Alex J Mitchell

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. doi Is it time to separate subjective cognitive complaints from the diagnosis of mild cognitive impairment?
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester General Hospital, Leicester, UK
    Age Ageing 37:497-9. 2008
  2. ncbi Short screening tools for cancer-related distress: a review and diagnostic validity meta-analysis
    Alex J Mitchell
    Leicester General Hospital, Leicester LE5 4PW, United Kingdom
    J Natl Compr Canc Netw 8:487-94. 2010
  3. pmc Does the academic performance of psychiatrists influence success in the NHS Clinical Excellence Award Scheme?
    Alex J Mitchell
    Leicester Partnership Trust, Leicester, UK
    JRSM Short Rep 2:21. 2011
  4. ncbi Which symptoms are indicative of depression in epilepsy settings? An analysis of the diagnostic significance of somatic and non-somatic symptoms
    Alex J Mitchell
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Affect Disord 150:861-7. 2013
  5. doi Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: a systematic review and meta-analysis
    Alex J Mitchell
    Department of Psycho oncology, Leicester Partnership Trust, Leicester, UK
    Lancet Oncol 14:721-32. 2013
  6. doi Screening for cancer-related distress: when is implementation successful and when is it unsuccessful?
    Alex J Mitchell
    Department of Psycho oncology, Leicestershire Partnership Trust, Leicester, UK
    Acta Oncol 52:216-24. 2013
  7. ncbi Ability of nurses to identify depression in primary care, secondary care and nursing homes--a meta-analysis of routine clinical accuracy
    Alex J Mitchell
    Liaison Psychiatry, Leicester General Hospital, Leicester LE5 4PW, United Kingdom
    Int J Nurs Stud 48:359-68. 2011
  8. pmc Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders--a systematic review and meta-analysis
    Alex J Mitchell
    Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, University of Leicester, Leicester, UK
    Schizophr Bull 39:306-18. 2013
  9. doi Which symptoms are indicative of DSMIV depression in cancer settings? An analysis of the diagnostic significance of somatic and non-somatic symptoms
    Alex J Mitchell
    Department of Cancer Studies and Molecular Medicine, University of Leicester, LE1 5WW, United Kingdom
    J Affect Disord 138:137-48. 2012
  10. doi Differences in the prescribing of medication for physical disorders in individuals with v. without mental illness: meta-analysis
    Alex J Mitchell
    Department of Psycho oncology, Leicestershire Partnership Trust, Leicester LE5 0TD, UK
    Br J Psychiatry 201:435-43. 2012

Detail Information

Publications54

  1. doi Is it time to separate subjective cognitive complaints from the diagnosis of mild cognitive impairment?
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester General Hospital, Leicester, UK
    Age Ageing 37:497-9. 2008
    ..Despite a close association, SCC may be neither necessary nor sufficient for a diagnosis of either MCI or dementia...
  2. ncbi Short screening tools for cancer-related distress: a review and diagnostic validity meta-analysis
    Alex J Mitchell
    Leicester General Hospital, Leicester LE5 4PW, United Kingdom
    J Natl Compr Canc Netw 8:487-94. 2010
    ..Nevertheless, short methods seem to be at least as successful as the HADS, although substantially more efficient and hence more acceptable, and therefore may be a suitable initial method of assessment in busy clinical settings...
  3. pmc Does the academic performance of psychiatrists influence success in the NHS Clinical Excellence Award Scheme?
    Alex J Mitchell
    Leicester Partnership Trust, Leicester, UK
    JRSM Short Rep 2:21. 2011
    ....
  4. ncbi Which symptoms are indicative of depression in epilepsy settings? An analysis of the diagnostic significance of somatic and non-somatic symptoms
    Alex J Mitchell
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE1 9HN, United Kingdom
    J Affect Disord 150:861-7. 2013
    ..However, there have been no previous studies which have investigated the validity of individual symptoms for comorbid depression in epilepsy, in particular the diagnostic value of somatic and non-somatic symptoms...
  5. doi Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: a systematic review and meta-analysis
    Alex J Mitchell
    Department of Psycho oncology, Leicester Partnership Trust, Leicester, UK
    Lancet Oncol 14:721-32. 2013
    ..We assessed whether depression and anxiety are more common in long-term survivors of cancer compared with their spouses and with healthy controls...
  6. doi Screening for cancer-related distress: when is implementation successful and when is it unsuccessful?
    Alex J Mitchell
    Department of Psycho oncology, Leicestershire Partnership Trust, Leicester, UK
    Acta Oncol 52:216-24. 2013
    ....
  7. ncbi Ability of nurses to identify depression in primary care, secondary care and nursing homes--a meta-analysis of routine clinical accuracy
    Alex J Mitchell
    Liaison Psychiatry, Leicester General Hospital, Leicester LE5 4PW, United Kingdom
    Int J Nurs Stud 48:359-68. 2011
    ..To clarify the ability of nurses and nursing assistants working in primary care, secondary care and nursing homes to identify depressed individuals using their clinical skills using meta-analysis of published studies...
  8. pmc Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders--a systematic review and meta-analysis
    Alex J Mitchell
    Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, University of Leicester, Leicester, UK
    Schizophr Bull 39:306-18. 2013
    ..Present findings strongly support the notion that patients with schizophrenia should be considered a high-risk group. Patients with schizophrenia should receive regular monitoring and adequate treatment of cardio-metabolic risk factors...
  9. doi Which symptoms are indicative of DSMIV depression in cancer settings? An analysis of the diagnostic significance of somatic and non-somatic symptoms
    Alex J Mitchell
    Department of Cancer Studies and Molecular Medicine, University of Leicester, LE1 5WW, United Kingdom
    J Affect Disord 138:137-48. 2012
    ..There have been few studies that have attempted to examine the phenomenology of comorbid depression, in particular the diagnostic value of individual somatic and non-somatic symptoms when attempting to diagnose depression following cancer...
  10. doi Differences in the prescribing of medication for physical disorders in individuals with v. without mental illness: meta-analysis
    Alex J Mitchell
    Department of Psycho oncology, Leicestershire Partnership Trust, Leicester LE5 0TD, UK
    Br J Psychiatry 201:435-43. 2012
    ..There is some concern that patients with mental illness may be in receipt of inferior medical care, including prescribed medication for medical conditions...
  11. doi How feasible is implementation of distress screening by cancer clinicians in routine clinical care?
    Alex J Mitchell
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, United Kingdom
    Cancer 118:6260-9. 2012
    ..There is considerable uncertainty regarding the acceptability of routine distress screening...
  12. doi Meta-analysis of screening and case finding tools for depression in cancer: evidence based recommendations for clinical practice on behalf of the Depression in Cancer Care consensus group
    Alex J Mitchell
    Leicester Partnership Trust, and Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester, UK
    J Affect Disord 140:149-60. 2012
    ..To examine the validity of screening and case-finding tools used in the identification of depression as defined by an ICD10/DSM-IV criterion standard...
  13. doi Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies
    Alex J Mitchell
    Leicester General Hospital, Leicester Partnership Trust, Leicester, UK
    Lancet Oncol 12:160-74. 2011
    ..We aimed to quantitatively summarise the prevalence of depression, anxiety, and adjustments disorders in these settings...
  14. doi Identification of patient-reported distress by clinical nurse specialists in routine oncology practice: a multicentre UK study
    Alex J Mitchell
    Leicester General Hospital, Leicester, UK
    Psychooncology 20:1076-83. 2011
    ..There is uncertainty regarding how well clinical nurse specialists are able to identify distress in cancer settings...
  15. doi Diagnostic validity and added value of the Geriatric Depression Scale for depression in primary care: a meta-analysis of GDS30 and GDS15
    Alex J Mitchell
    Leicester General Hospital, Leicester Partnership Trust, Leicester LE5 4PW, United Kingdom
    J Affect Disord 125:10-7. 2010
    ..We therefore conducted a meta-analysis analysing the diagnostic accuracy, clinical utility and added value of the GDS in primary care...
  16. doi Screening for distress and depression in cancer settings: 10 lessons from 40 years of primary-care research
    Alex J Mitchell
    Leicestershire Partnership Trust, Leicester, UK
    Psychooncology 20:572-84. 2011
    ..Both successes and failures have been documented. The purpose of this focussed narrative review was to summarise this research and present the key lessons for clinicians and researchers working in psychosocial oncology...
  17. ncbi Which version of the geriatric depression scale is most useful in medical settings and nursing homes? Diagnostic validity meta-analysis
    Alex J Mitchell
    Leicester General Hospital, Leicestershire Partnership Trust, UK
    Am J Geriatr Psychiatry 18:1066-77. 2010
    ..Therefore, the authors conducted a meta-analysis, analyzing the diagnostic accuracy of long, short, and ultrashort versions of the GDS and stratified this into those with and without cognitive impairment...
  18. doi Redefining diagnostic symptoms of depression using Rasch analysis: testing an item bank suitable for DSM-V and computer adaptive testing
    Alex J Mitchell
    Leicestershire Partnership Trust, and Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Leicester, UK
    Aust N Z J Psychiatry 45:846-52. 2011
    ..We aimed to redefine the optimal self-report symptoms of depression suitable for creation of an item bank that could be used in computer adaptive testing or to develop a simplified screening tool for DSM-V...
  19. pmc Is the prevalence of metabolic syndrome and metabolic abnormalities increased in early schizophrenia? A comparative meta-analysis of first episode, untreated and treated patients
    Alex J Mitchell
    Leicestershire Partnership Trust, Leicester, UK
    Schizophr Bull 39:295-305. 2013
    ..We aimed to discover whether metabolic complications of schizophrenia (SZ) are present in first episode (FE) and unmedicated (UM) patients, in comparison with patients established on antipsychotic medication (AP)...
  20. doi Receipt of preventive medical care and medical screening for patients with mental illness: a comparative analysis
    Oliver Lord
    Leicester Partnership Trust, Leicester, UK
    Gen Hosp Psychiatry 32:519-43. 2010
    ..There has been long-standing concern about the delivery of preventive and screening services to patients with mental illness...
  21. doi Can the Distress Thermometer be improved by additional mood domains? Part I. Initial validation of the Emotion Thermometers tool
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Psychooncology 19:125-33. 2010
    ..To examine the value of a new screening instrument in a visual-analogue format...
  22. doi Screening and case finding tools for the detection of dementia. Part I: evidence-based meta-analysis of multidomain tests
    Alex J Mitchell
    Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester, UK
    Am J Geriatr Psychiatry 18:759-82. 2010
    ..To evaluate the diagnostic accuracy of all brief multidomain alternatives to the Mini-Mental State Examination (MMSE) in the detection of dementia...
  23. doi Diagnostic validity of the Hospital Anxiety and Depression Scale (HADS) in cancer and palliative settings: a meta-analysis
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, University of Leicester LE1 5WW, United Kingdom
    J Affect Disord 126:335-48. 2010
    ..To examine the validity of the Hospital Anxiety and Depression Scale (HADS) in the identification of psychiatric complications of cancer, as defined by a robust criterion standard...
  24. ncbi Physical health and schizophrenia
    Alex J Mitchell
    Department of Liason Psychiatry, Brandon Unit, Leicester General Hospital, Leicester, UK
    Curr Opin Psychiatry 19:432-7. 2006
    ..It is debatable whether this is related to shared risk factors, antipsychotic medication or inherent to the condition itself. This review will describe this association and the recent advances in the field...
  25. doi Clinical recognition and recording of alcohol disorders by clinicians in primary and secondary care: meta-analysis
    Alex J Mitchell
    Leicester General Hospital, Leicester Partnership Trust, Leicester, UK
    Br J Psychiatry 201:93-100. 2012
    ..Clinicians have considerable difficulty identifying and helping those people with alcohol problems but no previous study has looked at this systematically...
  26. doi Clinical diagnosis of depression in primary care: a meta-analysis
    Alex J Mitchell
    Leicestershire Partnership Trust, Leicester General Hospital, Leicester, UK
    Lancet 374:609-19. 2009
    ..Most care for depression is delivered by general practitioners (GPs). We assessed the rate of true positives and negatives, and false positives and negatives in primary care when GPs make routine diagnoses of depression...
  27. ncbi Pooled results from 38 analyses of the accuracy of distress thermometer and other ultra-short methods of detecting cancer-related mood disorders
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester, United Kingdom
    J Clin Oncol 25:4670-81. 2007
    ..Ultra-short methods cannot be used alone to diagnose depression, anxiety, or distress in cancer patients but they may be considered as a first-stage screen to rule out cases of depression...
  28. doi Can general practitioners identify people with distress and mild depression? A meta-analysis of clinical accuracy
    Alex J Mitchell
    Leicester General Hospital, Leicestershire Partnership Trust, Leicester LE5 4PW, United Kingdom
    J Affect Disord 130:26-36. 2011
    ..There is increasing emphasis on distress and mild depression but uncertainty regarding how well general practitioners (GPs) identify these conditions. Further, the proportion of attendees suffering distress is also unclear...
  29. doi Do primary care physicians have particular difficulty identifying late-life depression? A meta-analysis stratified by age
    Alex J Mitchell
    Leicester General Hospital, Leicestershire Partnership Trust, Leicester Royal Infirmary, Leicester, UK
    Psychother Psychosom 79:285-94. 2010
    ..There is long-standing concern regarding poor recognition of depression in primary care, especially in older people...
  30. doi Revascularisation and mortality rates following acute coronary syndromes in people with severe mental illness: comparative meta-analysis
    Alex J Mitchell
    Department of Liaison Psychiatry, Leicestershire Partnership Trust and Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Leicester, UK
    Br J Psychiatry 198:434-41. 2011
    ..High levels of comorbid physical illness and excess mortality rates have been previously documented in people with severe mental illness, but outcomes following myocardial infarction and other acute coronary syndromes are less clear...
  31. doi Screening and case-finding tools for the detection of dementia. Part II: evidence-based meta-analysis of single-domain tests
    Alex J Mitchell
    Department of Liaison Psychiatry, Liecestershire Partnership Trust, Leicester General Hospital, Leicester, UK
    Am J Geriatr Psychiatry 18:783-800. 2010
    ..To evaluate the diagnostic validity of single-domain cognitive tests for detecting dementia. These methods were defined as those that focus mainly on one domain of cognitive function such as orientation, memory, or executive function...
  32. ncbi Clinical recognition of dementia and cognitive impairment in primary care: a meta-analysis of physician accuracy
    Alex J Mitchell
    Leicester General Hospital, Leicestershire Partnership Trust, UK
    Acta Psychiatr Scand 124:165-83. 2011
    ..We aimed to examine the ability of the general practitioners (GPs) to recognize a spectrum of cognitive impairment from mild cognitive impairment (MCI) to severe dementia in routine practice using their own clinical judgment...
  33. doi A meta-analysis of the accuracy of the mini-mental state examination in the detection of dementia and mild cognitive impairment
    Alex J Mitchell
    Department of Liaison Psychiatry, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    J Psychiatr Res 43:411-31. 2009
    ..In conclusion the MMSE offers modest accuracy with best value for ruling-out a diagnosis of dementia in community and primary care. For all other used it should be combined with or replaced by other methods...
  34. pmc International comparison of clinicians' ability to identify depression in primary care: meta-analysis and meta-regression of predictors
    Alex J Mitchell
    Department of Cancer Studies and Molecular Medicine, University of Leicester, UK
    Br J Gen Pract 61:e72-80. 2011
    ..There are international differences in the epidemiology of depression and the performance of primary care physicians but the factors underlying these national differences are uncertain...
  35. ncbi Acceptability of common screening methods used to detect distress and related mood disorders-preferences of cancer specialists and non-specialists
    Alex J Mitchell
    Liaison Psychiatry, University of Leicester, Brandon Unit, Leicester, UK
    Psychooncology 17:226-36. 2008
    ..We suggest that future field studies of screening tools should also measure the issue of acceptability...
  36. doi Quality of medical care for people with and without comorbid mental illness and substance misuse: systematic review of comparative studies
    Alex J Mitchell
    Department of Liaison Psychiatry, Leicester General Hospital, Leicester LE5 4PW, UK
    Br J Psychiatry 194:491-9. 2009
    ..There has been long-standing concern about the quality of medical care offered to people with mental illness...
  37. ncbi A comparative survey of missed initial and follow-up appointments to psychiatric specialties in the United kingdom
    Alex J Mitchell
    Department of Liaison Psychiatry, Leicester General Hospital, UK
    Psychiatr Serv 58:868-71. 2007
    ..This study examined the frequency of missed appointments among 9,511 initial outpatient appointments and 7,700 follow-up appointments across ten psychiatric subspecialties in a publicly funded mental health service in the United Kingdom...
  38. ncbi Reluctance to disclose difficult diagnoses: a narrative review comparing communication by psychiatrists and oncologists
    Alex J Mitchell
    Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Osbourne Building, Leicester LE1 5WW, UK
    Support Care Cancer 15:819-28. 2007
    ..National guidance in most medical specialties supports the full and open disclosure of diagnoses to patients...
  39. ncbi Prognosis of depression in old age compared to middle age: a systematic review of comparative studies
    Alex J Mitchell
    Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester, UK LE5 4PW
    Am J Psychiatry 162:1588-601. 2005
    ..The authors sought to identify research that has compared the prognosis of depression in late life with depression in midlife under similar conditions...
  40. pmc Do deficits in cardiac care influence high mortality rates in schizophrenia? A systematic review and pooled analysis
    Alex J Mitchell
    Department of Liaison Psychiatry, Leicester General Hospital, Leicester, UK
    J Psychopharmacol 24:69-80. 2010
    ..Every effort should be made to deliver high-quality medical care to people with severe mental illness...
  41. ncbi Do CSF biomarkers help clinicians predict the progression of mild cognitive impairment to dementia?
    Alex J Mitchell
    Department of Liaison Psychiatry, Leicester General Hospital, Leicester LE5 4PWl, UK
    Pract Neurol 10:202-7. 2010
    ....
  42. doi The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia: a meta-analysis
    Alex J Mitchell
    Department of Liaison Psychiatry, Brandon Unit, Leciester General Hospital, Leicester, UK
    Int J Geriatr Psychiatry 23:1191-202. 2008
    ..Subjective memory complaints (SMC) are frequently reported by individuals with objective evidence of cognitive decline although the exact rate of complaints and their diagnostic value is uncertain...
  43. doi Can the Distress Thermometer be improved by additional mood domains? Part II. What is the optimal combination of Emotion Thermometers?
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Psychooncology 19:134-40. 2010
    ..To examine the added value of an algorithmic combination of visual-analogue thermometers compared with the Distress Thermometer (DT) when attempting to detect depression, anxiety or distress in early cancer...
  44. ncbi Adherence behaviour with psychotropic medication is a form of self-medication
    Alex J Mitchell
    Leicester Royal Infirmary, Leicester, United Kingdom
    Med Hypotheses 68:12-21. 2007
    ..The self-medication hypothesis applied to prescribed psychotropic medication should assist rather than heed clinicians in improving adherence by taking a patient centred approach and where possible promoting patient autonomy...
  45. ncbi Depressed patients and treatment adherence
    Alex J Mitchell
    Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester LE5 4PW, UK
    Lancet 367:2041-3. 2006
  46. ncbi Accuracy of one or two simple questions to identify alcohol-use disorder in primary care: a meta-analysis
    Alex J Mitchell
    Leicestershire Partnership NHS Trust and honorary senior lecturer in liaison psychiatry, Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester
    Br J Gen Pract 64:e408-18. 2014
    ..Brief screening consisting of one or two questions might be used alone or in combination with longer tests as recommended by the Primary Care Service Framework...
  47. pmc Do ultra-short screening instruments accurately detect depression in primary care? A pooled analysis and meta-analysis of 22 studies
    Alex J Mitchell
    Department of Liaison Psychology, Leicester General Hospital, Leicester
    Br J Gen Pract 57:144-51. 2007
    ..Ultra-short (one-, two-, three- or four-item) tests have appeal due to their simple administration but their accuracy has not been established...
  48. ncbi Quality of life and its assessment in multiple sclerosis: integrating physical and psychological components of wellbeing
    Alex J Mitchell
    Department of Liasion Psychiatry, Brandon Mental Health Unit, Leicester General Hospital, Leicester, UK
    Lancet Neurol 4:556-66. 2005
    ..Subjective (self-report) HRQoL measures may serve to alert clinicians to areas that would otherwise be overlooked. Studies of new interventions should include an assessment of HRQoL not just impairment or disability alone...
  49. doi Clinical utility of screening for clinical depression and bipolar disorder
    Alex J Mitchell
    Department of Psycho oncology, Leicester Partnership Trust, Leicester LE5 0TD, UK
    Curr Opin Psychiatry 25:24-31. 2012
    ..Screening is usually based on finding discriminating symptoms, but not all tools perform equally well. Clinicians should be able to assess the clinical utility of screening tests as well as their accuracy and acceptability...
  50. ncbi Unusually rapid and severe cognitive deterioration after mild traumatic brain injury
    Steven Kemp
    St James s University Hospital, Leeds, UK
    Brain Inj 19:1269-76. 2005
    ..AB is presented as an unusual case of rapid progressive AD following a mild head injury...
  51. ncbi Clinical significance of recurrent psychogenic nonepileptic seizure status
    Markus Reuber
    Academic Unit of Neurology, Division of Genomic Medicine, University of Sheffield L Floor, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK
    J Neurol 250:1355-62. 2003
    ....
  52. ncbi Measuring outcome in psychogenic nonepileptic seizures: how relevant is seizure remission?
    Markus Reuber
    Academic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Epilepsia 46:1788-95. 2005
    ..To examine whether seizure remission is a comprehensive marker of outcome in psychogenic nonepileptic seizures (PNESs)...
  53. pmc Efficiency of a two-item pre-screen to reduce the burden of depression screening in pregnancy and postpartum: an IMPLICIT network study
    Ian M Bennett
    Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Am Board Fam Med 21:317-25. 2008
    ..Here we assess the diagnostic accuracy of a modified 2-item patient health questionnaire (PHQ-2) as a pre-screen in assessing depression...
  54. ncbi Depression as a risk factor for later dementia: a robust relationship?
    Alex J Mitchell
    Age Ageing 34:207-9. 2005