be born...
  4. ncbi request reprint Recollections of James Neel
    Newton E Morton
    Human Genetics Division, Duthie Building Mailpoint 808, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Mutat Res 543:97-104. 2003
    ..Without exception, we treasure recollections of a high-principled and warm-hearted colleague whose field studies were a model for their generation...
  5. ncbi request reprint Toward positional cloning with SNPs
    Newton E Morton
    Human Genetics, Southampton General Hospital, UK
    Curr Opin Mol Ther 4:259-64. 2002
    ....
  6. ncbi request reprint Darkness in El Dorado: human genetics on trial
    N E Morton
    Human Genetics Research Division, University of Southampton, Southampton SO16 6YD, UK
    J Genet 80:45-52. 2001
    ..Unless guidelines reflect an international consensus, the benefits of population studies to human welfare and science will be jeopardized. The World Health Organization guidelines should be extended to cover current research...
  7. pmc Linkage disequilibrium maps and association mapping
    Newton E Morton
    Human Genetics Division, Southampton General Hospital, Southampton, United Kingdom
    J Clin Invest 115:1425-30. 2005
    ..The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative methods for gene localization, are briefly described...
  8. pmc Genome scanning by composite likelihood
    Newton Morton
    Human Genetics Division, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Am J Hum Genet 80:19-28. 2007
    ..An extension to meta-analysis is proposed. Other approaches to genome scanning and meta-analysis should, if possible, be similarly extended so that their operating characteristics can be compared...
  9. doi request reprint Commentary: Growth of beanbag genetics
    Newton E Morton
    Genetic Epidemiology, Human Genetics Division, School of Medicine, University of Southampton Mailpoint 808, SO16 6YD, UK
    Int J Epidemiol 37:445-6. 2008
  10. pmc Significance levels in complex inheritance
    N E Morton
    Human Genetics, University of Southampton, Anne Hospital, Southampton, United Kingdom
    Am J Hum Genet 62:690-7. 1998
    ..The method sketched here combines multipoint linkage and allelic association to test efficiently for a regional candidate locus...
  11. pmc Tests and estimates of allelic association in complex inheritance
    N E Morton
    Human Genetics, University of Southampton, Level G, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, United Kingdom
    Proc Natl Acad Sci U S A 95:11389-93. 1998
    ..Isolated cases favor unrelated controls, and only in exceptional populations would avoidance of stratification justify a family-based design to map disease genes by allelic association...
  12. ncbi request reprint Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores
    J Wilkinson
    University Medicine, University of Southampton, Southampton, SO16 5YA, United Kingdom
    Genomics 53:251-9. 1998
    ..We hope that the methods presented will encourage researchers to use phenotypic information in a way that encourages meta-analysis...
  13. ncbi request reprint Genetic aspects of population policy
    N E Morton
    Department of Human Genetics, University of Southampton, Southampton General Hospital, UK
    Clin Genet 56:105-9. 1999
    ..This review traces the causes of this concern and the manner of its expression in the absence of an international voice for genetics that could address ethical and other common interests...
  14. ncbi request reprint Extended tracts of homozygosity in outbred human populations
    Jane Gibson
    Human Genetics Research Division, School of Medicine, University of Southampton, Southampton SO16 6YD, UK
    Hum Mol Genet 15:789-95. 2006
    ..Possible alternative mechanisms and the implications of long homozygous tracts in the genome are discussed...
  15. pmc Impact of population structure, effective bottleneck time, and allele frequency on linkage disequilibrium maps
    Weihua Zhang
    Human Genetics Division, Duthie Building Mailpoint 808, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 101:18075-80. 2004
    ....
  16. pmc Positional cloning by linkage disequilibrium
    Nikolas Maniatis
    Human Genetics Division, University of Southampton, Southampton SO16 6YD, United Kingdom
    Am J Hum Genet 74:846-55. 2004
    ..These results provide a guide to efficient positional cloning by SNPs and a benchmark against which the power of positional cloning by haplotype-based alternatives may be measured...
  17. ncbi request reprint Effects of single SNPs, haplotypes, and whole-genome LD maps on accuracy of association mapping
    Nikolas Maniatis
    Human Genetics Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Genet Epidemiol 31:179-88. 2007
    ..The results of the present study demonstrate the great potential of the genome HapMap LDU maps for high-resolution mapping of complex phenotypes...
  18. ncbi request reprint Allelic association with SNPs: metrics, populations, and the linkage disequilibrium map
    A Collins
    Human Genetics Research Division, University of Southampton, Southampton, UK
    Hum Mutat 17:255-62. 2001
    ..This is discussed in relation to the Xq25 cytogenetic band and the HFE gene region...
  19. ncbi request reprint Does haplotype diversity predict power for association mapping of disease susceptibility?
    Weihua Zhang
    Human Genetics Division, University of Southampton, Southampton General Hospital, SO16 6YD Southampton, UK
    Hum Genet 115:157-64. 2004
    ..TagSNPs that are assigned to bins instead of haplotype blocks also lose power compared with random SNPs. This evidence favours a multi-stage design in which both models and density change adaptively...
  20. pmc The first linkage disequilibrium (LD) maps: delineation of hot and cold blocks by diplotype analysis
    N Maniatis
    Human Genetics Division, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 99:2228-33. 2002
    ..Construction of a genomewide LD map requires data not yet available, which may be complemented but not replaced by a catalog of haplotypes...
  21. pmc Properties of linkage disequilibrium (LD) maps
    Weilhua Zhang
    Human Genetics Division, University of Southampton, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 99:17004-7. 2002
    ..No alternative representation of linkage disequilibrium (some of which are loosely called maps) has these properties, suggesting that LD maps are optimal for positional cloning of genes determining disease susceptibility...
  22. pmc Linkage disequilibrium in human populations
    Christine Lonjou
    Human Genetics Division, University of Southampton, Duthie Building MP 808, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 100:6069-74. 2003
    ....
  23. doi request reprint A comparison of methods to detect recombination hotspots
    William Tapper
    Human Genetics Division, School of Medicine, Southampton General Hospital, University of Southampton, Southampton, UK
    Hum Hered 66:157-69. 2008
    ..We determine the correspondence between LDMAP and LDhat, and between LDMAP and LDhot by comparison with linkage maps and hotspots that have been verified by sperm typing...
  24. pmc Combined segregation and linkage analysis of Graves disease with a thyroid autoantibody diathesis
    D C Shields
    Department of Child Health, University of Southampton, Princess Anne Hospital
    Am J Hum Genet 55:540-54. 1994
    ..6). Linkage analysis of the residual variation revealed no evidence of linkage to Gm, but a suggestion of linkage to Km...
  25. ncbi request reprint Mapping quantitative effects of oligogenes by allelic association
    W Zhang
    Human Genetics Division, Southampton General Hospital, UK
    Ann Hum Genet 66:211-21. 2002
    ..However, rigorous confirmation requires that the causal SNPs be identified. Both Malecot and parametric analysis appear to have high power by comparison with alternative methods for localizing oligogenes and their causal polymorphisms...
  26. ncbi request reprint Integration of gene maps: chromosome X
    L h Wang
    Department of Child Health, University of Southampton, United Kingdom
    Genomics 22:590-604. 1994
    ..The physical length is 164 Mb, with 62 Mb in the p arm. Current problems in map integration are discussed and some solutions proposed...
  27. ncbi request reprint A history of association mapping
    Newton E Morton
    Human Genetics Division, Southampton General Hospital, UK
    Methods Mol Biol 376:17-21. 2007
    ..The current exciting developments in association mapping are founded on theory, which has been developed since the beginning of the last century. I hereby review these developments in their historical context...
  28. ncbi request reprint Refined association mapping for a quantitative trait: weight in the H19-IGF2-INS-TH region
    W Zhang
    Human Genetics Division, University of Southampton, School of Medicine, Duthie Building MP 808, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Ann Hum Genet 70:848-56. 2006
    ..Identification of the causal SNP or SNPs within IGF2 will require typing of more variants in this region...
  29. pmc Closely linked cis-acting modifier of expansion of the CGG repeat in high risk FMR1 haplotypes
    S Ennis
    Genetic Epidemiology Group, Human Genetics MP808, Southampton General Hospital, Southampton, United Kingdom
    Hum Mutat 28:1216-24. 2007
    ..84, p=0.00002). We have verified that this SNP acts as a marker of repeat expansion in three independent samples...
  30. ncbi request reprint An investigation of FRAXA intermediate allele phenotype in a longitudinal sample
    S Ennis
    Genetic Epidemiology and Bioinformatics Group, Human Genetics Division MP808, Duthie Building, Southampton General Hospital, Southampton SO16 6YD, Hampshire, UK
    Ann Hum Genet 70:170-80. 2006
    ..Our findings demonstrate the non-random loss of participants from this cohort and highlight problems that may arise when such data are used in genetic association studies...
  31. pmc A map of the human genome in linkage disequilibrium units
    W Tapper
    Human Genetics Division, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 102:11835-9. 2005
    ..These considerations suggest an optimal strategy to eliminate holes quickly, greatly enhance the resolution of sex-specific linkage maps, and maximize the gain in association mapping by using LD maps...
  32. ncbi request reprint The optimal measure of linkage disequilibrium reduces error in association mapping of affection status
    N Maniatis
    Human Genetics Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Hum Mol Genet 14:145-53. 2005
    ..These tests are robust to large numbers of markers and are applicable to haplotypes, diplotypes, whole-genome association or candidate region studies...
  33. pmc Mapping a disease locus by allelic association
    A Collins
    Human Genetics, University of Southampton, Level G, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, United Kingdom
    Proc Natl Acad Sci U S A 95:1741-5. 1998
    ....
  34. ncbi request reprint Allelic association in the FRAX region
    S Ennis
    Human Genetics Research Division, Southampton General Hospital, Hampshire, UK
    Ann Hum Genet 64:513-8. 2000
    ..An explanation for these results is offered, and some speculations made about what will be found when SNPs are subjected to an equally intensive study in multiple regions...
  35. ncbi request reprint Linkage analysis of the 5q31-33 candidate region for asthma in 240 UK families
    J W Holloway
    Human Genetics, Division School of Medicine, University of Southampton, UK
    Genes Immun 2:20-4. 2001
    ..946 at location 171.3 cM and a standard error of 3.3 for the asthma quantitative score. There was no evidence of linkage with atopy, the atopy quantitative score or total serum IgE...
  36. pmc A sequence-based integrated map of chromosome 22
    W J Tapper
    Human Genetics Research Division, Southampton General Hospital, Southampton SO16 6YD, UK
    Genome Res 11:1290-5. 2001
    ..This sequence-based integrated map is represented in the genetic location database (LDB2000), which is available at http://cedar.genetics.soton.ac.uk/public_html/LDB2000.html...
  37. ncbi request reprint Haplotypic determinants of instability in the FRAX region: Concatenated mutation or founder effect?
    S Ennis
    Genetic Epidemiology, Human Genetics, Southampton General Hospital, Southampton, Hampshire, UK
    Hum Mutat 18:61-9. 2001
    ..Distinguishing concatenated mutation from founder effects is difficult within a single population. We present our evidence for and against concatenated mutation, and in the process describe a previously undefined mutation at FRAXE...
  38. ncbi request reprint Combination of linkage evidence in complex inheritance
    W Zhang
    Human Genetics Research Division, University of Southampton, Southampton General Hospital, Duthie Building, Tremona Road, Southampton SO16 6YD, UK
    Hum Hered 52:132-5. 2001
    ..Allelic association presents different problems not yet addressed...
  39. ncbi request reprint A tournament of linkage tests in complex inheritance
    W Zhang
    Human Genetics Research Division, University of Southampton, Southampton General Hospital, Duthie Building, Tremona Road, Southampton SO16 6YD, UK
    Hum Hered 52:140-8. 2001
    ..Performance on a standard set of simulated data is indispensable for recognising optimal methods...
  40. ncbi request reprint Recombination, interference and sequence: comparison of chromosomes 21 and 22
    W J Tapper
    Human Genetic Research Division, University of Southampton, UK
    Ann Hum Genet 66:75-86. 2002
    ..These repeats are widely distributed on chromosome 22, perhaps offering greater opportunities for double recombinants to occur within smaller regions, whereas they are largely subtelomeric in distribution on chromosome 21...
  41. ncbi request reprint A metric linkage disequilibrium map of a human chromosome
    W J Tapper
    Human Genetics Division, School of Medicine, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK
    Ann Hum Genet 67:487-94. 2003
    ..Further analyses which investigate selection of informative SNPs and the effect of SNP allele frequency and marker density will refine this estimate...
  42. pmc Mapping a gene for rheumatoid arthritis on chromosome 18q21
    William Tapper
    Human Genetics Division, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, Hampshire SO16 6YD, UK
    BMC Proc 1:S18. 2007
    ....
  43. doi request reprint Into the post-HapMap era
    Newton E Morton
    Human Genetics Division, University of Southampton, Southampton, United Kingdom
    Adv Genet 60:727-42. 2008
    ..Many questions remain to be answered if genetic epidemiology is to continue the significant contribution to medicine that its definition promises and its history illustrates...
  44. doi request reprint Mutations in phospholipase C epsilon 1 are not sufficient to cause diffuse mesangial sclerosis
    Rodney D Gilbert
    Wessex Regional Paediatric Nephro Urology Service, Southampton General Hospital, Southampton, UK
    Kidney Int 75:415-9. 2009
    ..We conclude this nonpenetrance may be due to compensatory mutations at a second locus and that mutation within PLCE1 is not always sufficient to cause diffuse mesangial sclerosis...

Research Grants3

  1. Linkage Disequilibrium: mapping and positional cloning
    Newton Morton; Fiscal Year: 2006
    ..abstract_text> ..