Research Topics
| P MitchellSummaryAffiliation: University of Newcastle Country: UK Publications
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Detail Information
Publications
Unruptured intracranial aneurysms: benign curiosity or ticking bomb?Patrick Mitchell
Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, UK
Lancet Neurol 3:85-92. 2004..Third, in all other cases treatment with surgical clipping or coil embolisation should be advised. And finally, if surgical treatment is not feasible then medical hypotensive treatment may be a viable alternative...
Regional differences in outcome from subarachnoid haemorrhage: comparative auditP Mitchell
Department of Neurosurgery, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE
BMJ 328:1234-5. 2004
Reliability assessment of computerized tomography scanning measurements in intracerebral hematomaParameswaran S Bhattathiri
Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
Neurosurg Focus 15:E6. 2003..CONCLUSIONS: The study quantifies the degree of inter- and intraobserver agreement regarding evaluation of CT scans in patients with ICH when conducted in accordance with a set protocol...
Surgery for malignant gliomas: mechanistic reasoning and slippery statisticsPatrick Mitchell
Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
Lancet Neurol 4:413-22. 2005..In this review we examine the prevailing mechanistic model and observational data; we assess how these are applied and the priorities they indicate for future research...
Side errors in neurosurgeryP Mitchell
Department of Neurosurgery, University of Newcastle upon Tyne, Newcastle General Hospital, UK
Acta Neurochir (Wien) 148:1289-92; discussion 1292. 2006..It is concluded that to prevent these mistakes emphasis should be placed on ensuring that the preoperative site check is completed more than on ensuring that unambiguous side information is available in the notes and imaging...
Surgical trial in lobar intracerebral haemorrhage (STICH II) protocolA David Mendelow
STICH Office, Neurosurgical Trials Unit, Newcastle University, 3 4 Claremont Terrace, Newcastle upon Tyne, NE2 4AE, UK
Trials 12:124. 2011..Primary outcome is death or severe disability defined using a prognosis based 8 point Glasgow Outcome Scale. Secondary outcomes include: Mortality, Rankin, Barthel, EuroQol, and Survival. TRIAL REGISTRATION: ISRCTN: ISRCTN22153967...
Could late rebleeding overturn the superiority of cranial aneurysm coil embolization over clip ligation seen in the International Subarachnoid Aneurysm Trial?Patrick Mitchell
Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, UK
J Neurosurg 108:437-42. 2008..In the ISAT, coil embolization appears to be safer than clip ligation at 1 year, and clip occlusion has better long-term efficacy at preventing rebleeding. This leaves open the question of which is better in the longer term...
Surgical options in ICH including decompressive craniectomyPatrick Mitchell
Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, England NE4 6BE, United Kingdom
J Neurol Sci 261:89-98. 2007..An important exception is ICHs arising from intracranial aneurysms where there is good evidence to support evacuation of the haematoma as well as repair of the aneurysm...
Blood pressure, fatigue, and the pathogenesis of aneurysmal subarachnoid hemorrhagePatrick Mitchell
Neurosurgery School of Surgical and Reproductive Sciences, Newcastle University, Newcastle General Hospital, NE4 6BE Newcastle upon Tyne, UK
Surg Neurol 66:574-80; discussion 580. 2006..We investigate the possible mechanisms of rupture to offer an explanation for this...
Regional differences in outcome from subarachnoid haemorrhageP Mitchell
Department of Neurosurgery, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle upon Tyne, UK
Acta Neurochir (Wien) 147:959-64; discussion 964. 2005..Considerable concern exists about misinterpretation of such data. The issue is well illustrated by this study...
Decompressive craniectomy with lattice duraplastyP Mitchell
Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, UK
Acta Neurochir (Wien) 146:159-60. 2004..Numerous cuts intersecting in a lattice pattern allow the dura to expand in a gradual and controlled manner minimising the chances of cortical laceration or venous kinking on the craniectomy edge...
The significance of crossovers after randomization in the STICH trialK S M Prasad
Regional Neurosciences Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
Acta Neurochir Suppl 96:61-4. 2006..Crossovers formed a worse prognostic group compared to non-crossovers. Surgery did not affect trial results, which were analyzed by intention-to-treat...
Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com)P J Hutchinson
Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Acta Neurochir Suppl 96:17-20. 2006..We describe the concept of decompressive craniectomy in traumatic brain injury and the rationale and protocol of the RESCUEicp study...
Prevention of intracerebral haemorrhagePatrick Mitchell
Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, UK
Curr Drug Targets 8:832-8. 2007..Although there is a wide range of such lesions available treatments come down to three modalities. These are surgical excision, stereotactic radiosurgery and endovascular embolisation...
Risk analysis of treatment of unruptured aneurysmsP Mitchell
Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
J Neurol Neurosurg Psychiatry 68:577-80. 2000..To calculate the expected number of life-years saved by surgical treatment of unruptured intracranial aneurysms at ages over 20 years...
Predicting the risk of rupture of intracranial aneurysms based on anatomical locationG Clarke
Biomedical Sciences, Faculty of Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, UK
Acta Neurochir (Wien) 147:259-63; discussion 263. 2005..The ISUIA post hoc hypothesis fails when tested on these data and the ISUIA data should be re-analysed with posterior communicating artery aneurysms grouped with the anterior circulation where they more traditionally belong...
Risk-benefit analysis of the treatment of unruptured intracranial aneurysmsR R Vindlacheruvu
Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, UK
J Neurol Neurosurg Psychiatry 76:234-9. 2005..These results are based on the findings of the ISUIA and are dependent on their accuracy...
Supraorbital eyebrow minicraniotomy for anterior circulation aneurysmsPatrick Mitchell
Department of Neurosurgery, Newcastle General Hospital, NE4 6BE Newcastle, UK
Surg Neurol 63:47-51; discussion 51. 2005..We report our experience with the minimally invasive supraorbital approach to aneurysms of the ipsilateral anterior cerebral circulation...
Failure testing cerebral arteries: are branch points weaker than unbranched vessels?P Mitchell
Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, UK
Br J Neurosurg 16:578-82. 2002..971 bar). This difference was significant with p < 0.001. Bursting pressure was found to decline at 2% per year of age. This figure was different from 0 with p = 0.003...
Detection of subarachnoid haemorrhage with magnetic resonance imagingP Mitchell
Department of Neurosurgery, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
J Neurol Neurosurg Psychiatry 70:205-11. 2001..To measure the sensitivity and specificity of five MRI sequences to subarachnoid haemorrhage...
In-vivo measurement of brain relaxation after lobectomiesN Mukerji
Department of Neurosurgery, Regional Neurosciences Centre, Newcastle General Hospital, Newcastle-upon-Tyne, UK
Br J Neurosurg 20:150-2. 2006..25(0.76 - 6.64) ml/h in this study. Further studies using more frequent data collection would allow for more accurate definition of the rate of relaxation...
A stereoscope for image-guided surgeryP Mitchell
Department of Neurosurgery, Royal Hallamshire Hospital Sheffield, UK
Br J Neurosurg 16:261-6; discussion 267-8. 2002..The instrument was used in six cases. A lateral accuracy of 10-15 mm was achieved and a depth accuracy of 5-10 mm...
Effect of awake Carotid Endarterectomy under local anaesthesia on peri-operative blood pressure: blood pressure is normalised when carotid stenosis is treated under local anaesthesiaP S Bhattathiri
Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, UK
Acta Neurochir (Wien) 147:839-45. 2005....
Proximal migration of a lumboperitoneal unishunt systemD Rodrigues
Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, UK
J Clin Neurosci 12:838-41. 2005..A rare case of proximal migration of LP shunt into the quadrigeminal cistern is also reported...
