D Miller

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. ncbi request reprint Spermatozoal RNA profiles of normal fertile men
    G Charles Ostermeier
    Department of Obstetrics and Gynecology, Center for Molecular Medicine and Genetics, and Institute for Scientific Computing, Wayne State University, Detroit, MI, USA
    Lancet 360:772-7. 2002
  2. doi request reprint Paternal DNA packaging in spermatozoa: more than the sum of its parts? DNA, histones, protamines and epigenetics
    David Miller
    Division of Reproduction and Early Development, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK
    Reproduction 139:287-301. 2010
  3. ncbi request reprint Evaluating the localization and DNA binding complexity of histones in mature sperm
    David Miller
    Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, West Yorkshire, UK
    Methods Mol Biol 927:459-75. 2013
  4. ncbi request reprint Spermatozoal RNA as reservoir, marker and carrier of epigenetic information: implications for cloning
    D Miller
    Reproduction and Early Development Unit, Leeds Institute of Genetics and Health Therapeutics, University of Leeds, Leeds, UK
    Reprod Domest Anim 42:2-9. 2007
  5. ncbi request reprint Ensuring continuity of the paternal genome: potential roles for spermatozoal RNA in mammalian embryogenesis
    David Miller
    Reproduction and Early Development Group, University Department of Obstetrics and Gynaecology, Level D, Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds, LI2 9NS, UK
    Soc Reprod Fertil Suppl 65:373-89. 2007
  6. ncbi request reprint The testis as a conduit for genomic plasticity: an advanced interdisciplinary workshop
    D Miller
    Reproduction and Early Development Group, Leeds Institute of Genetics and Health Therapeutics, University of Leeds, Leeds LS2 9JT, UK
    Biochem Soc Trans 35:605-8. 2007
  7. ncbi request reprint Spermatozoal RNA: Why is it there and what does it do?
    D Miller
    Reproduction and Early Development Research Group, Dept of Obstetrics and Gynaecology, University of Leeds, Level D, Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds, LS2 9NS, United Kingdom
    Gynecol Obstet Fertil 34:840-6. 2006
  8. ncbi request reprint Towards a better understanding of RNA carriage by ejaculate spermatozoa
    David Miller
    Reproduction and Early Development Research Group, Department of Obstetrics and Gynaecology, University of Leeds, Leeds General Infirmary, Belmont Grove, Leeds, UK
    Hum Reprod Update 12:757-67. 2006
  9. ncbi request reprint The controversy, potential and roles of spermatozoal RNA
    David Miller
    Reproduction and Early Development Group, University of Leeds, Department of Obstetrics and Gynaecology, Level D, Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds, LS2 9NS, UK
    Trends Mol Med 11:156-63. 2005
  10. ncbi request reprint A complex population of RNAs exists in human ejaculate spermatozoa: implications for understanding molecular aspects of spermiogenesis
    D Miller
    Centre for Reproduction Growth and Development, University of Leeds Division of Obstetrics and Gynaecology, Level D, Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds, UK
    Gene 237:385-92. 1999

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Spermatozoal RNA profiles of normal fertile men
    G Charles Ostermeier
    Department of Obstetrics and Gynecology, Center for Molecular Medicine and Genetics, and Institute for Scientific Computing, Wayne State University, Detroit, MI, USA
    Lancet 360:772-7. 2002
    ..Our aim was to determine whether we could use spermatozoal mRNAs to generate a genetic fingerprint of normal fertile men...
  2. doi request reprint Paternal DNA packaging in spermatozoa: more than the sum of its parts? DNA, histones, protamines and epigenetics
    David Miller
    Division of Reproduction and Early Development, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK
    Reproduction 139:287-301. 2010
    ..We also provide some thoughts on why this signature may be required in early embryogenesis...
  3. ncbi request reprint Evaluating the localization and DNA binding complexity of histones in mature sperm
    David Miller
    Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, West Yorkshire, UK
    Methods Mol Biol 927:459-75. 2013
    ..However, similar methods may be applicable to the sperm of other mammalian and even non-mammalian classes...
  4. ncbi request reprint Spermatozoal RNA as reservoir, marker and carrier of epigenetic information: implications for cloning
    D Miller
    Reproduction and Early Development Unit, Leeds Institute of Genetics and Health Therapeutics, University of Leeds, Leeds, UK
    Reprod Domest Anim 42:2-9. 2007
    ....
  5. ncbi request reprint Ensuring continuity of the paternal genome: potential roles for spermatozoal RNA in mammalian embryogenesis
    David Miller
    Reproduction and Early Development Group, University Department of Obstetrics and Gynaecology, Level D, Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds, LI2 9NS, UK
    Soc Reprod Fertil Suppl 65:373-89. 2007
    ....
  6. ncbi request reprint The testis as a conduit for genomic plasticity: an advanced interdisciplinary workshop
    D Miller
    Reproduction and Early Development Group, Leeds Institute of Genetics and Health Therapeutics, University of Leeds, Leeds LS2 9JT, UK
    Biochem Soc Trans 35:605-8. 2007
    ..In essence, could the testis be one of the favoured sites where genomic plasticity makes its mark?..
  7. ncbi request reprint Spermatozoal RNA: Why is it there and what does it do?
    D Miller
    Reproduction and Early Development Research Group, Dept of Obstetrics and Gynaecology, University of Leeds, Level D, Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds, LS2 9NS, United Kingdom
    Gynecol Obstet Fertil 34:840-6. 2006
    ..These data indicate that the spermatozoon is well matched to its role of delivering the paternal genome, but that additional male-benefits may also be accrued by the delivery of spermatozoal RNA...
  8. ncbi request reprint Towards a better understanding of RNA carriage by ejaculate spermatozoa
    David Miller
    Reproduction and Early Development Research Group, Department of Obstetrics and Gynaecology, University of Leeds, Leeds General Infirmary, Belmont Grove, Leeds, UK
    Hum Reprod Update 12:757-67. 2006
    ....
  9. ncbi request reprint The controversy, potential and roles of spermatozoal RNA
    David Miller
    Reproduction and Early Development Group, University of Leeds, Department of Obstetrics and Gynaecology, Level D, Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds, LS2 9NS, UK
    Trends Mol Med 11:156-63. 2005
    ....
  10. ncbi request reprint A complex population of RNAs exists in human ejaculate spermatozoa: implications for understanding molecular aspects of spermiogenesis
    D Miller
    Centre for Reproduction Growth and Development, University of Leeds Division of Obstetrics and Gynaecology, Level D, Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds, UK
    Gene 237:385-92. 1999
    ..This provides a unique opportunity to identify and investigate the many genes responsible for the structure and function/dysfunction of the male gamete using spermatozoal RNA as the template...
  11. ncbi request reprint Analysis and significance of messenger RNA in human ejaculated spermatozoa
    D Miller
    Division of Obstetrics and Gynaecology, Leeds General Infirmary, United Kingdom
    Mol Reprod Dev 56:259-64. 2000
    ..3. RNA isolated from spermatozoa or washed semen samples may facilitate the detection of mutations and deletions in testis-expressed AZF-linked genes...
  12. ncbi request reprint Environmental versus genetic sex determination: a possible factor in dinosaur extinction?
    David Miller
    University of Leeds, Leeds, United Kingdom
    Fertil Steril 81:954-64. 2004
    ..Current global warming also represents a risk for extant TSD species...
  13. ncbi request reprint In vivo DNA damage in gastric epithelial cells
    S M Everett
    The Centre for Digestive Diseases, The General Infirmary at Leeds, UK
    Mutat Res 468:73-85. 2000
    ..The comet assay is a reproducible measure of DNA damage in gastric epithelial cells. Damage accumulates in older, more superficial cells, and can be induced by oxidative stress...
  14. ncbi request reprint The effect of Helicobacter pylori infection on levels of DNA damage in gastric epithelial cells
    S M Everett
    The Centre for Digestive Diseases, The General Infirmary at Leeds, Great George Street, Leeds, LS1 3EX, UK
    Helicobacter 7:271-80. 2002
    ..The mechanism through which this occurs is not known. We aimed to determine the effect of H. pylori and gastritis on levels of DNA damage in gastric epithelial cells...
  15. ncbi request reprint Isolation, characterization and expression of the human Factor In the Germline alpha (FIGLA) gene in ovarian follicles and oocytes
    J Huntriss
    Academic Unit of Paediatrics, Obstetrics and Gynaecology, University of Leeds, D Floor, Clarendon Wing, Leeds General Infirmary, Belmont Grove, Leeds LS2 9NS, UK
    Mol Hum Reprod 8:1087-95. 2002
    ..This confirms our identification of the human homologue for this gene which maps to chromosome 2p12. Further work is required to understand its role in normal human oocyte development and the potential involvement in human infertility...
  16. pmc Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences
    Ali Arpanahi
    Reproduction and Early Development Unit, Leeds Institute of Genetics and Health Therapeutics, University of Leeds, Leeds, United Kingdom
    Genome Res 19:1338-49. 2009
    ..The ontology of genes under the control of endonuclease-sensitive regulatory regions implies a role for this phenomenon in subsequent embryonic development...
  17. ncbi request reprint Expression of Polycomb-group genes in human ovarian follicles, oocytes and preimplantation embryos
    M Hinkins
    Reproduction and Early Development Research Group, Faculty of Medicine and Health, University of Leeds, D Floor Clarendon Wing, Leeds General Infirmary, Leeds LS2 9NS, West Yorkshire, UK
    Reproduction 130:883-8. 2005
    ..YY1 and EZH2 transcripts were additionally detected in metaphase II oocytes...
  18. doi request reprint Paternal contributions: new functional insights for spermatozoal RNA
    Claudia Lalancette
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Cell Biochem 104:1570-9. 2008
    ..This review presents and discusses the functional significance of spermatozoal RNA in relation to some recent advances in the field...
  19. doi request reprint Characterization of nucleohistone and nucleoprotamine components in the mature human sperm nucleus
    Yan Li
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Wayne, MI 48201, USA
    Asian J Androl 10:535-41. 2008
    ..To simultaneously determine the localization of histones and protamines within human sperm nuclei...
  20. ncbi request reprint Reproductive biology: delivering spermatozoan RNA to the oocyte
    G Charles Ostermeier
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan 48201, USA
    Nature 429:154. 2004
    ....