O R Millington

Summary

Affiliation: University of Strathclyde
Country: UK

Publications

  1. ncbi Imaging of the host/parasite interplay in cutaneous leishmaniasis
    Owain R Millington
    Centre for Biophotonics, University of Strathclyde, Glasgow G4 0NR, UK
    Exp Parasitol 126:310-7. 2010
  2. ncbi Lymphocyte tracking and interactions in secondary lymphoid organs
    O R Millington
    Centre for Biophotonics, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0NR, UK
    Inflamm Res 56:391-401. 2007
  3. ncbi Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function
    Owain R Millington
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    J Biol 5:5. 2006
  4. ncbi Advances in imaging of new targets for pharmacological intervention in stroke: real-time tracking of T-cells in the ischaemic brain
    F Ortolano
    Centre for Biophotonics, University of Strathclyde, Glasgow, UK
    Br J Pharmacol 159:808-11. 2010
  5. ncbi Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells
    Owain R Millington
    Centre for Biophotonics, University of Strathclyde, Glasgow, United Kingdom
    PLoS Pathog 3:1380-7. 2007
  6. ncbi Imaging T-cell movement in the brain during experimental cerebral malaria
    F Ortolano
    Centre for Biophotonics, University of Strathclyde, Glasgow, UK
    Parasite Immunol 31:147-50. 2009
  7. ncbi Tracking lymphocytes in vivo
    Claire L Adams
    University of Glasgow, Western Infirmary, Glasgow, Scotland, UK
    Arch Immunol Ther Exp (Warsz) 52:173-87. 2004
  8. ncbi Characterization of CD4+ T-cell-dendritic cell interactions during secondary antigen exposure in tolerance and priming
    Catherine M Rush
    Centre for Biophotonics, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Immunology 128:463-71. 2009
  9. ncbi Murine neutrophils present Class II restricted antigen
    Shauna Culshaw
    Centre for Rheumatic Diseases, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Immunol Lett 118:49-54. 2008
  10. ncbi Immunomodulatory dendritic cells in intestinal lamina propria
    Fernando G Chirdo
    Division of Immunology, Infection and Inflammation, Western Infirmary, Glasgow, Scotland
    Eur J Immunol 35:1831-40. 2005

Collaborators

Detail Information

Publications16

  1. ncbi Imaging of the host/parasite interplay in cutaneous leishmaniasis
    Owain R Millington
    Centre for Biophotonics, University of Strathclyde, Glasgow G4 0NR, UK
    Exp Parasitol 126:310-7. 2010
    ..Here, we review some of the recent developments and discuss how these observations can be further developed to understand the immunology of cutaneous Leishmania infection in vivo...
  2. ncbi Lymphocyte tracking and interactions in secondary lymphoid organs
    O R Millington
    Centre for Biophotonics, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0NR, UK
    Inflamm Res 56:391-401. 2007
    ..Here we review some of these recent studies that provide a valuable insight into the mechanisms involved in the induction of immunity...
  3. ncbi Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function
    Owain R Millington
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK
    J Biol 5:5. 2006
    ....
  4. ncbi Advances in imaging of new targets for pharmacological intervention in stroke: real-time tracking of T-cells in the ischaemic brain
    F Ortolano
    Centre for Biophotonics, University of Strathclyde, Glasgow, UK
    Br J Pharmacol 159:808-11. 2010
    ..We aim to extend the technique of real-time in situ brain imaging of T-cells, previously shown in models of immunological diseases, to models of experimental stroke...
  5. ncbi Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells
    Owain R Millington
    Centre for Biophotonics, University of Strathclyde, Glasgow, United Kingdom
    PLoS Pathog 3:1380-7. 2007
    ..This altered cellular behaviour is associated with the suppression of DC costimulatory activity and functional T cell responses, potentially explaining why immunity is reduced during malaria infection...
  6. ncbi Imaging T-cell movement in the brain during experimental cerebral malaria
    F Ortolano
    Centre for Biophotonics, University of Strathclyde, Glasgow, UK
    Parasite Immunol 31:147-50. 2009
    ..We believe that this approach will help define host-parasite interactions and examine how intervening in these relationships affects the development of cerebral pathology...
  7. ncbi Tracking lymphocytes in vivo
    Claire L Adams
    University of Glasgow, Western Infirmary, Glasgow, Scotland, UK
    Arch Immunol Ther Exp (Warsz) 52:173-87. 2004
    ..This review summarizes some of the ways in which these techniques have led to discoveries in the role of signaling cascades, cell cycle progression, and apoptosis in maintaining an Ag-specific immune response...
  8. ncbi Characterization of CD4+ T-cell-dendritic cell interactions during secondary antigen exposure in tolerance and priming
    Catherine M Rush
    Centre for Biophotonics, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Immunology 128:463-71. 2009
    ..These findings have important consequences for many immunotherapeutics, which aim to manipulate secondary immune responses...
  9. ncbi Murine neutrophils present Class II restricted antigen
    Shauna Culshaw
    Centre for Rheumatic Diseases, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Immunol Lett 118:49-54. 2008
    ..These studies demonstrate that murine neutrophils present MHC Class II-restricted peptides and induce T cell proliferation, confirming findings in human neutrophils, and demonstrate a novel pro inflammatory effect of murine neutrophils...
  10. ncbi Immunomodulatory dendritic cells in intestinal lamina propria
    Fernando G Chirdo
    Division of Immunology, Infection and Inflammation, Western Infirmary, Glasgow, Scotland
    Eur J Immunol 35:1831-40. 2005
    ..LP DC also expressed significant levels of mRNA for IL-10 and type I IFN, but not IL-12, suggesting they may play a central and unique role in immune homeostasis in the gut...
  11. ncbi Imaging interactions between the immune and cardiovascular systems in vivo by multiphoton microscopy
    Owain R Millington
    Centre for Biophotonics, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Methods Mol Biol 616:193-206. 2010
    ..These methods provide an insight into the mechanisms involved in the activation and function of immune cells in vivo...
  12. ncbi Interleukin-15 is not required for the induction or maintenance of orally induced peripheral tolerance
    Owain R Millington
    Division of Immunology, Infection and Inflammation, Western Infirmary, University of Glasgow, UK
    Immunology 113:304-9. 2004
    ..Thus, oral tolerance does not involve an IL-15-dependent mechanism...
  13. ncbi In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance
    Bernd H Zinselmeyer
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Glasgow G11 6NT, Scotland, UK
    J Exp Med 201:1815-23. 2005
    ..This is the first comparison of the behavior of antigen-specific CD4+ T cells in situ in mucosal and systemic lymphoid tissues during the induction of priming versus tolerance in a physiologically relevant model in vivo...
  14. ncbi Induction of bystander suppression by feeding antigen occurs despite normal clonal expansion of the bystander T cell population
    Owain R Millington
    Division of Immunology, Infection, and Inflammation, University of Glasgow, Western Infirmary, Glasgow G11 6NT, Scotland, United Kingdom
    J Immunol 173:6059-64. 2004
    ..Thus, bystander suppression does not reflect clonal deletion or reduced clonal expansion of the bystander T cells, but may act by altering the functional differentiation of bystander T cells...
  15. ncbi Oral tolerance: overview and historical perspectives
    Allan McI Mowat
    Department of Immunology and Bacteriology, University of Glasgow, Western Infirmary, Glasgow, Scotland, UK
    Ann N Y Acad Sci 1029:1-8. 2004
    ..Dendritic cells in the Peyer's patches or mucosal lamina propria are the most likely APCs involved, but it remains to be determined exactly where these interactions occur and what the precise nature of the relevant dendritic cells is...
  16. ncbi Anatomical and cellular basis of immunity and tolerance in the intestine
    Allan McI Mowat
    Department of Immunology and Bacteriology, Division of Immunology, Inflammation and Infection, University of Glasgow, Western Infirmary, Glasgow, Scotland
    J Pediatr Gastroenterol Nutr 39:S723-4. 2004