Ashley Moffett

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Natural killer cells and pregnancy
    Ashley Moffett-King
    Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
    Nat Rev Immunol 2:656-63. 2002
  2. pmc Genome-wide expression profile of first trimester villous and extravillous human trophoblast cells
    R Apps
    Department of Pathology and Centre for Trophoblast Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Placenta 32:33-43. 2011
  3. pmc Evidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors
    Boris Novakovic
    Cancer, Disease and Developmental Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital and Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia
    BMC Genomics 12:529. 2011
  4. ncbi How Does the maternal immune system contribute to the development of pre-eclampsia?
    A Moffett
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Placenta 28:S51-6. 2007
  5. ncbi Implantation, embryo-maternal interactions, immunology and modulation of the uterine environment -- a workshop report
    A Moffett
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
    Placenta 27:S54-5. 2006
  6. pmc Natural killer cells, miscarriage, and infertility
    Ashley Moffett
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP
    BMJ 329:1283-5. 2004
  7. ncbi Expression and functions of human endogenous retroviruses in the placenta: an update
    A Muir
    Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Placenta 25:S16-25. 2004
  8. ncbi The immunological paradox of pregnancy: a reappraisal
    A Moffett
    Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Placenta 25:1-8. 2004
  9. ncbi Charlie Loke: contributions from Tennis Court Road--past, present and future
    Ashley Moffett
    Department of Pathology, University of Cambridge, Tennis Court Road, UK
    Placenta 24:S4-9. 2003
  10. ncbi Immunology of placentation in eutherian mammals
    Ashley Moffett
    King s College, Cambridge CB2 1ST, UK
    Nat Rev Immunol 6:584-94. 2006

Research Grants

  1. BIOLOGY OF HUMAN UTERINE NK CELLS
    Ashley Moffett; Fiscal Year: 2004

Collaborators

Detail Information

Publications32

  1. ncbi Natural killer cells and pregnancy
    Ashley Moffett-King
    Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
    Nat Rev Immunol 2:656-63. 2002
    ....
  2. pmc Genome-wide expression profile of first trimester villous and extravillous human trophoblast cells
    R Apps
    Department of Pathology and Centre for Trophoblast Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Placenta 32:33-43. 2011
    ..Since LAIR-2 is detectable in the urine of pregnant, but not non-pregnant women, trophoblast-derived LAIR-2 may also have systemic effects during pregnancy...
  3. pmc Evidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors
    Boris Novakovic
    Cancer, Disease and Developmental Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital and Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia
    BMC Genomics 12:529. 2011
    ..However, the factors contributing to this variation in gene expression remain poorly understood...
  4. ncbi How Does the maternal immune system contribute to the development of pre-eclampsia?
    A Moffett
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Placenta 28:S51-6. 2007
    ..The academic excitement of this work is the realisation that this is a novel form of allorecognition based on NK cells that operates entirely differently from self/non-self discrimination used by T cells...
  5. ncbi Implantation, embryo-maternal interactions, immunology and modulation of the uterine environment -- a workshop report
    A Moffett
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
    Placenta 27:S54-5. 2006
    ..4) New data were presented on the intriguing molecule, HLA-G, whose function is still unclear. 5) A discussion was initiated to debate the role of the innate and the adaptive immune systems in human implantation...
  6. pmc Natural killer cells, miscarriage, and infertility
    Ashley Moffett
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP
    BMJ 329:1283-5. 2004
  7. ncbi Expression and functions of human endogenous retroviruses in the placenta: an update
    A Muir
    Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Placenta 25:S16-25. 2004
    ..This review discusses our current knowledge of the placental expression of HERVs, in particular the envelope proteins of ERV3 and HERV-W which may have critical roles in placental function...
  8. ncbi The immunological paradox of pregnancy: a reappraisal
    A Moffett
    Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Placenta 25:1-8. 2004
    ..Future identification of trophoblast ligands and their respective receptors on uterine Natural Killer cells and other leukocytes is likely to offer the best insight as to how this symbiotic state is achieved...
  9. ncbi Charlie Loke: contributions from Tennis Court Road--past, present and future
    Ashley Moffett
    Department of Pathology, University of Cambridge, Tennis Court Road, UK
    Placenta 24:S4-9. 2003
  10. ncbi Immunology of placentation in eutherian mammals
    Ashley Moffett
    King s College, Cambridge CB2 1ST, UK
    Nat Rev Immunol 6:584-94. 2006
    ..At the implantation site, cells from the mother and the fetus intermingle during pregnancy. Unravelling what happens here is crucial to our understanding of why some human pregnancies are successful whereas others are not...
  11. pmc Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge, UK
    J Clin Invest 120:4102-10. 2010
    ..These findings highlight the complexity and central importance of specific combinations of activating KIR and HLA-C in maternal-fetal immune interactions that determine reproductive success...
  12. pmc Natural-killer cell ligands at the maternal-fetal interface: UL-16 binding proteins, MHC class-I chain related molecules, HLA-F and CD48
    Richard Apps
    Department of Pathology, University of Cambridge, Cambridge, UK
    Hum Reprod 23:2535-48. 2008
    ..Interactions between EVT cells and local decidual leukocytes are likely to contribute to immunological accommodation of the semi-allogeneic fetus...
  13. doi Natural killer cells in human pregnancy
    Victoria Male
    Department of Pathology, University of Cambridge, Cambridge, UK
    Methods Mol Biol 612:447-63. 2010
    ..Here, we describe methods for the isolation and culture of decidual NK cells, decidual stromal cells and trophoblast cells from human first trimester tissue samples...
  14. pmc Ex vivo functional responses to HLA-G differ between blood and decidual NK cells
    Richard Apps
    Department of Pathology and Center for Trophoblast Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Mol Hum Reprod 17:577-86. 2011
    ..These findings should be considered when inferring the activity of tissue NK cells from results obtained with cell lines, peripheral NK or cultured dNK cells...
  15. pmc A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1
    Richard Apps
    Department of Pathology, Cambridge University, Cambridge, UK
    Eur J Immunol 37:1924-37. 2007
    ..See accompanying commentary: (http://dx.doi.org/10.1002/eji.200737515)...
  16. pmc The effect of pregnancy on the uterine NK cell KIR repertoire
    Victoria Male
    Department of Pathology and Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Eur J Immunol 41:3017-27. 2011
    ....
  17. pmc Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies
    Richard Apps
    Department of Pathology, University of Cambridge, Cambridge, UK
    Immunology 127:26-39. 2009
    ....
  18. pmc Conformation of human leucocyte antigen-C molecules at the surface of human trophoblast cells
    Richard Apps
    Department of Pathology, Tennis Court Road, Cambridge, UK
    Immunology 124:322-8. 2008
    ..These findings have implications regarding the stability of trophoblast HLA-C molecules and how they interact with receptors on decidual leucocytes during placentation...
  19. ncbi Killer Ig-like receptor expression in uterine NK cells is biased toward recognition of HLA-C and alters with gestational age
    Andrew M Sharkey
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 181:39-46. 2008
    ....
  20. ncbi Nature of allelic sequence polymorphism at the KIR3DL3 locus
    Des C Jones
    Division of Immunology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    Immunogenetics 58:614-27. 2006
    ..Investigation of KIR3DL3 dN/dS ratios indicated a greater level of synonymous mutations consistent with purifying selection, although positive selection was detected acting on two sites within the stem region...
  21. doi Isolation of cells from the feto-maternal interface
    Victoria Male
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    Curr Protoc Immunol . 2012
    ..Here, we describe protocols for the isolation of leukocytes, stromal cells, and trophoblast cells from the feto-maternal interface...
  22. pmc Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations
    Susan E Hiby
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB21QP, UK
    Immunogenetics 62:65-73. 2010
    ....
  23. pmc Immature NK cells, capable of producing IL-22, are present in human uterine mucosa
    Victoria Male
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 185:3913-8. 2010
    ..IL-22 producers in this population might have a physiological role in this specialist mucosa dedicated to reproduction...
  24. doi A critical look at HLA-G
    Richard Apps
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
    Trends Immunol 29:313-21. 2008
    ..These findings suggest how a fetal molecule might influence the local maternal immune response...
  25. doi Maternal KIR and fetal HLA-C: a fine balance
    Olympe Chazara
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Leukoc Biol 90:703-16. 2011
    ..We discuss here the studies relating to KIR/HLA-C interactions with an emphasis on how these function during pregnancy to regulate placentation...
  26. ncbi Methods for isolation of cells from the human fetal-maternal interface
    Anita Trundley
    Department of Pathology, University of Cambridge, United Kingdom
    Methods Mol Med 122:109-22. 2006
    ....
  27. ncbi Molecular characterization of KIR3DL3
    Anita E Trundley
    Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK
    Immunogenetics 57:904-16. 2006
    ..We conclude that the KIR3DL3 gene is not a pseudogene but encodes a protein that is not expressed in healthy individuals. Protein expression might be induced under certain developmental or pathological situations...
  28. doi NK receptor interactions with MHC class I molecules in pregnancy
    John Trowsdale
    Immunology Division, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Semin Immunol 20:317-20. 2008
    ..The drive for novelty in HLA-C and KIR2D allelic diversity may relate not only to survival from infections but also to reproductive success...
  29. pmc BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages
    Andreia S Bernardo
    The Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, Cambridge CB2 0SZ, UK
    Cell Stem Cell 9:144-55. 2011
    ..We conclude that BMP induces human and mouse pluripotent stem cells primarily to form mesoderm, rather than trophoblast, acting through BRA and CDX2...
  30. ncbi Natural killer cells and reproduction
    Ashley Moffett-King
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Trends Immunol 23:332-3. 2002
  31. pmc Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success
    Susan E Hiby
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, England, UK
    J Exp Med 200:957-65. 2004
    ..In light of our findings, reproductive success may have been a factor in the evolution and maintenance of human HLA-C and KIR polymorphisms...
  32. ncbi The incidence of pre-eclampsia among couples consisting of Japanese women and Caucasian men'
    Ashley Moffett
    J Reprod Immunol 71:132-3; author reply 134. 2006

Research Grants3

  1. BIOLOGY OF HUMAN UTERINE NK CELLS
    Ashley Moffett; Fiscal Year: 2004
    ..It could lead to novel therapeutic approaches in a wide range of disorders including infertility, miscarriage, disorders due to defective placentation (pre-eclampsia and IUGR) and menstrual disorders. ..