Ashley Moffett-King

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Surface expression of HLA-C antigen by human extravillous trophoblast
    A King
    Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    Placenta 21:376-87. 2000
  2. ncbi Recognition of trophoblast HLA class I molecules by decidual NK cell receptors--a review
    A King
    Department of Pathology, University of Cambridge, UK
    Placenta 21:S81-5. 2000
  3. ncbi HLA-E is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells
    A King
    Department of Pathology, University of Cambridge
    Eur J Immunol 30:1623-31. 2000
  4. ncbi Natural killer cells and reproduction
    Ashley Moffett-King
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Trends Immunol 23:332-3. 2002
  5. ncbi Uterine NK cells and trophoblast HLA class I molecules
    A King
    Department of Pathology, University of Cambridge, United Kingdom
    Am J Reprod Immunol 37:459-62. 1997
  6. ncbi Expression of c-kit and kit ligand at the human maternofetal interface
    A M Sharkey
    Department of Obstetrics and Gynaecology, University of Cambridge, Rosie Maternity Hospital, UK
    Cytokine 6:195-205. 1994
  7. ncbi Natural killer cells and pregnancy
    Ashley Moffett-King
    Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
    Nat Rev Immunol 2:656-63. 2002
  8. ncbi Uterine leukocytes and decidualization
    A King
    Department of Pathology, University of Cambridge, UK
    Hum Reprod Update 6:28-36. 2000
  9. ncbi The influence of the maternal uterine immune response on placentation in human subjects
    A King
    Department of Pathology, University of Cambridge, UK
    Proc Nutr Soc 58:69-73. 1999
  10. ncbi Human uterine lymphocytes
    A King
    Department of Pathology, University of Cambridge, UK
    Hum Reprod Update 4:480-5. 1998

Collaborators

Detail Information

Publications21

  1. ncbi Surface expression of HLA-C antigen by human extravillous trophoblast
    A King
    Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
    Placenta 21:376-87. 2000
    ..Our results demonstrate that extravillous trophoblast expresses at least two HLA class I molecules, HLA-G and HLA-C on the cell surface...
  2. ncbi Recognition of trophoblast HLA class I molecules by decidual NK cell receptors--a review
    A King
    Department of Pathology, University of Cambridge, UK
    Placenta 21:S81-5. 2000
    ..One possible result is in an altered NK cell cytokine profile which modulates the invasive proclivity of the EVT. In this way placentation could be controlled...
  3. ncbi HLA-E is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells
    A King
    Department of Pathology, University of Cambridge
    Eur J Immunol 30:1623-31. 2000
    ....
  4. ncbi Natural killer cells and reproduction
    Ashley Moffett-King
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Trends Immunol 23:332-3. 2002
  5. ncbi Uterine NK cells and trophoblast HLA class I molecules
    A King
    Department of Pathology, University of Cambridge, United Kingdom
    Am J Reprod Immunol 37:459-62. 1997
    ..To investigate the proposal that NK cells in decidua may control trophoblast migration during implantation of the human placenta...
  6. ncbi Expression of c-kit and kit ligand at the human maternofetal interface
    A M Sharkey
    Department of Obstetrics and Gynaecology, University of Cambridge, Rosie Maternity Hospital, UK
    Cytokine 6:195-205. 1994
    ....
  7. ncbi Natural killer cells and pregnancy
    Ashley Moffett-King
    Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
    Nat Rev Immunol 2:656-63. 2002
    ....
  8. ncbi Uterine leukocytes and decidualization
    A King
    Department of Pathology, University of Cambridge, UK
    Hum Reprod Update 6:28-36. 2000
    ..In this review, the possibility that uterine leukocytes might influence the critical decision that the mid- to late secretory endometrium must make either to decidualize or to undergo menstruation is explored...
  9. ncbi The influence of the maternal uterine immune response on placentation in human subjects
    A King
    Department of Pathology, University of Cambridge, UK
    Proc Nutr Soc 58:69-73. 1999
    ....
  10. ncbi Human uterine lymphocytes
    A King
    Department of Pathology, University of Cambridge, UK
    Hum Reprod Update 4:480-5. 1998
    ..The findings indicate that decidual NK cells do have receptors for trophoblast HLA class I molecules. Experiments are underway to determine the effects of this interaction on NK cell function...
  11. ncbi Localization of leukemia inhibitory factor and its receptor in human placenta throughout pregnancy
    A M Sharkey
    Reproductive Molecular Research Group, Department of Obstetrics and Gynaecology, University of Cambridge, Rosie Maternity Hospital, Cambridge CB2 2SW, United Kingdom
    Biol Reprod 60:355-64. 1999
    ..LIF may also play a critical role in controlling angiogenesis in the placental villi, since human fetal endothelial cells express LIF-R, and mice lacking a functional LIF receptor gene show altered vascular development in the placenta...
  12. ncbi Regions of human chromosome 2 (2q32-q35) and mouse chromosome 1 show synteny with the pufferfish genome (Fugu rubripes)
    J P Schofield
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Genomics 45:158-67. 1997
    ..However, there was a match with the rat myosin light chain 2 (MLC-2) gene promoter and a MyoD transcription factor-binding site 874 bp upstream of the MYL-1 gene...
  13. ncbi Evaluation of trophoblast HLA-G antigen with a specific monoclonal antibody
    Y W Loke
    Research Group in Reproductive Immunobiology, University of Cambridge, United Kingdom
    Tissue Antigens 50:135-46. 1997
    ..This monoclonal antibody G233 will be highly useful in future experiments to elucidate the function of HLA-G...
  14. ncbi Human uterine natural killer cells
    A King
    Department of Pathology, University of Cambridge, UK
    Nat Immun 15:41-52. 1996
    ..Thus, the maternal-fetal interaction, and hence reproductive success, may depend on an NK allorecognition system...
  15. ncbi Molecular studies of trophoblast HLA-G: polymorphism, isoforms, imprinting and expression in preimplantation embryo
    S E Hiby
    Department of Pathology, University of Cambridge, United Kingdom
    Tissue Antigens 53:1-13. 1999
    ..There was no evidence of imprinting. In addition we did not find mRNA for HLA-G in human two to eight-cell embryos or in blastocyst or in sperm samples...
  16. ncbi Human uterine NK cells have a similar repertoire of killer inhibitory and activatory receptors to those found in blood, as demonstrated by RT-PCR and sequencing
    S E Hiby
    Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, U K
    Mol Immunol 34:419-30. 1997
    ..Fetal trophoblast cells infiltrating the decidua express HLA-G and HLA-C gene products. This suggests that maternal recognition of the fetus may be mediated by an NK allorecognition system...
  17. ncbi Expression of adhesion molecules by endovascular trophoblast and decidual endothelial cells: implications for vascular invasion during implantation
    T D Burrows
    Department of Pathology, University of Cambridge, UK
    Placenta 15:21-33. 1994
    ..Our data suggests that vascular invasion by trophoblast is regulated by the expression of appropriate adhesion molecules which permit interaction between endovascular trophoblast and decidual endothelial cells...
  18. ncbi In situ hybridization and northern blot demonstration of HLA-G mRNA in human trophoblast populations by locus-specific oligonucleotide
    G Chumbley
    Research Group in Human Reproductive Immunobiology, University of Cambridge, England
    Hum Immunol 37:17-22. 1993
    ..In addition, villous cytotrophoblast and villous mesenchymal cells also contained HLA-G transcripts, but villous syncytiotrophoblast was always negative...
  19. ncbi Paternal monoallelic expression of PEG3 in the human placenta
    S E Hiby
    Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
    Hum Mol Genet 10:1093-100. 2001
    ..By utilizing a polymorphism detected in exon 9, we have established that only the paternal allele is expressed in human placenta. Human PEG3 is therefore maternally imprinted as in mouse...
  20. ncbi Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties
    C Chang
    Division of Immunology, Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, United Kingdom
    J Immunol 163:4651-4. 1999
    ..In addition, we identify KAP10 as being able to bind the adapter protein Grb2. Based on our data, we suggest that this molecule is involved in stimulation and costimulation in cells of both myeloid and lymphoid origin...
  21. ncbi Steroid receptor expression in uterine natural killer cells
    Teresa A Henderson
    Obstetrics and Gynaecology Section, Department of Reproductive and Developmental Sciences, Centre for Reproductive Biology, Edinburgh, EH16 4SB, United Kingdom
    J Clin Endocrinol Metab 88:440-9. 2003
    ..These results raise the possibility that estrogens and glucocorticoids could be acting directly on uNK cells through ER beta and GR, respectively, to influence gene transcription in the endometrium and decidua...