J K Millar

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia
    J K Millar
    Medical Genetics Section The University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland
    Mol Psychiatry 6:173-8. 2001
  2. ncbi request reprint Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder
    R S Devon
    Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, UK
    Psychiatr Genet 11:71-8. 2001
  3. ncbi request reprint Disruption of two novel genes by a translocation co-segregating with schizophrenia
    J K Millar
    Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Molecular Medicine Centre and MRC Human Genetics Unit, both at Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 9:1415-23. 2000
  4. ncbi request reprint Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population
    P A Thomson
    Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, UK
    Mol Psychiatry 10:657-68, 616. 2005
  5. ncbi request reprint Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes
    D J Porteous
    Medical Genetics Section, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, EH4 2XU
    Cold Spring Harb Symp Quant Biol 68:383-94. 2003
  6. ncbi request reprint Cytogenetics and gene discovery in psychiatric disorders
    B S Pickard
    Medical Genetics, School of Molecular and Clinical Medicine, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Pharmacogenomics J 5:81-8. 2005
  7. ncbi request reprint Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria
    R James
    Medical Genetics Section, Department of Medical Sciences, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Mol Cell Neurosci 26:112-22. 2004
  8. ncbi request reprint Isolation and characterization of the mouse translin-associated protein X (Trax) gene
    R S Devon
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Mamm Genome 11:395-8. 2000
  9. ncbi request reprint Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site
    N J Brandon
    Merck Sharp and Dohme Research Labs, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    Mol Cell Neurosci 28:613-24. 2005
  10. ncbi request reprint A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42
    S MacGregor
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Kings Buildings, Edinburgh, UK
    Mol Psychiatry 9:1083-90. 2004

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia
    J K Millar
    Medical Genetics Section The University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland
    Mol Psychiatry 6:173-8. 2001
    ..Information regarding the structure of the DISC1 gene will facilitate assessment of its involvement in the aetiology of major mental illness in psychotic individuals unrelated to carriers of the translocation...
  2. ncbi request reprint Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder
    R S Devon
    Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, UK
    Psychiatr Genet 11:71-8. 2001
    ....
  3. ncbi request reprint Disruption of two novel genes by a translocation co-segregating with schizophrenia
    J K Millar
    Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Molecular Medicine Centre and MRC Human Genetics Unit, both at Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 9:1415-23. 2000
    ..Altogether, these observations indicate that DISC1 and DISC2 should be considered formal candidate genes for susceptibility to psychiatric illness...
  4. ncbi request reprint Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population
    P A Thomson
    Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, UK
    Mol Psychiatry 10:657-68, 616. 2005
    ..This result provides further supporting evidence for DISC1 as a susceptibility factor for both bipolar disorder and schizophrenia, consistent with the diagnoses in the original Scottish translocation family...
  5. ncbi request reprint Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes
    D J Porteous
    Medical Genetics Section, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, EH4 2XU
    Cold Spring Harb Symp Quant Biol 68:383-94. 2003
  6. ncbi request reprint Cytogenetics and gene discovery in psychiatric disorders
    B S Pickard
    Medical Genetics, School of Molecular and Clinical Medicine, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Pharmacogenomics J 5:81-8. 2005
    ..Cytogenetic events may provide important insights into neurochemical pathways and cellular processes critical for the development of complex psychiatric phenotypes in the population at large...
  7. ncbi request reprint Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria
    R James
    Medical Genetics Section, Department of Medical Sciences, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Mol Cell Neurosci 26:112-22. 2004
    ....
  8. ncbi request reprint Isolation and characterization of the mouse translin-associated protein X (Trax) gene
    R S Devon
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Mamm Genome 11:395-8. 2000
  9. ncbi request reprint Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site
    N J Brandon
    Merck Sharp and Dohme Research Labs, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    Mol Cell Neurosci 28:613-24. 2005
    ....
  10. ncbi request reprint A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42
    S MacGregor
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Kings Buildings, Edinburgh, UK
    Mol Psychiatry 9:1083-90. 2004
    ..These results, together with results from a number of other recent studies, stress the importance of the 1q42 region in susceptibility to both BPAD and SCZ...
  11. ncbi request reprint Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia
    J K Millar
    Department of Medical Sciences, The University of Edinburgh, Scotland, United Kingdom
    Genomics 67:69-77. 2000
    ..1. The TRAX gene consists of six exons with a putative CpG island at the 5' end. Four major transcripts are produced from this gene, of which the smallest, at 2.7 kb, had previously been identified...
  12. ncbi request reprint The DISC locus in psychiatric illness
    J E Chubb
    Medical Genetics Section, The Centre for Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 13:36-64. 2008
    ..DISC1 is a hub protein in a multidimensional risk pathway for major mental illness, and studies of this pathway are opening up opportunities for a better understanding of causality and possible mechanisms of intervention...
  13. ncbi request reprint Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice
    K Ishizuka
    Mol Psychiatry 12:897-9. 2007