Nicholas L Mills

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Global association of air pollution and heart failure: a systematic review and meta-analysis
    Anoop S V Shah
    BHF University Centre for Cardiovascular Science, University of Edinburgh, UK
    Lancet 382:1039-48. 2013
  2. pmc Diesel exhaust but not ozone increases fraction of exhaled nitric oxide in a randomized controlled experimental exposure study of healthy human subjects
    Stefan Barath
    Department of Public Health and Clinical Medicine, Division of Medicine, Umea University, Umea, Sweden
    Environ Health 12:36. 2013
  3. pmc Implications of lowering threshold of plasma troponin concentration in diagnosis of myocardial infarction: cohort study
    Nicholas L Mills
    BHF University Centre for Cardiovascular Science, Edinburgh University, UK
    BMJ 344:e1533. 2012
  4. pmc Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions
    Stefan Barath
    Department of Public Health and Clinical Medicine, Umea University, Sweden
    Part Fibre Toxicol 7:19. 2010
  5. pmc Exposure to diesel exhaust induces changes in EEG in human volunteers
    Bjorn Cruts
    Centre of Expertise in Life Sciences, Zuyd University, Heerlen, The Netherlands
    Part Fibre Toxicol 5:4. 2008
  6. pmc Experimental exposure to diesel exhaust increases arterial stiffness in man
    Magnus Lundback
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    Part Fibre Toxicol 6:7. 2009
  7. pmc Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust
    Sofian Metassan
    Division of Cardiovascular and Diabetes Research, Section on Mechanisms of Thrombosis, Leeds Institute for Genetics Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, UK
    Part Fibre Toxicol 7:17. 2010
  8. doi Implementation of a sensitive troponin I assay and risk of recurrent myocardial infarction and death in patients with suspected acute coronary syndrome
    Nicholas L Mills
    University British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Chancellor s Bldg, Edinburgh EH16 4SB, Scotland
    JAMA 305:1210-6. 2011
  9. doi Diesel exhaust inhalation does not affect heart rhythm or heart rate variability
    Nicholas L Mills
    Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK
    Heart 97:544-50. 2011
  10. ncbi Do inhaled carbon nanoparticles translocate directly into the circulation in humans?
    Nicholas L Mills
    Centre for Cardiovascular Science, The University of Edinburgh, Chancellor s Building, Edinburgh EH16 4SB, UK
    Am J Respir Crit Care Med 173:426-31. 2006

Detail Information

Publications53

  1. pmc Global association of air pollution and heart failure: a systematic review and meta-analysis
    Anoop S V Shah
    BHF University Centre for Cardiovascular Science, University of Edinburgh, UK
    Lancet 382:1039-48. 2013
    ..We did a systematic review and meta-analysis to assess the association between air pollution and acute decompensated heart failure including hospitalisation and heart failure mortality...
  2. pmc Diesel exhaust but not ozone increases fraction of exhaled nitric oxide in a randomized controlled experimental exposure study of healthy human subjects
    Stefan Barath
    Department of Public Health and Clinical Medicine, Division of Medicine, Umea University, Umea, Sweden
    Environ Health 12:36. 2013
    ..We evaluated FENO as a measure of airway inflammation after controlled exposure to diesel exhaust or ozone...
  3. pmc Implications of lowering threshold of plasma troponin concentration in diagnosis of myocardial infarction: cohort study
    Nicholas L Mills
    BHF University Centre for Cardiovascular Science, Edinburgh University, UK
    BMJ 344:e1533. 2012
    ..To assess the relation between troponin concentration, assay precision, and clinical outcomes in patients with suspected acute coronary syndrome...
  4. pmc Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions
    Stefan Barath
    Department of Public Health and Clinical Medicine, Umea University, Sweden
    Part Fibre Toxicol 7:19. 2010
    ..Controlled human exposure studies have demonstrated impaired vascular function after inhalation of exhaust generated by a diesel engine under idling conditions...
  5. pmc Exposure to diesel exhaust induces changes in EEG in human volunteers
    Bjorn Cruts
    Centre of Expertise in Life Sciences, Zuyd University, Heerlen, The Netherlands
    Part Fibre Toxicol 5:4. 2008
    ..abstract:..
  6. pmc Experimental exposure to diesel exhaust increases arterial stiffness in man
    Magnus Lundback
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    Part Fibre Toxicol 6:7. 2009
    ..abstract:..
  7. pmc Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust
    Sofian Metassan
    Division of Cardiovascular and Diabetes Research, Section on Mechanisms of Thrombosis, Leeds Institute for Genetics Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, UK
    Part Fibre Toxicol 7:17. 2010
    ..These data show that there are no prothrombotic changes in fibrin clot structure in young, healthy individuals exposed to diesel exhaust...
  8. doi Implementation of a sensitive troponin I assay and risk of recurrent myocardial infarction and death in patients with suspected acute coronary syndrome
    Nicholas L Mills
    University British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Chancellor s Bldg, Edinburgh EH16 4SB, Scotland
    JAMA 305:1210-6. 2011
    ....
  9. doi Diesel exhaust inhalation does not affect heart rhythm or heart rate variability
    Nicholas L Mills
    Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK
    Heart 97:544-50. 2011
    ..This study was undertaken to determine the effect of diesel exhaust inhalation on heart rhythm and heart rate variability in healthy volunteers and patients with coronary heart disease...
  10. ncbi Do inhaled carbon nanoparticles translocate directly into the circulation in humans?
    Nicholas L Mills
    Centre for Cardiovascular Science, The University of Edinburgh, Chancellor s Building, Edinburgh EH16 4SB, UK
    Am J Respir Crit Care Med 173:426-31. 2006
    ..It has been suggested that the nanoparticulate component of PM(10) is capable of translocating into the circulation with the potential for direct effects on the vasculature...
  11. ncbi Adverse cardiovascular effects of air pollution
    Nicholas L Mills
    Centre for Cardiovascular Science, University of Edinburgh, UK
    Nat Clin Pract Cardiovasc Med 6:36-44. 2009
    ..An increased understanding of the mediators and mechanisms of these processes is necessary if we are to develop strategies to protect individuals at risk and reduce the effect of air pollution on cardiovascular disease...
  12. pmc Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease
    Nicholas L Mills
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 116:709-15. 2008
    ..Exposure to fine particulate air pollution is associated with increased cardiovascular morbidity and mortality. We previously demonstrated that exposure to dilute diesel exhaust causes vascular dysfunction in humans...
  13. ncbi Air pollution and atherothrombosis
    Nicholas L Mills
    Centre for Cardiovascular Science, Edinburgh University, Edinburgh, United Kingdom
    Inhal Toxicol 19:81-9. 2007
    ....
  14. ncbi Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease
    Nicholas L Mills
    Centre for Cardiovascular Science, Edinburgh University, Edinburgh, Sweden
    N Engl J Med 357:1075-82. 2007
    ..We conducted a controlled exposure to dilute diesel exhaust in patients with stable coronary heart disease to determine the direct effect of air pollution on myocardial, vascular, and fibrinolytic function...
  15. ncbi Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis
    Nicholas L Mills
    Centre for Cardiovascular Science, Edinburgh University, Edinburgh, Scotland
    Circulation 112:3930-6. 2005
    ..The study aim was to investigate the effects of diesel exhaust inhalation on vascular and endothelial function in humans...
  16. ncbi Dissociation of phenotypic and functional endothelial progenitor cells in patients undergoing percutaneous coronary intervention
    N L Mills
    Centre for Cardiovascular Science, University of Edinburgh, Chancellor s Building, Edinburgh, EH16 4SU, UK
    Heart 95:2003-8. 2009
    ..We assessed the effect of local vascular injury during percutaneous coronary intervention (PCI) on circulating EPCs in patients with coronary artery disease...
  17. ncbi Exposure to nitrogen dioxide is not associated with vascular dysfunction in man
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, University of Edinburgh, United Kingdom
    Inhal Toxicol 22:192-8. 2010
    ..It is unclear whether these effects are mediated through combustion-derived particulate matter or gaseous components, such as nitrogen dioxide...
  18. pmc Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man
    Jeremy P Langrish
    University British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    J Am Heart Assoc 2:e004309. 2013
    ..Diesel exhaust inhalation causes cardiovascular dysfunction including impaired vascular reactivity, increased blood pressure, and arterial stiffness. We investigated the role of nitric oxide (NO) bioavailability in mediating these effects...
  19. pmc Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation
    Nicholas L Mills
    The BHF University Centre for Cardiovascular Science, Edinburgh University, The Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Eur Heart J 32:2660-71. 2011
    ..We assess the role of combustion-derived-nanoparticles in mediating the adverse cardiovascular effects of air pollution...
  20. ncbi Vascular dysfunction in chronic obstructive pulmonary disease
    John D Maclay
    Centre for Inflammation Research, Edinburgh University, Edinburgh, United Kingdom
    Am J Respir Crit Care Med 180:513-20. 2009
    ..It is unclear whether such associations relate to the presence of COPD or prior smoking habit...
  21. doi Particle traps prevent adverse vascular and prothrombotic effects of diesel engine exhaust inhalation in men
    Andrew J Lucking
    University of Edinburgh, Royal Infirmary, 49 Little France Crescent, Edinburgh, UK
    Circulation 123:1721-8. 2011
    ..The aim of the present study was to establish whether an exhaust particle trap could prevent these adverse cardiovascular effects in men...
  22. doi Nanoparticles and the cardiovascular system: a critical review
    Ken Donaldson
    Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Nanomedicine (Lond) 8:403-23. 2013
    ....
  23. ncbi Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humans
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, University of Edinburgh, 49 Little France Crescent, Edinburgh, United Kingdom
    Hypertension 54:910-5. 2009
    ..Given the tonic interaction between the ET and NO systems, we conclude that diesel exhaust inhalation alters vascular reactivity to ET-1 probably through its effects on NO bioavailability...
  24. ncbi The constituents and mechanisms of generation of 'endothelial cell--colony forming units'
    Gareth J Padfield
    British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Chancellor s Building, Edinburgh EH16 4SU, UK
    Cardiovasc Res 100:288-96. 2013
    ..The formation of endothelial cell-colony forming units (EC-CFUs) is increased by vascular injury, although their function in vivo is unclear. We, therefore, examined the constituents of EC-CFUs and the mechanisms of their generation...
  25. pmc Cardiovascular effects of tumour necrosis factor α antagonism in patients with acute myocardial infarction: a first in human study
    Gareth J Padfield
    British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Heart 99:1330-5. 2013
    ..We wished to determine the effects of TNF-α antagonism on endothelial function and platelet activation in patients with acute myocardial infarction...
  26. pmc Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease
    Jeremy P Langrish
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 120:367-72. 2012
    ..Air pollution exposure increases cardiovascular morbidity and mortality and is a major global public health concern...
  27. ncbi Diesel exhaust inhalation increases thrombus formation in man
    Andrew J Lucking
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Eur Heart J 29:3043-51. 2008
    ..The aim of this study is to investigate the effect of diesel exhaust inhalation on platelet activation and thrombus formation in men...
  28. pmc Diesel exhaust particulate increases the size and complexity of lesions in atherosclerotic mice
    Mark R Miller
    Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, EH16 4TJ Edinburgh, Scotland, UK
    Part Fibre Toxicol 10:61. 2013
    ..We hypothesized that DEP exposure would increase and destabilise atherosclerotic lesions in apolipoprotein E deficient (ApoE-/-) mice...
  29. doi Late outgrowth endothelial cells resemble mature endothelial cells and are not derived from bone marrow
    Olga Tura
    MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Stem Cells 31:338-48. 2013
    ..Our findings suggest that EOC do not arise from bone marrow and challenge the concept of a bone marrow-derived circulating precursor for endothelial cells...
  30. ncbi Increased platelet activation in patients with stable and acute exacerbation of COPD
    John D Maclay
    ELEGI Colt Laboratories, Centre for Inflammation Research, Edinburgh University, Edinburgh, UK
    Thorax 66:769-74. 2011
    ..Interaction between inflammatory cells and activated platelets is important in the pathogenesis of atherothrombosis and may contribute to cardiovascular risk in patients with COPD...
  31. doi Diagnosis of myocardial infarction following hospitalisation for exacerbation of COPD
    David A McAllister
    ELEGI Colt Laboratories, Queens Medial Research Institute, University of Edinburgh, Edinburgh, UK
    Eur Respir J 39:1097-103. 2012
    ..Overall, one in 12 patients met the criteria for myocardial infarction. Whether these patients would benefit from further cardiac investigation is unknown...
  32. pmc Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease
    David A McAllister
    ELEGI Colt Laboratories, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH164SB UK
    Am J Respir Crit Care Med 176:1208-14. 2007
    ....
  33. pmc Controlled exposures to air pollutants and risk of cardiac arrhythmia
    Jeremy P Langrish
    University of Edinburgh, University BHF Centre for Cardiovascular Science, Edinburgh, United Kingdom
    Environ Health Perspect 122:747-53. 2014
    ..Exposure to air pollutants can influence cardiac autonomic tone and reduce heart rate variability, and may increase the risk of cardiac arrhythmias, particularly in susceptible patient groups...
  34. pmc Forced expiratory volume in one second predicts length of stay and in-hospital mortality in patients undergoing cardiac surgery: a retrospective cohort study
    David A McAllister
    Centre for Population Health Sciences, University of Edinburgh, Midlothian, Edinburgh, United Kingdom
    PLoS ONE 8:e64565. 2013
    ..Objective measurements of physiological reserve and severity of co-morbid disease are required to improve risk stratification. We hypothesised that FEV1 would predict mortality and length of stay following cardiac surgery...
  35. doi Endothelial progenitor cells, atheroma burden and clinical outcome in patients with coronary artery disease
    Gareth J Padfield
    British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, Chancellor s Building, Edinburgh EH16 4SU, UK
    Heart 99:791-8. 2013
    ....
  36. doi Systemic elastin degradation in chronic obstructive pulmonary disease
    John D Maclay
    ELEGI Colt Laboratory, Queen s Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Thorax 67:606-12. 2012
    ..Development of emphysema and vascular stiffness in chronic obstructive pulmonary disease (COPD) may be due to a common mechanism of susceptibility to pulmonary and systemic elastin degradation...
  37. pmc Circulating endothelial progenitor cells are not affected by acute systemic inflammation
    Gareth J Padfield
    Centre for Cardiovascular Science, Univ of Edinburgh, Chancellor s Bldg, Edinburgh EH16 4SU, UK
    Am J Physiol Heart Circ Physiol 298:H2054-61. 2010
    ..We suggest that systemic inflammation is not the primary stimulus for EPC mobilization after acute vascular injury...
  38. pmc Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals
    Mark R Miller
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 117:611-6. 2009
    ..Diesel exhaust particulate (DEP) is a key arbiter of the adverse cardiovascular effects of air pollution...
  39. pmc Nanoparticles-a thoracic toxicology perspective
    Rodger Duffin
    MRC University of Edinburgh Centre for Inflammation Research, ELEGI Colt Laboratory, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK
    Yonsei Med J 48:561-72. 2007
    ..Bridging our toxicological knowledge between the environmental nanoparticles and the new engineered nanoparticles is a considerable challenge...
  40. ncbi 18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial
    Nikhil V Joshi
    Centre for Cardiovascular Science, Clinical Research Imaging Centre, and Division of Pathology, University of Edinburgh, Edinburgh, UK Electronic address
    Lancet 383:705-13. 2014
    ..We used combined PET and CT to identify ruptured and high-risk atherosclerotic plaques using the radioactive tracers (18)F-sodium fluoride ((18)F-NaF) and (18)F-fluorodeoxyglucose ((18)F-FDG)...
  41. pmc Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial
    David E Newby
    University of Edinburgh BHF Centre for Cardiovascular Science, Chancellor s Building, 49 Little France Crescent, Edinburgh, EH16 SU4, UK
    Trials 13:184. 2012
    ..However, this technology has not been robustly evaluated in its application to the clinic...
  42. doi Influence of the menstrual cycle, pregnancy, and preeclampsia on arterial stiffness
    Amy O Robb
    Centres for Reproductive Biology, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Hypertension 53:952-8. 2009
    ..These effects may contribute to adverse cardiovascular outcomes of pregnancy and preeclampsia...
  43. doi Cardiovascular effects of physiological and standard sex steroid replacement regimens in premature ovarian failure
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, EH16 4SA United Kingdom
    Hypertension 53:805-11. 2009
    ..These findings have major implications for the future cardiovascular health of young women who require long-term sex steroid replacement therapy...
  44. pmc Cardiovascular effects of a novel SIRT1 activator, SRT2104, in otherwise healthy cigarette smokers
    Sowmya Venkatasubramanian
    Centre for Cardiovascular Science, University of Edinburgh, UK
    J Am Heart Assoc 2:e000042. 2013
    ..We examined the effect of the oral SIRT1 activator SRT2104 on cardiovascular function in otherwise healthy cigarette smokers...
  45. doi Novel biopolymers to enhance endothelialisation of intra-vascular devices
    Salvatore Pernagallo
    School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, UK
    Adv Healthc Mater 1:646-56. 2012
    ....
  46. pmc Beneficial cardiovascular effects of reducing exposure to particulate air pollution with a simple facemask
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, Edinburgh University, Edinburgh, UK
    Part Fibre Toxicol 6:8. 2009
    ..abstract:..
  47. ncbi Understanding the role of endothelial progenitor cells in percutaneous coronary intervention
    Gareth J Padfield
    Centre for Cardiovascular Science, Edinburgh University, Edinburgh, United Kingdom
    J Am Coll Cardiol 55:1553-65. 2010
    ..Therapies designed to mobilize endothelial progenitors or to increase their ability to home to the site of stent implantation may have a role in the future management of patients undergoing percutaneous coronary intervention...
  48. pmc Systematic assessment in an animal model of the angiogenic potential of different human cell sources for therapeutic revascularization
    G Robin Barclay
    SNBTS Cell Therapy Research Group, Scottish Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Stem Cell Res Ther 3:23. 2012
    ..It should be possible to produce autologous EOC for therapeutic use, and evaluate the effect of EPC distinct from, or in synergy with, the proangiogenic effects of HPC therapies...
  49. doi Sensitive troponin assay predicts outcome in syncope
    Matthew J Reed
    Emergency Medicine Research Group Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, UK
    Emerg Med J 29:1001-3. 2012
    ..To assess whether plasma troponin concentration measured by a sensitive assay can predict 1-month and 1-year serious outcome, or all-cause death in patients presenting with syncope to the emergency department (ED)...
  50. doi In vivo mononuclear cell tracking using superparamagnetic particles of iron oxide: feasibility and safety in humans
    Jennifer M J Richards
    Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Circ Cardiovasc Imaging 5:509-17. 2012
    ....
  51. doi Reducing exposure to airborne particles: a novel strategy to improve cardiovascular health
    Nicholas L Mills
    Am J Respir Crit Care Med 177:366-7. 2008
  52. ncbi Persistent endothelial dysfunction in humans after diesel exhaust inhalation
    Håkan Törnqvist
    Department of Respiratory Medicine and Allergy, Umea University Hospital, SE 901 85 Umea, Sweden
    Am J Respir Crit Care Med 176:395-400. 2007
    ..We have previously demonstrated that inhalation of diesel exhaust causes an immediate (within 2 h) impairment of vascular and endothelial function in humans...