Salvador Moncada

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Nitric oxide, cell bioenergetics and neurodegeneration
    Salvador Moncada
    The Wolfson Institute for Biomedical Research, University College London, London, UK
    J Neurochem 97:1676-89. 2006
  2. ncbi request reprint Cytochrome c oxidase maintains mitochondrial respiration during partial inhibition by nitric oxide
    Miriam Palacios-Callender
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK
    J Cell Sci 120:160-5. 2007
  3. pmc Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?
    Alexander Galkin
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    J Biol Chem 284:36055-61. 2009
  4. doi request reprint Inactivation of nitric oxide by cytochrome c oxidase under steady-state oxygen conditions
    David C Unitt
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochim Biophys Acta 1797:371-7. 2010
  5. ncbi request reprint Inhibition of cellular respiration by endogenously produced carbon monoxide
    Gabriela D'Amico
    Wolfson Institute for Biomedical Research, University College London, UK
    J Cell Sci 119:2291-8. 2006
  6. ncbi request reprint Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol
    Thilo Hagen
    The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochem Biophys Res Commun 322:923-9. 2004
  7. ncbi request reprint Nitric oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response
    Weiming Xu
    Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, Gower Street, London, WC1E 6BT, UK
    Cell Res 15:63-5. 2005
  8. pmc Cytochrome c oxidase regulates endogenous nitric oxide availability in respiring cells: a possible explanation for hypoxic vasodilation
    Miriam Palacios-Callender
    The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 104:18508-13. 2007
  9. doi request reprint Mitochondrial dysfunction and HIF1alpha stabilization in inflammation
    Assegid Garedew
    The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    J Cell Sci 121:3468-75. 2008
  10. ncbi request reprint Nitric oxide and hypoxia
    Alexander Galkin
    The Wolfson Institute for Biomedical Research, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, U K
    Essays Biochem 43:29-42. 2007

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Nitric oxide, cell bioenergetics and neurodegeneration
    Salvador Moncada
    The Wolfson Institute for Biomedical Research, University College London, London, UK
    J Neurochem 97:1676-89. 2006
    ..Thus, whilst NO plays a physiological role in neuronal cell signalling, its over-production may cause neuronal energy compromise leading to neurodegeneration...
  2. ncbi request reprint Cytochrome c oxidase maintains mitochondrial respiration during partial inhibition by nitric oxide
    Miriam Palacios-Callender
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK
    J Cell Sci 120:160-5. 2007
    ..We suggest that this is a physiological mechanism regulated by the flux of electrons in the mitochondria and by the changing ratio of O2:NO, either during hypoxia or, as a consequence of increases in NO, as a result of cell stress...
  3. pmc Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?
    Alexander Galkin
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    J Biol Chem 284:36055-61. 2009
    ..These observations provide a mechanism to account for the severe cell injury that follows hypoxia and reoxygenation when accompanied by NO generation...
  4. doi request reprint Inactivation of nitric oxide by cytochrome c oxidase under steady-state oxygen conditions
    David C Unitt
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochim Biophys Acta 1797:371-7. 2010
    ..At both high and low O(2) concentrations the inactivation of NO is decreased when sodium azide is used to inhibit cytochrome c oxidase and decrease electron turnover...
  5. ncbi request reprint Inhibition of cellular respiration by endogenously produced carbon monoxide
    Gabriela D'Amico
    Wolfson Institute for Biomedical Research, University College London, UK
    J Cell Sci 119:2291-8. 2006
    ..Inhibition of cell respiration by endogenous CO through its interaction with cytochrome c oxidase might have an important role in inflammatory and hypoxic conditions...
  6. ncbi request reprint Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol
    Thilo Hagen
    The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochem Biophys Res Commun 322:923-9. 2004
    ..Since these actions of 2ME2 occur at higher concentrations than those known to inhibit cell proliferation, it remains to be established whether they contribute to its therapeutic effect...
  7. ncbi request reprint Nitric oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response
    Weiming Xu
    Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, Gower Street, London, WC1E 6BT, UK
    Cell Res 15:63-5. 2005
    ....
  8. pmc Cytochrome c oxidase regulates endogenous nitric oxide availability in respiring cells: a possible explanation for hypoxic vasodilation
    Miriam Palacios-Callender
    The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 104:18508-13. 2007
    ..The resultant increase in NO concentration could explain hypoxic vasodilation...
  9. doi request reprint Mitochondrial dysfunction and HIF1alpha stabilization in inflammation
    Assegid Garedew
    The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    J Cell Sci 121:3468-75. 2008
    ..Nevertheless, the amount of ATP generated is not sufficient to fulfil the energy requirements of the activated cells, probably leading to a progressive energy deficit with the consequent inhibition of cell proliferation and death...
  10. ncbi request reprint Nitric oxide and hypoxia
    Alexander Galkin
    The Wolfson Institute for Biomedical Research, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, U K
    Essays Biochem 43:29-42. 2007
    ..This chapter discusses the physiological and pathophysiological implications of the interactions of NO with the cytochrome c oxidase...
  11. doi request reprint Mitochondrial dynamics, biogenesis, and function are coordinated with the cell cycle by APC/C CDH1
    Assegid Garedew
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Cell Metab 15:466-79. 2012
    ..Thus, we have identified an important component of the molecular mechanism that coordinates cell proliferation with activation of the mitochondrial metabolic machinery that provides the necessary energy and biosynthetic substrates...
  12. ncbi request reprint AMPKalpha1 regulates the antioxidant status of vascular endothelial cells
    Sergio L Colombo
    Wolfson Institute for Biomedical Research, University College London, Gower Street, Cruciform Building, London WC1E6AE, UK
    Biochem J 421:163-9. 2009
    ....
  13. ncbi request reprint S-nitrosation of mitochondrial complex I depends on its structural conformation
    Alexander Galkin
    Wolfson Institute for Biomedical Research, University College London, London, UK
    J Biol Chem 282:37448-53. 2007
    ..The implications of this finding for hypoxic or pathophysiological conditions in vivo are discussed...
  14. ncbi request reprint Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages
    Matthew T Frost
    Wolfson Institute for Biomedical Research, University College London, Gower St, London WC1E 6BT, UK
    Am J Physiol Regul Integr Comp Physiol 288:R394-400. 2005
    ..Our results suggest that hypoxia amplified the mitochondrial inhibition induced by NO generated during inflammatory disease states...
  15. ncbi request reprint Sir John Robert Vane: 29 March 1927 - 19 November 2004
    Salvador Moncada
    The Wolfson Institute for Biomedical Research, University College London
    Biogr Mem Fellows R Soc 52:401-11. 2006
    ..During his distinguish career he published more than 700 scientific papers and wrote or editing 20 books. His many awards include the Nobel Prize in Physiology or Medicine (1982) and a knighthood in 1984...
  16. doi request reprint Fulfilling the metabolic requirements for cell proliferation
    Salvador Moncada
    Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
    Biochem J 446:1-7. 2012
    ..These findings have implications for the understanding of cell proliferation in general and, in particular, of cancer, its prevention and treatment...
  17. ncbi request reprint Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo
    Ramona S Scotland
    Wolfson Institute for Biomedical Research, University College London, London, United Kingdom
    Circulation 111:796-803. 2005
    ....
  18. ncbi request reprint Obituary: John R. Vane (1927-2004)
    Salvador Moncada
    Salvador Moncada is at the Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK E mail
    Nature 433:28. 2005
  19. ncbi request reprint Two phases of nitrergic neuropathy in streptozotocin-induced diabetic rats
    Selim Cellek
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Diabetes 52:2353-62. 2003
    ..Neurodegeneration is due to apoptotic cell death in the ganglia, which is selective for the nitrergic neurones...
  20. pmc Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production
    Juan M Funes
    Cancer Research U K Viral Oncology Group, University College London, London WC 1E 6BT, UK
    Proc Natl Acad Sci U S A 104:6223-8. 2007
    ..We did find, however, a reversible increase in the transcription of glycolytic enzymes in tumors generated by transformed MSC, indicating this is a secondary phenomenon resulting from adaptation of the tumor to its microenvironment...
  21. ncbi request reprint Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation
    Marisol Quintero
    The Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, London WC1E 6BT, UK
    Cancer Res 66:770-4. 2006
    ..We suggest that, in certain forms of cancer, NO might be responsible for the accumulation of HIF-1alpha by a mechanism dependent on free radicals...
  22. ncbi request reprint Adventures in pharmacology, aspirin, prostacyclin and nitric oxide
    Salvador Moncada
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Acta Cardiol 59:47-50. 2004
  23. pmc Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival
    Juan M Funes
    UCL Cancer Institute, University College London, Paul O Gorman Building, Huntley Street, London WC1E 6BT, UK
    Mol Cancer 13:20. 2014
    ..However, activating mutations in the Nrf2 pathway have been found to promote tumorigenesis in certain models. Therefore, the role of Nrf2 in cancer remains contentious...
  24. ncbi request reprint Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response
    Weiming Xu
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK
    Nat Cell Biol 6:1129-34. 2004
    ..The NO-mediated ER stress response is diminished in rho(0) cells devoid of mitochondrial DNA, consistent with our evidence that NO-dependent mitochondrial disruption is coupled to the ER stress response...
  25. ncbi request reprint Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha
    Thilo Hagen
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Science 302:1975-8. 2003
    ..Thus, the signaling consequences of hypoxia may be profoundly modified by nitric oxide...
  26. ncbi request reprint Monitoring cytochrome redox changes in the mitochondria of intact cells using multi-wavelength visible light spectroscopy
    Veronica S Hollis
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London, WC1E 6AE, UK
    Biochim Biophys Acta 1607:191-202. 2003
    ..Here we describe this novel methodology and demonstrate its validity by monitoring the action of known respiratory chain inhibitors, including the endogenous signalling molecule NO, on cytochrome redox states in human leukocytes...
  27. ncbi request reprint Does nitric oxide modulate mitochondrial energy generation and apoptosis?
    Salvador Moncada
    The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Mol Cell Biol 3:214-20. 2002
    ....
  28. ncbi request reprint Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272
    Adrian J Hobbs
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London WC1E 6AE, UK
    Vascul Pharmacol 40:149-54. 2003
    ....
  29. ncbi request reprint Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide
    Ines Corraliza
    Wolfson Institute for Biomedical Research, University College London, London, UK
    J Rheumatol 29:2261-5. 2002
    ..To investigate the expression of arginase isoforms in patients with different forms of arthritis and the possible implications of the synthesis of nitric oxide (NO)...
  30. pmc TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents
    Alessandra Valerio
    Integrated Laboratories Network, Center for Study and Research on Obesity, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    J Clin Invest 116:2791-8. 2006
    ..Our findings demonstrate that TNF-alpha impairs mitochondrial biogenesis and function in different tissues of obese rodents by downregulating eNOS expression and suggest a novel pathophysiological process that sustains obesity...
  31. ncbi request reprint Discrepancies between nitroglycerin and NO-releasing drugs on mitochondrial oxygen consumption, vasoactivity, and the release of NO
    Cristina Nunez
    Departamento de Farmacologia, Facultad de Medicina, Universidad de Valencia, Blasco Ibañez, Valencia, Spain
    Circ Res 97:1063-9. 2005
    ....
  32. pmc Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation? In vivo and in vitro studies
    Nicholas J Edmunds
    Department of Physiology, The Medical School, The University of Birmingham, Vincent Drive, Birmingham B15 2TT, UK
    J Physiol 546:521-7. 2003
    ..We propose that in vivo, shear-released NO increases the apparent K(m) of endothelial cytochrome oxidase for O(2), allowing the endothelium to act as an O(2) sensor, releasing adenosine in response to moderate falls in O(2)...
  33. pmc Mitochondria as signaling organelles in the vascular endothelium
    Marisol Quintero
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London WC1E 6AE, U K
    Proc Natl Acad Sci U S A 103:5379-84. 2006
    ..Diversion of O(2) away from endothelial cell mitochondria by NO might also facilitate oxygenation of vascular smooth muscle cells...
  34. ncbi request reprint Nitric oxide and mitochondrial signaling: from physiology to pathophysiology
    Jorge D Erusalimsky
    Cardiff School of Health Sciences, University of Wales Institute Cardiff, Western Avenue, Cardiff, CF5 2YB, UK
    Arterioscler Thromb Vasc Biol 27:2524-31. 2007
    ..We also discuss instances in which the effects of NO on the electron transport chain might lead to mitochondrial dysfunction and pathology...
  35. ncbi request reprint Pioneers in cardiology: Salvador Moncada, MD, PhD, FRS
    Emma Baines
    Circulation 114:f185-6. 2006
  36. ncbi request reprint Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
    Enzo Nisoli
    Integrated Laboratories Network, Department of Preclinical Sciences, Luigi Sacco Hospital, Milan University, 20157 Milan, Italy
    Science 310:314-7. 2005
    ..These effects were strongly attenuated in eNOS null-mutant mice. Thus, nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals...
  37. pmc Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways
    Jesús Mateo
    Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, c Sinesio Delgado 4, 28029 Madrid, Spain
    Biochem J 376:537-44. 2003
    ..We suggest that, although stabilization of HIF-1alpha by high concentrations of NO might have implications in pathophysiological processes, the inhibitory effect of lower NO concentrations is likely to be of physiological relevance...
  38. ncbi request reprint Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression
    Linda Connelly
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 278:26480-7. 2003
    ....
  39. ncbi request reprint BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro
    Jas S Kalsi
    Wolfson Institute for Biomedical Research, University College London, United Kingdom
    J Urol 169:761-6. 2003
    ..We investigated the effect of BAY41-2272 on human and rabbit corpus cavernosum...
  40. ncbi request reprint NCX-4016, a nitric oxide-releasing aspirin, protects endothelial cells against apoptosis by modulating mitochondrial function
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, 06122 Perugia, Italy
    FASEB J 16:1645-7. 2002
    ..In contrast to DETA-NO, NCX-4016 did not increase mitochondrial oxidative stress. These data demonstrated that NCX-4016 conveys NO directly inside endothelial cells and modulates mitochondrial function...
  41. ncbi request reprint Mitochondrial biogenesis as a cellular signaling framework
    Enzo Nisoli
    Center for Study and Research on Obesity, Department of Preclinical Sciences, LITA Vialba, Luigi Sacco Hospital, University of Milan, Via G B Grassi 74, 20157, Milan, Italy
    Biochem Pharmacol 67:1-15. 2004
    ..Some of these are now being elucidated. Generation of nitric oxide (NO) appears to be a novel player in this scenario, possibly acting as a unifying molecular switch to trigger the whole mitochondriogenic process...
  42. pmc Inhibition of mitochondrial respiration by endogenous nitric oxide: a critical step in Fas signaling
    Belen Beltran
    Centro Nacional de Investigaciones Cardiovasculares, C Sinesio Delgado, 6 Pab 5 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 99:8892-7. 2002
    ..The significance of the two phases in relation to cell survival and death remains to be studied...
  43. ncbi request reprint Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway
    Angeles Almeida
    Unidad de Investigacion, Hospital Universitario de Salamanca, 37007 Salamanca, Spain
    Nat Cell Biol 6:45-51. 2004
    ..Thus the virtual absence of PFK2 in neurons may explain their extreme sensitivity to energy depletion and degeneration...
  44. ncbi request reprint Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
    Enzo Nisoli
    Department of Preclinical Sciences, Center for Study and Research on Obesity, Luigi Sacco Hospital, University of Milan, Milan 20157, Italy
    Science 299:896-9. 2003
    ..Thus, a nitric oxide-cGMP-dependent pathway controls mitochondrial biogenesis and body energy balance...
  45. pmc Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment
    Amrita Ahluwalia
    William Harvey Research Institute, Barts and The London, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Proc Natl Acad Sci U S A 101:1386-91. 2004
    ..These data demonstrate that sGC plays a key antiinflammatory role by inhibiting P-selectin expression and leukocyte recruitment...
  46. pmc Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase
    Miriam Palacios-Callender
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 101:7630-5. 2004
    ..This, in turn, favors the release of O(2)(-), which initiates the transcriptional activation of NF-kappa B as an early signaling stress response...
  47. pmc Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals
    Enzo Nisoli
    Department of Preclinical Sciences, Laboratorio Interdisciplinare Technologie Avanzate LITA Vialba, University of Milan, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 101:16507-12. 2004
    ..We conclude that NO/cGMP stimulates mitochondrial biogenesis, both in vitro and in vivo, and that this stimulation is associated with increased mitochondrial function, resulting in enhanced formation of ATP...
  48. ncbi request reprint Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death
    Palwinder Mander
    Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom
    J Neurosci Res 79:208-15. 2005
    ..Brain inflammation can thus sensitize to hypoxia-induced death, which may be important in pathologies such as stroke, neurodegeneration, and brain aging...
  49. ncbi request reprint Can endogenous gaseous messengers control mitochondrial biogenesis in mammalian cells?
    Enzo Nisoli
    Department of Preclinical Sciences, Center for Study and Research on Obesity, LITA Vialba, Luigi Sacco Hospital, University of Milan, Via G B Grassi 74, 20157 Milan, Italy
    Prostaglandins Other Lipid Mediat 73:9-27. 2004
    ..Some of these are now being elucidated. Generation of nitric oxide (NO) appears to be a novel player in this scenario, possibly acting as a unifying molecular switch to trigger the whole process of the mitochondrial biogenesis...
  50. ncbi request reprint Salvador Moncada
    Karen Birmingham
    Nat Med 8:98. 2002
  51. ncbi request reprint Nitric oxide from inducible nitric oxide synthase sensitizes the inflamed aorta to hypoxic damage via respiratory inhibition
    Vilmante Borutaite
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom
    Shock 23:319-23. 2005
    ..This NO-induced sensitization of aorta to mild hypoxia may be important in sepsis and other pathologies where iNOS is expressed...
  52. pmc From pollutant gas to biological messenger: the diverse actions of nitric oxide in cancer
    Peter A Brennan
    Maxillofacial Department, Poole Hospital, Dorset, UK
    Ann R Coll Surg Engl 84:75-8. 2002
    ..This review summarises the brief history of this molecule, gives an overview of its many effects in the common solid tumours and discusses how targeting of NO production may have possible future therapeutic benefit...
  53. ncbi request reprint Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3' kinase, and Akt
    Rico Barsacchi
    Vita Salute University DIBIT H San Raffaele Institute, Milan, Italy
    Mol Pharmacol 63:886-95. 2003
    ..The novel pathway of activation of eNOS described here may have broad biological relevance because neutral sphingomyelinase is activated not only by TNF-alpha but also by a variety of other physiological and pathological stimuli...
  54. doi request reprint The deleterious effect of high concentrations of D-glucose requires pro-inflammatory preconditioning
    Nuria Lafuente
    Departamento de Farmacologia y Terapeutica, Facultad de Medicina, Universidad Autonoma de Madrid, Spain
    J Hypertens 26:478-85. 2008
    ..The present study investigated whether high concentrations of D-glucose can trigger pro-inflammatory mechanisms in human aortic smooth muscle cells...
  55. pmc Characterization of the non-nitrergic NANC relaxation responses in the rabbit vaginal wall
    Tom Ziessen
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT
    Br J Pharmacol 135:546-54. 2002
    ..These results suggest that a neuronal factor elicits non-nitrergic NANC responses in the rabbit vaginal wall. The identity of this factor remains to be established...
  56. ncbi request reprint Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells
    Rowland W Rees
    Wolfson Institute for Biomedical Research, University College London, United Kingdom
    J Urol 170:2517-22. 2003
    ..Therefore, we investigated the effect of Y-27632 on prostatic smooth muscle proliferation and tone...
  57. ncbi request reprint Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome?
    Enzo Nisoli
    Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, Milan University, Milan, Italy
    Circ Res 100:795-806. 2007
    ..Here we summarize some recent findings and propose a hypothesis for the high cardiovascular risk linked to the metabolic syndrome...
  58. ncbi request reprint The contribution of Salvador Moncada to our understanding of the biology of nitric oxide
    Emilio Clementi
    Dept Pharmaco Biology, University of Calabria, 87036 Rende, E Medea Scientific Institute, 23842 Bosisio Parini, Italy
    IUBMB Life 55:563-5. 2003
    ..This review article will lead the reader through the landmark events in this adventure, highlighting the fundamental role played by Salvador Moncada and his team.
  59. pmc GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo
    Wendy K Alderton
    Respiratory and Inflammation Centre of Excellence for Drug Discovery, GlaxoSmithKline Research, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK
    Br J Pharmacol 145:301-12. 2005
    ....
  60. ncbi request reprint Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis
    Arnold G Herman
    Division of Pharmacology, University of Antwerpen, Campus Drie Eiken, Wilrijk, B 2610 Antwerpen, Belgium
    Eur Heart J 26:1945-55. 2005
    ....