A H Morice

Summary

Affiliation: University of Hull
Country: UK

Publications

  1. pmc Management of patients with chronic cough using a clinical protocol: a prospective observational study
    Josephine C Ojoo
    Department of Cardiovascular and Respiratory Studies, Castle Hill Hospital, University of Hull, Cottingham, HU16 5JQ, UK
    Cough 9:2. 2013
  2. pmc Chronic Cough in Musculoskeletal disorders: Using high resolution oesophageal manometry in search of an Aetiology
    Sega Pathmanathan
    Division of Cardiovascular and Respiratory Studies, Hull York Medical School, University of Hull, Castle Hill Hospital, Cottingham HU16 5JQ, UK
    Cough 8:6. 2012
  3. pmc Fundoplication in chronic intractable cough
    Shoaib Faruqi
    Department of Cardiovascular and Respiratory Studies, Castle Hill Hospital, Hull York Medical School, University of Hull, Cottingham, HU16 5JQ, UK
    Cough 8:3. 2012
  4. pmc Chronic cough hypersensitivity syndrome
    Alyn H Morice
    Cardiovascular and Respiratory Studies, Respiratory Medicine, Hull York Medical School, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Cough 9:14. 2013
  5. pmc Chronic cough associated with Crohn's disease
    Shoaib Faruqi
    Department of Respiratory Medicine, Castle Hill Hospital, Castle Road, Cottingham, HU16 5JQ, UK
    Cough 6:6. 2010
  6. pmc Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough
    Alex Molassiotis
    School of Nursing, University of Manchester, UK
    Cough 6:9. 2010
  7. pmc Validation of the ERS standard citric acid cough challenge in healthy adult volunteers
    Caroline E Wright
    Division of Cardiovascular and Respiratory Studies, Castle Hill Hospital, Cottingham, UK
    Cough 6:8. 2010
  8. pmc Anxiety and panic fear in adults with asthma: prevalence in primary care
    Cindy L Cooper
    ScHARR, University of Sheffield, Sheffield, UK
    BMC Fam Pract 8:62. 2007
  9. ncbi Is reflux cough due to gastroesophageal reflux disease or laryngopharyngeal reflux?
    Alyn H Morice
    Cardiovascular and Respiratory Studies, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire, UK
    Lung 186:S103-6. 2008
  10. ncbi Post-nasal drip syndrome--a symptom to be sniffed at?
    Alyn H Morice
    University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Pulm Pharmacol Ther 17:343-5. 2004

Collaborators

Detail Information

Publications57

  1. pmc Management of patients with chronic cough using a clinical protocol: a prospective observational study
    Josephine C Ojoo
    Department of Cardiovascular and Respiratory Studies, Castle Hill Hospital, University of Hull, Cottingham, HU16 5JQ, UK
    Cough 9:2. 2013
    ..abstract:..
  2. pmc Chronic Cough in Musculoskeletal disorders: Using high resolution oesophageal manometry in search of an Aetiology
    Sega Pathmanathan
    Division of Cardiovascular and Respiratory Studies, Hull York Medical School, University of Hull, Castle Hill Hospital, Cottingham HU16 5JQ, UK
    Cough 8:6. 2012
    ..This technique may provide important clues into aetiological mechanism in patients with conditions predisposing to reflux into the airways...
  3. pmc Fundoplication in chronic intractable cough
    Shoaib Faruqi
    Department of Cardiovascular and Respiratory Studies, Castle Hill Hospital, Hull York Medical School, University of Hull, Cottingham, HU16 5JQ, UK
    Cough 8:3. 2012
    ..abstract:..
  4. pmc Chronic cough hypersensitivity syndrome
    Alyn H Morice
    Cardiovascular and Respiratory Studies, Respiratory Medicine, Hull York Medical School, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Cough 9:14. 2013
    ..Cough Hypersensitivity Syndrome is a more applicable label to embrace the clinical manifestations of this disabling disease...
  5. pmc Chronic cough associated with Crohn's disease
    Shoaib Faruqi
    Department of Respiratory Medicine, Castle Hill Hospital, Castle Road, Cottingham, HU16 5JQ, UK
    Cough 6:6. 2010
    ..These changes were thought to be due to Crohn's disease involving the lungs and responded well to treatment with cortico-steroids. We report this uncommon radiological association with Crohn's disease...
  6. pmc Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough
    Alex Molassiotis
    School of Nursing, University of Manchester, UK
    Cough 6:9. 2010
    ..The aim of the present paper is to present a clinical guideline developed in the UK through scrutiny of the literature and expert opinion, in order to aid decision making in clinicians and highlight good practice...
  7. pmc Validation of the ERS standard citric acid cough challenge in healthy adult volunteers
    Caroline E Wright
    Division of Cardiovascular and Respiratory Studies, Castle Hill Hospital, Cottingham, UK
    Cough 6:8. 2010
    ..The results correlate well with the MD challenge but offer greater intra-day and inter-day reproducibility. TRIAL REGISTRATION: Current controlled trials ISRCTN98385033...
  8. pmc Anxiety and panic fear in adults with asthma: prevalence in primary care
    Cindy L Cooper
    ScHARR, University of Sheffield, Sheffield, UK
    BMC Fam Pract 8:62. 2007
    ....
  9. ncbi Is reflux cough due to gastroesophageal reflux disease or laryngopharyngeal reflux?
    Alyn H Morice
    Cardiovascular and Respiratory Studies, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire, UK
    Lung 186:S103-6. 2008
    ....
  10. ncbi Post-nasal drip syndrome--a symptom to be sniffed at?
    Alyn H Morice
    University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Pulm Pharmacol Ther 17:343-5. 2004
    ..The lack of any clear pathological or biochemical tests makes the syndrome both a catch-all and a dustbin...
  11. ncbi Opiate therapy in chronic cough
    Alyn H Morice
    Department of Academic Medicine, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire, UK
    Am J Respir Crit Care Med 175:312-5. 2007
    ..There is currently no evidence supporting the use of antitussives in chronic treatment-resistant cough...
  12. pmc Therapeutic comparison of a new budesonide/formoterol pMDI with budesonide pMDI and budesonide/formoterol DPI in asthma
    A H Morice
    Academic Medicine, University of Hull, East Yorkshire, UK
    Int J Clin Pract 61:1874-83. 2007
    ....
  13. ncbi ERS guidelines on the assessment of cough
    A H Morice
    Cardiovascular and Respiratory Studies, Respiratory Medicine, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire, and Imperial College London, UK
    Eur Respir J 29:1256-76. 2007
  14. ncbi Efficacy and safety of a new pressurised metered-dose inhaler formulation of budesonide/formoterol in children with asthma: a superiority and therapeutic equivalence study
    Alyn H Morice
    Respiratory Medicine, University of Hull, East Yorkshire, UK
    Pulm Pharmacol Ther 21:152-9. 2008
    ....
  15. ncbi Evidence based guidelines--a step too far?
    Alyn H Morice
    Head of Academic Department of Medicine, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire, UK
    Pulm Pharmacol Ther 19:230-2. 2006
    ..We examine the evidence behind this fashion and conclude that there is a grave danger of bias and distortion of the data from this approach...
  16. ncbi Comparable long-term safety and efficacy of a novel budesonide/formoterol pressurized metered-dose inhaler versus budesonide/formoterol Turbuhaler in adolescents and adults with asthma
    Alyn H Morice
    Respiratory Medicine, Academic Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Pulm Pharmacol Ther 21:32-9. 2008
    ..The novel HFA pMDI formulation of budesonide/formoterol is an equally well tolerated and effective treatment for adults and adolescents with asthma as the budesonide/formoterol DPI...
  17. pmc Cough. 1: Chronic cough in adults
    A H Morice
    Academic Department of Medicine, Respiratory Medicine, University of Hull, Castle Hill Hospital, Cottingham HU16 5JQ, UK
    Thorax 58:901-7. 2003
    ..The investigation and treatment of chronic cough in adults is generally rewarding, provided there is an understanding of its aetiology, particularly when it arises from sites outside the respiratory tract...
  18. ncbi The diagnosis and management of chronic cough
    A H Morice
    Division of Academic Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Eur Respir J 24:481-92. 2004
  19. pmc Cough. 5: The type 1 vanilloid receptor: a sensory receptor for cough
    A H Morice
    Department of Respiratory Medicine, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire HU16 5JQ, UK
    Thorax 59:257-8. 2004
    ..Evidence is presented to support the proposal that activation of the type 1 vanilloid receptor (VR1) is an important sensory mechanism in cough...
  20. doi Chronic cough: epidemiology
    A H Morice
    Department of Cardiovascular and Respiratory Studies, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire, UK
    Chron Respir Dis 5:43-7. 2008
    ..Failure to make, particularly this latter, diagnosis leads to enormous consequences in terms of loss of employment, healthcare utilisation and a psychosocial morbidity...
  21. ncbi Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine
    Laura R Sadofsky
    Division of Cardiovascular and Respiratory Studies, Hull York Medical School, University of Hull, Castle Hill Hospital, Cottingham, United Kingdom
    Exp Lung Res 34:681-93. 2008
    ..Thus, the inhibition of TRPV1 activation by dexbrompheniramine may provide one potential mechanism whereby this antihistamine exerts its therapeutic effect in chronic cough...
  22. doi The cough hypersensitivity syndrome: a novel paradigm for understanding cough
    Alyn H Morice
    Cardiovascular and Respiratory Studies, Hull York Medical School, Castle Hill Hospital, University of Hull, Cottingham, East Yorkshire, HU16 5JQ, UK
    Lung 188:S87-90. 2010
    ..However, the similarities between the different phenotypes far outweigh differences in a unifying diagnosis of the cough hypersensitivity syndrome, providing a more rational understanding of chronic cough...
  23. ncbi A boy with a disabling cough
    Josephine C Ojoo
    Academic Department of Medicine, University of Hull, Castle Hill Hospital, Cottingham, HU16 5JQ, Hull, UK
    Lancet 361:674. 2003
  24. doi COPD in young patients: a pre-specified analysis of the four-year trial of tiotropium (UPLIFT)
    A H Morice
    Cardiovascular and Respiratory Studies, HullYork Medicine School, University of Hull, Castlehill Hospital, Cottingham, East Yorkshire, UK
    Respir Med 104:1659-67. 2010
    ..Tiotropium also resulted in a significant reduction in the decline in post-bronchodilator FEV(1), suggesting possible disease modification by tiotropium in younger patients with COPD...
  25. ncbi Epidemiology of cough
    Alyn H Morice
    Academic Department of Medicine, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire, HU16 5JQ, UK
    Pulm Pharmacol Ther 15:253-9. 2002
    ..Whilst this is also true of cough-predominant asthma, the origin of cough in chronic disease may also lie in the oesophagus, nose or sinuses leading to errors in diagnosis and treatment...
  26. ncbi Rebuttal: cough is an expiratory sound
    Alyn H Morice
    Cardiovascular and Respiratory Studies, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire, UK
    Lung 186:S7-9. 2008
    ..We undertook a survey of clinicians and scientists working in the field and asked them to count examples of different coughs. The clinical definition was adopted by the majority and we suggest that it should be the gold standard...
  27. pmc Recommendations for the management of cough in adults
    A H Morice
    University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire HU16 5JQ, UK
    Thorax 61:i1-24. 2006
  28. ncbi The effect of the nitric oxide synthase inhibitor N-gamma-nitro-L-argine methyl ester on hypoxic pulmonary vasoconstriction
    R D Jones
    Section of Respiratory Medicine, Academic Department of Medicine, The University of Hull, Castle Hill Hospital, Cottingham, UK
    Eur J Pharmacol 402:111-7. 2000
    ..This suggests basal pulmonary nitric oxide release occurs, as well as in response to agonist-induced contraction, but not hypoxic pulmonary vasoconstriction...
  29. ncbi NADPH oxidase: a universal oxygen sensor?
    R D Jones
    Section of Respiratory Medicine, Academic Department of Medicine, The University of Hull, Hull, UK
    Free Radic Biol Med 29:416-24. 2000
    ....
  30. ncbi Hydrogen peroxide--an intracellular signal in the pulmonary circulation: involvement in hypoxic pulmonary vasoconstriction
    R D Jones
    Section of Respiratory Medicine, Academic Department of Medicine, The University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire, HU16 5JQ, UK
    Pharmacol Ther 88:153-61. 2000
    ....
  31. ncbi The NADPH oxidase inhibitors iodonium diphenyl and cadmium sulphate inhibit hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries
    R D Jones
    Academic Department of Medicine, The University of Hull, Castle Hill Hospital, Cottingham, UK
    Physiol Res 49:587-96. 2000
    ..This suggests that an NADPH oxidase-like enzyme is involved in HPV and could act as the pulmonary oxygen sensor...
  32. ncbi The role of the asthma nurse in treatment compliance and self-management following hospital admission
    A H Morice
    Academic Department of Medicine, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire, UK
    Respir Med 95:851-6. 2001
    ..Asthma nurse intervention appeared to increase knowledge of asthma management, maintained throughout the study period, but had no significant impact on reducing re-admissions to hospital...
  33. ncbi Pulmonary vasodilation in the rat by insulin in vitro could indicate potential hazard for inhaled insulin
    M Aye
    Academic Department of Medicine, University of Hull, Hull, UK
    Diabetologia 46:1199-202. 2003
    ..Insulin is known to be a systemic vasodilator but its effect on the pulmonary circulation is not known. Inhaled particulate insulin can generate locally high concentrations in the lung which could be physiologically important...
  34. ncbi Effects of perinatal exposure to hypoxia upon the pulmonary circulation of the adult rat
    R D Jones
    Section of Respiratory Medicine, Division of Academic Medicine, University of Hull, Castle Hill Hospital, Cottingham, United Kingdom
    Physiol Res 53:11-7. 2004
    ..01), and PGF2(2alpha) (1.40+/-0.14 vs. 2.47+/-0.44 mN/mm, P<0.05). Perinatal exposure to hypoxia had a profound effect upon the adult pulmonary circulation, which could predispose to cardiopulmonary diseases in adulthood...
  35. pmc Abnormal oesophageal motility in patients with chronic cough
    J A Kastelik
    Division of Academic Medicine, Postgraduate Medical Institute, University of Hull, Hull, UK
    Thorax 58:699-702. 2003
    ..The aim of this study was to determine the prevalence of abnormal oesophageal motility in a selected group of patients with chronic cough...
  36. ncbi Gastroesophageal reflux and chronic cough
    C F Everett
    Academic Department of Medicine, Respiratory Medicine, University of Hull, Castle Hill Hospital, Cottingham, UK
    Minerva Gastroenterol Dietol 50:205-13. 2004
    ..Surgical fundoplication can also be effective when performed in appropriately selected individuals...
  37. doi The online Cough Clinic: developing guideline-based diagnosis and advice
    P W Dettmar
    Technostics Ltd, The Deep Business Centre, Hull, UK
    Eur Respir J 34:819-24. 2009
    ..Internet diagnosis by expert algorithm provides a novel mechanism for patients to access guideline-recommended therapies and enhances dialogue between patients and physicians...
  38. pmc Vasoconstrictive effects of endothelin-1, endothelin-3, and urotensin II in isolated perfused human lungs and isolated human pulmonary arteries
    R T Bennett
    Department of Cardiothoracic Surgery, Castle Hill Hospital, Hull and East Yorkshire Hospitals NHS Trust, Cottingham, UK
    Thorax 59:401-7. 2004
    ....
  39. ncbi Pergolide-induced lung disease in patients with Parkinson's disease
    J A Kastelik
    Academic Department of Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire, U K
    Respir Med 96:548-50. 2002
  40. pmc Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms
    A C Ford
    Division of Academic Medicine, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire HU16 5JQ, UK
    Thorax 61:975-9. 2006
    ..In particular, we have examined the relative association between cough and symptoms of gastrointestinal disease...
  41. ncbi Investigation and management of chronic cough using a probability-based algorithm
    J A Kastelik
    Division of Academic Medicine, Postgraduate Medical Institute, University of Hull, Hull, UK
    Eur Respir J 25:235-43. 2005
    ..It is concluded that this protocol has the potential to improve management by providing a structured approach, reducing the number of investigations performed, and minimising unnecessary delays in treatment...
  42. pmc Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis
    J C Ojoo
    Division of Academic Medicine, Postgraduate Medical Institute, University of Hull, Hull, UK
    Thorax 60:22-6. 2005
    ..It has been proposed that the pH of airway lining fluid may regulate the fractional exhaled concentration of nitric oxide (Fe(NO)) in respiratory disease...
  43. pmc Patients' and carers' preferences in two models of care for acute exacerbations of COPD: results of a randomised controlled trial
    J C Ojoo
    Academic Department of Medicine, University of Hull, Castle Hill Hospital, Cottingham, Hull HU16 5JQ, UK
    Thorax 57:167-9. 2002
    ....
  44. ncbi What story do the pictures of cough tell us?
    Alyn H Morice
    Chest 130:316-7. 2006
  45. pmc Adrenal axis suppression unrelated to the dynamics of dosing with beclomethasone monopropionate
    Siobhan A Mulrennan
    Division of Academic Medicine, University of Hull, Hull, UK
    Br J Clin Pharmacol 63:288-91. 2007
    ..This effect may depend on the delivery system, which in turn alters drug deposition and adsorption. We hypothesized that adrenal suppression depends on the rate of steroid absorption rather than the total steroid dose received...
  46. ncbi Sex-related differences in cough reflex sensitivity in patients with chronic cough
    Jack A Kastelik
    Academic Department of Medicine, University of Hull, Castle Hill Hospital, Cottingham, United Kingdom
    Am J Respir Crit Care Med 166:961-4. 2002
    ..57, p < 0.0001). These findings indicate a sex difference in cough sensitivity in patients with chronic cough, as previously reported in healthy volunteers. This may explain the female preponderance in cough clinics...
  47. ncbi Measurement of gastric emptying in gastroesophageal reflux-related chronic cough
    Jack A Kastelik
    Academic Department of Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Chest 122:2038-41. 2002
    ..We tested the hypothesis that gastric emptying is delayed in patients with GER-related chronic cough...
  48. ncbi Difficulties in the interpretation of lung function tests in the diagnosis of asthma and chronic obstructive pulmonary disease
    Anan S Raghunath
    Academic Department of Primary Care and Public Health, University of Hull, United Kingdom
    J Asthma 43:657-60. 2006
    ....
  49. ncbi Bronchoprotection with formoterol via dry powder and metered-dose inhalers in patients with asthma
    Brian J Lipworth
    Department of Medicine and Therapeutics Asthma and Allergy Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    Ann Allergy Asthma Immunol 95:283-90. 2005
    ..Objective: To evaluate the methacholine bronchoprotection afforded by formoterol, 12 microg, delivered via Clickhaler and Aerolizer dry powder inhalers and a pressurized metered-dose inhaler (pMDI) in mild-to-moderate asthmatic patients...
  50. ncbi Clinical history in gastroesophageal cough
    Caroline F Everett
    Academic Department of Medicine, Institute of Postgraduate Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire, UK
    Respir Med 101:345-8. 2007
    ..These data suggest that, contrary to previous reports, a symptom complex which is characteristic of reflux cough can be identified...
  51. ncbi Expression and characterization of the intracellular vanilloid receptor (TRPV1) in bronchi from patients with chronic cough
    Jennifer E Mitchell
    Department of Cellular Pathology, Hull Royal Infirmary, Hull, United Kingdom
    Exp Lung Res 31:295-306. 2005
    ..Increase in TRPV1 activity may have a role in the airway hypersensitivity seen in chronic cough...
  52. pmc Gastro-oesophageal reflux and tachykinins in asthma and chronic cough
    Alyn H Morice
    Thorax 62:468-9. 2007
  53. ncbi Reproducibility and validity of a Yan-style portable citric acid cough challenge
    Chris Michael Barber
    Sheffield Occupational and Environmental Lung Injury Centre, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Pulm Pharmacol Ther 18:177-80. 2005
    ..The results correlate well with an existing Mefar dosimeter challenge, but give two to three times greater cough thresholds...
  54. pmc Assessment of antitussive efficacy of dextromethorphan in smoking related cough: objective vs. subjective measures
    James Ramsay
    University of Hull, Cardiovascular and Respiratory Studies, Castle Hill Hospital, Cottingham, East Yorkshire, UK
    Br J Clin Pharmacol 65:737-41. 2008
    ..Its efficacy in altering cough reflex sensitivity has been shown in healthy volunteers. In contrast evidence for an effect on clinically important cough is poor...
  55. ncbi A widely available method for the assessment of aerosol delivery in cystic fibrosis
    Jack A Kastelik
    Academic Department of Respiratory Medicine, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, East Yorkshire HU16 5JQ, UK
    Pulm Pharmacol Ther 15:513-9. 2002
    ..05). The measurement of aerosol deposition from nebulisers can be performed using a simple and widely available methodology, and may improve nebuliser selection in CF patients...
  56. ncbi Roflumilast for chronic obstructive pulmonary disease
    Alyn H Morice
    Lancet 366:1845; author reply 1846-7. 2005