David H Miller

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Advances in imaging to support the development of novel therapies for multiple sclerosis
    D H Miller
    Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Clin Pharmacol Ther 91:621-34. 2012
  2. doi request reprint Firategrast for relapsing remitting multiple sclerosis: a phase 2, randomised, double-blind, placebo-controlled trial
    David H Miller
    Department of Neuroinflammation, London, UK
    Lancet Neurol 11:131-9. 2012
  3. doi request reprint Clinically isolated syndromes
    David H Miller
    Nuclear Magnetic Resonance Research Unit, UCL Institute of Neurology, London, UK
    Lancet Neurol 11:157-69. 2012
  4. ncbi request reprint Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: evidence that axonal loss is a substrate of MRI-detected atrophy
    S Anand Trip
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, UK
    Neuroimage 31:286-93. 2006
  5. doi request reprint Scanning laser polarimetry quantification of retinal nerve fiber layer thinning following optic neuritis
    S Anand Trip
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, United Kingdom
    J Neuroophthalmol 30:235-42. 2010
  6. ncbi request reprint Adaptive cortical plasticity in higher visual areas after acute optic neuritis
    Ahmed T Toosy
    Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 57:622-33. 2005
  7. doi request reprint A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, UK
    Brain 133:2592-602. 2010
  8. ncbi request reprint Optic radiation changes after optic neuritis detected by tractography-based group mapping
    Olga Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Hum Brain Mapp 25:308-16. 2005
  9. doi request reprint Gray matter atrophy is related to long-term disability in multiple sclerosis
    Leonora K Fisniku
    Nuclear Magnetic Resonance Research Unit, Institute of Neurology, University College London, UK
    Ann Neurol 64:247-54. 2008
  10. doi request reprint Early factors associated with axonal loss after optic neuritis
    Andrew P D Henderson
    NMR Research Unit, University College London, Institute of Neurology, London, United Kingdom
    Ann Neurol 70:955-63. 2011

Detail Information

Publications78

  1. doi request reprint Advances in imaging to support the development of novel therapies for multiple sclerosis
    D H Miller
    Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Clin Pharmacol Ther 91:621-34. 2012
    ..Retinal axonal loss measured using optical coherence tomography (OCT) can assess acute neuroprotection in optic neuritis...
  2. doi request reprint Firategrast for relapsing remitting multiple sclerosis: a phase 2, randomised, double-blind, placebo-controlled trial
    David H Miller
    Department of Neuroinflammation, London, UK
    Lancet Neurol 11:131-9. 2012
    ..We assessed the safety and efficacy of firategrast, a small oral anti-α4β-integrin molecule, in patients with relapsing remitting MS...
  3. doi request reprint Clinically isolated syndromes
    David H Miller
    Nuclear Magnetic Resonance Research Unit, UCL Institute of Neurology, London, UK
    Lancet Neurol 11:157-69. 2012
    ..Targets for future therapeutic progress are to achieve safe and effective long-term immunomodulation with neuroprotection and repair...
  4. ncbi request reprint Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: evidence that axonal loss is a substrate of MRI-detected atrophy
    S Anand Trip
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, UK
    Neuroimage 31:286-93. 2006
    ..By inference, axonal loss due to other post-inflammatory brain lesions is likely to contribute to the global MRI measure of brain atrophy in multiple sclerosis...
  5. doi request reprint Scanning laser polarimetry quantification of retinal nerve fiber layer thinning following optic neuritis
    S Anand Trip
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, United Kingdom
    J Neuroophthalmol 30:235-42. 2010
    ..This study was designed to use SLP to measure axonal loss following a single episode of optic neuritis and to determine if there is a relationship between the degree of axonal loss and the degree of residual visual dysfunction...
  6. ncbi request reprint Adaptive cortical plasticity in higher visual areas after acute optic neuritis
    Ahmed T Toosy
    Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 57:622-33. 2005
    ..The key findings of this study are from the second analysis and suggest a genuine adaptive role for cortical reorganization within extrastriate visual areas early after optic neuritis...
  7. doi request reprint A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, UK
    Brain 133:2592-602. 2010
    ..Optical coherence tomography-measured retinal nerve fibre layer loss after 6 months is a suitable outcome measure for proof-of-concept trials of acute neuroprotection in optic neuritis...
  8. ncbi request reprint Optic radiation changes after optic neuritis detected by tractography-based group mapping
    Olga Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Hum Brain Mapp 25:308-16. 2005
    ..These findings suggest that the group mapping techniques might be used to assess changes in the optic radiations in patients after an episode of optic neuritis. The changes we have observed may be secondary to the optic nerve damage...
  9. doi request reprint Gray matter atrophy is related to long-term disability in multiple sclerosis
    Leonora K Fisniku
    Nuclear Magnetic Resonance Research Unit, Institute of Neurology, University College London, UK
    Ann Neurol 64:247-54. 2008
    ..To determine the relation of gray matter (GM) and white matter (WM) brain volumes, and WM lesion load, with clinical outcomes 20 years after first presentation with clinically isolated syndrome suggestive of multiple sclerosis (MS)...
  10. doi request reprint Early factors associated with axonal loss after optic neuritis
    Andrew P D Henderson
    NMR Research Unit, University College London, Institute of Neurology, London, United Kingdom
    Ann Neurol 70:955-63. 2011
    ..We investigated clinical, electrophysiological, and imaging measures at presentation and after 3 months as potential markers of axonal loss following optic neuritis...
  11. doi request reprint Neuroplasticity predicts outcome of optic neuritis independent of tissue damage
    Thomas M Jenkins
    Department of Brain Repair and Rehabilitation, University College London UCL Institute of Neurology, University College London, London, UK
    Ann Neurol 67:99-113. 2010
    ..To investigate the reasons behind good recovery following ON, despite residual optic nerve demyelination and neuroaxonal damage...
  12. ncbi request reprint Upper cervical cord area in early relapsing-remitting multiple sclerosis: cross-sectional study of factors influencing cord size
    Waqar Rashid
    MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    J Magn Reson Imaging 23:473-6. 2006
    ..To determine whether the upper cervical cord area (UCCA) is influenced by disease effect in early relapsing-remitting multiple sclerosis (MS), using statistical modeling to account for potential covariates...
  13. ncbi request reprint Optic nerve diffusion tensor imaging in optic neuritis
    S Anand Trip
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 30:498-505. 2006
    ..57, P = 0.006) and lambda( perpendicular) (r = -0.56, P = 0.007). These findings suggest that optic nerve DT-MRI measures provide an indication of the structural integrity of axons...
  14. doi request reprint Exploring the relationship between white matter and gray matter damage in early primary progressive multiple sclerosis: an in vivo study with TBSS and VBM
    Benedetta Bodini
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom
    Hum Brain Mapp 30:2852-61. 2009
    ..Longitudinal studies will determine whether the GM atrophy precedes or follows the NAWM damage. The methodology that we described may be useful to investigate other neurological disorders affecting both the WM and the GM...
  15. ncbi request reprint An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    Brain 131:277-87. 2008
    ..This may indicate a difference in the extent of the pathological processes that cause axonal loss in the retina, and by inference the optic nerve, in secondary progressive MS and primary progressive MS...
  16. ncbi request reprint Normal-appearing brain t1 relaxation time predicts disability in early primary progressive multiple sclerosis
    Francesco Manfredonia
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, England
    Arch Neurol 64:411-5. 2007
    ....
  17. ncbi request reprint A serial MRI study following optic nerve mean area in acute optic neuritis
    Simon J Hickman
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 127:2498-505. 2004
    ..Over the longer term, there was loss of tissue. The lack of association between 1 year optic nerve mean area and visual outcome may reflect a mild loss of tissue, redundancy or remodelling of function...
  18. doi request reprint Magnetization transfer ratio in gray matter: a potential surrogate marker for progression in early primary progressive multiple sclerosis
    Zhaleh Khaleeli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, England
    Arch Neurol 65:1454-9. 2008
    ..Magnetization transfer imaging has the potential to provide a surrogate marker for progression in primary progressive multiple sclerosis (PPMS)...
  19. doi request reprint Assessing structure and function of the afferent visual pathway in multiple sclerosis and associated optic neuritis
    Madhan Kolappan
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    J Neurol 256:305-19. 2009
    ..These collective investigative methods have advanced knowledge of pathophysiological mechanisms in MS and optic neuritis. Relevant ongoing studies and future directions are discussed...
  20. ncbi request reprint Grey and white matter volume changes in early primary progressive multiple sclerosis: a longitudinal study
    Jaume Sastre-Garriga
    Institute of Neurology, University College London, London, UK
    Brain 128:1454-60. 2005
    ..The former may be predicted by the degree of inflammation, while the latter seems to be independent of it. SIENA and SPM-based methods appear to provide complementary information...
  21. pmc Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation
    Klaus Schmierer
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
    Magn Reson Med 59:268-77. 2008
    ..01) whereas postfixation T(2) (r = 0.92; P < 0.01), T(1) (r = 0.89; P < 0.01), and f(B) (r = -0.86; P < 0.01) were superior. All diffusivity measures (except for D(ax) in unfixed tissue) were predictors of myelin content...
  22. doi request reprint Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics
    Olga Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London
    Hum Brain Mapp 30:615-24. 2009
    ....
  23. doi request reprint Diffusion MRI-based cortical complexity alterations associated with executive function in multiple sclerosis
    Nils Muhlert
    NMR Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    J Magn Reson Imaging 38:54-63. 2013
    ....
  24. pmc Cerebral arterial bolus arrival time is prolonged in multiple sclerosis and associated with disability
    David Paling
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK
    J Cereb Blood Flow Metab 34:34-42. 2014
    ..Bolus arrival time was longer in patients with greater disability independent of atrophy and T2 lesion load, suggesting alterations in cerebral arterial hemodynamics may be a marker of clinically relevant pathology. ..
  25. pmc Combining tractography and cortical measures to test system-specific hypotheses in multiple sclerosis
    Nikos Gorgoraptis
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, UK
    Mult Scler 16:555-65. 2010
    ..Combining tractography and cortical measures is a useful approach in testing hypotheses which are specific to clinically relevant functional systems in multiple sclerosis, and can be applied to other neurological diseases...
  26. ncbi request reprint Visual recovery following acute optic neuritis--a clinical, electrophysiological and magnetic resonance imaging study
    Simon J Hickman
    NMR Research Unit, Dept of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Neurol 251:996-1005. 2004
    ....
  27. pmc Quantitative magnetization transfer imaging in postmortem multiple sclerosis brain
    Klaus Schmierer
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
    J Magn Reson Imaging 26:41-51. 2007
    ....
  28. ncbi request reprint Cerebral atrophy measurement in clinically isolated syndromes and relapsing remitting multiple sclerosis: a comparison of registration-based methods
    Valerie M Anderson
    MS NMR Research Unit, University College London, Institute of Neurology, Queen Square, London, UK
    J Neuroimaging 17:61-8. 2007
    ....
  29. ncbi request reprint A study of subtle blood brain barrier disruption in a placebo-controlled trial of natalizumab in relapsing remitting multiple sclerosis
    Derek Soon
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London, WC1N 3BG, United Kingdom
    J Neurol 254:306-14. 2007
    ..12). There is evidence of a subtle BBB leakage within visibly non-enhancing lesions in RRMS that was not modified by alpha4 integrin blockade in this substudy cohort...
  30. doi request reprint Sodium accumulation is associated with disability and a progressive course in multiple sclerosis
    David Paling
    NMR Research Unit, Department of Neuroinflammation, Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Brain 136:2305-17. 2013
    ..Increased total sodium concentration is likely to reflect neuroaxonal pathophysiology leading to clinical progression and increased disability...
  31. doi request reprint Longitudinal evaluation of clinically early relapsing-remitting multiple sclerosis with diffusion tensor imaging
    Waqar Rashid
    MS NMR Research Unit, Dept of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, United Kingdom
    J Neurol 255:390-7. 2008
    ..In conclusion, although subtle NABT abnormalities were detected in early RR MS, the absence of longitudinal change suggests a limited role for global DTI assessment of NABT in following the early disease course...
  32. ncbi request reprint Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis
    S Anand Trip
    NMR Research Unit, Department of Neuroinflammation, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 58:383-91. 2005
    ..This noninvasive RNFL imaging technique could be used in trials of experimental treatments that aim to protect optic nerves from axonal loss...
  33. ncbi request reprint Application of a B-spline active surface technique to the measurement of cervical cord volume in multiple sclerosis from three-dimensional MR images
    Simon J Hickman
    NMR Research Unit, Institute of Neurology, University College London, London, UK
    J Magn Reson Imaging 18:368-71. 2003
    ..To evaluate the ability of a B-spline active surface technique to detect cervical spinal cord atrophy due to multiple sclerosis (MS) compared with intensity-based contouring...
  34. ncbi request reprint Selective magnetization transfer ratio decrease in the visual cortex following optic neuritis
    Bertrand Audoin
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Brain 129:1031-9. 2006
    ....
  35. ncbi request reprint Effect of natalizumab on conversion of gadolinium enhancing lesions to T1 hypointense lesions in relapsing multiple sclerosis
    Catherine M Dalton
    Institute of Neurology, London, UK
    J Neurol 251:407-13. 2004
    ..Its effect on evolution of new Gd enhancing lesions to T1 hypointense lesions is unknown...
  36. doi request reprint Contiguous-slice zonally oblique multislice (CO-ZOOM) diffusion tensor imaging: examples of in vivo spinal cord and optic nerve applications
    Nicholas G Dowell
    NMR Research Unit, Institute of Neurology, University College London, London, UK
    J Magn Reson Imaging 29:454-60. 2009
    ..To describe and demonstrate a new technique that allows diffusion tensor imaging of small structures such as the spinal cord (SC) and optic nerve (ON) with contiguous slices and reduced image distortions using a narrow field of view (FOV)...
  37. ncbi request reprint Detecting treatment effects on brain atrophy in relapsing remitting multiple sclerosis: sample size estimates
    Valerie M Anderson
    MS NMR Research Unit, University College London Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 254:1588-94. 2007
    ....
  38. pmc Biomarker report from the phase II lamotrigine trial in secondary progressive MS - neurofilament as a surrogate of disease progression
    Sharmilee Gnanapavan
    Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom
    PLoS ONE 8:e70019. 2013
    ..The current study was an additional study to investigate the value of neurofilament (NfH) and other biomarkers in predicting prognosis and/or response to treatment...
  39. ncbi request reprint A study of the mechanisms of normal-appearing white matter damage in multiple sclerosis using diffusion tensor imaging--evidence of Wallerian degeneration
    Olga Ciccarelli
    NMR Research Unit, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK
    J Neurol 250:287-92. 2003
    ....
  40. ncbi request reprint Characterizing function-structure relationships in the human visual system with functional MRI and diffusion tensor imaging
    Ahmed T Toosy
    NMR Research Unit, Institute of Neurology, University College London, London WC1N 3BG, UK
    Neuroimage 21:1452-63. 2004
    ..The results support the hypothesis that the visual cortical fMRI response is constrained by the external anatomical connections of the subserving optic radiations...
  41. doi request reprint High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosis
    Klaus Schmierer
    UCL Institute of Neurology, Department of Neuroinflammation, NMR Research Unit, London, UK
    Brain 133:858-67. 2010
    ....
  42. ncbi request reprint A method for measuring the cross sectional area of the anterior portion of the optic nerve in vivo using a fast 3D MRI sequence
    Marios C Yiannakas
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Magn Reson Imaging 31:1486-91. 2010
    ....
  43. ncbi request reprint Optic nerve diffusion measurement from diffusion-weighted imaging in optic neuritis
    Simon J Hickman
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    AJNR Am J Neuroradiol 26:951-6. 2005
    ..DW imaging of the optic nerves, however, presents many challenges. The goal of this study was to measure ADC in patients with optic neuritis by using zonal oblique multisection echoplanar imaging...
  44. pmc Diffusion tensor imaging of post mortem multiple sclerosis brain
    Klaus Schmierer
    Institute of Neurology, University College London, NMR Research Unit, Box 117, Queen Square, London WC1N 3BG, UK
    Neuroimage 35:467-77. 2007
    ..70, p<0.001) and (ii) MD (r=-0.66, p<0.001). In conclusion, this study suggests that FA and MD are affected by myelin content and - to a lesser degree - axonal count in post mortem MS brain...
  45. doi request reprint Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial
    Raju Kapoor
    Department of Neuroinflammation, National Hospital for Neurology and Neurosurgery and the Institute of Neurology, Queen Square, London, UK
    Lancet Neurol 9:681-8. 2010
    ..In this phase 2 trial, we aimed to assess whether the sodium-channel blocker lamotrigine is also neuroprotective in patients with secondary progressive multiple sclerosis...
  46. ncbi request reprint Localization of grey matter atrophy in early RRMS : A longitudinal study
    Bertrand Audoin
    NMR Research Group, Institute of Neurology, Queen Square, London, UK
    J Neurol 253:1495-501. 2006
    ..This study suggests that early in the clinical course of RRMS, the thalamic atrophy is more consistently apparent than regional cortical atrophy...
  47. pmc MS cortical lesions on DIR: not quite what they seem?
    Varun Sethi
    Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom
    PLoS ONE 8:e78879. 2013
    ..In this study, we systematically investigated if the use of high resolution PSIR scans changes the classification of CGM lesions, when compared with standard resolution DIR scans...
  48. pmc Gray matter atrophy rate as a marker of disease progression in AD
    Valerie M Anderson
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
    Neurobiol Aging 33:1194-202. 2012
    ..Jacobian integration could be useful for measuring GM atrophy rate in Alzheimer's disease as a marker of disease progression and treatment efficacy...
  49. doi request reprint ADvanced IMage Algebra (ADIMA): a novel method for depicting multiple sclerosis lesion heterogeneity, as demonstrated by quantitative MRI
    Marios C Yiannakas
    Department of Neuroinflammation, University College London, Institute of Neurology, London, UK
    Mult Scler 19:732-41. 2013
    ..This may partly reflect pathological heterogeneity in WMLs, which is not apparent on T2w scans...
  50. ncbi request reprint Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes
    Catherine M Dalton
    NMR Research Group, Institute of Neurology, London, UK
    Brain 127:1101-7. 2004
    ..Longer-term follow-up is required to determine whether early grey matter atrophy is associated with subsequent disability or cognitive impairment...
  51. doi request reprint A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis
    Jeremy Chataway
    National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, UK
    Mult Scler 17:81-8. 2011
    ....
  52. ncbi request reprint Grey and white matter atrophy in early clinical stages of primary progressive multiple sclerosis
    Jaume Sastre-Garriga
    Institute of Neurology, UCL, 23 Queen Square, London WC1N 3BG, UK
    Neuroimage 22:353-9. 2004
    ..There is little information available on grey and white matter (GM and WM) atrophy in primary progressive multiple sclerosis (PPMS) and on their relationships with clinical and other magnetic resonance imaging (MRI) measures...
  53. ncbi request reprint Disability and lesion load in MS: a reassessment with MS functional composite score and 3D fast FLAIR
    Olga Ciccarelli
    NMR Research Unit, Institute of Neurology, London, UK
    J Neurol 249:18-24. 2002
    ..The MSFC score did not improve the clinico-radiological paradox that is found in MS, despite including information on cognitive function...
  54. ncbi request reprint Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions
    Nils Muhlert
    Department of Neuroinflammation, NMR Research Unit, UCL Institute of Neurology, London, UK Cognitive Neuroscience, Department of Psychology, Cardiff University, Cardiff, UK
    J Neurol Neurosurg Psychiatry 85:833-9. 2014
    ..We used structural and metabolic brain imaging to test two hypotheses: (i) glutamate levels in grey matter regions are abnormal in MS, and (ii) patients show a relationship between glutamate concentration and memory performance...
  55. doi request reprint Changing associations between cognitive impairment and imaging in multiple sclerosis as the disease progresses
    Sophia A Penny
    UCL Institute of Neurology, Queen Square, London, UK
    J Neuropsychiatry Clin Neurosci 25:134-40. 2013
    ..Our findings suggest that gray-matter pathology, reflected by atrophy measurements, becomes increasingly important in determining cognition as MS progresses...
  56. doi request reprint Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI
    Varun Sethi
    Queen Square MS Center, NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 83:877-82. 2012
    ....
  57. ncbi request reprint Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis
    Catherine M Dalton
    NMR Research Unit, Institute of Neurology, University College London, United Kingdom
    Ann Neurol 52:47-53. 2002
    ..The high specificity, positive predictive value, and accuracy of the new criteria for clinically definite MS support their clinical relevance...
  58. pmc Effects of formalin fixation on magnetic resonance indices in multiple sclerosis cortical gray matter
    Klaus Schmierer
    UCL Institute of Neurology, Department of Neuroinflammation, NMR Research Unit, London, United Kingdom
    J Magn Reson Imaging 32:1054-60. 2010
    ..Fixation induces tissue alterations that may confound inference of in vivo observations from MRI/histology correlation studies...
  59. ncbi request reprint MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study
    Josephine K Swanton
    Nuclear Magnetic Resonance Research Unit, Department of Neuroinflammation and Headache, Institute of Neurology, University College London, London, UK
    Lancet Neurol 6:677-86. 2007
    ..We applied all three criteria in a large cohort of CIS patients to assess their performance by use of conversion to clinically definite multiple sclerosis (CDMS) as the outcome...
  60. ncbi request reprint Principal component and linear discriminant analysis of T1 histograms of white and grey matter in multiple sclerosis
    Daniel J Tozer
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, WC1N 3BG London, UK
    Magn Reson Imaging 24:793-800. 2006
    ..Although in these histograms PCA and LDA did not add greatly to the discriminatory power of traditional histogram parameters, they provide marginally better performance, while relying only on data-driven feature selection...
  61. doi request reprint Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes
    Declan T Chard
    NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    J Magn Reson Imaging 32:223-8. 2010
    ....
  62. doi request reprint MRI acquisition and analysis protocol for in vivo intraorbital optic nerve segmentation at 3T
    Marios C Yiannakas
    Nuclear Magnetic Resonance Research Unit, University College London Institute of Neurology, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:4235-40. 2013
    ..To present a new acquisition and analysis protocol for reliable and reproducible segmentation of the entire intraorbital optic nerve (ION) mean cross-sectional area by means of magnetic resonance imaging (MRI) at 3 tesla (T)...
  63. pmc Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1a
    Ee Tuan Lim
    Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Negat Results Biomed 3:4. 2004
    ..Furthermore there is no correlation between S100B levels and the primary and secondary outcome measures...
  64. ncbi request reprint The relationship between lesion and normal appearing brain tissue abnormalities in early relapsing remitting multiple sclerosis
    Colette M Griffin
    NMR Research Unit, Institute of Neurology, London, UK
    J Neurol 249:193-9. 2002
    ..The purpose was to determine whether abnormalities are already detectable in normal appearing tissues in early MS, and if so how they correlate with lesion characteristics...
  65. ncbi request reprint Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance
    David H Miller
    Department of Neuroinflammation, Institute of Neurology, London, UK
    Brain 125:1676-95. 2002
    ..Atrophy provides a sensitive measure of the neurodegenerative component of multiple sclerosis and should be measured in trials evaluating potential anti-inflammatory, remyelinating or neuroprotective therapies...
  66. doi request reprint Recent advances in neuroimaging of multiple sclerosis
    Waqar Rashid
    MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    Semin Neurol 28:46-55. 2008
    ..With increased sophistication and improved analysis of these techniques, understanding of the pathology underlying MS may increase, and objective quantification of the natural history of MS is possible...
  67. ncbi request reprint Overview of London trial of intramuscular interferon-beta Ia in primary-progressive multiple sclerosis
    David H Miller
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:S56-7. 2004
    ..A larger study would be required to evaluate treatment on disability in this patient cohort and further work is needed to elucidate the relationship between quantitative MR and clinical measures over the longer term...
  68. ncbi request reprint A controlled trial of natalizumab for relapsing multiple sclerosis
    David H Miller
    Department of Neuroinflammation, Institute of Neurology, London, United Kingdom
    N Engl J Med 348:15-23. 2003
    ..Natalizumab is an alpha4 integrin antagonist that reduced the development of brain lesions in experimental models and in a preliminary study of patients with multiple sclerosis...
  69. ncbi request reprint Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain
    Klaus Schmierer
    Department of Neuroinflammation, MS NMR Research Unit, University College London, United Kingdom
    Ann Neurol 56:407-15. 2004
    ..MTR was significantly higher in remyelinated than demyelinated lesions (means: 30.0 [standard deviation, 2.9] vs 23.8 [standard deviation, 4.3], p = 0.008). In conclusion, MTR is affected by myelin content in MS white matter...
  70. ncbi request reprint Monitoring disease activity and progression in primary progressive multiple sclerosis using MRI: sub-voxel registration to identify lesion changes and to detect cerebral atrophy
    Valerie L Stevenson
    NMR Research Unit, Institute of Neurology, London
    J Neurol 249:171-7. 2002
    ....
  71. doi request reprint Reduced R2' in multiple sclerosis normal appearing white matter and lesions may reflect decreased myelin and iron content
    David Paling
    NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 83:785-92. 2012
    ..R(2)' may detect features of multiple sclerosis (MS) not evident with conventional MRI...
  72. ncbi request reprint The reproducibility and sensitivity of brain tissue volume measurements derived from an SPM-based segmentation methodology
    Declan T Chard
    NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    J Magn Reson Imaging 15:259-67. 2002
    ....
  73. ncbi request reprint Primary-progressive multiple sclerosis
    David H Miller
    Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Lancet Neurol 6:903-12. 2007
    ..Future research should focus on the clarification of the mechanisms of axonal loss, improvements to the design of clinical trials, and the development of effective neuroprotective treatments...
  74. ncbi request reprint Magnetic resonance imaging measures of brain atrophy in multiple sclerosis
    Valerie M Anderson
    Department of Neuroinflammation, Institute of Neurology, University College of London, London, United Kingdom
    J Magn Reson Imaging 23:605-18. 2006
    ....
  75. ncbi request reprint Brain atrophy, interferon beta, and treatment trials in multiple sclerosis
    David H Miller
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London WC1N 3BG, UK
    Lancet 364:1463-4. 2004
  76. ncbi request reprint MRI monitoring of MS in clinical trials
    David H Miller
    NMR Research Unit, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, WC1N 3BG, London, UK
    Clin Neurol Neurosurg 104:236-43. 2002
  77. ncbi request reprint Reproducibility of in vivo metabolite quantification with proton magnetic resonance spectroscopic imaging
    Declan T Chard
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
    J Magn Reson Imaging 15:219-25. 2002
    ..3 mL) and the linear combination model (LCModel). MATERIALS and..
  78. ncbi request reprint A longitudinal study of abnormalities on MRI and disability from multiple sclerosis
    Peter A Brex
    Nuclear Magnetic Resonance Research Unit, Institute of Neurology, Queen Sq, London, United Kingdom
    N Engl J Med 346:158-64. 2002
    ..We sought to determine the relation between early lesion volume, changes in volume, and long-term disability...