Research Topics
| David H MillerSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Advances in imaging to support the development of novel therapies for multiple sclerosisD H Miller
Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
Clin Pharmacol Ther 91:621-34. 2012..Retinal axonal loss measured using optical coherence tomography (OCT) can assess acute neuroprotection in optic neuritis...- Clinically isolated syndromesDavid H Miller
Nuclear Magnetic Resonance Research Unit, UCL Institute of Neurology, London, UK
Lancet Neurol 11:157-69. 2012..Targets for future therapeutic progress are to achieve safe and effective long-term immunomodulation with neuroprotection and repair... - Firategrast for relapsing remitting multiple sclerosis: a phase 2, randomised, double-blind, placebo-controlled trialDavid H Miller
Department of Neuroinflammation, London, UK
Lancet Neurol 11:131-9. 2012..We assessed the safety and efficacy of firategrast, a small oral anti-α4β-integrin molecule, in patients with relapsing remitting MS... 
Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: evidence that axonal loss is a substrate of MRI-detected atrophyS Anand Trip
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, UK
Neuroimage 31:286-93. 2006..By inference, axonal loss due to other post-inflammatory brain lesions is likely to contribute to the global MRI measure of brain atrophy in multiple sclerosis...- Scanning laser polarimetry quantification of retinal nerve fiber layer thinning following optic neuritisS Anand Trip
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, United Kingdom
J Neuroophthalmol 30:235-42. 2010..This study was designed to use SLP to measure axonal loss following a single episode of optic neuritis and to determine if there is a relationship between the degree of axonal loss and the degree of residual visual dysfunction... - Adaptive cortical plasticity in higher visual areas after acute optic neuritisAhmed T Toosy
Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
Ann Neurol 57:622-33. 2005..The key findings of this study are from the second analysis and suggest a genuine adaptive role for cortical reorganization within extrastriate visual areas early after optic neuritis... - A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trialsAndrew P D Henderson
NMR Research Unit, Institute of Neurology, University College London, London, UK
Brain 133:2592-602. 2010..Optical coherence tomography-measured retinal nerve fibre layer loss after 6 months is a suitable outcome measure for proof-of-concept trials of acute neuroprotection in optic neuritis... - Optic radiation changes after optic neuritis detected by tractography-based group mappingOlga Ciccarelli
Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom
Hum Brain Mapp 25:308-16. 2005..These findings suggest that the group mapping techniques might be used to assess changes in the optic radiations in patients after an episode of optic neuritis. The changes we have observed may be secondary to the optic nerve damage... - Gray matter atrophy is related to long-term disability in multiple sclerosisLeonora K Fisniku
Nuclear Magnetic Resonance Research Unit, Institute of Neurology, University College London, UK
Ann Neurol 64:247-54. 2008..To determine the relation of gray matter (GM) and white matter (WM) brain volumes, and WM lesion load, with clinical outcomes 20 years after first presentation with clinically isolated syndrome suggestive of multiple sclerosis (MS)... - Neuroplasticity predicts outcome of optic neuritis independent of tissue damageThomas M Jenkins
Department of Brain Repair and Rehabilitation, University College London UCL Institute of Neurology, University College London, London, UK
Ann Neurol 67:99-113. 2010..To investigate the reasons behind good recovery following ON, despite residual optic nerve demyelination and neuroaxonal damage... - Upper cervical cord area in early relapsing-remitting multiple sclerosis: cross-sectional study of factors influencing cord sizeWaqar Rashid
MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
J Magn Reson Imaging 23:473-6. 2006..In evaluations of disease-related changes in the UCCA in cross-sectional studies, TICV and gender should be considered as potentially confounding covariates... - Early factors associated with axonal loss after optic neuritisAndrew P D Henderson
NMR Research Unit, University College London, Institute of Neurology, London, United Kingdom
Ann Neurol 70:955-63. 2011..We investigated clinical, electrophysiological, and imaging measures at presentation and after 3 months as potential markers of axonal loss following optic neuritis... - Optic nerve diffusion tensor imaging in optic neuritisS Anand Trip
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neuroimage 30:498-505. 2006..57, P = 0.006) and lambda( perpendicular) (r = -0.56, P = 0.007). These findings suggest that optic nerve DT-MRI measures provide an indication of the structural integrity of axons... - Exploring the relationship between white matter and gray matter damage in early primary progressive multiple sclerosis: an in vivo study with TBSS and VBMBenedetta Bodini
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom
Hum Brain Mapp 30:2852-61. 2009..Longitudinal studies will determine whether the GM atrophy precedes or follows the NAWM damage. The methodology that we described may be useful to investigate other neurological disorders affecting both the WM and the GM... - An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomographyAndrew P D Henderson
NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
Brain 131:277-87. 2008..This may indicate a difference in the extent of the pathological processes that cause axonal loss in the retina, and by inference the optic nerve, in secondary progressive MS and primary progressive MS... - Normal-appearing brain t1 relaxation time predicts disability in early primary progressive multiple sclerosisFrancesco Manfredonia
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, England
Arch Neurol 64:411-5. 2007.... - A serial MRI study following optic nerve mean area in acute optic neuritisSimon J Hickman
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Brain 127:2498-505. 2004..Over the longer term, there was loss of tissue. The lack of association between 1 year optic nerve mean area and visual outcome may reflect a mild loss of tissue, redundancy or remodelling of function... - Magnetization transfer ratio in gray matter: a potential surrogate marker for progression in early primary progressive multiple sclerosisZhaleh Khaleeli
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, England
Arch Neurol 65:1454-9. 2008..Magnetization transfer imaging has the potential to provide a surrogate marker for progression in primary progressive multiple sclerosis (PPMS)... - Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritisMadhan Kolappan
NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
J Neurol 256:305-19. 2009..These collective investigative methods have advanced knowledge of pathophysiological mechanisms in MS and optic neuritis. Relevant ongoing studies and future directions are discussed... - Investigation of white matter pathology in ALS and PLS using tract-based spatial statisticsOlga Ciccarelli
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London
Hum Brain Mapp 30:615-24. 2009.... 
Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixationKlaus Schmierer
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
Magn Reson Med 59:268-77. 2008..01) whereas postfixation T(2) (r = 0.92; P < 0.01), T(1) (r = 0.89; P < 0.01), and f(B) (r = -0.86; P < 0.01) were superior. All diffusivity measures (except for D(ax) in unfixed tissue) were predictors of myelin content...- Grey and white matter volume changes in early primary progressive multiple sclerosis: a longitudinal studyJaume Sastre-Garriga
Institute of Neurology, University College London, London, UK
Brain 128:1454-60. 2005..The former may be predicted by the degree of inflammation, while the latter seems to be independent of it. SIENA and SPM-based methods appear to provide complementary information... - Quantitative magnetization transfer imaging in postmortem multiple sclerosis brainKlaus Schmierer
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
J Magn Reson Imaging 26:41-51. 2007.... - Visual recovery following acute optic neuritis--a clinical, electrophysiological and magnetic resonance imaging studySimon J Hickman
NMR Research Unit, Dept. of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
J Neurol 251:996-1005. 2004.... - Combining tractography and cortical measures to test system-specific hypotheses in multiple sclerosisNikos Gorgoraptis
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, UK
Mult Scler 16:555-65. 2010..Combining tractography and cortical measures is a useful approach in testing hypotheses which are specific to clinically relevant functional systems in multiple sclerosis, and can be applied to other neurological diseases... - Cerebral atrophy measurement in clinically isolated syndromes and relapsing remitting multiple sclerosis: a comparison of registration-based methodsValerie M Anderson
MS NMR Research Unit, University College London, Institute of Neurology, Queen Square, London, UK
J Neuroimaging 17:61-8. 2007.... - Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritisS Anand Trip
NMR Research Unit, Department of Neuroinflammation, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
Ann Neurol 58:383-91. 2005..This noninvasive RNFL imaging technique could be used in trials of experimental treatments that aim to protect optic nerves from axonal loss... - Longitudinal evaluation of clinically early relapsing-remitting multiple sclerosis with diffusion tensor imagingWaqar Rashid
MS NMR Research Unit, Dept of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, United Kingdom
J Neurol 255:390-7. 2008..In conclusion, although subtle NABT abnormalities were detected in early RR MS, the absence of longitudinal change suggests a limited role for global DTI assessment of NABT in following the early disease course... - Selective magnetization transfer ratio decrease in the visual cortex following optic neuritisBertrand Audoin
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
Brain 129:1031-9. 2006.... - Application of a B-spline active surface technique to the measurement of cervical cord volume in multiple sclerosis from three-dimensional MR imagesSimon J Hickman
NMR Research Unit, Institute of Neurology, University College London, London, UK
J Magn Reson Imaging 18:368-71. 2003..However, this methodology is less sensitive at detecting small serial changes compared with the previously reported method... - Detecting treatment effects on brain atrophy in relapsing remitting multiple sclerosis: sample size estimatesValerie M Anderson
MS NMR Research Unit, University College London Institute of Neurology, Queen Square, London, WC1N 3BG, UK
J Neurol 254:1588-94. 2007.... - Effect of natalizumab on conversion of gadolinium enhancing lesions to T1 hypointense lesions in relapsing multiple sclerosisCatherine M Dalton
Institute of Neurology, London, UK
J Neurol 251:407-13. 2004.... - Contiguous-slice zonally oblique multislice (CO-ZOOM) diffusion tensor imaging: examples of in vivo spinal cord and optic nerve applicationsNicholas G Dowell
NMR Research Unit, Institute of Neurology, University College London, London, UK
J Magn Reson Imaging 29:454-60. 2009..To describe and demonstrate a new technique that allows diffusion tensor imaging of small structures such as the spinal cord (SC) and optic nerve (ON) with contiguous slices and reduced image distortions using a narrow field of view (FOV)... - Diffusion tensor imaging of post mortem multiple sclerosis brainKlaus Schmierer
Institute of Neurology, University College London, NMR Research Unit, Box 117, Queen Square, London WC1N 3BG, UK
Neuroimage 35:467-77. 2007..70, p<0.001) and (ii) MD (r=-0.66, p<0.001). In conclusion, this study suggests that FA and MD are affected by myelin content and - to a lesser degree - axonal count in post mortem MS brain... - A method for measuring the cross sectional area of the anterior portion of the optic nerve in vivo using a fast 3D MRI sequenceMarios C Yiannakas
Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
J Magn Reson Imaging 31:1486-91. 2010.... - A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging--evidence of Wallerian degenerationOlga Ciccarelli
NMR Research Unit, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK
J Neurol 250:287-92. 2003.... - High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosisKlaus Schmierer
UCL Institute of Neurology, Department of Neuroinflammation, NMR Research Unit, London, UK
Brain 133:858-67. 2010.... - Characterizing function-structure relationships in the human visual system with functional MRI and diffusion tensor imagingAhmed T Toosy
NMR Research Unit, Institute of Neurology, University College London, London WC1N 3BG, UK
Neuroimage 21:1452-63. 2004..The results support the hypothesis that the visual cortical fMRI response is constrained by the external anatomical connections of the subserving optic radiations... - Optic nerve diffusion measurement from diffusion-weighted imaging in optic neuritisSimon J Hickman
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
AJNR Am J Neuroradiol 26:951-6. 2005.... - A study of subtle blood brain barrier disruption in a placebo-controlled trial of natalizumab in relapsing remitting multiple sclerosisDerek Soon
Department of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, United Kingdom
J Neurol 254:306-14. 2007..12). There is evidence of a subtle BBB leakage within visibly non-enhancing lesions in RRMS that was not modified by alpha4 integrin blockade in this substudy cohort... - Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trialRaju Kapoor
Department of Neuroinflammation, National Hospital for Neurology and Neurosurgery and the Institute of Neurology, Queen Square, London, UK
Lancet Neurol 9:681-8. 2010..In this phase 2 trial, we aimed to assess whether the sodium-channel blocker lamotrigine is also neuroprotective in patients with secondary progressive multiple sclerosis... - Localization of grey matter atrophy in early RRMS : A longitudinal studyBertrand Audoin
NMR Research Group, Institute of Neurology, Queen Square, London, UK
J Neurol 253:1495-501. 2006..This study suggests that early in the clinical course of RRMS, the thalamic atrophy is more consistently apparent than regional cortical atrophy... - Grey and white matter atrophy in early clinical stages of primary progressive multiple sclerosisJaume Sastre-Garriga
Institute of Neurology, UCL, 23 Queen Square, London WC1N 3BG, UK
Neuroimage 22:353-9. 2004..CONCLUSIONS: Brain atrophy is seen in the early stages of PPMS and affects both GM and WM. WM atrophy appears more closely related to clinical outcome and WM focal damage than GM atrophy in this patient group... - Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromesCatherine M Dalton
NMR Research Group, Institute of Neurology, London, UK
Brain 127:1101-7. 2004..Longer-term follow-up is required to determine whether early grey matter atrophy is associated with subsequent disability or cognitive impairment... - A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosisJeremy Chataway
National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, UK
Mult Scler 17:81-8. 2011.... - Disability and lesion load in MS: a reassessment with MS functional composite score and 3D fast FLAIROlga Ciccarelli
NMR Research Unit, Institute of Neurology, London, UK
J Neurol 249:18-24. 2002..The MSFC score did not improve the clinico-radiological paradox that is found in MS, despite including information on cognitive function... - Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRIVarun Sethi
Queen Square MS Center, NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
J Neurol Neurosurg Psychiatry 83:877-82. 2012.... - Effects of formalin fixation on magnetic resonance indices in multiple sclerosis cortical gray matterKlaus Schmierer
UCL Institute of Neurology, Department of Neuroinflammation, NMR Research Unit, London, United Kingdom
J Magn Reson Imaging 32:1054-60. 2010..Fixation induces tissue alterations that may confound inference of in vivo observations from MRI/histology correlation studies... - Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosisCatherine M Dalton
NMR Research Unit, Institute of Neurology, University College London, United Kingdom
Ann Neurol 52:47-53. 2002..The high specificity, positive predictive value, and accuracy of the new criteria for clinically definite MS support their clinical relevance... - Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumesDeclan T Chard
NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
J Magn Reson Imaging 32:223-8. 2010.... - MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective studyJosephine K Swanton
Nuclear Magnetic Resonance Research Unit, Department of Neuroinflammation and Headache, Institute of Neurology, University College London, London, UK
Lancet Neurol 6:677-86. 2007..We applied all three criteria in a large cohort of CIS patients to assess their performance by use of conversion to clinically definite multiple sclerosis (CDMS) as the outcome... - Principal component and linear discriminant analysis of T1 histograms of white and grey matter in multiple sclerosisDaniel J Tozer
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, WC1N 3BG London, UK
Magn Reson Imaging 24:793-800. 2006..Although in these histograms PCA and LDA did not add greatly to the discriminatory power of traditional histogram parameters, they provide marginally better performance, while relying only on data-driven feature selection... - Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevanceDavid H Miller
Department of Neuroinflammation, Institute of Neurology, London, UK
Brain 125:1676-95. 2002..Atrophy provides a sensitive measure of the neurodegenerative component of multiple sclerosis and should be measured in trials evaluating potential anti-inflammatory, remyelinating or neuroprotective therapies... - Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1aEe Tuan Lim
Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
J Negat Results Biomed 3:4. 2004..Furthermore there is no correlation between S100B levels and the primary and secondary outcome measures... - The relationship between lesion and normal appearing brain tissue abnormalities in early relapsing remitting multiple sclerosisColette M Griffin
NMR Research Unit, Institute of Neurology, London, UK
J Neurol 249:193-9. 2002..The lack of correlation between NAWM and lesion abnormalities suggests that they have developed by at least partly independent mechanisms. T1 may be more sensitive than MTR in detecting subtle pathological changes in NAWM and NAGM... - Recent advances in neuroimaging of multiple sclerosisWaqar Rashid
MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
Semin Neurol 28:46-55. 2008..With increased sophistication and improved analysis of these techniques, understanding of the pathology underlying MS may increase, and objective quantification of the natural history of MS is possible... - A controlled trial of natalizumab for relapsing multiple sclerosisDavid H Miller
Department of Neuroinflammation, Institute of Neurology, London, United Kingdom
N Engl J Med 348:15-23. 2003..Natalizumab is an alpha4 integrin antagonist that reduced the development of brain lesions in experimental models and in a preliminary study of patients with multiple sclerosis... - Overview of London trial of intramuscular interferon-beta Ia in primary-progressive multiple sclerosisDavid H Miller
Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Mult Scler 10:S56-7. 2004..A larger study would be required to evaluate treatment on disability in this patient cohort and further work is needed to elucidate the relationship between quantitative MR and clinical measures over the longer term... - Monitoring disease activity and progression in primary progressive multiple sclerosis using MRI: sub-voxel registration to identify lesion changes and to detect cerebral atrophyValerie L Stevenson
NMR Research Unit, Institute of Neurology, London
J Neurol 249:171-7. 2002.... - Magnetization transfer ratio and myelin in postmortem multiple sclerosis brainKlaus Schmierer
Department of Neuroinflammation, MS NMR Research Unit, University College London, United Kingdom
Ann Neurol 56:407-15. 2004..MTR was significantly higher in remyelinated than demyelinated lesions (means: 30.0 [standard deviation, 2.9] vs 23.8 [standard deviation, 4.3], p = 0.008). In conclusion, MTR is affected by myelin content in MS white matter... - Reduced R2' in multiple sclerosis normal appearing white matter and lesions may reflect decreased myelin and iron contentDavid Paling
NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 83:785-92. 2012..R(2)' may detect features of multiple sclerosis (MS) not evident with conventional MRI... - Magnetic resonance imaging measures of brain atrophy in multiple sclerosisValerie M Anderson
Department of Neuroinflammation, Institute of Neurology, University College of London, London, United Kingdom
J Magn Reson Imaging 23:605-18. 2006.... - The reproducibility and sensitivity of brain tissue volume measurements derived from an SPM-based segmentation methodologyDeclan T Chard
NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
J Magn Reson Imaging 15:259-67. 2002.... - Primary-progressive multiple sclerosisDavid H Miller
Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
Lancet Neurol 6:903-12. 2007..Future research should focus on the clarification of the mechanisms of axonal loss, improvements to the design of clinical trials, and the development of effective neuroprotective treatments... - Brain atrophy, interferon beta, and treatment trials in multiple sclerosisDavid H Miller
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London WC1N 3BG, UK
Lancet 364:1463-4. 2004 - Reproducibility of in vivo metabolite quantification with proton magnetic resonance spectroscopic imagingDeclan T Chard
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
J Magn Reson Imaging 15:219-25. 2002..3 mL) and the linear combination model (LCModel). MATERIALS and.. - MRI monitoring of MS in clinical trialsDavid H Miller
NMR Research Unit, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK
Clin Neurol Neurosurg 104:236-43. 2002 - A longitudinal study of abnormalities on MRI and disability from multiple sclerosisPeter A Brex
Nuclear Magnetic Resonance Research Unit, Institute of Neurology, Queen Sq, London, United Kingdom
N Engl J Med 346:158-64. 2002..This relation is only moderate, so the volume of the lesions alone may not be an adequate basis for decisions about the use of disease-modifying treatment...