Research Topics
Genomes and Genes
| Rhona MirskySummaryAffiliation: University College London Country: UK Publications
| Collaborators
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Detail Information
Publications
Schwann cell development, differentiation and myelinationR Mirsky
Department of Anatomy and Developmental Biology, University College London, UK
Curr Opin Neurobiol 6:89-96. 1996..The tetraspan group has emerged as a set of proteins with prominent functions in Schwann cell biology...- The neurobiology of Schwann cellsR Mirsky
Department of Anatomy and Developmental Biology, University College London, UK
Brain Pathol 9:293-311. 1999..Finally, the relationship between selected extracellular matrix components, integrins and the cytoskeleton is explored and related to disease... - Schwann cell-derived desert hedgehog signals nerve sheath formationR Mirsky
Department of Anatomy and Developmental Biology, University College London, United Kingdom
Ann N Y Acad Sci 883:196-202. 1999.... - Schwann cells as regulators of nerve developmentRhona Mirsky
Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT, London, UK
J Physiol Paris 96:17-24. 2002..Schwann cells thus signal not only to themselves but also to the other cellular components within the nerve to act as major regulators of nerve development... 
Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiationRhona Mirsky
Department of Cell and Developmental Biology, University College London, London, UK
J Peripher Nerv Syst 13:122-35. 2008....
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticityAshwin Woodhoo
Department of Cell and Developmental Biology, University College London, UK
Nat Neurosci 12:839-47. 2009..These findings are relevant for understanding the molecular mechanisms that control Schwann cell plasticity and underlie nerve pathology, including demyelinating neuropathies and tumorigenesis...- c-Jun is a negative regulator of myelinationDavid B Parkinson
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, England, UK
J Cell Biol 181:625-37. 2008..Negative regulation of myelination is likely to have significant implications for three areas of Schwann cell biology: the molecular analysis of plasticity, demyelinating pathologies, and the response of peripheral nerves to injury... - TGFbeta type II receptor signaling controls Schwann cell death and proliferation in developing nervesMaurizio D'Antonio
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 26:8417-27. 2006..This is the first in vivo evidence for a growth factor receptor involved in promoting Schwann cell division during development and the first genetic evidence for a receptor that controls normal developmental Schwann cell death... - A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathyPeter Arthur-Farraj
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
Neurobiol Dis 24:159-69. 2006..Furthermore, mutant Egr2 upregulates cyclin D1 and reduces levels of the cell cycle inhibitor, p27. These observations add significant new evidence to explain how this mutation leads to congenital hypomyelinating neuropathy in humans... - Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and deathDavid B Parkinson
Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT UK
J Cell Biol 164:385-94. 2004..Krox-20 also up-regulates the scaffold protein JNK-interacting protein 1 (JIP-1). We propose this as a possible component of the mechanism by which Krox-20 regulates JNK activity during Schwann cell development... - The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehogSoheila Sharghi-Namini
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 26:6364-76. 2006..1999). The complexity of the defects raises a number of important questions about the Dhh-dependent cell-cell signaling network in peripheral nerves... - c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regenerationPeter J Arthur-Farraj
Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
Neuron 75:633-47. 2012..We conclude that a single glial transcription factor is essential for restoration of damaged nerves, acting to control the transdifferentiation of myelin and Remak Schwann cells to dedicated repair cells in damaged tissue... - Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cellsDavid B Parkinson
Department of Anatomy and Developmental Biology, University College London, Gower Street, UK
Mol Cell Neurosci 23:13-27. 2003..Thus the axonal signals responsible for myelination are only partially transduced in Schwann cells by mechanisms that depend on Krox-20... - Mouse schwann cells need both NRG1 and cyclic AMP to myelinatePeter Arthur-Farraj
Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Glia 59:720-33. 2011..They demonstrate unambiguously the promyelin effects of NRG1 in purified cells, and they show that the cAMP pathway determines whether NRG1 drives proliferation or induces myelin differentiation... - The trunk neural crest and its early glial derivatives: a study of survival responses, developmental schedules and autocrine mechanismsAshwin Woodhoo
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
Mol Cell Neurosci 25:30-41. 2004..They show that survival mechanisms among PNS glia differ early in development and that satellite cell development runs ahead of schedule compared to Schwann cells in several significant features... - Negative regulation of myelination: relevance for development, injury, and demyelinating diseaseKristjan R Jessen
Department of Cell and Developmental Biology, University College London, London, United Kingdom
Glia 56:1552-65. 2008..In neuropathies, however, activation of these pathways is likely to be harmful because they may be key contributors to demyelination, a situation which would open new routes for clinical intervention... - Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous systemMaria B Duran Alonso
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
J Biol Chem 279:25653-64. 2004..Zfp-57 mRNA is up-regulated in Schwann cells in response to leukemia inhibitory factor and fibroblast growth factor 2... - c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signalingXavier Fontana
Mammalian Genetics Laboratory, Cancer Research UK, London Research Institute, London, England, UK
J Cell Biol 198:127-41. 2012..These results reveal an unexpected function for c-Jun in SCs in response to axonal injury, and identify paracrine Ret signaling as an important mediator of c-Jun function in SCs during regeneration... - Gene profiling and bioinformatic analysis of Schwann cell embryonic development and myelinationDavid Michalovich
Department of Anatomy and Developmental Biology, University College London, London, United Kingdom
Glia 53:501-15. 2006.... - The origin and development of glial cells in peripheral nervesKristjan R Jessen
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
Nat Rev Neurosci 6:671-82. 2005..Embryonic nerves therefore offer a particular opportunity to analyse the early steps of gliogenesis from transient multipotent stem cells, and to understand how this process is integrated with organogenesis of peripheral nerves... - A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytesNatalia Kazakova
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
Dev Biol 297:1-13. 2006..Timed application of the RA synthesis inhibitor DEAB to wild type embryos showed that RA signalling is required at least 48 h before the onset of myelin protein synthesis in both CNS and PNS... - beta-Neuregulin and autocrine mediated survival of Schwann cells requires activity of Ets family transcription factorsDavid B Parkinson
Department of Anatomy and Developmental Biology, University College London, Gower Street, United Kingdom
Mol Cell Neurosci 20:154-67. 2002..These data demonstrate that distinct autocrine and beta-neuregulin survival signals converge in their requirement for Ets dependent transcription in Schwann cell survival... - c-Jun expression in human neuropathies: a pilot studyElspeth J Hutton
MRC Centre for Neuromuscular Diseases, Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK
J Peripher Nerv Syst 16:295-303. 2011..Pathological dermal myelinated nerve fibres also show clear nuclear c-Jun expression. Further studies of c-Jun expression will help clarify its role in human neuropathies... - Role of N-cadherin in Schwann cell precursors of growing nervesIna B Wanner
Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, Florida 33136, USA
Glia 54:439-59. 2006.... - Novel method for studying myelination in vivo reveals that EDTA is a potent inhibitor of myelin protein and mRNA expression during development of the rat sciatic nerveStathis Meintanis
Department of Biochemistry, Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 115 21 Athens, Greece
Glia 48:132-44. 2004.... - Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIFGeorge K Tofaris
Cambridge Centre for Brain Repair and Department of Neurology, University of Cambridge, Cambridge CB2 2PY, United Kingdom
J Neurosci 22:6696-703. 2002..They also provide evidence for an autocrine-signaling cascade involving IL-6, LIF, and MCP-1, which amplifies the Schwann cell-derived chemotactic signals gradually, in agreement with the delayed entry of macrophages to injured nerves... - Desert hedgehog-patched 2 expression in peripheral nerves during Wallerian degeneration and regenerationSepideh N Bajestan
Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Neurobiol 66:243-55. 2006..These results suggest that the Dhh-Ptc2 signaling pathway may be involved in the maintenance of adult nerves and may be one of the factors that directly or indirectly determines the response of peripheral nerves to injury...