A Jennifer Morton

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment
    A Jennifer Morton
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Hum Mol Genet 23:3375-83. 2014
  2. pmc Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats
    Daniel Duzdevich
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e17119. 2011
  3. pmc Temporal separation of aggregation and ubiquitination during early inclusion formation in transgenic mice carrying the Huntington's disease mutation
    Belvin Gong
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e41450. 2012
  4. pmc Adaptation to experimental jet-lag in R6/2 mice despite circadian dysrhythmia
    Nigel I Wood
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 8:e55036. 2013
  5. pmc Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse
    Catherine Kielar
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e32636. 2012
  6. doi Circadian and sleep disorder in Huntington's disease
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Exp Neurol 243:34-44. 2013
  7. ncbi A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1 PD, UK
    Eur J Neurosci 21:855-70. 2005
  8. doi Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 33:331-41. 2009
  9. pmc Executive decision-making in the domestic sheep
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e15752. 2011
  10. ncbi Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom
    J Neurosci 25:157-63. 2005

Collaborators

Detail Information

Publications66

  1. ncbi Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment
    A Jennifer Morton
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Hum Mol Genet 23:3375-83. 2014
    ..HD sheep will be useful models for probing the mechanisms underlying circadian behavioural disorder in HD. ..
  2. pmc Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats
    Daniel Duzdevich
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e17119. 2011
    ..In the R6/2 mouse model of Huntington's disease (HD), expansion of the CAG trinucleotide repeat length beyond about 300 repeats induces a novel phenotype associated with a reduction in transcription of the transgene...
  3. pmc Temporal separation of aggregation and ubiquitination during early inclusion formation in transgenic mice carrying the Huntington's disease mutation
    Belvin Gong
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e41450. 2012
    ..Our findings have significant implications for the role of the ubiquitin-proteasome system in the formation of aggregates, as they suggest that this system is not involved until after the first aggregates form...
  4. pmc Adaptation to experimental jet-lag in R6/2 mice despite circadian dysrhythmia
    Nigel I Wood
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 8:e55036. 2013
    ..If similar abnormalities are present in HD patients, they may suffer exaggerated jet-lag. Since the underlying molecular clock mechanism remains intact, light may be a useful treatment for circadian dysfunction in HD...
  5. pmc Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse
    Catherine Kielar
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e32636. 2012
    ..Therefore, understanding the effects of Cplx depletion in brains from Cplx1(-/-) mice may also shed light on the mechanisms underlying pathophysiology in disorders in which loss of Cplx1 occurs...
  6. doi Circadian and sleep disorder in Huntington's disease
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Exp Neurol 243:34-44. 2013
    ..Thus treatment of sleep disturbance in HD is necessarily empirical. A better understanding of the relationship between sleep/circadian abnormalities and HD pathology is needed, if treatment of this aspect of HD is to be optimized...
  7. ncbi A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1 PD, UK
    Eur J Neurosci 21:855-70. 2005
    ..Our study shows that cognitive decline caused by a genetic mutation can be slowed by a combination drug treatment, and gives hope that cognitive symptoms in HD can be treated...
  8. doi Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 33:331-41. 2009
    ..This mouse may represent a better model for adult-onset HD than R6/2 mice with shorter repeats...
  9. pmc Executive decision-making in the domestic sheep
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e15752. 2011
    ..Sheep have great potential, not only for use as a large animal model of HD, but also for studying cognitive function and the evolution of complex behaviours in normal animals...
  10. ncbi Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease
    A Jennifer Morton
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom
    J Neurosci 25:157-63. 2005
    ..We propose that circadian sleep disturbances are an important pathological feature of HD, that they arise from pathology within the SCN molecular oscillation, and that their treatment will bring appreciable benefits to HD patients...
  11. ncbi Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease
    A J Morton
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    Brain Res Bull 56:111-7. 2001
    ....
  12. ncbi Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease
    A J Morton
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    J Neurochem 76:166-72. 2001
    ..Our results suggest that changes in neurotransmitter release might contribute to the neuronal dysfunction seen in these mice...
  13. ncbi Mice transgenic for the human Huntington's disease mutation have reduced sensitivity to kainic acid toxicity
    A J Morton
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    Brain Res Bull 52:51-9. 2000
    ..The significance of these findings is discussed in the context of the R6/2 mouse as a model for HD...
  14. ncbi Ecstasy: pharmacology and neurotoxicity
    Jenny Morton
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Curr Opin Pharmacol 5:79-86. 2005
    ....
  15. ncbi Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, UK
    Hum Mol Genet 14:2369-85. 2005
    ..These results support the idea that altered expression of complexins in disease states may contribute to the symptomatology of disorders in which they are dysregulated...
  16. ncbi Differential morphology and composition of inclusions in the R6/2 mouse and PC12 cell models of Huntington's disease
    Jonathan Wanderer
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK
    Histochem Cell Biol 127:473-84. 2007
    ..Their role in the pathogenesis of HD is likely to depend on their location as well as their composition...
  17. ncbi Depletion of Complexin II does not affect disease progression in a mouse model of Huntington's disease (HD); support for role for complexin II in behavioural pathology in a mouse model of HD
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Brain Res Bull 72:108-20. 2007
    ..This indicates that loss of complexin II is part of the mechanism underlying the R6/2 phenotype. Whether it is causal or compensatory remains to be determined...
  18. ncbi Regional and progressive changes in brain expression of complexin II in a mouse transgenic for the Huntington's disease mutation
    Whitney Freeman
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Brain Res Bull 63:45-55. 2004
    ..We suggest that downregulation of expression of mRNA encoding SNARE-associated proteins, first CPLXII and later CPLXI and alpha-SNAP, contributes to the progressive neuropathology of the R6/2 mouse model of Huntington's disease...
  19. ncbi Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding
    Elizabeth S Maywood
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, United Kingdom
    J Neurosci 30:10199-204. 2010
    ..Thus, even subtle imbalances in liver function may exacerbate symptoms of HD, where neurological function is already compromised...
  20. ncbi Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease
    Patrick N Pallier
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom
    J Neurosci 27:7869-78. 2007
    ....
  21. doi Progressive imbalance in the interaction between spatial and procedural memory systems in the R6/2 mouse model of Huntington's disease
    Alessandro Ciamei
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    Neurobiol Learn Mem 92:417-28. 2009
    ..We conclude that following striatal decline in R6/2 mice between 8 and 12 weeks of age, hippocampal functions emerge to drive the escape response of R6/2 mice...
  22. pmc Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease
    Nigel I Wood
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e9077. 2010
    ..We have also shown previously that HD patients and R6/2 mice have disrupted circadian rhythms, treatment of which may improve cognition, general health, and survival...
  23. doi Management of sleep/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease
    Patrick N Pallier
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    Brain Res 1279:90-8. 2009
    ..We suggest that focused management of sleep and wakefulness will slow the progression of cognitive decline and apathy in neurological conditions where sleep is disordered...
  24. doi Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Hum Mol Genet 19:3402-12. 2010
    ....
  25. doi The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: influence of non-motor factors on locomotor function
    Patrick N Pallier
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    Brain Res Bull 78:347-55. 2009
    ....
  26. ncbi Complexin 1 knockout mice exhibit marked deficits in social behaviours but appear to be cognitively normal
    Cheney J G Drew
    Department of Pharmacology, University fo Cambridge, UK
    Hum Mol Genet 16:2288-305. 2007
    ..Abnormalities in complexin 1 levels in the brain may therefore contribute to the psycho-social aspects of human diseases in which this protein is dysregulated...
  27. ncbi Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients
    Stanley E Lazic
    Centre for Brain Repair, University of Cambridge, CB2 2PY, UK
    Brain Res 1151:219-26. 2007
    ..These results suggest that olfactory impairments observed in HD patients may be the result of reduced plasticity in the primary olfactory cortex...
  28. ncbi Complexin II is essential for normal neurological function in mice
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, UK
    Hum Mol Genet 12:2431-48. 2003
    ..Given that decreased expression of CPLXII is seen in HD and schizophrenic patients, a role for CPLXII depletion should be considered in other diseases where motor, cognitive and psychiatric symptoms co-exist...
  29. ncbi Systemic administration of Congo red does not improve motor or cognitive function in R6/2 mice
    Nigel I Wood
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 25:342-53. 2007
    ..We suggest that this is due to the inability of Congo red to cross the blood-brain barrier. Since it does not improve the behavioural deterioration that is a key feature of HD, Congo red is unlikely to be useful as a therapy for HD...
  30. ncbi Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II
    J Michael Edwardson
    Department of Pharmacology, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    J Biol Chem 278:30849-53. 2003
    ..Complexin II depletion in the brain may account for some of the abnormalities in neurotransmission associated with HD...
  31. ncbi Early motor development is abnormal in complexin 1 knockout mice
    Dervila Glynn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 25:483-95. 2007
    ..A role for complexin I depletion should be considered in diseases where deficits in early sensory and motor development exist, such as autism and schizophrenia...
  32. ncbi Differential messenger RNA expression of complexins in mouse brain
    Whitney Freeman
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Brain Res Bull 63:33-44. 2004
    ....
  33. ncbi Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation
    Nigel I Wood
    Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK
    Brain Res Bull 61:375-83. 2003
    ..The improvement in rotarod performance suggests that lithium may improve motor symptoms as well as depression in some HD patients...
  34. ncbi A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse
    Helen E Gibson
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Eur J Neurosci 22:1701-12. 2005
    ..This impairment in MF LTP could contribute to spatial learning deficits observed in R6/2 and Cplx2-/- mice...
  35. doi "Brain training" improves cognitive performance and survival in a transgenic mouse model of Huntington's disease
    Nigel I Wood
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 42:427-37. 2011
    ..While brain training was not beneficial for all mice, it produced no deleterious effects, and so warrants further study in rodent models of HD...
  36. doi Increased thirst and drinking in Huntington's disease and the R6/2 mouse
    Nigel I Wood
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    Brain Res Bull 76:70-9. 2008
    ..We suggest that increased thirst may be an important and clinically relevant biomarker for the study of disease progression in HD...
  37. ncbi Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents
    Mark J Hunt
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK
    Exp Brain Res 166:220-9. 2005
    ..However, chronic treatment with these hypoglycaemic agents had no effect on either the course of the diabetes or the disease in R6/2 mice...
  38. doi Paradoxical function of orexin/hypocretin circuits in a mouse model of Huntington's disease
    Rhiannan H Williams
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 42:438-45. 2011
    ..Together, these data suggest that the orexin system remains functional and modifiable in HD mice, although its circadian activity profile is disrupted and no longer follows that of the SCN...
  39. ncbi The role of dopamine in motor symptoms in the R6/2 transgenic mouse model of Huntington's disease
    Miriam A Hickey
    Department of Pharmacology, University of Cambridge, UK
    J Neurochem 81:46-59. 2002
    ..These results suggest that dysfunctional DA neurotransmission contributes to phenotype development in R6/2 mice and thus also may be important in symptom progression in HD...
  40. pmc Voxel-based morphometry with templates and validation in a mouse model of Huntington's disease
    Stephen J Sawiak
    Wolfson Brain Imaging Centre, University of Cambridge, Box 65 Addenbrooke s Hospital, Cambridge, CB2 0QQ, UK Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, Cambridge, CB2 3EB, UK
    Magn Reson Imaging 31:1522-31. 2013
    ..The method is rapid compared to manual delineation and reliable. The templates created here for the mouse brain are freely released for other users in addition to an open-source software toolbox for performing mouse VBM. ..
  41. doi The methamphetamine-sensitive circadian oscillator is dysfunctional in a transgenic mouse model of Huntington's disease
    Marc Cuesta
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK
    Neurobiol Dis 45:145-55. 2012
    ....
  42. doi Progressive sleep and electroencephalogram changes in mice carrying the Huntington's disease mutation
    Sandor Kantor
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, UK
    Brain 136:2147-58. 2013
    ....
  43. ncbi Calcineurin inhibitors cause an acceleration of the neurological phenotype in a mouse transgenic for the human Huntington's disease mutation
    David Hernandez-Espinosa
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, United Kingdom
    Brain Res Bull 69:669-79. 2006
    ..Together, our data suggest a central role for CaN in the deleterious phenotype of the R6/2 mouse. Treatments aimed at preventing the loss of CaN or stimulating its function may be beneficial in the treatment of HD...
  44. ncbi Atrophy and degeneration in sciatic nerve of presymptomatic mice carrying the Huntington's disease mutation
    Anna Wade
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    Brain Res 1188:61-8. 2008
    ..We suggest that degenerative changes in axons are likely to contribute to the early pathological phenotype in HD, even in the absence of frank neuronal cell loss...
  45. doi Asymptomatic sleep abnormalities are a common early feature in patients with Huntington's disease
    Anna O G Goodman
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom
    Curr Neurol Neurosci Rep 11:211-7. 2011
    ..These results suggest that although marked changes in sleep architecture are present in early HD and can be detected using polysomnography, patients do not necessarily recognize or report these abnormalities...
  46. ncbi Limbic neurogenesis/plasticity in the R6/2 mouse model of Huntington's disease
    Wendy Phillips
    Cambridge Centre for Brain Repair, Addenbrooke s Hospital, Cambridge, UK
    Neuroreport 17:1623-7. 2006
    ..These results support the possibility that impaired neurogenesis and/or plasticity could contribute to cognitive and psychiatric impairments in Huntington's disease...
  47. ncbi Rigidity in social and emotional memory in the R6/2 mouse model of Huntington's disease
    Alessandro Ciamei
    Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK
    Neurobiol Learn Mem 89:533-44. 2008
    ..Further, social and emotional memories appear to be encoded in a rigid way that is not influenced by subsequent learning or by arousal levels...
  48. doi The metabolic profile of early Huntington's disease--a combined human and transgenic mouse study
    Anna O G Goodman
    Cambridge Centre for Brain Repair, E D Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    Exp Neurol 210:691-8. 2008
    ..The reason for this is not known but may reflect a catabolic state secondary to hypothalamic pathology, as abnormalities have been reported in the hypothalamus early in the disease course...
  49. ncbi Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity
    M A Hickey
    Department of Pharmacology, University of Cambridge, Cambridge, England
    J Neurochem 75:2163-71. 2000
    ..The existence of similar compensatory mechanisms may explain why, in humans, HD is a late-onset disorder, despite early expression of the genetic mutation...
  50. pmc Syncollin is required for efficient zymogen granule exocytosis
    Barbara Wäsle
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Biochem J 385:721-7. 2005
    ..We conclude that syncollin is required for efficient exocytosis in the pancreatic acinar cell, and that it plays a particularly important role in compound exocytosis...
  51. pmc Huntington's disease mouse models online: high-resolution MRI images with stereotaxic templates for computational neuroanatomy
    Stephen J Sawiak
    Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e53361. 2012
    ..There will be no constraints placed on the use of the datasets included here. The original data will be easily and permanently accessible via the University of Cambridge data repository (http://www.dspace.cam.ac.uk/handle/1810/243361)...
  52. ncbi Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation
    K P Murphy
    Department of Pharmacology, Centre for Brain Repair, Parke Davis Neuroscience Research, Department of Experimental Psychology, University of Cambridge, CB2 1QJ, United Kingdom
    J Neurosci 20:5115-23. 2000
    ..The temporal and regional changes in synaptic plasticity within the hippocampus mirror the appearance of neuronal intranuclear inclusions, suggesting a relationship between polyglutamine aggregation and dysfunction...
  53. pmc Restriction endonuclease TseI cleaves A:A and T:T mismatches in CAG and CTG repeats
    Long Ma
    EaStCHEM School of Chemistry, University of Edinburgh, The King s Buildings, Edinburgh EH9 3JJ, UK
    Nucleic Acids Res 41:4999-5009. 2013
    ....
  54. doi Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry
    S J Sawiak
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neurobiol Dis 33:20-7. 2009
    ..These data indicate that VBM will be a valuable technique for in vivo measurement of developing pathology in HD transgenic mice, and may be particularly useful for correlating histologically undetectable changes with behavioral deficits...
  55. doi Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease
    S J Sawiak
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neurobiol Dis 33:12-9. 2009
    ..Having obtained proof-of-principle for the technique using ex vivo tissue, it is now our intention to carry out in vivo measurement of developing pathology in HD transgenic mice, and correlate this with behavioral deficits...
  56. ncbi Dopamine-dependent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease
    V W S Kung
    Department of Physiology, Development and Neuroscience, Anatomy School, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Neuroscience 146:1571-80. 2007
    ..As dopamine-dependent plasticity is a proposed model of striatum-based motor and cognitive functions, this impairment could contribute to deficits seen in R6/2 mice...
  57. ncbi Abnormalities of neurogenesis in the R6/2 mouse model of Huntington's disease are attributable to the in vivo microenvironment
    Wendy Phillips
    Cambridge Centre for Brain Repair, Cambridge CB2 2PY, United Kingdom
    J Neurosci 25:11564-76. 2005
    ..These results suggest that abnormal neurogenesis in the R6/2 mouse is not attributable to an intrinsic impairment of the NPC itself but is attributable to the environment in which the cell is located...
  58. pmc The touchscreen cognitive testing method for rodents: how to get the best out of your rat
    Timothy J Bussey
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Learn Mem 15:516-23. 2008
    ..Taken together, these experiments served to optimize the touchscreen method and have demonstrated its usefulness as a high-throughput method for the cognitive testing of rodents...
  59. doi Behavioral therapy reverses circadian deficits in a transgenic mouse model of Huntington's disease
    Marc Cuesta
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute, Montreal, Quebec H4H 1R3, Canada
    Neurobiol Dis 63:85-91. 2014
    ..Until effective treatments are found for HD, strategies that reduce deleterious effects of disordered physiology should be part of HD patient treatment programs. ..
  60. ncbi Time-lapse analysis of aggregate formation in an inducible PC12 cell model of Huntington's disease reveals time-dependent aggregate formation that transiently delays cell death
    B Gong
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Brain Res Bull 75:146-57. 2008
    ..Together our data are compatible with a toxic role for aggregates/aggregation and support the 'toxic precursor' hypothesis. However, they also suggest that at some stages, the process of aggregate formation is cytoprotective...
  61. ncbi Methamphetamine toxicity in mice is potentiated by exposure to loud music
    A J Morton
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, UK
    Neuroreport 12:3277-81. 2001
    ..A greater increase in reactive gliosis was also seen after exposure to METH and loud music. Thus, METH appears to be more toxic when taken while exposed to loud music...
  62. ncbi Endothelins induce Fos expression in neurons and glia in organotypic cultures of rat cerebellum
    A M Sullivan
    Department of Pharmacology, University of Cambridge, England
    J Neurochem 67:1409-18. 1996
    ..It appears likely that ETs play an important neuromodulatory role in the cerebellum...
  63. ncbi Increased metabolism in the R6/2 mouse model of Huntington's disease
    Jorien M M van der Burg
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University BMC A10, Lund, Sweden
    Neurobiol Dis 29:41-51. 2008
    ..Together, these data demonstrate that weight loss in R6/2 mice is associated with increased metabolism and changes in several weight-regulating factors...
  64. ncbi Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system
    A Jennifer Morton
    Nat Methods 3:767. 2006
  65. ncbi Microglia density decreases with age in a mouse model of Huntington's disease
    Li Ma
    Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand
    Glia 43:274-80. 2003
    ..Such changes in the dynamic status of microglia may lead to an impairment of their neurosupportive functions. Further studies are needed to understand better the role of microglia in aging and neurodegeneration...
  66. ncbi Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington's disease mutation
    Richard R Ribchester
    Division of Neuroscience, University of Edinburgh, George Square, Edinburgh EH8 9JZ, UK
    Eur J Neurosci 20:3092-114. 2004
    ..However, irrespective of the cause, the abnormalities at neuromuscular junctions we report here are likely to contribute to the pathological phenotype in R6/2 mice, particularly in late stages of the disease...