Research Topics
| David MillerSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessmentsPeter Connick
Dept, of Clinical Neurosciences, University of Cambridge, UK
Trials 12:62. 2011..Illustrated by the MSCIMS trial protocol, we describe a novel methodology based on detailed assessment of the anterior visual pathway as a model of wider disease processes--the "sentinel lesion approach"...- Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1aEe Tuan Lim
Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
J Negat Results Biomed 3:4. 2004..Furthermore there is no correlation between S100B levels and the primary and secondary outcome measures... - MRI characteristics are predictive for CDMS in monofocal, but not in multifocal patients with a clinically isolated syndromeJessica M Nielsen
MS Center, Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
BMC Neurol 9:19. 2009..Here we assess the predictive value of clinically defined dissemination in space at first presentation for time to clinically definite MS (CDMS)... - MRI monitoring of MS in clinical trialsDavid H Miller
NMR Research Unit, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK
Clin Neurol Neurosurg 104:236-43. 2002 - A controlled trial of natalizumab for relapsing multiple sclerosisDavid H Miller
Department of Neuroinflammation, Institute of Neurology, London, United Kingdom
N Engl J Med 348:15-23. 2003..Natalizumab is an alpha4 integrin antagonist that reduced the development of brain lesions in experimental models and in a preliminary study of patients with multiple sclerosis... - Primary-progressive multiple sclerosisDavid H Miller
Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
Lancet Neurol 6:903-12. 2007..Future research should focus on the clarification of the mechanisms of axonal loss, improvements to the design of clinical trials, and the development of effective neuroprotective treatments... - Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevanceDavid H Miller
Department of Neuroinflammation, Institute of Neurology, London, UK
Brain 125:1676-95. 2002..Atrophy provides a sensitive measure of the neurodegenerative component of multiple sclerosis and should be measured in trials evaluating potential anti-inflammatory, remyelinating or neuroprotective therapies... - Role of magnetic resonance imaging within diagnostic criteria for multiple sclerosisD H Miller
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
Ann Neurol 56:273-8. 2004..The IP criteria are timely and concrete and introduce an important concept to MS diagnosis. Future modifications, based on emerging evidence, should further facilitate their implementation and improve their accuracy... - MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MSD H Miller
Institute of Neurology, University College London, London, UK
Neurology 68:1390-401. 2007..We report the effect of natalizumab on MRI measures from the AFFIRM study... - Overview of London trial of intramuscular interferon-beta Ia in primary-progressive multiple sclerosisDavid H Miller
Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Mult Scler 10:S56-7. 2004..A larger study would be required to evaluate treatment on disability in this patient cohort and further work is needed to elucidate the relationship between quantitative MR and clinical measures over the longer term... - Multiple sclerosis: new insights and therapeutic progressDavid Miller
Institute of Neurology, University College London, London, UK
Lancet Neurol 6:5-6. 2007 - Biomarkers and surrogate outcomes in neurodegenerative disease: lessons from multiple sclerosisDavid H Miller
Multiple Sclerosis NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, London WC1N 3BG, United Kingdom
NeuroRx 1:284-94. 2004..Because the MR surrogates for neuroaxonal loss are not yet validated as predicting future disability, definitive trials should continue to monitor an appropriate disability endpoint... - Clinically isolated syndromes suggestive of multiple sclerosis, part 2: non-conventional MRI, recovery processes, and managementDavid Miller
MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
Lancet Neurol 4:341-8. 2005..Continued clinical and laboratory investigation of patients with a CIS should be encouraged... - Magnetic resonance studies of abnormalities in the normal appearing white matter and grey matter in multiple sclerosisD H Miller
NMR Research Unit, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
J Neurol 250:1407-19. 2003..In future, new imaging modalities are needed that provide a more specific measure of histopathological and cellular aspects of the disease process in vivo... - Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosisDavid Miller
MS NMR Research Unit, Institute of Neurology, University College London, London, UK
Lancet Neurol 4:281-8. 2005..Development of more reliable prognostic markers will enable new treatments to be targeted for those who are most likely to benefit. We encourage continued clinical and laboratory assessment of patients with a CIS... - Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosisJ Sastre-Garriga
Institute of Neurology, London, United Kingdom
Arch Neurol 62:569-73. 2005..CONCLUSION: Metabolite changes, which differ in CGM and NAWM, occur in early PPMS and are linked with disability... - Long-term clinical outcome of primary progressive MS: predictive value of clinical and MRI dataJ Sastre-Garriga
Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK
Neurology 65:633-5. 2005..Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS... - Recovery after spinal cord relapse in multiple sclerosis is predicted by radial diffusivityPatrick Freund
Department of Brain Repair and Rehabilitation, NMR Unit, UCL Institute of Neurology, London, UK
Mult Scler 16:1193-202. 2010.... - Cognitive impairment in multiple sclerosis can be predicted by imaging early in the diseaseM Summers
Institute of Neurology, University College London, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 79:955-8. 2008..Cognitive impairment is common in multiple sclerosis (MS) and adds significantly to the burden of the disease. The ability to predict future cognitive impairment from imaging obtained at disease onset has not been investigated... - Gray and white matter volume changes in early RRMS: a 2-year longitudinal studyM Tiberio
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, London WC1N 3BG, UK
Neurology 64:1001-7. 2005..Fluctuations in inflammatory WM lesions appear to be related to volume changes in WM over this time period... - From diffusion tractography to quantitative white matter tract measures: a reproducibility studyO Ciccarelli
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neuroimage 18:348-59. 2003..In conclusion, these findings underline the importance of assessing the reliability of diffusion tractography before investigating white matter pathology... - Lesion enhancement diminishes with time in primary progressive multiple sclerosisZ Khaleeli
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London WC1N 3BG, UK
Mult Scler 16:317-24. 2010..02). In conclusion, a proportion of patients with PPMS may undergo an early inflammatory phase, which has some impact on subsequent mobility... - Diffusion tractography based group mapping of major white-matter pathways in the human brainO Ciccarelli
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neuroimage 19:1545-55. 2003..In the future, group mapping could investigate in vivo white matter differences between normal subjects and patients affected by neurological and psychiatric diseases... - Two-year follow-up study of primary and transitional progressive multiple sclerosisG T Ingle
NMR Research Unit, Institute of Neurology, London, UK
Mult Scler 8:108-14. 2002..Measurable changes in MRI parameters can be detected in PPMS patients over a relatively short period of time. MRI quantification is likely to be useful in elucidating disease mechanisms in PPMS and in the execution of clinical trials... - Diffusion tensor imaging of early relapsing-remitting multiple sclerosis with histogram analysis using automated segmentation and brain volume correctionW Rashid
MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Mult Scler 10:9-15. 2004.... - Metabolite changes in early relapsing-remitting multiple sclerosis. A two year follow-up studyM Tiberio
NMR Research Group, Institute of Neurology, Queen Square, London, UK
J Neurol 253:224-30. 2006..Compared with other MR imaging measures, serial (1)H-MRSI may be relatively less sensitive to progressive pathological tissue changes in early RRMS... - Early MRI in optic neuritis: the risk for clinically definite multiple sclerosisJ K Swanton
Department of Neuroinflammation and NMR Research Unit, UCL Institute of Neurology, London, UK
Mult Scler 16:156-65. 2010..1, 2.4 and 4.9, respectively). No non-conventional measure predicted CDMS. It was concluded that new T2 lesions on an early follow-up scan were the strongest independent predictor of CDMS... - In vivo 1H-magnetic resonance spectroscopy of the spinal cord in humansB Gomez-Anson
NMR Research Unit, Institute of Neurology, University College London, UK
Neuroradiology 42:515-7. 2000..We present this technique, its current limitations, and possible future technological improvements and potential applications... - Chronic inflammatory demyelinating polyradiculoneuropathy: MRI study of brain and spinal cordM Laura
Centre for Neuromuscular Diseases and Department of Molecular Neurosciences, National Hospital for Neurology, London, UK
Neurology 64:914-6. 2005..No CNS demyelination was found, but the mean cervical cord area was significantly smaller in CIDP patients vs control subjects. Spinal cord atrophy may be related to degeneration secondary to axonal loss... - Cord atrophy separates early primary progressive and relapsing remitting multiple sclerosisM Bieniek
NMR Research Unit, Institute of Neurology, University College London, London, UK
J Neurol Neurosurg Psychiatry 77:1036-9. 2006..This is concordant with myelopathy being the usual clinical presentation of PPMS. Measurement of cord atrophy seems to be clinically relevant in PPMS treatment trials... - Quantitative magnetization transfer mapping of bound protons in multiple sclerosisD Tozer
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
Magn Reson Med 50:83-91. 2003..Whole-brain histograms of these parameters are also presented, showing differences between patients and controls... - Relationship of triple dose contrast enhanced lesions with clinical measures and brain atrophy in early relapsing-remitting multiple sclerosis: a two-year longitudinal studyW Rashid
Department of Neuroinflammation, MS NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
Mult Scler 13:178-85. 2007..041), but there was no consistent correlation with clinical and MRI outcomes at two years. More prolonged follow-up is warranted to clarify the relationship between early inflammatory lesions and long-term clinical course... - Is multiple sclerosis a generalized disease of the central nervous system? An MRI perspectiveDeclan Chard
NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
Curr Opin Neurol 22:214-8. 2009..In this review, we address some of the main themes underlying this issue, drawing on evidence especially from MRI, but also from histopathological studies... - Progressive grey matter atrophy in clinically early relapsing-remitting multiple sclerosisD T Chard
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Mult Scler 10:387-91. 2004..0021 per year in the NC subjects, difference P = 0.010). These results suggest that while both GM and WM atrophy are seen early in the clinical course of MS, they may not occur concurrently and may evolve at different rates... - Serial magnetization transfer imaging in acute optic neuritisS J Hickman
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Brain 127:692-700. 2004..Remyelination may have influenced subsequent MTR changes. The observations support using MTR to monitor symptomatic demyelinating lesions... - Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosisP Kapeller
NMR Research Unit, Institute of Neurology, University College London, UK
Mult Scler 8:207-10. 2002..Elevated Ins in MS NAWM appeared functionally relevant It may indicate glial cell proliferation or gliosis... - Predicting progression in primary progressive multiple sclerosis: a 10-year multicenter studyZhaleh Khaleeli
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
Ann Neurol 63:790-3. 2008..These predictors of long-term disability provide some insight into disease progression... - Grey matter magnetization transfer ratio independently correlates with neurological deficit in secondary progressive multiple sclerosisT Hayton
Dept of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
J Neurol 256:427-35. 2009..The apparent paucity of correlation between MRI measures and EDSS is likely to represent the relative insensitivity of the latter measure in this study group... - In vivo diffusion tensor imaging of the human optic nerve: pilot study in normal controlsC A M Wheeler-Kingshott
Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
Magn Reson Med 56:446-51. 2006..Measurements of the principal eigenvalue of the DT and its orthogonal component were also in agreement with those expected from a highly directional structural organization... - Early MRI in optic neuritis: the risk for disabilityJ K Swanton
NMR Unit, Institute of Neurology, Queen Square, London WC1N 3BG, UK
Neurology 72:542-50. 2009..MRI findings influence the risk of patients with optic neuritis (ON) developing clinically definite (CD) multiple sclerosis (MS) but their influence on future disability is less clear... - Normal-appearing grey and white matter T1 abnormality in early relapsing-remitting multiple sclerosis: a longitudinal studyG R Davies
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
Mult Scler 13:169-77. 2007..To investigate the presence and evolution of T(1) relaxation time abnormalities in normal-appearing white matter (NAWM) and grey matter (GM), early in the course of relapsing-remitting multiple sclerosis (MS)... - Quantification of optic nerve head topography in optic neuritis: a pilot studyS A Trip
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Br J Ophthalmol 90:1128-31. 2006..To investigate optic nerve head topography in patients with optic neuritis compared to controls using the Heidelberg retina tomograph-II (HRT-II) and to determine if detected changes are related to visual function and electrophysiology... - Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosisO Ciccarelli
Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London UK
Brain 129:1859-71. 2006..The development of such connectivity measures raises their potential as markers of disease progression in ALS, and provides guidance for their use in other neurological diseases... - Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosisO Ciccarelli
Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, London, UK
J Neurol 253:882-91. 2006..This may inform future treatment strategies... - Complementary roles of grey matter MTR and T2 lesions in predicting progression in early PPMSC Tur
Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK
J Neurol Neurosurg Psychiatry 82:423-8. 2011.... - Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosisO Ciccarelli
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
Brain 130:2220-31. 2007..These measures were found to correlate with acute disability. Our findings suggest that it would be worthwhile performing longitudinal studies and extending these novel techniques to other neurological diseases affecting the spinal cord... - Magnetization transfer histograms in clinically isolated syndromes suggestive of multiple sclerosisK T M Fernando
NMR Research Unit, Institute of Neurology, King s College, London, UK
Brain 128:2911-25. 2005..MTR abnormalities occur in the NAWM and NAGM at the earliest clinical stages of multiple sclerosis... - Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosisL K Fisniku
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, UK
Brain 131:808-17. 2008.... - Different white matter lesion characteristics correlate with distinct grey matter abnormalities on magnetic resonance imaging in secondary progressive multiple sclerosisJ Furby
Department of Neuroinflammation, Institute of Neurology, Queen Square, London WC1N3BG, UK
Mult Scler 15:687-94. 2009.... - A longitudinal study of cognition in primary progressive multiple sclerosisS J Camp
Department of Clinical Neurology, Institute of Neurology, London, UK
Brain 128:2891-8. 2005..266, P = 0.017; r = -0.303, P = 0.012). It is probable that multiple factors underlie this weak relation between the cognitive and MRI measures... - Correlation of apparent myelin measures obtained in multiple sclerosis patients and controls from magnetization transfer and multicompartmental T2 analysisD J Tozer
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London WC1N 3BG, UK
Magn Reson Med 53:1415-22. 2005..3) was seen for GM. These results indicate that the two techniques measure, to some extent, the same thing (most likely myelin content), but that other factors, such as inflammation, mean they may provide complementary information... - Magnetisation transfer ratio in the normal appearing white matter predicts progression of disability over 1 year in early primary progressive multiple sclerosisZ Khaleeli
Department of Brain Repair and Rehabilitation, Nuclear Magnetic Resonance Unit, Institute of Neurology, University College London, London, UK
J Neurol Neurosurg Psychiatry 78:1076-82. 2007..We investigated the predictive value of MTI and the longitudinal changes developing over 1 year in early PPMS... - A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosisS M Leary
NMR Research Unit, Institute of Neurology, Queen Square, London, UK
Magn Reson Imaging 18:455-9. 2000..This emphasizes the need to perform absolute quantification of metabolite concentrations rather than ratios and the importance of age-matching in (1)H MRS studies of multiple sclerosis... - Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosisD T Chard
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Brain 125:2342-52. 2002..The correlation of clinical impairment with a raised NAWM Ins may indicate that glial proliferation also relates to function at this stage of the disease... - Continuing optic nerve atrophy following optic neuritis: a serial MRI studyS J Hickman
NMR Research Unit, Institute of Neurology, University College London, UK
Mult Scler 8:339-42. 2002..Optic neuritis provides a model to study the effect of inflammatory demyelination through the ability to accurately measure visual function and to visualize and measure the optic nerves using magnetic resonance imaging... - Progressive ventricular enlargement in patients with clinically isolated syndromes is associated with the early development of multiple sclerosisC M Dalton
NMR Research Unit, Institute of Neurology, London, UK
J Neurol Neurosurg Psychiatry 73:141-7. 2002..This suggests that MR measures have a complementary role in monitoring the course of MS, even from the earliest clinical stage... - A preliminary longitudinal study of the retinal nerve fiber layer in progressive multiple sclerosisAndrew P D Henderson
NMR Research Unit, Institute of Neurology, University College London, London, UK
J Neurol 257:1083-91. 2010..Further studies are needed using higher-resolution OCT systems and in larger groups of patients, to elucidate the timing and mechanism of RNFL loss that is observed in clinically unaffected nerves in MS... - Reproducibility of magnetic resonance imaging measurements of spinal cord atrophy: the role of quality assuranceS M Leary
NMR Research Unit, Institute of Neurology, London, United Kingdom
Magn Reson Imaging 17:773-6. 1999..Quality assurance is an essential and practical component of all serial MRI studies, without which the clinical implications of change cannot be reliably evaluated... - A longitudinal study of MRI-detected atrophy in secondary progressive multiple sclerosisJ Furby
Department of Neuroinflammation, Institute of Neurology, Queen Square, London, UK
J Neurol 257:1508-16. 2010..Measures of WB, GM and SC atrophy all have attributes for use as surrogate markers in secondary progressive MS trials and improvement in the reliability of the GM and SC volume measurements may enhance these further... - MRI only conversion to multiple sclerosis following a clinically isolated syndromeD T Chard
Department of Neuroinflammation, UCL Institute of Neurology, University College London, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 82:176-9. 2011..This study investigated the frequency of radiological without clinical conversion to MS after long term follow-up as this has not previously been defined... - Brain atrophy in clinically early relapsing-remitting multiple sclerosisD T Chard
NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, UK
Brain 125:327-37. 2002..The lack of correlation between lesion load measures and WMF suggests that pathological changes in white matter may occur by mechanisms which are at least partly independent from overt lesion genesis in early multiple sclerosis... - Analysis of MTR histograms in multiple sclerosis using principal components and multiple discriminant analysisJ Dehmeshki
NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
Magn Reson Med 46:600-9. 2001..Multiple regression analysis of EDSS with the first three PCs as independent variables was significant (r = 0.83 for secondary progressive MS, and r = 0.80 for all MS patients)... - Fatigue is not associated with raised inflammatory markers in multiple sclerosisG Giovannoni
Department of Neurochemistry, Institute of Neurology, London, United Kingdom
Neurology 57:676-81. 2001..The pathogenesis of fatigue in patients with MS is poorly understood... - Serum inflammatory markers and clinical/MRI markers of disease progression in multiple sclerosisG Giovannoni
Department of Neurochemistry, University of London, UK
J Neurol 248:487-95. 2001..These findings, although preliminary, pose interesting questions on the role of nitric oxide in the pathogenesis of MS. Inducible NO production in the early stages of the disease may be beneficial... - A modified protocol to improve the detection of enhancing brain and spinal cord lesions in multiple sclerosisN C Silver
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
J Neurol 248:215-24. 2001..The modified brain protocol reduces sample size requirements for crossover studies but not necessarily for parallel design trials... - Immunological time-course of gadolinium-enhancing MRI lesions in patients with multiple sclerosisG Giovannoni
National Hospital for Neurology and Neurosurgery and Institute of Neurology, London, UK
Eur Neurol 44:222-8. 2000..Failure to do this may explain the poor and unpredictable correlations between immunological markers and Gd-enhanced MRI activity, which cannot be accurately aged in cross-sectional and serial monthly MRI studies... - Spinal cord repair in MS: does mitochondrial metabolism play a role?O Ciccarelli
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neurology 74:721-7. 2010.... - Interferon beta-1a in primary progressive MS: an exploratory, randomized, controlled trialS M Leary
NMR Research Unit, Institute of Neurology, University College London, UK
Neurology 60:44-51. 2003..025). CONCLUSIONS: This study has demonstrated that interferon beta-1a 30 microg was well tolerated, identified useful outcome measures, but showed no efficacy on the primary outcome measure or on most of the secondary outcome measures... - Precise estimate of fundamental in-vivo MT parameters in human brain in clinically feasible timesA Ramani
NMR Research Unit, Dept Clinical Neurology, Institute of Neurology, Queen s Square, University College London, London, WC1N 3BG, England
Magn Reson Imaging 20:721-31. 2002..All this has been achieved using MT images collected within a timeframe that is clinically feasible. We hope that this new technique will shed light on the properties and dynamics of water compartments within the brain... - Texture analysis of magnetization transfer maps from patients with clinically isolated syndrome and multiple sclerosisD J Tozer
UCL Institute of Neurology, London, UK
J Magn Reson Imaging 30:506-13. 2009..To investigate the behavior of texture parameters derived from the gray level co-occurrence matrix from gray matter (GM) and white matter (WM) (with lesions removed) segments of magnetization transfer ratio maps from controls and patients... - The optic nerve sheath on MRI in acute optic neuritisS J Hickman
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neuroradiology 47:51-5. 2005..Optic nerve sheath enhancement suggests that meningeal inflammation occurs in optic neuritis, in agreement with pathological studies of both optic neuritis and multiple sclerosis... - Cervical spinal cord MTR histogram analysis in multiple sclerosis using a 3D acquisition and a B-spline active surface segmentation techniqueS J Hickman
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
Magn Reson Imaging 22:891-5. 2004..0 pu, p = 0.03) and peak location (45.2 versus 46.8, p = 0.03). The spinal cord volumes obtained from the two sequences were associated with each other (parameter estimate 0.972, 95% confidence intervals 0.742, 1.202, p < 0.001)... - The longitudinal relation between brain lesion load and atrophy in multiple sclerosis: a 14 year follow up studyD T Chard
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1, UK
J Neurol Neurosurg Psychiatry 74:1551-4. 2003.... - Corticosteroids do not prevent optic nerve atrophy following optic neuritisS J Hickman
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 74:1139-41. 2003 - Preliminary magnetic resonance study of the macromolecular proton fraction in white matter: a potential marker of myelin?G R Davies
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
Mult Scler 9:246-9. 2003..In particular, f may provide a more direct indication of myelin content in WM... - Clinical correlation of brain MRI and MRS abnormalities in patients with Wilson diseaseR A Page
University Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
Neurology 63:638-43. 2004..These changes appear to be present despite prior clinical improvement and may imply a need for additional treatment... - MRI measures show significant cerebellar gray matter volume loss in multiple sclerosis and are associated with cerebellar dysfunctionV M Anderson
Nuclear Magnetic Resonance Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
Mult Scler 15:811-7. 2009..Regional atrophy measures may offer useful information about the causes of specific clinical deficits in multiple sclerosis (MS)... - Neuropathological abnormalities in schizophrenia: evidence from magnetization transfer imagingJ Foong
NMR Research Unit, Institute of Neurology, London, UK
Brain 124:882-92. 2001..Longitudinal studies are needed to determine whether these abnormalities are related to disease progression or other disease manifestations such as cognitive changes... - Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRIR A Farrell
Department of Neuroinflammation, Institute of Neurology, UCL, Queen Square, London, UK
Neurology 73:32-8. 2009..Evidence suggests that Epstein-Barr virus (EBV) plays a role in triggering or perpetuating disease activity in multiple sclerosis (MS)... - Magnetization transfer ratio abnormalities reflect clinically relevant grey matter damage in multiple sclerosisL K Fisniku
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
Mult Scler 15:668-77. 2009..In multiple sclerosis, grey matter (GM) damage appears more clinically relevant than either white matter damage or lesion load... - High field MRI correlates of myelin content and axonal density in multiple sclerosis--a post-mortem study of the spinal cordJ P Mottershead
Dept. of Neuroinflammation, MS NMR Research Unit, Institute of Neurology, UCL, WC1N 3BG, London, UK
J Neurol 250:1293-301. 2003..Further studies are warranted to investigate the potential of new quantitative MR measures to enable a distinction between axonal loss and demyelination and between demyelinated and remyelinated lesions... - Identifying brain regions for integrative sensorimotor processing with ankle movementsO Ciccarelli
Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
Exp Brain Res 166:31-42. 2005..In future, similar fMRI studies using passive movements have potential to elucidate abnormalities of sensorimotor integration in central nervous system diseases that affect motor function... - Optic nerve magnetization transfer imaging and measures of axonal loss and demyelination in optic neuritisS A Trip
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
Mult Scler 13:875-9. 2007..Because axonal loss following optic neuritis also results in myelin loss, the relative contributions of the two pathological conditions to the MTR measures cannot be estimated from this study... - Is the frequency of abnormalities on magnetic resonance imaging in isolated optic neuritis related to the prevalence of multiple sclerosis? A global comparisonJ K Swanton
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 77:1070-2. 2006..These observations may support the hypothesis that optic neuritis is more likely to be associated with abnormalities on MRI and to be due to multiple sclerosis in geographical regions where multiple sclerosis is more common... - Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosisK T M Fernando
Institute of Neurology, Queen Square, London WC1N 3BG, UK
Brain 127:1361-9. 2004..The early increase in Ins may reflect a process of pathogenic importance in multiple sclerosis NAWM. Follow-up studies will investigate whether the increase in NAWM Ins is of prognostic importance for future relapses and disability... - Hippocampal atrophy in relapsing-remitting and primary progressive MS: a comparative studyV M Anderson
Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
Mult Scler 16:1083-90. 2010..In multiple sclerosis (MS), demyelination and neuroaxonal damage are seen in the hippocampus, and MRI has revealed hippocampal atrophy... - Grey matter pathology in clinically early multiple sclerosis: evidence from magnetic resonance imagingDeclan Chard
NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
J Neurol Sci 282:5-11. 2009..In this review, we focus on the early stages of relapse onset MS, considering the nature, extent and evolution of GM pathology, as determined using magnetic resonance imaging... - Energy failure in multiple sclerosis and its investigation using MR techniquesDavid Paling
NMR Research Unit, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
J Neurol 258:2113-27. 2011.... - Dissecting structure-function interactions in acute optic neuritis to investigate neuroplasticityThomas Jenkins
Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, United Kingdom
Hum Brain Mapp 31:276-86. 2010..Longitudinal studies will clarify whether different extra-striate cortical regions play a role in adaptive plasticity in the acute and chronic stages of injury... - Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trialsNish Chaturvedi
International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK
Lancet 372:1394-402. 2008..We therefore designed the DIabetic REtinopathy Candesartan Trials (DIRECT) Programme to assess whether candesartan could reduce the incidence and progression of retinopathy in type 1 diabetes... - Progressive change in primary progressive multiple sclerosis normal-appearing white matter: a serial diffusion magnetic resonance imaging studyKlaus Schmierer
Klinik fur Neurologie, Charite, Humboldt Universitat Berlin, Germany
Mult Scler 10:182-7. 2004..Our preliminary findings suggest that the processes causing structural damage in NAWM and lesions in patients with PPMS are partially linked and that changes of water diffusion in NAWM depicted by DW-MRI are clinically relevant... - Visual recovery following acute optic neuritis--a clinical, electrophysiological and magnetic resonance imaging studySimon J Hickman
NMR Research Unit, Dept. of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
J Neurol 251:996-1005. 2004.... - A serial MRI study following optic nerve mean area in acute optic neuritisSimon J Hickman
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Brain 127:2498-505. 2004..Over the longer term, there was loss of tissue. The lack of association between 1 year optic nerve mean area and visual outcome may reflect a mild loss of tissue, redundancy or remodelling of function... - Brain atrophy, interferon beta, and treatment trials in multiple sclerosisDavid H Miller
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London WC1N 3BG, UK
Lancet 364:1463-4. 2004 - Grey and white matter volume changes in early primary progressive multiple sclerosis: a longitudinal studyJaume Sastre-Garriga
Institute of Neurology, University College London, London, UK
Brain 128:1454-60. 2005..The former may be predicted by the degree of inflammation, while the latter seems to be independent of it. SIENA and SPM-based methods appear to provide complementary information... - Optic radiation changes after optic neuritis detected by tractography-based group mappingOlga Ciccarelli
Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom
Hum Brain Mapp 25:308-16. 2005..These findings suggest that the group mapping techniques might be used to assess changes in the optic radiations in patients after an episode of optic neuritis. The changes we have observed may be secondary to the optic nerve damage... - Adaptive cortical plasticity in higher visual areas after acute optic neuritisAhmed T Toosy
Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
Ann Neurol 57:622-33. 2005..The key findings of this study are from the second analysis and suggest a genuine adaptive role for cortical reorganization within extrastriate visual areas early after optic neuritis... - The distribution of magnetic resonance imaging response to interferonbeta-1b in multiple sclerosisMaria Pia Sormani
Neuroimaging Research Unit, Dept. of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
J Neurol 252:1455-8. 2005..This study might be regarded as a first step toward the definition of markers potentially useful to identify IFNbeta treatment responders and non-responders with regard to T2 lesion activity... - Gray matter atrophy is related to long-term disability in multiple sclerosisLeonora K Fisniku
Nuclear Magnetic Resonance Research Unit, Institute of Neurology, University College London, UK
Ann Neurol 64:247-54. 2008..To determine the relation of gray matter (GM) and white matter (WM) brain volumes, and WM lesion load, with clinical outcomes 20 years after first presentation with clinically isolated syndrome suggestive of multiple sclerosis (MS)... - Detecting treatment effects on brain atrophy in relapsing remitting multiple sclerosis: sample size estimatesValerie M Anderson
MS NMR Research Unit, University College London Institute of Neurology, Queen Square, London, WC1N 3BG, UK
J Neurol 254:1588-94. 2007.... - Grey and white matter atrophy in early clinical stages of primary progressive multiple sclerosisJaume Sastre-Garriga
Institute of Neurology, UCL, 23 Queen Square, London WC1N 3BG, UK
Neuroimage 22:353-9. 2004..CONCLUSIONS: Brain atrophy is seen in the early stages of PPMS and affects both GM and WM. WM atrophy appears more closely related to clinical outcome and WM focal damage than GM atrophy in this patient group...