Amy L Milton

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 26:5881-7. 2006
  2. doi request reprint Drink, drugs and disruption: memory manipulation for the treatment of addiction
    A L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
    Curr Opin Neurobiol 23:706-12. 2013
  3. doi request reprint Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory
    Amy L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 33:1109-15. 2013
  4. doi request reprint The persistence of maladaptive memory: addiction, drug memories and anti-relapse treatments
    Amy L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
    Neurosci Biobehav Rev 36:1119-39. 2012
  5. doi request reprint Antagonism at NMDA receptors, but not β-adrenergic receptors, disrupts the reconsolidation of pavlovian conditioned approach and instrumental transfer for ethanol-associated conditioned stimuli
    Amy L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 219:751-61. 2012
  6. doi request reprint The psychological and neurochemical mechanisms of drug memory reconsolidation: implications for the treatment of addiction
    Amy L Milton
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Eur J Neurosci 31:2308-19. 2010
  7. ncbi request reprint Intra-amygdala and systemic antagonism of NMDA receptors prevents the reconsolidation of drug-associated memory and impairs subsequently both novel and previously acquired drug-seeking behaviors
    Amy L Milton
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:8230-7. 2008
  8. doi request reprint Reconsolidation of appetitive memories for both natural and drug reinforcement is dependent on {beta}-adrenergic receptors
    Amy L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
    Learn Mem 15:88-92. 2008
  9. ncbi request reprint Reconsolidation and extinction of conditioned fear: inhibition and potentiation
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 26:10051-6. 2006
  10. pmc The basolateral amygdala and nucleus accumbens core mediate dissociable aspects of drug memory reconsolidation
    Florence R M Theberge
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Learn Mem 17:444-53. 2010

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Cue-induced cocaine seeking and relapse are reduced by disruption of drug memory reconsolidation
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 26:5881-7. 2006
    ..Reconsolidation blockade may thus provide a potential therapeutic strategy for the prevention of relapse in drug addiction...
  2. doi request reprint Drink, drugs and disruption: memory manipulation for the treatment of addiction
    A L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
    Curr Opin Neurobiol 23:706-12. 2013
    ..More work is needed before these therapies are ready for translation to the clinic, but if found clinically effective memory manipulation promises a radical new way of treating addiction. ..
  3. doi request reprint Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory
    Amy L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 33:1109-15. 2013
    ..These data demonstrate that glutamatergic signaling mechanisms within the basolateral amygdala differentially and dissociably mediate the retrieval, destabilization, and restabilization of previously consolidated fear memories...
  4. doi request reprint The persistence of maladaptive memory: addiction, drug memories and anti-relapse treatments
    Amy L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
    Neurosci Biobehav Rev 36:1119-39. 2012
    ..Understanding the psychological, neurobiological and molecular basis of these drug memories may produce new methods of pro-abstinence, anti-relapse treatments for addiction...
  5. doi request reprint Antagonism at NMDA receptors, but not β-adrenergic receptors, disrupts the reconsolidation of pavlovian conditioned approach and instrumental transfer for ethanol-associated conditioned stimuli
    Amy L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 219:751-61. 2012
    ..However, it is unknown whether the drug cue memory representations underlying conditioned approach and PIT depend upon the same mechanisms...
  6. doi request reprint The psychological and neurochemical mechanisms of drug memory reconsolidation: implications for the treatment of addiction
    Amy L Milton
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Eur J Neurosci 31:2308-19. 2010
    ..We also discuss here the subsequent translation to the clinic of this preclinical work...
  7. ncbi request reprint Intra-amygdala and systemic antagonism of NMDA receptors prevents the reconsolidation of drug-associated memory and impairs subsequently both novel and previously acquired drug-seeking behaviors
    Amy L Milton
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:8230-7. 2008
    ..These data suggest that drugs modulating glutamatergic transmission at the NMDA receptor may be useful in the future treatment of relapse prevention in drug addiction through memory reconsolidation blockade...
  8. doi request reprint Reconsolidation of appetitive memories for both natural and drug reinforcement is dependent on {beta}-adrenergic receptors
    Amy L Milton
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
    Learn Mem 15:88-92. 2008
    ....
  9. ncbi request reprint Reconsolidation and extinction of conditioned fear: inhibition and potentiation
    Jonathan L C Lee
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 26:10051-6. 2006
    ..These results have important implications for the use of reconsolidation blockade and potentiation of extinction as treatment strategies for maladaptive memory disorders...
  10. pmc The basolateral amygdala and nucleus accumbens core mediate dissociable aspects of drug memory reconsolidation
    Florence R M Theberge
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Learn Mem 17:444-53. 2010
    ..However reconsolidation of memory representations formed during Pavlovian conditioning are differentially localized in each site...
  11. doi request reprint Reconsolidation and extinction are dissociable and mutually exclusive processes: behavioral and molecular evidence
    Emiliano Merlo
    Behavioural and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 34:2422-31. 2014
    ....