Gudrun E Moore

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Paternally expressed, imprinted insulin-like growth factor-2 in chorionic villi correlates significantly with birth weight
    Charalambos Demetriou
    Fetal Development and Growth Research Group, Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London, United Kingdom Department of Obstetrics and Gynaecology, St Mary s Campus, Imperial College London, London, United Kingdom
    PLoS ONE 9:e85454. 2014
  2. pmc Fat dads must not be blamed for their children's health problems
    Gudrun E Moore
    Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    BMC Med 11:30. 2013
  3. pmc Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes
    Erwin Pauws
    UCL Institute of Child Health, 30 Guilford Street, WC1N 1EH London, UK
    Hum Mol Genet 18:4171-9. 2009
  4. ncbi request reprint Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression
    David Monk
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Hum Mol Genet 18:3066-74. 2009
  5. pmc Maternal inheritance of a promoter variant in the imprinted PHLDA2 gene significantly increases birth weight
    Miho Ishida
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London, UK
    Am J Hum Genet 90:715-9. 2012
  6. pmc Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing
    David Monk
    Institute of Child Health, London, UK
    Genome Res 18:1270-81. 2008
  7. doi request reprint Investigation of SUMO pathway genes in the etiology of nonsyndromic cleft lip with or without cleft palate
    Eloisa Carta
    UCL Institute of Child Health, London, United Kingdom
    Birth Defects Res A Clin Mol Teratol 94:459-63. 2012
  8. pmc Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS
    Veronica A Kinsler
    Paediatric Dermatology Department, Great Ormond Street Hospital for Children, London, UK
    J Invest Dermatol 133:2229-36. 2013
  9. pmc Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development
    Veronica A Kinsler
    Department of Paediatric Dermatology, Great Ormond Street Hospital for Children, London, UK
    J Invest Dermatol 132:2026-32. 2012
  10. pmc The effects of culture on genomic imprinting profiles in human embryonic and fetal mesenchymal stem cells
    Jennifer Frost
    Institute of Reproductive and Developmental Biology, Imperial Colleg, London, UK
    Epigenetics 6:52-62. 2011

Collaborators

Detail Information

Publications24

  1. pmc Paternally expressed, imprinted insulin-like growth factor-2 in chorionic villi correlates significantly with birth weight
    Charalambos Demetriou
    Fetal Development and Growth Research Group, Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London, United Kingdom Department of Obstetrics and Gynaecology, St Mary s Campus, Imperial College London, London, United Kingdom
    PLoS ONE 9:e85454. 2014
    ..Conversely the maternally expressed growth suppressor, PHLDA2, has a significant negative correlation between its term placental expression and birth weight...
  2. pmc Fat dads must not be blamed for their children's health problems
    Gudrun E Moore
    Clinical and Molecular Genetics Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    BMC Med 11:30. 2013
    ..These data imply that paternal obesity affects the normal IGF2 methylation in the sperm and this in turn alters the expression of IGF2 in the baby...
  3. pmc Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes
    Erwin Pauws
    UCL Institute of Child Health, 30 Guilford Street, WC1N 1EH London, UK
    Hum Mol Genet 18:4171-9. 2009
    ..These findings could have important implications for the molecular diagnosis in patients with isolated SMCP and/or unexplained choanal atresia...
  4. ncbi request reprint Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression
    David Monk
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Hum Mol Genet 18:3066-74. 2009
    ..The strong conservation of the opposite allelic expression in placenta versus brain supports the hypothesis that GRB10 imprinting evolved to mediate diverse roles in mammalian growth and behaviour...
  5. pmc Maternal inheritance of a promoter variant in the imprinted PHLDA2 gene significantly increases birth weight
    Miho Ishida
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London, UK
    Am J Hum Genet 90:715-9. 2012
    ..Moreover, when the mother was homozygous for RS1, the influence on birth weight was 155 g (p = 0.04; 95% CI = 9-300), which is a similar magnitude to the reduction in birth weight caused by maternal smoking...
  6. pmc Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing
    David Monk
    Institute of Child Health, London, UK
    Genome Res 18:1270-81. 2008
    ..This unexpected general lack of repressive histone modifications suggests that this domain may utilize a different silencing mechanism as compared to other imprinted domains...
  7. doi request reprint Investigation of SUMO pathway genes in the etiology of nonsyndromic cleft lip with or without cleft palate
    Eloisa Carta
    UCL Institute of Child Health, London, United Kingdom
    Birth Defects Res A Clin Mol Teratol 94:459-63. 2012
    ..SUMO1 has been implicated as having a role in the causation of cleft lip with or without cleft palate (CLP), both directly and through association studies in humans and, perhaps more controversially, in transgenic mouse studies...
  8. pmc Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS
    Veronica A Kinsler
    Paediatric Dermatology Department, Great Ormond Street Hospital for Children, London, UK
    J Invest Dermatol 133:2229-36. 2013
    ..These results suggest that single postzygotic NRAS mutations are responsible for multiple CMN and associated neurological lesions in the majority of cases. ..
  9. pmc Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development
    Veronica A Kinsler
    Department of Paediatric Dermatology, Great Ormond Street Hospital for Children, London, UK
    J Invest Dermatol 132:2026-32. 2012
    ..The effect of germline MC1R genotype on development and severity of CMN led us to investigate potential broader effects on growth, revealing a role for MC1R in normal fetal development...
  10. pmc The effects of culture on genomic imprinting profiles in human embryonic and fetal mesenchymal stem cells
    Jennifer Frost
    Institute of Reproductive and Developmental Biology, Imperial Colleg, London, UK
    Epigenetics 6:52-62. 2011
    ..Since DMR integrity was maintained in fMSC but not hES cells, we postulate that specific hES cell derivation and culturing practices result in changes in methylation at DMRs...
  11. pmc The growth hormone receptor gene deleted for exon three (GHRd3) polymorphism is associated with birth and placental weight
    Raja Padidela
    Developmental Endocrinology Research Group, UCL Institute of Child Health, University College London, London, UK
    Clin Endocrinol (Oxf) 76:236-40. 2012
    ..An association of these isoforms has been found with small for gestational age (SGA) infants but does not influence adult height. The role of this polymorphism in the birth size spectrum in the general population is unclear...
  12. pmc Telomeric NAP1L4 and OSBPL5 of the KCNQ1 cluster, and the DECORIN gene are not imprinted in human trophoblast stem cells
    Jennifer M Frost
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London, UK
    PLoS ONE 5:e11595. 2010
    ..However, as early development is less divergent between species, placental specific imprinting may be present in very early gestation in both mice and humans...
  13. doi request reprint The role of imprinted genes in humans
    Miho Ishida
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Mol Aspects Med 34:826-40. 2013
    ....
  14. ncbi request reprint Intrauterine growth restriction--genetic causes and consequences
    David Monk
    Institute of Developmental and Reproductive Biology, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Semin Fetal Neonatal Med 9:371-8. 2004
    ..These human models will allow us to elucidate key genes and mechanisms important in normal fetal growth...
  15. pmc A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation
    Andrew J Wood
    Department of Medical and Molecular Genetics, King s College London, London, United Kingdom
    PLoS Genet 3:e20. 2007
    ..The striking correlation between imprinting and X chromosome provenance suggests that retrotransposed elements with homology to the X chromosome can be selectively targeted for methylation during mammalian oogenesis...
  16. pmc The importance of imprinting in the human placenta
    Jennifer M Frost
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London, United Kingdom
    PLoS Genet 6:e1001015. 2010
    ..Finally, we illustrate the importance of imprinting in the postnatal human in terms of several human imprinting disorders, with consideration of the brain as a key organ for imprinted gene expression after birth...
  17. ncbi request reprint Intellectual disability, unusual facial morphology and hand anomalies in sibs
    Sérgio B Sousa
    Servico de Genetica Medica, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal Clinical and Molecular Genetics Unit, UCL Institute of Child Health, London, UK
    Am J Med Genet A 161:2401-6. 2013
    ..2013 Wiley Periodicals, Inc. ..
  18. pmc Evaluation of allelic expression of imprinted genes in adult human blood
    Jennifer M Frost
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London, United Kingdom
    PLoS ONE 5:e13556. 2010
    ..In general, the expression profiles of imprinted genes are well characterised during human and mouse fetal development, but not in human adults...
  19. pmc TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repression
    Artemisia M Andreou
    Institute of Child Health, University College London, London, WC1N 1EH, UK
    Am J Hum Genet 81:700-12. 2007
    ..Thus, we suggest that SUMO modification may represent a common pathway that regulates normal craniofacial development and is involved in the pathogenesis of both Mendelian and idiopathic forms of orofacial clefting...
  20. pmc The emerging role of epigenetic mechanisms in the etiology of neural tube defects
    Nicholas D E Greene
    Neural Development Unit, Institute of Child Health, UCL, London, UK
    Epigenetics 6:875-83. 2011
    ..Alterations in the epigenetic status can be directly modified by various environmental insults or maternal dietary factors...
  21. pmc The role of imprinted genes in humans
    Gudrun E Moore
    Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Genome Biol 12:106. 2011
    ..Detailed comprehensive molecular analysis using families and multiple matched tissues is essential to determine whether imprinted genes have a functional role in humans...
  22. ncbi request reprint Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy
    Saskia W C van Mil
    Maternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Imperial College London, London, England
    Gastroenterology 133:507-16. 2007
    ..It can cause premature delivery and intrauterine death. Bile acid synthesis, metabolism, and transport are regulated by the bile acid sensor FXR, and we hypothesized that genetic variation in FXR confers susceptibility to ICP...
  23. ncbi request reprint Genomic imprinting in fetal growth and development
    Megan P Hitchins
    Department of Fetal and Maternal Medicine, Institute of Reproductive and Developmental Biology, Imperial College Faculty of Medicine, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    Expert Rev Mol Med 4:1-19. 2002
    ..The characteristics of imprinted genes, their regulation and the phenotypes associated with altered imprinting are discussed...
  24. ncbi request reprint Imprinted methylation profiles for proximal mouse chromosomes 11 and 7 as revealed by methylation-sensitive representational difference analysis
    David Monk
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Mamm Genome 14:805-16. 2003
    ..No such mutations were found...