Research Topics
| Amanda MocroftSummaryAffiliation: University College London Country: UK Publications
| Collaborators
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Detail Information
Publications
Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patientsAmanda Mocroft
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, Division of Population Health, University College London Medical School, Royal Free Campus, London, UK
AIDS 24:1667-78. 2010..Chronic kidney disease (CKD) in HIV-positive persons might be caused by both HIV and traditional or non-HIV-related factors. Our objective was to investigate long-term exposure to specific antiretroviral drugs and CKD...- The clinical benefits of antiretroviral therapy in severely immunocompromised HIV-1-infected patients with and without complete viral suppressionAmanda Mocroft
Research Department of Infection and Population Health, University College London, London, UK
Antivir Ther 17:1291-300. 2012..The aim of this study was to determine whether there is a protective effect of combination antiretroviral therapy (cART) on the development of clinical events in patients with ongoing severe immunosuppression... - Haemoglobin and anaemia in the SMART studyAmanda Mocroft
University College Medical School, London, UK
Antivir Ther 16:329-37. 2011..Data from randomized trials on the development of anaemia after interruption of therapy are not well-described... - Serious fatal and nonfatal non-AIDS-defining illnesses in EuropeAmanda Mocroft
Research Department of Infection and Population Health, University College Medical School, London, UK
J Acquir Immune Defic Syndr 55:262-70. 2010..Little is known about the incidence and risk factors for serious non-AIDS-defining events... - Estimated average annual rate of change of CD4(+) T-cell counts in patients on combination antiretroviral therapyAmanda Mocroft
Research Department of Infection and Population Health, University College London Medical School, London, UK
Antivir Ther 15:563-70. 2010..Patients receiving combination antiretroviral therapy (cART) might continue treatment with a virologically failing regimen. We sought to identify annual change in CD4(+) T-cell count according to levels of viraemia in patients on cART... - Detection of HIV drug resistance during antiretroviral treatment and clinical progression in a large European cohort studyAlessandro Cozzi-Lepri
Research Department of Infection and Population Health, Royal Free and University College Medical School, London, UK
AIDS 22:2187-98. 2008..To investigate the relationship between detection of HIV drug resistance by 2 years from starting antiretroviral therapy and the subsequent risk of progression to AIDS and death... 
Incidence of abacavir hypersensitivity reactions in euroSIDAWendy P Bannister
Royal Free and University College Medical School, London, UK
Antivir Ther 13:687-96. 2008..The aim of the study was to investigate the incidence of abacavir-related hypersensitivity reaction (HSR) and associated deaths in EuroSIDA HIV-1-infected patients...- Comparison of genotypic resistance profiles and virological response between patients starting nevirapine and efavirenz in EuroSIDAWendy P Bannister
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
AIDS 22:367-76. 2008..To compare virological outcome and genotypic resistance profiles in HIV-1-infected patients starting non-nucleoside reverse transcriptase inhibitor (NNRTI)-containing regimens... - Short-term clinical disease progression in HIV-1-positive patients taking combination antiretroviral therapy: the EuroSIDA risk-scoreAmanda Mocroft
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
AIDS 21:1867-75. 2007..To derive and validate a clinically applicable prognostic score for predicting short-term disease progression in HIV-infected patients taking combination antiretroviral therapy (cART)... - Chronic renal failure among HIV-1-infected patientsAmanda Mocroft
Royal Free Centre for HIV Medicine, and Department of Primary Care and Population Sciences, Royal Free and University College Medical Schools, Royal Free Campus, Rowland Hill Street, London, UK
AIDS 21:1119-27. 2007..The role of exposure to antiretrovirals in chronic renal failure (CRF) is not well understood. Glomerular filtration rates (GFR) are estimated using the Cockcroft-Gault (CG) or Modification of Diet in Renal Disease (MDRD) equations... - Relationship between antiretrovirals used as part of a cART regimen and CD4 cell count increases in patients with suppressed viremiaAmanda Mocroft
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
AIDS 20:1141-50. 2006..It is unknown if the CD4 cell count response differs according to antiretroviral drugs used in combination antiretroviral therapy (cART) in patients with maximal virological suppression [viral load (VL) < 50 copies/ml]... - Risk of discontinuation of nevirapine due to toxicities in antiretroviral-naive and -experienced HIV-infected patients with high and low CD4+ T-cell countsAmanda Mocroft
Royal Free and University College Medical School, London, UK
Antivir Ther 12:325-33. 2007.... - Virological rebound after suppression on highly active antiretroviral therapyAmanda Mocroft
Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
AIDS 17:1741-51. 2003..Treatment-naive patients were at a lower risk of rebound, but among drug-experienced patients, those who added new nucleosides had a lower risk of rebound, as were patients with a good immunological response... - HIV-1 subtypes and response to combination antiretroviral therapy in EuropeWendy P Bannister
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
Antivir Ther 11:707-15. 2006..Antiretroviral drugs have predominantly been developed in Western Europe/North America on the basis of the most prevalent subtype, B. However, non-B subtypes are increasingly spreading worldwide... - The role of antiretroviral therapy in the incidence of pancreatitis in HIV-positive individuals in the EuroSIDA studyColette J Smith
Royal Free and University College Medical School, London, UK
AIDS 22:47-56. 2008..This study investigated the incidence of pancreatitis and its association with antiretroviral therapy (ART), focussing on stavudine and didanosine... - Does less frequent routine monitoring of patients on a stable, fully suppressed cART regimen lead to an increased risk of treatment failure?Joanne Reekie
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, Royal Free and University College Medical School, London, UK
AIDS 22:2381-90. 2008..To investigate whether HIV-infected patients on a stable and fully suppressive combination antiretroviral therapy (cART) regimen could safely be monitored less often than the current recommendations of every 3 months... 
Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational studyRebecca K Lodwick
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
Lancet 376:340-5. 2010..We aimed to examine this by analysis of pooled data from industrialised countries...- Regional differences in AIDS and non-AIDS related mortality in HIV-positive individuals across Europe and Argentina: the EuroSIDA studyJoanne Reekie
Medical School, University College London, London, United Kingdom
PLoS ONE 7:e41673. 2012..This analysis aimed to establish whether there are regional differences in the mortality rate of HIV-positive individuals across Europe, and Argentina... - Fatal and nonfatal AIDS and non-AIDS events in HIV-1-positive individuals with high CD4 cell counts according to viral load strataJoanne Reekie
University College London Medical School, London, UK
AIDS 25:2259-68. 2011..9 copies/ml) and high (≥ 10000 copies/ml)... - Are specific antiretrovirals associated with an increased risk of discontinuation due to toxicities or patient/physician choice in patients with hepatitis C virus coinfection?Amanda Mocroft
Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
Antivir Ther 10:779-90. 2005..Little information to address this concern is available from clinical trials as patients with HCV are often excluded... - Causes of death in HIV infection: the key determinant to define the clinical response to anti-HIV therapyAmanda Mocroft
Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
AIDS 18:2333-7. 2004..Compared with homosexual individuals, IDU had an increased incidence of new AIDS/death, but only for non-HIV deaths. There is an urgent need to define and standardize causes of death in observational studies... - Is there evidence for an increase in the death rate from liver-related disease in patients with HIV?Amanda Mocroft
Royal Free Centre for HIV Medicine and Dept Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
AIDS 19:2117-25. 2005..Increases in deaths due to liver-related disease (LRD) among HIV-infected individuals have been reported although the influence of combination antiretroviral therapy (cART) on LRD is controversial... - Limited but increasing use of treatment for hepatitis C across Europe in patients coinfected with HIV and hepatitis CAmanda Mocroft
Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
Scand J Infect Dis 38:1092-7. 2006..6 - 6.1) to 32.6 per 1000 PYFU at/after 2004 (95% CI 22.5 - 42.7). Although prescription of HCV therapy is increasing in HIV-coinfected patients, it remains infrequent and variable across regions of Europe... - Regional changes over time in initial virologic response rates to combination antiretroviral therapy across EuropeWendy P Bannister
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
J Acquir Immune Defic Syndr 42:229-37. 2006..Regional variations may identify differences in available antiretroviral drugs or patient management... - Relationship between current level of immunodeficiency and non-acquired immunodeficiency syndrome-defining malignanciesJoanne Reekie
University College London Medical School, London, UK
Cancer 116:5306-15. 2010..However, conflicting data have been reported on the relationship between immunodeficiency and the development of some non-AIDS-defining malignancies... - Interruption of antiretroviral therapy is associated with increased plasma cystatin CAmanda Mocroft
University College London Medical School, London, UK
AIDS 23:71-82. 2009.... - Hepatitis B and C co-infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adultsAmanda Mocroft
Research Department of Infection and Population Health, University College London Medical School, London, United Kingdom
PLoS ONE 7:e40245. 2012..Future studies should validate the relationship between HCV viremia and CKD. Trial registration: ClinicalTrials.gov NCT00027352; NCT00004978... - Starting highly active antiretroviral therapy: why, when and response to HAARTAmanda Mocroft
Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St, London NW3 2PF, UK
J Antimicrob Chemother 54:10-3. 2004..There has been a switch to more conservative therapy recently, given concerns about toxicities and the difficulties of adhering to a complicated regimen long term... - Biomarkers of impaired renal functionFrank A Post
King s College London School of Medicine, London, UK
Curr Opin HIV AIDS 5:524-30. 2010..Several biomarkers are available for monitoring renal function, although no consensus exists on how best to apply these tools in HIV infection. This review describes recent findings for the more common renal biomarkers... - Highly active antiretroviral therapy and cervical intraepithelial neoplasiaAntonia L Moore
Center for HIV Medicine, Royal Free Hospital, London, UK
AIDS 16:927-9. 2002..Such studies will provide the basis for guidelines for monitoring CIN in HIV-positive women in the HAART era...