S M Moghimi

Summary

Affiliation: University of Brighton
Country: UK

Publications

  1. ncbi request reprint Modulation of murine liver macrophage clearance of liposomes by diethylstilbestrol. The effect of vesicle surface charge and a role for the complement receptor Mac-1 (CD11b/CD18) of newly recruited macrophages in liposome recognition
    S M Moghimi
    Department of Biochemistry, Charing Cross Hospital, Fulham Palace Road, W6 8RF, London, UK
    J Control Release 78:55-65. 2002
  2. ncbi request reprint Causative factors behind poloxamer 188 (Pluronic F68, Flocor)-induced complement activation in human sera. A protective role against poloxamer-mediated complement activation by elevated serum lipoprotein levels
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewis Road, Brighton BN2 4GJ, UK
    Biochim Biophys Acta 1689:103-13. 2004
  3. ncbi request reprint The effect of methoxy-PEG chain length and molecular architecture on lymph node targeting of immuno-PEG liposomes
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton BN2 4GJ, UK
    Biomaterials 27:136-44. 2006
  4. ncbi request reprint A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton BN2 4GJ, UK
    Mol Ther 11:990-5. 2005
  5. ncbi request reprint Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Cockcroft Bldg, Lewes Rd, Brighton BN2 4GJ, UK
    FASEB J 20:2591-3. 2006
  6. ncbi request reprint Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, BN2 4GJ, Brighton, UK
    Prog Lipid Res 42:463-78. 2003
  7. ncbi request reprint Real-time evidence of surface modification at polystyrene lattices by poloxamine 908 in the presence of serum: in vivo conversion of macrophage-prone nanoparticles to stealth entities by poloxamine 908
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, BN2 4GJ, Brighton, UK
    FEBS Lett 547:177-82. 2003
  8. ncbi request reprint Modulation of lymphatic distribution of subcutaneously injected poloxamer 407-coated nanospheres: the effect of the ethylene oxide chain configuration
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
    FEBS Lett 540:241-4. 2003
  9. ncbi request reprint Liposome recognition by resident and newly recruited murine liver macrophages
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, BN2 4GJ, UK
    J Liposome Res 12:67-70. 2002
  10. ncbi request reprint Recent developments in polymeric nanoparticle engineering and their applications in experimental and clinical oncology
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
    Anticancer Agents Med Chem 6:553-561. 2006

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Modulation of murine liver macrophage clearance of liposomes by diethylstilbestrol. The effect of vesicle surface charge and a role for the complement receptor Mac-1 (CD11b/CD18) of newly recruited macrophages in liposome recognition
    S M Moghimi
    Department of Biochemistry, Charing Cross Hospital, Fulham Palace Road, W6 8RF, London, UK
    J Control Release 78:55-65. 2002
    ..DES appears to offer a new approach in dissecting the mechanisms of liposome-macrophage interaction...
  2. ncbi request reprint Causative factors behind poloxamer 188 (Pluronic F68, Flocor)-induced complement activation in human sera. A protective role against poloxamer-mediated complement activation by elevated serum lipoprotein levels
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Lewis Road, Brighton BN2 4GJ, UK
    Biochim Biophys Acta 1689:103-13. 2004
    ..Our findings could provide the basis of novel approaches to the prevention of poloxamer-mediated complement activation...
  3. ncbi request reprint The effect of methoxy-PEG chain length and molecular architecture on lymph node targeting of immuno-PEG liposomes
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton BN2 4GJ, UK
    Biomaterials 27:136-44. 2006
    ..These approaches have established important compositional and structural variables that control lymphatic targeting of immuno-PEG liposomes and their application in experimental medicine and biology is discussed...
  4. ncbi request reprint A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton BN2 4GJ, UK
    Mol Ther 11:990-5. 2005
    ..The reported observations have important implications for the design and execution of gene therapy protocols as well for controlling intracellular distribution of drugs with cationic-based polymer-delivery systems...
  5. ncbi request reprint Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Cockcroft Bldg, Lewes Rd, Brighton BN2 4GJ, UK
    FASEB J 20:2591-3. 2006
    ..Our findings provide a rational conceptual basis for development of safer vesicles for site-specific drug delivery and controlled release at pathological sites...
  6. ncbi request reprint Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, BN2 4GJ, Brighton, UK
    Prog Lipid Res 42:463-78. 2003
    ..For example, stimulated or newly recruited macrophages can recognize and rapidly internalize sterically protected nanoparticles by opsonic-independent mechanisms. These concepts are also examined...
  7. ncbi request reprint Real-time evidence of surface modification at polystyrene lattices by poloxamine 908 in the presence of serum: in vivo conversion of macrophage-prone nanoparticles to stealth entities by poloxamine 908
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, BN2 4GJ, Brighton, UK
    FEBS Lett 547:177-82. 2003
    ....
  8. ncbi request reprint Modulation of lymphatic distribution of subcutaneously injected poloxamer 407-coated nanospheres: the effect of the ethylene oxide chain configuration
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
    FEBS Lett 540:241-4. 2003
    ..These experiments provide a rational approach for the design and engineering of nano-vehicles for optimal lymphatic targeting and are discussed...
  9. ncbi request reprint Liposome recognition by resident and newly recruited murine liver macrophages
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, BN2 4GJ, UK
    J Liposome Res 12:67-70. 2002
    ..Within two weeks of hepatic residency complement receptors no longer participate in liposome recognition and uptake...
  10. ncbi request reprint Recent developments in polymeric nanoparticle engineering and their applications in experimental and clinical oncology
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
    Anticancer Agents Med Chem 6:553-561. 2006
    ....
  11. ncbi request reprint Enhanced lymph node retention of subcutaneously injected IgG1-PEG2000-liposomes through pentameric IgM antibody-mediated vesicular aggregation
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton BN2 4GJ, UK
    Biochim Biophys Acta 1778:51-5. 2008
    ..This lymph node targeting approach may be amenable for the design and surface engineering of any rapidly drained nanoparticulate system bearing peptides and proteins that can be aggregated with a desired monoclonal pentameric IgM...
  12. ncbi request reprint Activation of the human complement system by cholesterol-rich and PEGylated liposomes-modulation of cholesterol-rich liposome-mediated complement activation by elevated serum LDL and HDL levels
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology, School of Pharmacy, University of Brighton, Brighton, UK
    J Liposome Res 16:167-74. 2006
    ..The net anionic charge on the phosphate moiety of the phospholipid-mPEG conjugate seemed to play a critical role in activation of both the classical and alternative pathways of the complement system...
  13. ncbi request reprint Re-establishing the long circulatory behaviour of poloxamine-coated particles after repeated intravenous administration: applications in cancer drug delivery and imaging
    S M Moghimi
    Department of Pharmaceutical Sciences, University of Nottingham, UK
    Biochim Biophys Acta 1472:399-403. 1999
    ..These observations are of interest in experimental drug delivery, particularly in experimental cancer therapy (diagnostic imaging and drug delivery), involving multiple injections of poloxamine-based long circulating nanosized vehicles...
  14. ncbi request reprint Poloxamers and poloxamines in nanoparticle engineering and experimental medicine
    S M Moghimi
    The Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, Cockcroft Building, University of Brighton, BN2 4GJ, Brighton, UK
    Trends Biotechnol 18:412-20. 2000
    ..Although this is a progressive, rapidly advancing field in biotechnology, the future will depend on the recognition and rectification of a range of toxicity issues, which have to be addressed but have frequently been ignored until now...
  15. ncbi request reprint Recognition by macrophages and liver cells of opsonized phospholipid vesicles and phospholipid headgroups
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, UK
    Pharm Res 18:1-8. 2001
    ..g., classes A, B, and D), Fc-gammaRI and FcgammaRII-B2 may participate in phospholipid recognition. These concepts are also discussed...
  16. ncbi request reprint Long-circulating and target-specific nanoparticles: theory to practice
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, United Kingdom
    Pharmacol Rev 53:283-318. 2001
    ..With regard to the targeting issues, attention is particularly focused on the importance of physiological barriers and disease states...
  17. ncbi request reprint Chemical camouflage of nanospheres with a poorly reactive surface: towards development of stealth and target-specific nanocarriers
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
    Biochim Biophys Acta 1590:131-9. 2002
    ..Despite their stealth property to hepatic Kupffer cell recognition, these nanospheres were cleared by the splenic red pulp macrophages...
  18. ncbi request reprint Concentration dependent structural ordering of poloxamine 908 on polystyrene nanoparticles and their modulatory role on complement consumption
    O Al-Hanbali
    The Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton BN2 4GJ, UK
    J Nanosci Nanotechnol 6:3126-33. 2006
    ..This relationship between surface characteristics of poloxamine nanoparticles and their in vivo performance is discussed...
  19. ncbi request reprint Capture of stealth nanoparticles by the body's defences
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, UK
    Crit Rev Ther Drug Carrier Syst 18:527-50. 2001
    ..A critical discussion of the future of this interesting area of nano-biotechnology/engineering is also provided...
  20. ncbi request reprint PEGylation of microspheres generates a heterogeneous population of particles with differential surface characteristics and biological performance
    J K Gbadamosi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, BN2 4GJ, Brighton, UK
    FEBS Lett 532:338-44. 2002
    ..These observations may also be relevant with respect to successful surface camouflaging of cells, drug depots and implantable devices...
  21. doi request reprint Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process
    I Hamad
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
    Mol Immunol 46:225-32. 2008
    ....
  22. ncbi request reprint Current progress and future prospects of liposomes in dermal drug delivery
    S M Moghimi
    Department of Biochemistry, Charing Cross Hospital Medical School, London, UK
    J Microencapsul 10:155-62. 1993
    ..This review emphasizes the evaluation of topically applied liposomal formulation both at experimental and clinical levels. Mechanism(s) by which liposomes facilitate deposition of drugs in various layers of the skin is also discussed...
  23. ncbi request reprint Particulate nanomedicines
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton BN2 4GJ, UK
    Adv Drug Deliv Rev 58:1451-5. 2006
  24. doi request reprint Critical issues in site-specific targeting of solid tumours: the carrier, the tumour barriers and the bioavailable drug
    Islam Hamad
    University of Brighton, Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, Brighton BN2 4GJ, UK
    Expert Opin Drug Deliv 5:205-19. 2008
    ....
  25. ncbi request reprint Therapeutic synthetic polymers: a game of Russian roulette?
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, BN2 4GJ UK
    Drug Discov Today 7:998-1001. 2002
    ..Acceptance of the importance of immunotoxicological factors in response to the presence of these macromolecules must be addressed if emergent technologies, such as polymer-based gene-delivery systems, are going to succeed...
  26. ncbi request reprint Synthetic polymers in 21st century therapeutics: the way forward
    A Christy Hunter
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, UK
    Drug Discov Today 8:154-6. 2003
  27. ncbi request reprint Nanomedicine: current status and future prospects
    S Moein Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK
    FASEB J 19:311-30. 2005
    ..Potential pitfalls or side effects associated with nanoparticles are also discussed...
  28. ncbi request reprint Low and high molecular weight poly(L-lysine)s/poly(L-lysine)-DNA complexes initiate mitochondrial-mediated apoptosis differently
    Peter Symonds
    Cancer Research UK, Tumour Cytokine Biology Group, University Hospital, Nottingham NG7 2UH, UK
    FEBS Lett 579:6191-8. 2005
    ..The importance of our data in relation to design of novel and safer cationic non-viral vectors for human gene therapy is discussed...
  29. ncbi request reprint Lipid-based nanosystems and complexes in experimental and clinical therapeutics
    S Moein Moghimi
    Curr Drug Deliv 2:295. 2005
  30. ncbi request reprint Modification of the Stewart biphasic colorimetric assay for stable and accurate quantitative determination of Pluronic and Tetronic block copolymers for application in biological systems
    Othman Al-Hanbali
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, East Sussex BN2 4GJ, UK
    Anal Biochem 361:287-93. 2007
    ..In such systems the colorimetric assay directly determines the fraction of unbound (free) copolymer in the presence of proteins...