Research Topics
Species | A V MoormanSummaryAffiliation: University of Southampton Country: UK Publications
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Detail Information
Publications
No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalitiesA V Moorman
Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
Leukemia 19:557-63. 2005..However, characterization of these ACA is important to determine their potential role in initiation of MLL driven leukemogenesis...
Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroupsA V Moorman
Leukaemia Research Fund Centre for Clinical Epidemiology, University of Leeds, 30 Hyde Terrace, Leeds LS2 9LN, UK
Br J Cancer 86:60-2. 2002..This supports the hypothesis that distinct cytogenetic subgroups of acute myeloid leukaemia have separate aetiologies...- Age-specific incidence rates for cytogenetically-defined subtypes of acute myeloid leukaemiaA V Moorman
Leukaemia Research Fund Centre for Clinical Epidemiology, University of Leeds University, Leeds, UK
Br J Cancer 86:1061-3. 2002..This observation indicates that acute myeloid leukaemia can develop via multiple pathways, and underlines the importance of cytogenetics in understanding this disease... - Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)Anthony V Moorman
Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, United Kingdom
Blood 109:2327-30. 2007.... - Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trialAnthony V Moorman
Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
Blood 109:3189-97. 2007.... - Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemiaAnthony V Moorman
Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, MP 822, Duthie Bldg, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom
Blood 102:2756-62. 2003..0001). These findings confirm that the outcome of children with HeH is heterogeneous and that specific trisomies can identify patients with the greatest and least risk of treatment failure... - Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemiaH M Robinson
Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
Leukemia 19:564-71. 2005..This study shows that the incidence of deletions from the der(9) in childhood ALL is at least as high as that reported for CML... - Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 casesL Harewood
Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, UK
Leukemia 17:547-53. 2003..Although this series is not the first report of this abnormality, it is the largest, permitting a detailed description of the variety of morphological forms that duplicated chromosome 21 can assume... 
Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12Christine J Harrison
Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Queen Victoria Road, Newcastle upon Tyne, UK
J Clin Oncol 28:2674-81. 2010..Because AML is rare in children, the true prognostic significance of individual chromosomal abnormalities in this age group remains unclear...- Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21Qian An
Cancer Sciences Division, University of Southampton, Southampton, UK
Haematologica 94:1164-9. 2009..This study provides insight into the breakpoint complexity underlying dicentric chromosomal formation in acute lymphoblastic leukemia and highlights putative target gene loci... - Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemiaKerry E Barber
Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
Genes Chromosomes Cancer 46:478-86. 2007..In addition to its role as a fusion partner gene, we propose that TCF3 can also act as a tumor suppressor gene in BCP-ALL... - The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR1Helen Parker
Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
Genes Chromosomes Cancer 47:1118-25. 2008..The target of the interaction between TBL1XR1 and the signaling pathways described here may be exploited in cancer therapy... - Interphase molecular cytogenetic screening for chromosomal abnormalities of prognostic significance in childhood acute lymphoblastic leukaemia: a UK Cancer Cytogenetics Group StudyChristine J Harrison
Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, General Hospital, Southampton SO16 6YD, UK
Br J Haematol 129:520-30. 2005..This study highlights the importance of iFISH as a complementary tool to cytogenetics in routine screening for significant chromosomal abnormalities in ALL... - ETV6/RUNX1 fusion at diagnosis and relapse: some prognostic indicationsMary Martineau
LRF Cytogenetics Group, Cancer Sciences Division, University of Southampton, United Kingdom
Genes Chromosomes Cancer 43:54-71. 2005..In comparing our data with previously reported cases, a picture is beginning to emerge of certain diagnostic features, which may provide circumstantial evidence of an increased risk of relapse... - MLL translocations with concurrent 3' deletions: interpretation of FISH resultsKerry E Barber
Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, United Kingdom
Genes Chromosomes Cancer 41:266-71. 2004.... - Three distinct subgroups of hypodiploidy in acute lymphoblastic leukaemiaChristine J Harrison
Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
Br J Haematol 125:552-9. 2004..Thus cytogenetics, or at least a clear definition of the modal chromosome number, is essential at diagnosis in order to stratify patients with hypodiploidy into the appropriate risk group for treatment... - Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemiaJ M Allan
Molecular Epidemiology Unit, Academic Unit of Epidemiology and Health Services Research, School of Medicine, University of Leeds, Leeds LS2 9JT, United Kingdom
Proc Natl Acad Sci U S A 98:11592-7. 2001..01; 95% CI, 0.50-2.07). These data suggest that inheritance of at least one Val allele at GSTP1 codon 105 confers a significantly increased risk of developing t-AML after cytotoxic chemotherapy, but not after radiotherapy... - Genetic polymorphisms in microsomal epoxide hydrolase and susceptibility to adult acute myeloid leukaemia with defined cytogenetic abnormalitiesPierre Lebailly
Molecular Epidemiology Unit, Epidemiology and Health Services Research, School of Medicine, University of Leeds, UK
Br J Haematol 116:587-94. 2002.... - Is trisomy 5 a distinct cytogenetic subgroup in acute lymphoblastic leukemia?Rachel L Harris
Cancer Sciences Division, University of Southampton, MP 822, Duthie Building, Southampton General Hospital, SO16 6YD Southampton, UK
Cancer Genet Cytogenet 148:159-62. 2004..We conclude that trisomy 5 as the sole numerical abnormality occurs predominantly in older children, may be associated with a poor outcome, and may represent a distinct, albeit rare, cytogenetic subgroup in ALL... - Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridizationJ C Strefford
Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, UK
Oncogene 26:4306-18. 2007..This is the first report of genome-wide detection of CNA in ALL patients using aCGH, and it has demonstrated a higher level of karyotype complexity than anticipated from conventional cytogenetic analysis... - Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trialAnthony V Moorman
Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
Lancet Oncol 11:429-38. 2010..Also, little is known about the association between cytogenetics and the characteristics of relapse (eg, time and site of relapse) that are known to predict outcome after relapse... - Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancerQian An
Cancer Genomics and Leukaemia Research Cytogenetics Groups, Cancer Sciences Division, University of Southampton, Southampton, SO16 6YD, United Kingdom
Proc Natl Acad Sci U S A 105:17050-4. 2008..It can be extrapolated that this strategy will reveal that the same mechanisms operate in cancer pathogenesis in general... - t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)Lisa J Russell
Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
Blood 111:387-91. 2008..This study defines a new subgroup of BCP-ALL characterized by ID4 over-expression and CDKN2A and PAX5 deletions. Preliminary survival data suggest that this subgroup may be associated with a good response to therapy... - Early response to induction is predictive of survival in childhood Philadelphia chromosome positive acute lymphoblastic leukaemia: results of the Medical Research Council ALL 97 trialAnindita Roy
Cancer Research UK Children's Cancer Group, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Br J Haematol 129:35-44. 2005..BMT in CR1 appeared to reduce the risk of a subsequent BM relapse. These results show significant improvement on previous MRC trials; future therapeutic strategies should include early intensive therapy and BMT in CR1... - Sex ratios and the risks of haematological malignanciesRay A Cartwright
Leukaemia Research Fund Centre for Clinical Epidemiology at the University of Leeds, Leeds, UK
Br J Haematol 118:1071-7. 2002..The myeloid sex ratios are all characterized by slight female excess in early adulthood followed by marked male excess. The reasons for these patterns are discussed... - Involvement of the MLL gene in T-lineage acute lymphoblastic leukemiaAnthony V Moorman
Blood 100:2273-4. 2002 - Outcome after first relapse in childhood acute lymphoblastic leukaemia - lessons from the United Kingdom R2 trialAnindita Roy
Cancer Research UK Children's Cancer Group, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Br J Haematol 130:67-75. 2005.... - RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 yearsDavid T Bowen
Division of Pathology and Neuroscience, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
Blood 106:2113-9. 2005..RAS mutation did not influence clinical outcome (overall/disease-free survival, complete remission, relapse rate) either for the entire cohort or within cytogenetic risk groups... - Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemiaAlicja M Gruszka-Westwood
Section of Haematological Oncology, Institute of Cancer Research, London, United Kingdom
Genes Chromosomes Cancer 41:191-202. 2004..In conclusion, we have shown that tri-/tetrasomies in hyperdiploid ALL lead to an increase in the expression of associated sequences. The choice of a biologically relevant reference is crucial for data interpretation... - Sequential influences of leukemia-specific and genetic factors on p-glycoprotein expression in blasts from 817 patients entered into the National Cancer Research Network acute myeloid leukemia 14 and 15 trialsClaire H Seedhouse
Academic Haematology, Nottingham University Hospitals, University of Nottingham, Nottingham, United Kingdom
Clin Cancer Res 13:7059-66. 2007..P-glycoprotein (Pgp) is a major prognostic factor for chemotherapy failure in acute myeloid leukemia (AML). This study compared the influence of genetic and leukemia-specific factors on Pgp... - Acute leukemia in children with Down's syndrome: the importance of population based studyRebecca James
Haematologica 93:1262-3. 2008 - t(14;19)(q32;q13): a recurrent translocation in B-cell precursor acute lymphoblastic leukemiaHazel M Robinson
Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
Genes Chromosomes Cancer 39:88-92. 2004..This newly described translocation constitutes a distinct cytogenetic subgroup that is confined to older children and younger adults with B-cell precursor acute lymphoblastic leukemia... - Breakpoints of variant 9;22 translocations in chronic myeloid leukemia locate preferentially in the CG-richest regions of the genomeAndrew M Fisher
Wessex Regional Genetics Laboratory, Salisbury District Hospital, UK
Genes Chromosomes Cancer 43:383-9. 2005..We found that the frequency of the former, 9.3%, was significantly higher than that of the latter, 2.6%... - Intrachromosomal amplification of chromosome 21 (iAMP21) may arise from a breakage-fusion-bridge cycleHazel M Robinson
Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, UK
Genes Chromosomes Cancer 46:318-26. 2007..These findings suggested that iAMP21 had arisen from a breakage-fusion-bridge cycle: a mechanism previously described in tumors, which we report for the first time in ALL...