David Miller

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments
    Peter Connick
    Dept, of Clinical Neurosciences, University of Cambridge, UK
    Trials 12:62. 2011
  2. pmc Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1a
    Ee Tuan Lim
    Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Negat Results Biomed 3:4. 2004
  3. pmc MRI characteristics are predictive for CDMS in monofocal, but not in multifocal patients with a clinically isolated syndrome
    Jessica M Nielsen
    MS Center, Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
    BMC Neurol 9:19. 2009
  4. ncbi request reprint MRI monitoring of MS in clinical trials
    David H Miller
    NMR Research Unit, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK
    Clin Neurol Neurosurg 104:236-43. 2002
  5. ncbi request reprint A controlled trial of natalizumab for relapsing multiple sclerosis
    David H Miller
    Department of Neuroinflammation, Institute of Neurology, London, United Kingdom
    N Engl J Med 348:15-23. 2003
  6. ncbi request reprint Primary-progressive multiple sclerosis
    David H Miller
    Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Lancet Neurol 6:903-12. 2007
  7. ncbi request reprint Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance
    David H Miller
    Department of Neuroinflammation, Institute of Neurology, London, UK
    Brain 125:1676-95. 2002
  8. ncbi request reprint Role of magnetic resonance imaging within diagnostic criteria for multiple sclerosis
    D H Miller
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 56:273-8. 2004
  9. ncbi request reprint MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MS
    D H Miller
    Institute of Neurology, University College London, London, UK
    Neurology 68:1390-401. 2007
  10. ncbi request reprint Overview of London trial of intramuscular interferon-beta Ia in primary-progressive multiple sclerosis
    David H Miller
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:S56-7. 2004

Detail Information

Publications139 found, 100 shown here

  1. pmc The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments
    Peter Connick
    Dept, of Clinical Neurosciences, University of Cambridge, UK
    Trials 12:62. 2011
    ..Illustrated by the MSCIMS trial protocol, we describe a novel methodology based on detailed assessment of the anterior visual pathway as a model of wider disease processes--the "sentinel lesion approach"...
  2. pmc Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1a
    Ee Tuan Lim
    Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Negat Results Biomed 3:4. 2004
    ..Furthermore there is no correlation between S100B levels and the primary and secondary outcome measures...
  3. pmc MRI characteristics are predictive for CDMS in monofocal, but not in multifocal patients with a clinically isolated syndrome
    Jessica M Nielsen
    MS Center, Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
    BMC Neurol 9:19. 2009
    ..Here we assess the predictive value of clinically defined dissemination in space at first presentation for time to clinically definite MS (CDMS)...
  4. ncbi request reprint MRI monitoring of MS in clinical trials
    David H Miller
    NMR Research Unit, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK
    Clin Neurol Neurosurg 104:236-43. 2002
  5. ncbi request reprint A controlled trial of natalizumab for relapsing multiple sclerosis
    David H Miller
    Department of Neuroinflammation, Institute of Neurology, London, United Kingdom
    N Engl J Med 348:15-23. 2003
    ..Natalizumab is an alpha4 integrin antagonist that reduced the development of brain lesions in experimental models and in a preliminary study of patients with multiple sclerosis...
  6. ncbi request reprint Primary-progressive multiple sclerosis
    David H Miller
    Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Lancet Neurol 6:903-12. 2007
    ..Future research should focus on the clarification of the mechanisms of axonal loss, improvements to the design of clinical trials, and the development of effective neuroprotective treatments...
  7. ncbi request reprint Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance
    David H Miller
    Department of Neuroinflammation, Institute of Neurology, London, UK
    Brain 125:1676-95. 2002
    ..Atrophy provides a sensitive measure of the neurodegenerative component of multiple sclerosis and should be measured in trials evaluating potential anti-inflammatory, remyelinating or neuroprotective therapies...
  8. ncbi request reprint Role of magnetic resonance imaging within diagnostic criteria for multiple sclerosis
    D H Miller
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 56:273-8. 2004
    ..The IP criteria are timely and concrete and introduce an important concept to MS diagnosis. Future modifications, based on emerging evidence, should further facilitate their implementation and improve their accuracy...
  9. ncbi request reprint MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MS
    D H Miller
    Institute of Neurology, University College London, London, UK
    Neurology 68:1390-401. 2007
    ..We report the effect of natalizumab on MRI measures from the AFFIRM study...
  10. ncbi request reprint Overview of London trial of intramuscular interferon-beta Ia in primary-progressive multiple sclerosis
    David H Miller
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:S56-7. 2004
    ..A larger study would be required to evaluate treatment on disability in this patient cohort and further work is needed to elucidate the relationship between quantitative MR and clinical measures over the longer term...
  11. ncbi request reprint Multiple sclerosis: new insights and therapeutic progress
    David Miller
    Institute of Neurology, University College London, London, UK
    Lancet Neurol 6:5-6. 2007
  12. pmc Biomarkers and surrogate outcomes in neurodegenerative disease: lessons from multiple sclerosis
    David H Miller
    Multiple Sclerosis NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, London WC1N 3BG, United Kingdom
    NeuroRx 1:284-94. 2004
    ..Because the MR surrogates for neuroaxonal loss are not yet validated as predicting future disability, definitive trials should continue to monitor an appropriate disability endpoint...
  13. ncbi request reprint Clinically isolated syndromes suggestive of multiple sclerosis, part 2: non-conventional MRI, recovery processes, and management
    David Miller
    MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Lancet Neurol 4:341-8. 2005
    ..Continued clinical and laboratory investigation of patients with a CIS should be encouraged...
  14. ncbi request reprint Magnetic resonance studies of abnormalities in the normal appearing white matter and grey matter in multiple sclerosis
    D H Miller
    NMR Research Unit, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol 250:1407-19. 2003
    ..In future, new imaging modalities are needed that provide a more specific measure of histopathological and cellular aspects of the disease process in vivo...
  15. ncbi request reprint Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis
    David Miller
    MS NMR Research Unit, Institute of Neurology, University College London, London, UK
    Lancet Neurol 4:281-8. 2005
    ..Development of more reliable prognostic markers will enable new treatments to be targeted for those who are most likely to benefit. We encourage continued clinical and laboratory assessment of patients with a CIS...
  16. ncbi request reprint Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis
    J Sastre-Garriga
    Institute of Neurology, London, United Kingdom
    Arch Neurol 62:569-73. 2005
    ..Abnormalities in normal-appearing brain tissues may contribute to disability in primary progressive multiple sclerosis (PPMS), where few lesions are seen on conventional imaging...
  17. ncbi request reprint Long-term clinical outcome of primary progressive MS: predictive value of clinical and MRI data
    J Sastre-Garriga
    Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK
    Neurology 65:633-5. 2005
    ..Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS...
  18. pmc Recovery after spinal cord relapse in multiple sclerosis is predicted by radial diffusivity
    Patrick Freund
    Department of Brain Repair and Rehabilitation, NMR Unit, UCL Institute of Neurology, London, UK
    Mult Scler 16:1193-202. 2010
    ....
  19. doi request reprint Cognitive impairment in multiple sclerosis can be predicted by imaging early in the disease
    M Summers
    Institute of Neurology, University College London, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 79:955-8. 2008
    ..Cognitive impairment is common in multiple sclerosis (MS) and adds significantly to the burden of the disease. The ability to predict future cognitive impairment from imaging obtained at disease onset has not been investigated...
  20. ncbi request reprint Gray and white matter volume changes in early RRMS: a 2-year longitudinal study
    M Tiberio
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, London WC1N 3BG, UK
    Neurology 64:1001-7. 2005
    ..Previous work has suggested that at this stage of the disease, gray matter (GM) atrophy progresses more rapidly than the white matter (WM) atrophy...
  21. ncbi request reprint From diffusion tractography to quantitative white matter tract measures: a reproducibility study
    O Ciccarelli
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 18:348-59. 2003
    ..In conclusion, these findings underline the importance of assessing the reliability of diffusion tractography before investigating white matter pathology...
  22. doi request reprint Lesion enhancement diminishes with time in primary progressive multiple sclerosis
    Z Khaleeli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London WC1N 3BG, UK
    Mult Scler 16:317-24. 2010
    ..02). In conclusion, a proportion of patients with PPMS may undergo an early inflammatory phase, which has some impact on subsequent mobility...
  23. ncbi request reprint Diffusion tractography based group mapping of major white-matter pathways in the human brain
    O Ciccarelli
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 19:1545-55. 2003
    ..In the future, group mapping could investigate in vivo white matter differences between normal subjects and patients affected by neurological and psychiatric diseases...
  24. ncbi request reprint Two-year follow-up study of primary and transitional progressive multiple sclerosis
    G T Ingle
    NMR Research Unit, Institute of Neurology, London, UK
    Mult Scler 8:108-14. 2002
    ..Measurable changes in MRI parameters can be detected in PPMS patients over a relatively short period of time. MRI quantification is likely to be useful in elucidating disease mechanisms in PPMS and in the execution of clinical trials...
  25. ncbi request reprint Diffusion tensor imaging of early relapsing-remitting multiple sclerosis with histogram analysis using automated segmentation and brain volume correction
    W Rashid
    MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:9-15. 2004
    ....
  26. ncbi request reprint Metabolite changes in early relapsing-remitting multiple sclerosis. A two year follow-up study
    M Tiberio
    NMR Research Group, Institute of Neurology, Queen Square, London, UK
    J Neurol 253:224-30. 2006
    ..Compared with other MR imaging measures, serial (1)H-MRSI may be relatively less sensitive to progressive pathological tissue changes in early RRMS...
  27. doi request reprint Early MRI in optic neuritis: the risk for clinically definite multiple sclerosis
    J K Swanton
    Department of Neuroinflammation and NMR Research Unit, UCL Institute of Neurology, London, UK
    Mult Scler 16:156-65. 2010
    ..1, 2.4 and 4.9, respectively). No non-conventional measure predicted CDMS. It was concluded that new T2 lesions on an early follow-up scan were the strongest independent predictor of CDMS...
  28. ncbi request reprint In vivo 1H-magnetic resonance spectroscopy of the spinal cord in humans
    B Gomez-Anson
    NMR Research Unit, Institute of Neurology, University College London, UK
    Neuroradiology 42:515-7. 2000
    ..We present this technique, its current limitations, and possible future technological improvements and potential applications...
  29. ncbi request reprint Chronic inflammatory demyelinating polyradiculoneuropathy: MRI study of brain and spinal cord
    M Laura
    Centre for Neuromuscular Diseases and Department of Molecular Neurosciences, National Hospital for Neurology, London, UK
    Neurology 64:914-6. 2005
    ..No CNS demyelination was found, but the mean cervical cord area was significantly smaller in CIDP patients vs control subjects. Spinal cord atrophy may be related to degeneration secondary to axonal loss...
  30. pmc Cord atrophy separates early primary progressive and relapsing remitting multiple sclerosis
    M Bieniek
    NMR Research Unit, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 77:1036-9. 2006
    ..An improved understanding of the causes of early progressive disability in primary progressive multiple sclerosis (PPMS) could provide mechanistic targets for therapeutic intervention...
  31. ncbi request reprint Quantitative magnetization transfer mapping of bound protons in multiple sclerosis
    D Tozer
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Magn Reson Med 50:83-91. 2003
    ..Whole-brain histograms of these parameters are also presented, showing differences between patients and controls...
  32. ncbi request reprint Relationship of triple dose contrast enhanced lesions with clinical measures and brain atrophy in early relapsing-remitting multiple sclerosis: a two-year longitudinal study
    W Rashid
    Department of Neuroinflammation, MS NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
    Mult Scler 13:178-85. 2007
    ..041), but there was no consistent correlation with clinical and MRI outcomes at two years. More prolonged follow-up is warranted to clarify the relationship between early inflammatory lesions and long-term clinical course...
  33. ncbi request reprint Is multiple sclerosis a generalized disease of the central nervous system? An MRI perspective
    Declan Chard
    NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    Curr Opin Neurol 22:214-8. 2009
    ..In this review, we address some of the main themes underlying this issue, drawing on evidence especially from MRI, but also from histopathological studies...
  34. ncbi request reprint Progressive grey matter atrophy in clinically early relapsing-remitting multiple sclerosis
    D T Chard
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:387-91. 2004
    ..0021 per year in the NC subjects, difference P = 0.010). These results suggest that while both GM and WM atrophy are seen early in the clinical course of MS, they may not occur concurrently and may evolve at different rates...
  35. ncbi request reprint Serial magnetization transfer imaging in acute optic neuritis
    S J Hickman
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 127:692-700. 2004
    ..Remyelination may have influenced subsequent MTR changes. The observations support using MTR to monitor symptomatic demyelinating lesions...
  36. ncbi request reprint Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis
    P Kapeller
    NMR Research Unit, Institute of Neurology, University College London, UK
    Mult Scler 8:207-10. 2002
    ..Elevated Ins in MS NAWM appeared functionally relevant It may indicate glial cell proliferation or gliosis...
  37. doi request reprint Predicting progression in primary progressive multiple sclerosis: a 10-year multicenter study
    Zhaleh Khaleeli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 63:790-3. 2008
    ..These predictors of long-term disability provide some insight into disease progression...
  38. doi request reprint Grey matter magnetization transfer ratio independently correlates with neurological deficit in secondary progressive multiple sclerosis
    T Hayton
    Dept of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 256:427-35. 2009
    ..The apparent paucity of correlation between MRI measures and EDSS is likely to represent the relative insensitivity of the latter measure in this study group...
  39. ncbi request reprint In vivo diffusion tensor imaging of the human optic nerve: pilot study in normal controls
    C A M Wheeler-Kingshott
    Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Magn Reson Med 56:446-51. 2006
    ..Measurements of the principal eigenvalue of the DT and its orthogonal component were also in agreement with those expected from a highly directional structural organization...
  40. doi request reprint Early MRI in optic neuritis: the risk for disability
    J K Swanton
    NMR Unit, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurology 72:542-50. 2009
    ..MRI findings influence the risk of patients with optic neuritis (ON) developing clinically definite (CD) multiple sclerosis (MS) but their influence on future disability is less clear...
  41. ncbi request reprint Normal-appearing grey and white matter T1 abnormality in early relapsing-remitting multiple sclerosis: a longitudinal study
    G R Davies
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
    Mult Scler 13:169-77. 2007
    ..To investigate the presence and evolution of T(1) relaxation time abnormalities in normal-appearing white matter (NAWM) and grey matter (GM), early in the course of relapsing-remitting multiple sclerosis (MS)...
  42. pmc Quantification of optic nerve head topography in optic neuritis: a pilot study
    S A Trip
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Br J Ophthalmol 90:1128-31. 2006
    ..To investigate optic nerve head topography in patients with optic neuritis compared to controls using the Heidelberg retina tomograph-II (HRT-II) and to determine if detected changes are related to visual function and electrophysiology...
  43. ncbi request reprint Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis
    O Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London UK
    Brain 129:1859-71. 2006
    ..The development of such connectivity measures raises their potential as markers of disease progression in ALS, and provides guidance for their use in other neurological diseases...
  44. ncbi request reprint Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosis
    O Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, London, UK
    J Neurol 253:882-91. 2006
    ..This may inform future treatment strategies...
  45. doi request reprint Complementary roles of grey matter MTR and T2 lesions in predicting progression in early PPMS
    C Tur
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 82:423-8. 2011
    ....
  46. ncbi request reprint Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis
    O Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
    Brain 130:2220-31. 2007
    ..These measures were found to correlate with acute disability. Our findings suggest that it would be worthwhile performing longitudinal studies and extending these novel techniques to other neurological diseases affecting the spinal cord...
  47. ncbi request reprint Magnetization transfer histograms in clinically isolated syndromes suggestive of multiple sclerosis
    K T M Fernando
    NMR Research Unit, Institute of Neurology, King s College, London, UK
    Brain 128:2911-25. 2005
    ..MTR abnormalities occur in the NAWM and NAGM at the earliest clinical stages of multiple sclerosis...
  48. doi request reprint Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis
    L K Fisniku
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, UK
    Brain 131:808-17. 2008
    ....
  49. doi request reprint Different white matter lesion characteristics correlate with distinct grey matter abnormalities on magnetic resonance imaging in secondary progressive multiple sclerosis
    J Furby
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London WC1N3BG, UK
    Mult Scler 15:687-94. 2009
    ....
  50. ncbi request reprint A longitudinal study of cognition in primary progressive multiple sclerosis
    S J Camp
    Department of Clinical Neurology, Institute of Neurology, London, UK
    Brain 128:2891-8. 2005
    ..266, P = 0.017; r = -0.303, P = 0.012). It is probable that multiple factors underlie this weak relation between the cognitive and MRI measures...
  51. ncbi request reprint Correlation of apparent myelin measures obtained in multiple sclerosis patients and controls from magnetization transfer and multicompartmental T2 analysis
    D J Tozer
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London WC1N 3BG, UK
    Magn Reson Med 53:1415-22. 2005
    ..3) was seen for GM. These results indicate that the two techniques measure, to some extent, the same thing (most likely myelin content), but that other factors, such as inflammation, mean they may provide complementary information...
  52. pmc Magnetisation transfer ratio in the normal appearing white matter predicts progression of disability over 1 year in early primary progressive multiple sclerosis
    Z Khaleeli
    Department of Brain Repair and Rehabilitation, Nuclear Magnetic Resonance Unit, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 78:1076-82. 2007
    ..We investigated the predictive value of MTI and the longitudinal changes developing over 1 year in early PPMS...
  53. ncbi request reprint A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis
    S M Leary
    NMR Research Unit, Institute of Neurology, Queen Square, London, UK
    Magn Reson Imaging 18:455-9. 2000
    ..This emphasizes the need to perform absolute quantification of metabolite concentrations rather than ratios and the importance of age-matching in (1)H MRS studies of multiple sclerosis...
  54. ncbi request reprint Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis
    D T Chard
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 125:2342-52. 2002
    ..The correlation of clinical impairment with a raised NAWM Ins may indicate that glial proliferation also relates to function at this stage of the disease...
  55. ncbi request reprint Continuing optic nerve atrophy following optic neuritis: a serial MRI study
    S J Hickman
    NMR Research Unit, Institute of Neurology, University College London, UK
    Mult Scler 8:339-42. 2002
    ..Optic neuritis provides a model to study the effect of inflammatory demyelination through the ability to accurately measure visual function and to visualize and measure the optic nerves using magnetic resonance imaging...
  56. pmc Progressive ventricular enlargement in patients with clinically isolated syndromes is associated with the early development of multiple sclerosis
    C M Dalton
    NMR Research Unit, Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 73:141-7. 2002
    ..Cerebral atrophy is recognised in established MS, but its time of onset and whether, in early disease, it is related to MRI lesion load or clinical outcome is less certain...
  57. doi request reprint A preliminary longitudinal study of the retinal nerve fiber layer in progressive multiple sclerosis
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, UK
    J Neurol 257:1083-91. 2010
    ..Further studies are needed using higher-resolution OCT systems and in larger groups of patients, to elucidate the timing and mechanism of RNFL loss that is observed in clinically unaffected nerves in MS...
  58. ncbi request reprint Reproducibility of magnetic resonance imaging measurements of spinal cord atrophy: the role of quality assurance
    S M Leary
    NMR Research Unit, Institute of Neurology, London, United Kingdom
    Magn Reson Imaging 17:773-6. 1999
    ..Quality assurance is an essential and practical component of all serial MRI studies, without which the clinical implications of change cannot be reliably evaluated...
  59. doi request reprint A longitudinal study of MRI-detected atrophy in secondary progressive multiple sclerosis
    J Furby
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London, UK
    J Neurol 257:1508-16. 2010
    ..Measures of WB, GM and SC atrophy all have attributes for use as surrogate markers in secondary progressive MS trials and improvement in the reliability of the GM and SC volume measurements may enhance these further...
  60. doi request reprint MRI only conversion to multiple sclerosis following a clinically isolated syndrome
    D T Chard
    Department of Neuroinflammation, UCL Institute of Neurology, University College London, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 82:176-9. 2011
    ..This study investigated the frequency of radiological without clinical conversion to MS after long term follow-up as this has not previously been defined...
  61. ncbi request reprint Brain atrophy in clinically early relapsing-remitting multiple sclerosis
    D T Chard
    NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, UK
    Brain 125:327-37. 2002
    ..The lack of correlation between lesion load measures and WMF suggests that pathological changes in white matter may occur by mechanisms which are at least partly independent from overt lesion genesis in early multiple sclerosis...
  62. ncbi request reprint Analysis of MTR histograms in multiple sclerosis using principal components and multiple discriminant analysis
    J Dehmeshki
    NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    Magn Reson Med 46:600-9. 2001
    ..Multiple regression analysis of EDSS with the first three PCs as independent variables was significant (r = 0.83 for secondary progressive MS, and r = 0.80 for all MS patients)...
  63. ncbi request reprint Fatigue is not associated with raised inflammatory markers in multiple sclerosis
    G Giovannoni
    Department of Neurochemistry, Institute of Neurology, London, United Kingdom
    Neurology 57:676-81. 2001
    ..The pathogenesis of fatigue in patients with MS is poorly understood...
  64. ncbi request reprint Serum inflammatory markers and clinical/MRI markers of disease progression in multiple sclerosis
    G Giovannoni
    Department of Neurochemistry, University of London, UK
    J Neurol 248:487-95. 2001
    ..These findings, although preliminary, pose interesting questions on the role of nitric oxide in the pathogenesis of MS. Inducible NO production in the early stages of the disease may be beneficial...
  65. ncbi request reprint A modified protocol to improve the detection of enhancing brain and spinal cord lesions in multiple sclerosis
    N C Silver
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Neurol 248:215-24. 2001
    ..The modified brain protocol reduces sample size requirements for crossover studies but not necessarily for parallel design trials...
  66. ncbi request reprint Immunological time-course of gadolinium-enhancing MRI lesions in patients with multiple sclerosis
    G Giovannoni
    National Hospital for Neurology and Neurosurgery and Institute of Neurology, London, UK
    Eur Neurol 44:222-8. 2000
    ..Failure to do this may explain the poor and unpredictable correlations between immunological markers and Gd-enhanced MRI activity, which cannot be accurately aged in cross-sectional and serial monthly MRI studies...
  67. pmc Spinal cord repair in MS: does mitochondrial metabolism play a role?
    O Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neurology 74:721-7. 2010
    ....
  68. ncbi request reprint Interferon beta-1a in primary progressive MS: an exploratory, randomized, controlled trial
    S M Leary
    NMR Research Unit, Institute of Neurology, University College London, UK
    Neurology 60:44-51. 2003
    ..Patients with primary progressive MS have atypical clinical and MRI characteristics and have been excluded from most therapeutic trials. The authors report a randomized, controlled trial restricted to primary progressive MS...
  69. ncbi request reprint Precise estimate of fundamental in-vivo MT parameters in human brain in clinically feasible times
    A Ramani
    NMR Research Unit, Dept Clinical Neurology, Institute of Neurology, Queen s Square, University College London, London, WC1N 3BG, England
    Magn Reson Imaging 20:721-31. 2002
    ..All this has been achieved using MT images collected within a timeframe that is clinically feasible. We hope that this new technique will shed light on the properties and dynamics of water compartments within the brain...
  70. doi request reprint Texture analysis of magnetization transfer maps from patients with clinically isolated syndrome and multiple sclerosis
    D J Tozer
    UCL Institute of Neurology, London, UK
    J Magn Reson Imaging 30:506-13. 2009
    ..To investigate the behavior of texture parameters derived from the gray level co-occurrence matrix from gray matter (GM) and white matter (WM) (with lesions removed) segments of magnetization transfer ratio maps from controls and patients...
  71. ncbi request reprint The optic nerve sheath on MRI in acute optic neuritis
    S J Hickman
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroradiology 47:51-5. 2005
    ..Optic nerve sheath enhancement suggests that meningeal inflammation occurs in optic neuritis, in agreement with pathological studies of both optic neuritis and multiple sclerosis...
  72. ncbi request reprint Cervical spinal cord MTR histogram analysis in multiple sclerosis using a 3D acquisition and a B-spline active surface segmentation technique
    S J Hickman
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Magn Reson Imaging 22:891-5. 2004
    ..0 pu, p = 0.03) and peak location (45.2 versus 46.8, p = 0.03). The spinal cord volumes obtained from the two sequences were associated with each other (parameter estimate 0.972, 95% confidence intervals 0.742, 1.202, p < 0.001)...
  73. pmc The longitudinal relation between brain lesion load and atrophy in multiple sclerosis: a 14 year follow up study
    D T Chard
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1, UK
    J Neurol Neurosurg Psychiatry 74:1551-4. 2003
    ..The temporal relation between these processes remains unclear...
  74. pmc Corticosteroids do not prevent optic nerve atrophy following optic neuritis
    S J Hickman
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 74:1139-41. 2003
  75. ncbi request reprint Preliminary magnetic resonance study of the macromolecular proton fraction in white matter: a potential marker of myelin?
    G R Davies
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Mult Scler 9:246-9. 2003
    ..In particular, f may provide a more direct indication of myelin content in WM...
  76. ncbi request reprint Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson disease
    R A Page
    University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    Neurology 63:638-43. 2004
    ..However, neurologic deficits may persist despite adequate treatment. MRI is used to assess patients with WD, but previous attempts to correlate clinical progression with the investigation findings have often been unsuccessful...
  77. doi request reprint MRI measures show significant cerebellar gray matter volume loss in multiple sclerosis and are associated with cerebellar dysfunction
    V M Anderson
    Nuclear Magnetic Resonance Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
    Mult Scler 15:811-7. 2009
    ..Regional atrophy measures may offer useful information about the causes of specific clinical deficits in multiple sclerosis (MS)...
  78. ncbi request reprint Neuropathological abnormalities in schizophrenia: evidence from magnetization transfer imaging
    J Foong
    NMR Research Unit, Institute of Neurology, London, UK
    Brain 124:882-92. 2001
    ..Longitudinal studies are needed to determine whether these abnormalities are related to disease progression or other disease manifestations such as cognitive changes...
  79. pmc Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI
    R A Farrell
    Department of Neuroinflammation, Institute of Neurology, UCL, Queen Square, London, UK
    Neurology 73:32-8. 2009
    ..Evidence suggests that Epstein-Barr virus (EBV) plays a role in triggering or perpetuating disease activity in multiple sclerosis (MS)...
  80. pmc Magnetization transfer ratio abnormalities reflect clinically relevant grey matter damage in multiple sclerosis
    L K Fisniku
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Mult Scler 15:668-77. 2009
    ..In multiple sclerosis, grey matter (GM) damage appears more clinically relevant than either white matter damage or lesion load...
  81. ncbi request reprint High field MRI correlates of myelin content and axonal density in multiple sclerosis--a post-mortem study of the spinal cord
    J P Mottershead
    Dept of Neuroinflammation, MS NMR Research Unit, Institute of Neurology, UCL, WC1N 3BG, London, UK
    J Neurol 250:1293-301. 2003
    ..Further studies are warranted to investigate the potential of new quantitative MR measures to enable a distinction between axonal loss and demyelination and between demyelinated and remyelinated lesions...
  82. ncbi request reprint Identifying brain regions for integrative sensorimotor processing with ankle movements
    O Ciccarelli
    Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 166:31-42. 2005
    ..In future, similar fMRI studies using passive movements have potential to elucidate abnormalities of sensorimotor integration in central nervous system diseases that affect motor function...
  83. ncbi request reprint Optic nerve magnetization transfer imaging and measures of axonal loss and demyelination in optic neuritis
    S A Trip
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Mult Scler 13:875-9. 2007
    ..Because axonal loss following optic neuritis also results in myelin loss, the relative contributions of the two pathological conditions to the MTR measures cannot be estimated from this study...
  84. pmc Is the frequency of abnormalities on magnetic resonance imaging in isolated optic neuritis related to the prevalence of multiple sclerosis? A global comparison
    J K Swanton
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 77:1070-2. 2006
    ..These observations may support the hypothesis that optic neuritis is more likely to be associated with abnormalities on MRI and to be due to multiple sclerosis in geographical regions where multiple sclerosis is more common...
  85. ncbi request reprint Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis
    K T M Fernando
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 127:1361-9. 2004
    ..The early increase in Ins may reflect a process of pathogenic importance in multiple sclerosis NAWM. Follow-up studies will investigate whether the increase in NAWM Ins is of prognostic importance for future relapses and disability...
  86. doi request reprint Hippocampal atrophy in relapsing-remitting and primary progressive MS: a comparative study
    V M Anderson
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
    Mult Scler 16:1083-90. 2010
    ..In multiple sclerosis (MS), demyelination and neuroaxonal damage are seen in the hippocampus, and MRI has revealed hippocampal atrophy...
  87. doi request reprint Grey matter pathology in clinically early multiple sclerosis: evidence from magnetic resonance imaging
    Declan Chard
    NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    J Neurol Sci 282:5-11. 2009
    ..In this review, we focus on the early stages of relapse onset MS, considering the nature, extent and evolution of GM pathology, as determined using magnetic resonance imaging...
  88. doi request reprint Energy failure in multiple sclerosis and its investigation using MR techniques
    David Paling
    NMR Research Unit, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 258:2113-27. 2011
    ....
  89. doi request reprint Dissecting structure-function interactions in acute optic neuritis to investigate neuroplasticity
    Thomas Jenkins
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Hum Brain Mapp 31:276-86. 2010
    ..Longitudinal studies will clarify whether different extra-striate cortical regions play a role in adaptive plasticity in the acute and chronic stages of injury...
  90. doi request reprint Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials
    Nish Chaturvedi
    International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK
    Lancet 372:1394-402. 2008
    ..We therefore designed the DIabetic REtinopathy Candesartan Trials (DIRECT) Programme to assess whether candesartan could reduce the incidence and progression of retinopathy in type 1 diabetes...
  91. ncbi request reprint Progressive change in primary progressive multiple sclerosis normal-appearing white matter: a serial diffusion magnetic resonance imaging study
    Klaus Schmierer
    Klinik fur Neurologie, Charite, Humboldt Universitat Berlin, Germany
    Mult Scler 10:182-7. 2004
    ..Our preliminary findings suggest that the processes causing structural damage in NAWM and lesions in patients with PPMS are partially linked and that changes of water diffusion in NAWM depicted by DW-MRI are clinically relevant...
  92. ncbi request reprint Visual recovery following acute optic neuritis--a clinical, electrophysiological and magnetic resonance imaging study
    Simon J Hickman
    NMR Research Unit, Dept of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Neurol 251:996-1005. 2004
    ....
  93. ncbi request reprint A serial MRI study following optic nerve mean area in acute optic neuritis
    Simon J Hickman
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 127:2498-505. 2004
    ..Over the longer term, there was loss of tissue. The lack of association between 1 year optic nerve mean area and visual outcome may reflect a mild loss of tissue, redundancy or remodelling of function...
  94. ncbi request reprint Brain atrophy, interferon beta, and treatment trials in multiple sclerosis
    David H Miller
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London WC1N 3BG, UK
    Lancet 364:1463-4. 2004
  95. ncbi request reprint Grey and white matter volume changes in early primary progressive multiple sclerosis: a longitudinal study
    Jaume Sastre-Garriga
    Institute of Neurology, University College London, London, UK
    Brain 128:1454-60. 2005
    ..The former may be predicted by the degree of inflammation, while the latter seems to be independent of it. SIENA and SPM-based methods appear to provide complementary information...
  96. ncbi request reprint Optic radiation changes after optic neuritis detected by tractography-based group mapping
    Olga Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Hum Brain Mapp 25:308-16. 2005
    ..These findings suggest that the group mapping techniques might be used to assess changes in the optic radiations in patients after an episode of optic neuritis. The changes we have observed may be secondary to the optic nerve damage...
  97. ncbi request reprint Adaptive cortical plasticity in higher visual areas after acute optic neuritis
    Ahmed T Toosy
    Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 57:622-33. 2005
    ..The key findings of this study are from the second analysis and suggest a genuine adaptive role for cortical reorganization within extrastriate visual areas early after optic neuritis...
  98. ncbi request reprint The distribution of magnetic resonance imaging response to interferonbeta-1b in multiple sclerosis
    Maria Pia Sormani
    Neuroimaging Research Unit, Dept of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    J Neurol 252:1455-8. 2005
    ..This study might be regarded as a first step toward the definition of markers potentially useful to identify IFNbeta treatment responders and non-responders with regard to T2 lesion activity...
  99. doi request reprint Gray matter atrophy is related to long-term disability in multiple sclerosis
    Leonora K Fisniku
    Nuclear Magnetic Resonance Research Unit, Institute of Neurology, University College London, UK
    Ann Neurol 64:247-54. 2008
    ..To determine the relation of gray matter (GM) and white matter (WM) brain volumes, and WM lesion load, with clinical outcomes 20 years after first presentation with clinically isolated syndrome suggestive of multiple sclerosis (MS)...
  100. ncbi request reprint Detecting treatment effects on brain atrophy in relapsing remitting multiple sclerosis: sample size estimates
    Valerie M Anderson
    MS NMR Research Unit, University College London Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 254:1588-94. 2007
    ....
  101. ncbi request reprint Grey and white matter atrophy in early clinical stages of primary progressive multiple sclerosis
    Jaume Sastre-Garriga
    Institute of Neurology, UCL, 23 Queen Square, London WC1N 3BG, UK
    Neuroimage 22:353-9. 2004
    ..There is little information available on grey and white matter (GM and WM) atrophy in primary progressive multiple sclerosis (PPMS) and on their relationships with clinical and other magnetic resonance imaging (MRI) measures...