Rory Mitchell

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor
    Rory Mitchell
    Medical Research Council Membrane and Adapter Proteins Co operative Group, Membrane Biology Interdisciplinary Research Group, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, EH8 9XD, United Kingdom
    J Biol Chem 278:33818-30. 2003
  2. ncbi request reprint Role of the conserved NPxxY motif of the 5-HT2A receptor in determining selective interaction with isoforms of ADP-ribosylation factor (ARF)
    Melanie S Johnson
    Membrane Biology Interdisciplinary Research Group, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, Scotland, EH8 9XD, UK
    Cell Signal 18:1793-800. 2006
  3. ncbi request reprint Selective interaction of ARF1 with the carboxy-terminal tail domain of the 5-HT2A receptor
    Derek N Robertson
    University of Edinburgh, School of Biomedical and Clinical Laboratory Sciences, Hugh Robson Building, George Square, Edinburgh, Scotland, EH8 9XD, UK
    Mol Pharmacol 64:1239-50. 2003
  4. ncbi request reprint Functional interactions between native Gs-coupled 5-HT receptors in HEK-293 cells and the heterologously expressed serotonin transporter
    Melanie S Johnson
    MRC Membrane and Adapter Proteins Co operative Group, School of Biomedical and Clinical Laboratory Sciences, Edinburgh University, George Square, Edinburgh EH8 9XD, UK
    Cell Signal 15:803-11. 2003
  5. pmc Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Diabetes Care 33:714-20. 2010
  6. ncbi request reprint Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain
    Clare J Proudfoot
    Centre for Neuroscience Research, Division of Veterinary Biomedical Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    Curr Biol 16:1591-605. 2006
  7. doi request reprint Postherpetic neuralgia: from preclinical models to the clinic
    Ada Delaney
    Centre for Neuroregeneration, University of Edinburgh, Edinburgh, United Kingdom
    Neurotherapeutics 6:630-7. 2009
  8. doi request reprint The TRPM8 channel forms a complex with the 5-HT(1B) receptor and phospholipase D that amplifies its reversal of pain hypersensitivity
    Ignacio Viñuela-Fernández
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, United Kingdom
    Neuropharmacology 79:136-51. 2014
  9. ncbi request reprint Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice
    Emer M Garry
    Division of Preclinical Veterinary Sciences, R D SVS, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    Curr Biol 13:321-8. 2003
  10. ncbi request reprint Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit
    Emer M Garry
    Centre for Neuroscience Research, Division of Preclinical Veterinary Sciences, Royal Dick School of Veterinary Studies, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    Mol Cell Neurosci 24:10-22. 2003

Collaborators

Detail Information

Publications12

  1. ncbi request reprint ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor
    Rory Mitchell
    Medical Research Council Membrane and Adapter Proteins Co operative Group, Membrane Biology Interdisciplinary Research Group, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, EH8 9XD, United Kingdom
    J Biol Chem 278:33818-30. 2003
    ..Examples of other G protein-coupled receptors assessed in comparison display alternative pathways of protein kinase C- or ARF6-dependent activation of PLD2...
  2. ncbi request reprint Role of the conserved NPxxY motif of the 5-HT2A receptor in determining selective interaction with isoforms of ADP-ribosylation factor (ARF)
    Melanie S Johnson
    Membrane Biology Interdisciplinary Research Group, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, Scotland, EH8 9XD, UK
    Cell Signal 18:1793-800. 2006
    ..These data suggest that the presence of the N or a D in this highly conserved motif is an important, but not exclusive, determinant of which ARF isoform interacts with the GPCR...
  3. ncbi request reprint Selective interaction of ARF1 with the carboxy-terminal tail domain of the 5-HT2A receptor
    Derek N Robertson
    University of Edinburgh, School of Biomedical and Clinical Laboratory Sciences, Hugh Robson Building, George Square, Edinburgh, Scotland, EH8 9XD, UK
    Mol Pharmacol 64:1239-50. 2003
    ....
  4. ncbi request reprint Functional interactions between native Gs-coupled 5-HT receptors in HEK-293 cells and the heterologously expressed serotonin transporter
    Melanie S Johnson
    MRC Membrane and Adapter Proteins Co operative Group, School of Biomedical and Clinical Laboratory Sciences, Edinburgh University, George Square, Edinburgh EH8 9XD, UK
    Cell Signal 15:803-11. 2003
    ..Thus, when antidepressants were used to block SERT activity, 5-HT receptor signalling was effectively clamped within a mid-range...
  5. pmc Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes study
    Rebecca M Reynolds
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Diabetes Care 33:714-20. 2010
    ..We aimed to determine whether fasting cortisol levels are associated with cognitive ability and estimated lifetime cognitive change in an elderly population with type 2 diabetes...
  6. ncbi request reprint Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain
    Clare J Proudfoot
    Centre for Neuroscience Research, Division of Veterinary Biomedical Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    Curr Biol 16:1591-605. 2006
    ..Molecular receptors for cooling have been identified in sensory nerves, and we demonstrate here how activation of one of these, TRPM8, produces profound, mechanistically novel analgesia in chronic pain states...
  7. doi request reprint Postherpetic neuralgia: from preclinical models to the clinic
    Ada Delaney
    Centre for Neuroregeneration, University of Edinburgh, Edinburgh, United Kingdom
    Neurotherapeutics 6:630-7. 2009
    ..Here we give an overview of recent findings from preclinical models and clinical research on PHN...
  8. doi request reprint The TRPM8 channel forms a complex with the 5-HT(1B) receptor and phospholipase D that amplifies its reversal of pain hypersensitivity
    Ignacio Viñuela-Fernández
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, United Kingdom
    Neuropharmacology 79:136-51. 2014
    ..Identification of this novel receptor/effector/channel complex and its impact on nociceptive processing give new insights into possible strategies for enhanced analgesia in chronic pain...
  9. ncbi request reprint Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice
    Emer M Garry
    Division of Preclinical Veterinary Sciences, R D SVS, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    Curr Biol 13:321-8. 2003
    ..Disruption of CaM kinase II docking to the NMDA receptor and activation may be responsible for the lack of neuropathic behavioral reflex sensitization in PSD-95 mutant mice...
  10. ncbi request reprint Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit
    Emer M Garry
    Centre for Neuroscience Research, Division of Preclinical Veterinary Sciences, Royal Dick School of Veterinary Studies, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    Mol Cell Neurosci 24:10-22. 2003
    ..These studies suggest a critical involvement of protein:protein complexes associated with the AMPA receptor in neuropathic pain, and the possibility that they may have potential as novel therapeutic targets...
  11. ncbi request reprint NMDA receptor antagonist treatment at the time of nerve injury prevents injury-induced changes in spinal NR1 and NR2B subunit expression and increases the sensitivity of residual pain behaviours to subsequently administered NMDA receptor antagonists
    John A Wilson
    Department of Anaesthesia, Critical Care and Pain Medicine, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK
    Pain 117:421-32. 2005
    ....
  12. ncbi request reprint A role of the ubiquitin-proteasome system in neuropathic pain
    Andrew Moss
    Department of Preclinical Veterinary Sciences, The Royal Dick School of Veterinary Studies, The University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    J Neurosci 22:1363-72. 2002
    ....