Anne C Moore
Affiliation: University of Oxford
- Progress in DNA-based heterologous prime-boost immunization strategies for malariaAnne C Moore
Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Immunol Rev 199:126-43. 2004..We summarize the preclinical design and development of these heterologous prime-boost vaccines and discuss the encouraging results that have been observed in vaccinated humans...
- Anti-CD25 antibody enhancement of vaccine-induced immunogenicity: increased durable cellular immunity with reduced immunodominanceAnne C Moore
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, United Kingdom
J Immunol 175:7264-73. 2005..Vaccine strategies incorporating anti-CD25 lead to improved protection against pre-erythrocytic malaria challenge. These data underpin new strategies for the design and development of more efficacious vaccines in clinical settings...
- Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium bergheiArturo Reyes-Sandoval
The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Eur J Immunol 38:732-41. 2008..Our data suggest that T(EM) cells are important as a first line of defense against fast-replicating pathogens such as murine Plasmodium and demonstrate the potential of replication-defective SAd as future malaria vaccines for humans...
- Effective induction of high-titer antibodies by viral vector vaccinesSimon J Draper
The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK
Nat Med 14:819-21. 2008..Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro...
- Combination of protein and viral vaccines induces potent cellular and humoral immune responses and enhanced protection from murine malaria challengeClaire L Hutchings
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
Infect Immun 75:5819-26. 2007....
- Recombinant viral vaccines expressing merozoite surface protein-1 induce antibody- and T cell-mediated multistage protection against malariaSimon J Draper
The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Cell Host Microbe 5:95-105. 2009..Multistage immunity against malaria can thus be achieved by using viral vectors recombinant for MSP-1...
- Novel protein and poxvirus-based vaccine combinations for simultaneous induction of humoral and cell-mediated immunityClaire L Hutchings
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
J Immunol 175:599-606. 2005....
- The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessmentAnna L Goodman
The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
Sci Rep 3:1706. 2013..An improved understanding of the mechanisms responsible for protection, or failure of protection, against P. berghei merozoites could guide the development of an efficacious vaccine against P. falciparum...
- A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxvirusesEric Prieur
Weatherall Institute of Molecular Medicine and Cellular Immunology, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Proc Natl Acad Sci U S A 101:290-5. 2004..The use of polyprotein constructs in nonreplicating poxviruses should broaden the target antigen range of vaccine-induced immunity and increase the number of potential epitopes available for immunogenetically diverse human populations...
- Immunity against heterosubtypic influenza virus induced by adenovirus and MVA expressing nucleoprotein and matrix protein-1Teresa Lambe
The Jenner Institute, University of Oxford, Oxford, United Kingdom
Sci Rep 3:1443. 2013..These data may be of relevance for the design of optimal immunization regimens for human influenza vaccines, especially for influenza-naïve infants...
- Combination vaccines: synergistic simultaneous induction of antibody and T-cell immunityAnne C Moore
Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX2 7BN, UK
Expert Rev Vaccines 6:111-21. 2007..Combination vaccines, where an antibody-inducing subunit protein vaccine is coadministered with a T-cell-inducing poxvirus-based vaccine fulfill these requirements and induce sterile immunity to pathogen challenge...
- Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malariaNathan W Schmidt
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 105:14017-22. 2008..Furthermore, the extremely large threshold in memory CD8 T cell frequencies required for long-term protection in mice may have important implications for development of effective malaria vaccines...
- Effects of antigen and genetic adjuvants on immune responses to human immunodeficiency virus DNA vaccines in miceAnne C Moore
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 3005, USA
J Virol 76:243-50. 2002....
- Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 20-2002. A 37-year-old man with fever, hepatosplenomegaly, and a cutaneous foot lesion after a trip to AfricaAnne C Moore
N Engl J Med 346:2069-76. 2002