Affiliation: University College London
- Science and society: genetic counselling and customary consanguineous marriageBernadette Modell
Royal Free and University College Medical School, Highgate Hill, London N19 5LW, UK
Nat Rev Genet 3:225-9. 2002....
- Global epidemiology of haemoglobin disorders and derived service indicatorsBernadette Modell
WHO Collaborating Centre for Community Control of Hereditary Disorders, UCL Centre for Health Informatics and Multiprofessional Education CHIME, Archway Campus, Highgate Hill, London N195LW, England
Bull World Health Organ 86:480-7. 2008..Carriers and at-risk couples should be informed of their risk and the options for reducing it. Screening for haemoglobin disorders should form part of basic health services in most countries...
- A national register for surveillance of inherited disorders: beta thalassaemia in the United KingdomB Modell
Royal Free and University College Medical School, University College London, Department of Primary Care and Population Sciences, England
Bull World Health Organ 79:1006-13. 2001..To demonstrate the value of a national register for surveillance of services for an inherited disorder...
- Epidemiology of haemoglobin disorders in Europe: an overviewB Modell
UCL Centre for Health Informatics and Multiprofessional Education CHIME, London, UK, and Department of Haematology, Herlev Hospital, University of Copenhagen, Denmark
Scand J Clin Lab Invest 67:39-69. 2007..This article presents an overview of the changing picture and a method for assessing service needs...
- Improved survival of thalassaemia major in the UK and relation to T2* cardiovascular magnetic resonanceBernadette Modell
UCL Centre for Health Informatics and Multiprofessional Education, Holborn Union Building, Whittington Campus, Highgate Hill, London, N19 5LW, UK
J Cardiovasc Magn Reson 10:42. 2008..A study of survival and causes of death was undertaken which aimed to include the possible impact of T2* cardiovascular magnetic resonance (CMR)...
- Delivering genetic screening to the communityB Modell
Department of Primary Care and Population Sciences, University College London, Royal Free Hospital Schools of Medicine, UK
Ann Med 29:591-9. 1997..Here I propose that modern information technology has a central role in providing communities with adequate access to correct genetic information...
- A multidisciplinary approach for improving services in primary care: randomised controlled trial of screening for haemoglobin disordersM Modell
Royal Free and University College Medical School, Whittington Hospital, London N19 5NF
BMJ 317:788-91. 1998....
- Microcytosis, iron deficiency and thalassaemia in a multi-ethnic community: a pilot studyB Wonke
Haematology Department, Whittington Hospital, and Royal Free and University College Medical School Department of Primary Care and Population Sciences, Highgate Hill, London, UK
Scand J Clin Lab Invest 67:87-95. 2007....
- Quality of life in thalassemiaP Telfer
Department of Haematology, St Bartholomew s Hospital, London, UK
Ann N Y Acad Sci 1054:273-82. 2005..Practical measures could be taken to address these issues...
- GPs' opinions of their role in prenatal genetic services: a cross-sectional surveyNadeem Qureshi
Royal Free and University College Medical School RF and UCMS Department of Primary Care and Population Sciences, Holborn Union Building, Whittington Campus, Highgate Hill, London N19 5LW, UK
Fam Pract 23:106-10. 2006..Couples who both carry the same recessive disorder have a 1 in 4 risk of an affected child in every pregnancy...
- Screening extended families for genetic hemoglobin disorders in PakistanSuhaib Ahmed
Armed Forces Institute of Pathology, Rawalpindi, Pakistan
N Engl J Med 347:1162-8. 2002..In such communities, gene variants are trapped within extended families, so that an affected child is a marker of a group at high genetic risk...
- Transfusion-dependent thalassaemia: a new eraVasili Berdoukas
Med J Aust 188:68-9. 2008
- Fourteen-year experience of prenatal diagnosis of thalassemia in IranHossein Najmabadi
Kariminejad Najmabadi Pathology and Genetics Center, Tehran, Iran
Community Genet 9:93-7. 2006..The success of this system in Iran, a multiethnic and Islamic-based country, would mean that it might be applied as an adaptive system for neighboring and other Islamic countries...
- The Olivieri caseGeorge Constantinou
N Engl J Med 348:860-3; author reply 860-3. 2003
- Iranian national thalassaemia screening programmeAshraf Samavat
Genetics Office, Disease Management Centre, Ministry of Health and Medical Education, Tehran, Iran
BMJ 329:1134-7. 2004
- Recommendations for introducing genetics services in developing countriesAla Alwan
World Health Organization, PO Box 811547, Amman 11181, Jordan
Nat Rev Genet 4:61-8. 2003..DNA diagnosis is relatively inexpensive, helps to develop skills in molecular biology and provides a basis for developing national expertise in genomics...
- Medical genetics in developing countriesArnold Christianson
Division of Human Genetics, National Health Laboratory Service and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa
Annu Rev Genomics Hum Genet 5:219-65. 2004..We present a new pragmatic approach for the care and prevention of congenital disorders in these countries, pioneered initially by the World Health Organization...
- Informing carriers of beta-thalassemia: giving the good newsMaria Karetti
George Marsh Sickle Cell and Thalassaemia Centre, St Anne s Hospital, London NW3, UK
Genet Test 8:109-13. 2004..This information has now been incorporated into the comprehensive information system for hemoglobin disorders available at http://www.chime.ucl.ac.uk/ApoGI/...
- A different molecular pattern of beta-thalassemia mutations in northeast BrazilAderson S Araújo
Hospital de Hematologia da Fundação Hemope, Recife, Brazil
Hemoglobin 27:211-7. 2003..2%, codon 39 (C --> T) 3.5%, and codon 30 (AGG --> AGC) 1.1%. These data show different patterns of beta-thal mutations in two regions of Brazil, demonstrating a thus far unrevealed heterogeneity of the disease in the country...
- Timeline: Raising the profile of genetics in primary careNadeem Qureshi
Division of Primary Care, School of Community Health Sciences, Medical School, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, United Kingdom
Nat Rev Genet 5:783-90. 2004....