A V Moorman

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, United Kingdom
    Blood 109:2327-30. 2007
  2. ncbi request reprint No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities
    A V Moorman
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Leukemia 19:557-63. 2005
  3. pmc Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups
    A V Moorman
    Leukaemia Research Fund Centre for Clinical Epidemiology, University of Leeds, 30 Hyde Terrace, Leeds LS2 9LN, UK
    Br J Cancer 86:60-2. 2002
  4. pmc Age-specific incidence rates for cytogenetically-defined subtypes of acute myeloid leukaemia
    A V Moorman
    Leukaemia Research Fund Centre for Clinical Epidemiology, University of Leeds University, Leeds, UK
    Br J Cancer 86:1061-3. 2002
  5. ncbi request reprint Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Blood 109:3189-97. 2007
  6. ncbi request reprint Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia
    Anthony V Moorman
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, MP 822, Duthie Bldg, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom
    Blood 102:2756-62. 2003
  7. ncbi request reprint Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases
    L Harewood
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, UK
    Leukemia 17:547-53. 2003
  8. ncbi request reprint Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemia
    H M Robinson
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Leukemia 19:564-71. 2005
  9. ncbi request reprint Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Queen Victoria Road, Newcastle upon Tyne, UK
    J Clin Oncol 28:2674-81. 2010
  10. pmc Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21
    Qian An
    Cancer Sciences Division, University of Southampton, Southampton, UK
    Haematologica 94:1164-9. 2009

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, United Kingdom
    Blood 109:2327-30. 2007
    ....
  2. ncbi request reprint No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities
    A V Moorman
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Leukemia 19:557-63. 2005
    ..However, characterization of these ACA is important to determine their potential role in initiation of MLL driven leukemogenesis...
  3. pmc Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups
    A V Moorman
    Leukaemia Research Fund Centre for Clinical Epidemiology, University of Leeds, 30 Hyde Terrace, Leeds LS2 9LN, UK
    Br J Cancer 86:60-2. 2002
    ..This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies...
  4. pmc Age-specific incidence rates for cytogenetically-defined subtypes of acute myeloid leukaemia
    A V Moorman
    Leukaemia Research Fund Centre for Clinical Epidemiology, University of Leeds University, Leeds, UK
    Br J Cancer 86:1061-3. 2002
    ..This observation indicates that acute myeloid leukaemia can develop via multiple pathways, and underlines the importance of cytogenetics in understanding this disease...
  5. ncbi request reprint Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Blood 109:3189-97. 2007
    ....
  6. ncbi request reprint Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia
    Anthony V Moorman
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, MP 822, Duthie Bldg, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom
    Blood 102:2756-62. 2003
    ..0001). These findings confirm that the outcome of children with HeH is heterogeneous and that specific trisomies can identify patients with the greatest and least risk of treatment failure...
  7. ncbi request reprint Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases
    L Harewood
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, UK
    Leukemia 17:547-53. 2003
    ..Although this series is not the first report of this abnormality, it is the largest, permitting a detailed description of the variety of morphological forms that duplicated chromosome 21 can assume...
  8. ncbi request reprint Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemia
    H M Robinson
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Leukemia 19:564-71. 2005
    ..This study shows that the incidence of deletions from the der(9) in childhood ALL is at least as high as that reported for CML...
  9. ncbi request reprint Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12
    Christine J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Queen Victoria Road, Newcastle upon Tyne, UK
    J Clin Oncol 28:2674-81. 2010
    ..Because AML is rare in children, the true prognostic significance of individual chromosomal abnormalities in this age group remains unclear...
  10. pmc Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21
    Qian An
    Cancer Sciences Division, University of Southampton, Southampton, UK
    Haematologica 94:1164-9. 2009
    ..This study provides insight into the breakpoint complexity underlying dicentric chromosomal formation in acute lymphoblastic leukemia and highlights putative target gene loci...
  11. ncbi request reprint Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group Study
    Christine J Harrison
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, General Hospital, Southampton SO16 6YD, UK
    Br J Haematol 129:520-30. 2005
    ..This study highlights the importance of iFISH as a complementary tool to cytogenetics in routine screening for significant chromosomal abnormalities in ALL...
  12. ncbi request reprint ETV6/RUNX1 fusion at diagnosis and relapse: some prognostic indications
    Mary Martineau
    LRF Cytogenetics Group, Cancer Sciences Division, University of Southampton, United Kingdom
    Genes Chromosomes Cancer 43:54-71. 2005
    ..In comparing our data with previously reported cases, a picture is beginning to emerge of certain diagnostic features, which may provide circumstantial evidence of an increased risk of relapse...
  13. ncbi request reprint MLL translocations with concurrent 3' deletions: interpretation of FISH results
    Kerry E Barber
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, United Kingdom
    Genes Chromosomes Cancer 41:266-71. 2004
    ....
  14. ncbi request reprint Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia
    Kerry E Barber
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 46:478-86. 2007
    ..In addition to its role as a fusion partner gene, we propose that TCF3 can also act as a tumor suppressor gene in BCP-ALL...
  15. ncbi request reprint Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemia
    Christine J Harrison
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Br J Haematol 125:552-9. 2004
    ..Thus cytogenetics, or at least a clear definition of the modal chromosome number, is essential at diagnosis in order to stratify patients with hypodiploidy into the appropriate risk group for treatment...
  16. doi request reprint The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR1
    Helen Parker
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 47:1118-25. 2008
    ..The target of the interaction between TBL1XR1 and the signaling pathways described here may be exploited in cancer therapy...
  17. ncbi request reprint An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome
    C J Harrison
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Leukemia 28:1015-21. 2014
    ..This now well-defined patient subgroup should be recognised by World Health Organisation (WHO) as a distinct entity of BCP-ALL. ..
  18. pmc Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia
    J M Allan
    Molecular Epidemiology Unit, Academic Unit of Epidemiology and Health Services Research, School of Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom
    Proc Natl Acad Sci U S A 98:11592-7. 2001
    ..01; 95% CI, 0.50-2.07). These data suggest that inheritance of at least one Val allele at GSTP1 codon 105 confers a significantly increased risk of developing t-AML after cytotoxic chemotherapy, but not after radiotherapy...
  19. ncbi request reprint Hyperdiploidy with 49-65 chromosomes represents a heterogeneous cytogenetic subgroup of acute myeloid leukemia with differential outcome
    L Chilton
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Level 5, Sir James Spence Institute, Newcastle University, Newcastle upon Tyne, UK
    Leukemia 28:321-8. 2014
    ..Instead they should be assessed for the presence of specific chromosomal abnormalities, which are known to harbour an adverse effect. ..
  20. ncbi request reprint High hyperdiploidy among adolescents and adults with acute lymphoblastic leukaemia (ALL): cytogenetic features, clinical characteristics and outcome
    L Chilton
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Leukemia 28:1511-8. 2014
    ..47 (95% CI: 0.27-0.84) (P=0.01), 3.73 (1.51-9.21) (P=0.004) and 2.63 (1.25-5.54) (P=0.01), respectively. In conclusion, HeH is an important subtype of ALL at all ages and displays outcome heterogeneity according to chromosomal gain. ..
  21. ncbi request reprint Is trisomy 5 a distinct cytogenetic subgroup in acute lymphoblastic leukemia?
    Rachel L Harris
    Cancer Sciences Division, University of Southampton, MP 822, Duthie Building, Southampton General Hospital, SO16 6YD Southampton, UK
    Cancer Genet Cytogenet 148:159-62. 2004
    ..We conclude that trisomy 5 as the sole numerical abnormality occurs predominantly in older children, may be associated with a poor outcome, and may represent a distinct, albeit rare, cytogenetic subgroup in ALL...
  22. ncbi request reprint Genetic polymorphisms in microsomal epoxide hydrolase and susceptibility to adult acute myeloid leukaemia with defined cytogenetic abnormalities
    Pierre Lebailly
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, School of Medicine, University of Leeds, UK
    Br J Haematol 116:587-94. 2002
    ....
  23. ncbi request reprint Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridization
    J C Strefford
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, UK
    Oncogene 26:4306-18. 2007
    ..This is the first report of genome-wide detection of CNA in ALL patients using aCGH, and it has demonstrated a higher level of karyotype complexity than anticipated from conventional cytogenetic analysis...
  24. pmc Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer
    Qian An
    Cancer Genomics and Leukaemia Research Cytogenetics Groups, Cancer Sciences Division, University of Southampton, Southampton, SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 105:17050-4. 2008
    ..It can be extrapolated that this strategy will reveal that the same mechanisms operate in cancer pathogenesis in general...
  25. doi request reprint Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Lancet Oncol 11:429-38. 2010
    ..Also, little is known about the association between cytogenetics and the characteristics of relapse (eg, time and site of relapse) that are known to predict outcome after relapse...
  26. ncbi request reprint t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
    Lisa J Russell
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Blood 111:387-91. 2008
    ..This study defines a new subgroup of BCP-ALL characterized by ID4 over-expression and CDKN2A and PAX5 deletions. Preliminary survival data suggest that this subgroup may be associated with a good response to therapy...
  27. ncbi request reprint Involvement of the MLL gene in T-lineage acute lymphoblastic leukemia
    Anthony V Moorman
    Blood 100:2273-4. 2002
  28. ncbi request reprint Sex ratios and the risks of haematological malignancies
    Ray A Cartwright
    Leukaemia Research Fund Centre for Clinical Epidemiology at the University of Leeds, Leeds, UK
    Br J Haematol 118:1071-7. 2002
    ..The myeloid sex ratios are all characterized by slight female excess in early adulthood followed by marked male excess. The reasons for these patterns are discussed...
  29. ncbi request reprint Early response to induction is predictive of survival in childhood Philadelphia chromosome positive acute lymphoblastic leukaemia: results of the Medical Research Council ALL 97 trial
    Anindita Roy
    Cancer Research UK Children s Cancer Group, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Br J Haematol 129:35-44. 2005
    ..BMT in CR1 appeared to reduce the risk of a subsequent BM relapse. These results show significant improvement on previous MRC trials; future therapeutic strategies should include early intensive therapy and BMT in CR1...
  30. ncbi request reprint Outcome after first relapse in childhood acute lymphoblastic leukaemia - lessons from the United Kingdom R2 trial
    Anindita Roy
    Cancer Research UK Children s Cancer Group, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Br J Haematol 130:67-75. 2005
    ....
  31. ncbi request reprint RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years
    David T Bowen
    Division of Pathology and Neuroscience, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
    Blood 106:2113-9. 2005
    ..RAS mutation did not influence clinical outcome (overall/disease-free survival, complete remission, relapse rate) either for the entire cohort or within cytogenetic risk groups...
  32. ncbi request reprint t(14;19)(q32;q13): a recurrent translocation in B-cell precursor acute lymphoblastic leukemia
    Hazel M Robinson
    Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 39:88-92. 2004
    ..This newly described translocation constitutes a distinct cytogenetic subgroup that is confined to older children and younger adults with B-cell precursor acute lymphoblastic leukemia...
  33. doi request reprint Acute leukemia in children with Down's syndrome: the importance of population based study
    Rebecca James
    Haematologica 93:1262-3. 2008
  34. ncbi request reprint Sequential influences of leukemia-specific and genetic factors on p-glycoprotein expression in blasts from 817 patients entered into the National Cancer Research Network acute myeloid leukemia 14 and 15 trials
    Claire H Seedhouse
    Academic Haematology, Nottingham University Hospitals, University of Nottingham, Nottingham, United Kingdom
    Clin Cancer Res 13:7059-66. 2007
    ..P-glycoprotein (Pgp) is a major prognostic factor for chemotherapy failure in acute myeloid leukemia (AML). This study compared the influence of genetic and leukemia-specific factors on Pgp...
  35. ncbi request reprint Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemia
    Alicja M Gruszka-Westwood
    Section of Haematological Oncology, Institute of Cancer Research, London, United Kingdom
    Genes Chromosomes Cancer 41:191-202. 2004
    ..In conclusion, we have shown that tri-/tetrasomies in hyperdiploid ALL lead to an increase in the expression of associated sequences. The choice of a biologically relevant reference is crucial for data interpretation...
  36. ncbi request reprint Intrachromosomal amplification of chromosome 21 (iAMP21) may arise from a breakage-fusion-bridge cycle
    Hazel M Robinson
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
    Genes Chromosomes Cancer 46:318-26. 2007
    ..These findings suggested that iAMP21 had arisen from a breakage-fusion-bridge cycle: a mechanism previously described in tumors, which we report for the first time in ALL...
  37. ncbi request reprint Breakpoints of variant 9;22 translocations in chronic myeloid leukemia locate preferentially in the CG-richest regions of the genome
    Andrew M Fisher
    Wessex Regional Genetics Laboratory, Salisbury District Hospital, UK
    Genes Chromosomes Cancer 43:383-9. 2005
    ..We found that the frequency of the former, 9.3%, was significantly higher than that of the latter, 2.6%...