Affiliation: University of Edinburgh
- ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptorRory Mitchell
Medical Research Council Membrane and Adapter Proteins Co operative Group, Membrane Biology Interdisciplinary Research Group, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, EH8 9XD, United Kingdom
J Biol Chem 278:33818-30. 2003..Examples of other G protein-coupled receptors assessed in comparison display alternative pathways of protein kinase C- or ARF6-dependent activation of PLD2...
- Role of the conserved NPxxY motif of the 5-HT2A receptor in determining selective interaction with isoforms of ADP-ribosylation factor (ARF)Melanie S Johnson
Membrane Biology Interdisciplinary Research Group, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, Scotland, EH8 9XD, UK
Cell Signal 18:1793-800. 2006..These data suggest that the presence of the N or a D in this highly conserved motif is an important, but not exclusive, determinant of which ARF isoform interacts with the GPCR...
- Selective interaction of ARF1 with the carboxy-terminal tail domain of the 5-HT2A receptorDerek N Robertson
University of Edinburgh, School of Biomedical and Clinical Laboratory Sciences, Hugh Robson Building, George Square, Edinburgh, Scotland, EH8 9XD, UK
Mol Pharmacol 64:1239-50. 2003....
- Functional interactions between native Gs-coupled 5-HT receptors in HEK-293 cells and the heterologously expressed serotonin transporterMelanie S Johnson
MRC Membrane and Adapter Proteins Co operative Group, School of Biomedical and Clinical Laboratory Sciences, Edinburgh University, George Square, Edinburgh EH8 9XD, UK
Cell Signal 15:803-11. 2003..Thus, when antidepressants were used to block SERT activity, 5-HT receptor signalling was effectively clamped within a mid-range...
- Morning cortisol levels and cognitive abilities in people with type 2 diabetes: the Edinburgh type 2 diabetes studyRebecca M Reynolds
Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
Diabetes Care 33:714-20. 2010..We aimed to determine whether fasting cortisol levels are associated with cognitive ability and estimated lifetime cognitive change in an elderly population with type 2 diabetes...
- Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic painClare J Proudfoot
Centre for Neuroscience Research, Division of Veterinary Biomedical Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
Curr Biol 16:1591-605. 2006..Molecular receptors for cooling have been identified in sensory nerves, and we demonstrate here how activation of one of these, TRPM8, produces profound, mechanistically novel analgesia in chronic pain states...
- Postherpetic neuralgia: from preclinical models to the clinicAda Delaney
Centre for Neuroregeneration, University of Edinburgh, Edinburgh, United Kingdom
Neurotherapeutics 6:630-7. 2009..Here we give an overview of recent findings from preclinical models and clinical research on PHN...
- The TRPM8 channel forms a complex with the 5-HT(1B) receptor and phospholipase D that amplifies its reversal of pain hypersensitivityIgnacio Viñuela-Fernández
Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, United Kingdom
Neuropharmacology 79:136-51. 2014..Identification of this novel receptor/effector/channel complex and its impact on nociceptive processing give new insights into possible strategies for enhanced analgesia in chronic pain...
- Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant miceEmer M Garry
Division of Preclinical Veterinary Sciences, R D SVS, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
Curr Biol 13:321-8. 2003..Disruption of CaM kinase II docking to the NMDA receptor and activation may be responsible for the lack of neuropathic behavioral reflex sensitization in PSD-95 mutant mice...
- Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunitEmer M Garry
Centre for Neuroscience Research, Division of Preclinical Veterinary Sciences, Royal Dick School of Veterinary Studies, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
Mol Cell Neurosci 24:10-22. 2003..These studies suggest a critical involvement of protein:protein complexes associated with the AMPA receptor in neuropathic pain, and the possibility that they may have potential as novel therapeutic targets...
- NMDA receptor antagonist treatment at the time of nerve injury prevents injury-induced changes in spinal NR1 and NR2B subunit expression and increases the sensitivity of residual pain behaviours to subsequently administered NMDA receptor antagonistsJohn A Wilson
Department of Anaesthesia, Critical Care and Pain Medicine, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK
Pain 117:421-32. 2005....
- A role of the ubiquitin-proteasome system in neuropathic painAndrew Moss
Department of Preclinical Veterinary Sciences, The Royal Dick School of Veterinary Studies, The University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
J Neurosci 22:1363-72. 2002....