Hugh R P Miller

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Expression profiling reveals novel innate and inflammatory responses in the jejunal epithelial compartment during infection with Trichinella spiralis
    Pamela A Knight
    Division of Veterinary Clinical Studies, University of Edinburgh, Roslin, Midlothian, United Kingdom
    Infect Immun 72:6076-86. 2004
  2. pmc Aberrant mucosal mast cell protease expression in the enteric epithelium of nematode-infected mice lacking the integrin alphavbeta6, a transforming growth factor-beta1 activator
    Pamela A Knight
    Dept of Veterinary Clinical Studies, Easter Bush Veterinary Centre, The University of Edinburgh, Midlothian EH25 9RG, UK
    Am J Pathol 171:1237-48. 2007
  3. doi request reprint Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse-high specificity indicates high substrate selectivity
    Mattias K Andersson
    Department of Cell and Molecular Biology, Uppsala University, The Biomedical Center, Box 596, SE 751 24 Uppsala, Sweden
    Mol Immunol 45:2548-58. 2008
  4. pmc Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut
    Hugh R P Miller
    Department of Veterinary Clinical Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, UK
    Immunology 105:375-90. 2002
  5. pmc Expression of integrin-alphaE by mucosal mast cells in the intestinal epithelium and its absence in nematode-infected mice lacking the transforming growth factor-beta1-activating integrin alphavbeta6
    Jeremy K Brown
    Department of Veterinary Clinical Studies, Easter Bush Veterinary Centre, The University of Edinburgh, Midlothian, Scotland, United Kingdom
    Am J Pathol 165:95-106. 2004
  6. ncbi request reprint Trichinella spiralis induces de novo expression of group IVC phospholipase A2 in the intestinal epithelium
    Jeremy K Brown
    Division of Veterinary Clinical Studies, The University of Edinburgh, Easter Bush Veterinary Centre, Midlothian, EH25 9RG, United Kingdom
    Int J Parasitol 38:143-7. 2008
  7. ncbi request reprint The proteome of mouse mucosal mast cell homologues: the role of transforming growth factor beta1
    Alan D Pemberton
    Division of Veterinary Clinical Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, UK
    Proteomics 6:623-31. 2006
  8. ncbi request reprint Innate BALB/c enteric epithelial responses to Trichinella spiralis: inducible expression of a novel goblet cell lectin, intelectin-2, and its natural deletion in C57BL/10 mice
    Alan D Pemberton
    Division of Veterinary Clinical Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, United Kingdom
    J Immunol 173:1894-901. 2004
  9. ncbi request reprint Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta
    Anne T French
    Division of Veterinary Clinical Sciences, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
    Int J Parasitol 38:467-75. 2008
  10. pmc Expression of three intelectins in sheep and response to a Th2 environment
    Anne T French
    Royal Dick School of Veterinary Studies, Division of Veterinary Clinical Sciences University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, United Kingdom
    Vet Res 40:53. 2009

Collaborators

Detail Information

Publications30

  1. pmc Expression profiling reveals novel innate and inflammatory responses in the jejunal epithelial compartment during infection with Trichinella spiralis
    Pamela A Knight
    Division of Veterinary Clinical Studies, University of Edinburgh, Roslin, Midlothian, United Kingdom
    Infect Immun 72:6076-86. 2004
    ..The early epithelial responses may be associated both with repair (Sprr2A) and with the development of innate immunity (Siat4c and Relmbeta)...
  2. pmc Aberrant mucosal mast cell protease expression in the enteric epithelium of nematode-infected mice lacking the integrin alphavbeta6, a transforming growth factor-beta1 activator
    Pamela A Knight
    Dept of Veterinary Clinical Studies, Easter Bush Veterinary Centre, The University of Edinburgh, Midlothian EH25 9RG, UK
    Am J Pathol 171:1237-48. 2007
    ....
  3. doi request reprint Extended cleavage specificity of mMCP-1, the major mucosal mast cell protease in mouse-high specificity indicates high substrate selectivity
    Mattias K Andersson
    Department of Cell and Molecular Biology, Uppsala University, The Biomedical Center, Box 596, SE 751 24 Uppsala, Sweden
    Mol Immunol 45:2548-58. 2008
    ....
  4. pmc Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut
    Hugh R P Miller
    Department of Veterinary Clinical Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, UK
    Immunology 105:375-90. 2002
    ..Importantly, granule proteinases released extracellularly contribute to the recruitment of inflammatory cells and may thus be involved in innate responses to infection...
  5. pmc Expression of integrin-alphaE by mucosal mast cells in the intestinal epithelium and its absence in nematode-infected mice lacking the transforming growth factor-beta1-activating integrin alphavbeta6
    Jeremy K Brown
    Department of Veterinary Clinical Studies, Easter Bush Veterinary Centre, The University of Edinburgh, Midlothian, Scotland, United Kingdom
    Am J Pathol 165:95-106. 2004
    ..Because a major function of integrin-alpha(v)beta(6) is to activate latent TGF-beta(1,) these findings strongly support a role for TGF-beta(1) in both the recruitment and differentiation of murine MMCs during nematode infection...
  6. ncbi request reprint Trichinella spiralis induces de novo expression of group IVC phospholipase A2 in the intestinal epithelium
    Jeremy K Brown
    Division of Veterinary Clinical Studies, The University of Edinburgh, Easter Bush Veterinary Centre, Midlothian, EH25 9RG, United Kingdom
    Int J Parasitol 38:143-7. 2008
    ..We propose that epithelial PLA2g4c accounts for the increased lysophospholipase activity observed during intestinal nematodiasis and that it plays a major role in the inflammatory response to nematodes...
  7. ncbi request reprint The proteome of mouse mucosal mast cell homologues: the role of transforming growth factor beta1
    Alan D Pemberton
    Division of Veterinary Clinical Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, UK
    Proteomics 6:623-31. 2006
    ..Galectin-1 is located on the cell surface where it mediates cellular adhesion to basement membranes. Regulation of its expression by TGF-beta1 may be of relevance to mast cell adhesion within the epithelium...
  8. ncbi request reprint Innate BALB/c enteric epithelial responses to Trichinella spiralis: inducible expression of a novel goblet cell lectin, intelectin-2, and its natural deletion in C57BL/10 mice
    Alan D Pemberton
    Division of Veterinary Clinical Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, United Kingdom
    J Immunol 173:1894-901. 2004
    ..spiralis infection suggest that this novel lectin may serve a protective role in the innate immune response to parasite infection...
  9. ncbi request reprint Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta
    Anne T French
    Division of Veterinary Clinical Sciences, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
    Int J Parasitol 38:467-75. 2008
    ..Intelectin may play an important role in the mucosal response to gastrointestinal nematode infections in ruminants...
  10. pmc Expression of three intelectins in sheep and response to a Th2 environment
    Anne T French
    Royal Dick School of Veterinary Studies, Division of Veterinary Clinical Sciences University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, United Kingdom
    Vet Res 40:53. 2009
    ..circumcincta challenge infection. Upregulation of sITLN2 and sITLN3 was shown in sheep lung following D. filaria natural infection. Intelectins may play an important role in the mucosal response to nematode infections in ruminants...
  11. ncbi request reprint Integrin-alphavbeta6, a putative receptor for foot-and-mouth disease virus, is constitutively expressed in ruminant airways
    Jeremy K Brown
    Department of Veterinary Clinical Studies, The University of Edinburgh, Easter Bush Veterinary Centre, Midlothian, EH25 9RG, UK
    J Histochem Cytochem 54:807-16. 2006
    ..The latter finding suggests that ruminant airway epithelium presents a highly accessible target for initiation of infection with FMDV by inhalation...
  12. ncbi request reprint TGF-beta 1 regulates adhesion of mucosal mast cell homologues to laminin-1 through expression of integrin alpha 7
    Anne Rosbottom
    Department of Veterinary Pathology, University of Edinburgh, Roslin, Midlothian, UK EH25 9RG
    J Immunol 169:5689-95. 2002
    ..05), demonstrating a novel role for this molecule in adhesion of a hemopoietic cell to laminin-1...
  13. pmc Novel gene expression responses in the ovine abomasal mucosa to infection with the gastric nematode Teladorsagia circumcincta
    Pamela A Knight
    The Roslin Institute and R D SVS, University of Edinburgh, Roslin, Midlothian, EH25 9RG, Scotland, UK
    Vet Res 42:78. 2011
    ..The changes in gene expression levels described here may reflect roles in direct anti-parasitic effects, immuno-modulation or tissue repair...
  14. ncbi request reprint Apical junction complex protein expression in the canine colon: differential expression of claudin-2 in the colonic mucosa in dogs with idiopathic colitis
    Alison E Ridyard
    Division of Veterinary Clinical Studies, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Midlothian, United Kingdom
    J Histochem Cytochem 55:1049-58. 2007
    ..However, claudin-2 expression markedly increased in the proximal crypt and luminal colonic epithelium in affected dogs, suggesting a role in the pathogenesis of canine LPC...
  15. ncbi request reprint The expression of intelectin in sheep goblet cells and upregulation by interleukin-4
    Anne T French
    Division of Veterinary Clinical Sciences, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
    Vet Immunol Immunopathol 120:41-6. 2007
    ..Putative roles for intelectin have included an antibacterial role and an alteration of the character of mucus. Our data suggest ITLNs may play an important role in the mucosal response in allergy and parasitic infections...
  16. ncbi request reprint Anaphylactic release of mucosal mast cell granule proteases: role of serpins in the differential clearance of mouse mast cell proteases-1 and -2
    Alan D Pemberton
    Division of Veterinary Clinical Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, United Kingdom
    J Immunol 176:899-904. 2006
    ....
  17. ncbi request reprint Primary antibody-Fab fragment complexes: a flexible alternative to traditional direct and indirect immunolabeling techniques
    Jeremy K Brown
    Department of Veterinary Clinical Studies, University of Edinburgh, Easter Bush Veterinary Centre, Midlothian EH25 9RG, UK
    J Histochem Cytochem 52:1219-30. 2004
    ....
  18. pmc Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1
    Pamela A Knight
    Department of Veterinary Clinical Studies, University of Edinburgh, Midlothian, Scotland
    Am J Pathol 161:771-9. 2002
    ....
  19. ncbi request reprint Proteomic analysis of mouse jejunal epithelium and its response to infection with the intestinal nematode, Trichinella spiralis
    Alan D Pemberton
    Division of Veterinary Clinical Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, UK
    Proteomics 4:1101-8. 2004
    ..As a result, candidate molecules have been identified for further focused studies on their role in the host response to intestinal nematode infection...
  20. ncbi request reprint Evaluation of Th1, Th2 and immunosuppressive cytokine mRNA expression within the colonic mucosa of dogs with idiopathic lymphocytic-plasmacytic colitis
    Alison E Ridyard
    Department of Veterinary Clinical Studies, Royal Dick School of Veterinary Studies, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
    Vet Immunol Immunopathol 86:205-14. 2002
    ..05). These results indicate that LPC is associated with activation of CD4+ T-helper lymphocytes and increased production of T-helper-1-type cytokines...
  21. ncbi request reprint Chemokine and cytokine expression in murine intestinal epithelium following Nippostrongylus brasiliensis infection
    Anne Rosbottom
    Department of Veterinary Pathology, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, UK
    Parasite Immunol 24:67-75. 2002
    ..In an intestinal epithelial cell line (CMT-93), there was constitutive expression of SCF, TGFalpha1, fractalkine and MCP-1. The results show that, in vivo, epithelium is a potentially important source of mast cell chemoattractants...
  22. ncbi request reprint Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts
    Alan D Pemberton
    Department of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Edinburgh, UK
    Eur J Biochem 269:1171-80. 2002
    ..These results suggest that duodenase can induce pulmonary artery fibroblast DNA synthesis in a PtdIns 3-kinase-dependent manner via a G-protein-coupled receptor which is activated by a proteolytic mechanism...
  23. ncbi request reprint Temporal distribution of distinct mast cell phenotypes during intestinal schistosomiasis in mice
    Frederik De Jonge
    Laboratory of Cell Biology and Histology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
    Parasite Immunol 24:225-31. 2002
    ..The recruitment of each mast cell population is time-dependent and occurs at different locations. These data suggest that mastocytosis is associated with motility-related gastrointestinal symptoms and egg excretion...
  24. pmc Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract
    Alexander M Owyang
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 203:843-9. 2006
    ..Therefore, IL-25 is not only a critical mediator of type 2 immunity, but is also required for the regulation of inflammation in the gastrointestinal tract...
  25. ncbi request reprint Effect of intestinal inflammation on capsaicin-sensitive afferents in the ileum of Schistosoma mansoni-infected mice
    Frederik De Jonge
    Laboratory of Cell Biology and Histology, Department of Biomedical Sciences, University of Antwerp RUCA, Groenenborgerlaan 171, 2020 Antwerp, Belgium
    Histochem Cell Biol 119:477-84. 2003
    ..Morphological evidence is provided of a neuroimmune interaction between mucosal mast cells and EPANs in schistosoma-infected mice...
  26. pmc Mast cells disrupt epithelial barrier function during enteric nematode infection
    Jacqueline R McDermott
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Proc Natl Acad Sci U S A 100:7761-6. 2003
    ..These results provide the mechanism whereby mucosal mast cells mediate parasite expulsion from the intestine...
  27. pmc Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors
    Charlotte L Weller
    Leukocyte Biology Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, England, UK
    J Exp Med 201:1961-71. 2005
    ..Finally, LTB(4) was a potent chemoattractant for human cord blood-derived immature, but not mature, mast cells. These results suggest an autocrine role for LTB(4) in regulating tissue mast cell numbers...
  28. ncbi request reprint The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity
    David Artis
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:5626-34. 2004
    ..In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites...
  29. pmc RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract
    David Artis
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:13596-600. 2004
    ..Together, these results suggest that intestinal goblet cell-derived RELMbeta may be a novel Th2 cytokine-induced immune-effector molecule in resistance to GI nematode infection...
  30. ncbi request reprint Mouse mast cell protease-1 is required for the enteropathy induced by gastrointestinal helminth infection in the mouse
    Catherine E Lawrence
    Department of Immunology, SIBS, Strathclyde University, Glasgow, United Kingdom
    Gastroenterology 127:155-65. 2004
    ..Therefore, the aims of this study were to dissect the role of mast cells and mast cell proteases in the induction of parasite-induced enteropathy...