Jonathan Mill

Summary

Affiliation: University of Exeter
Country: UK

Publications

  1. doi request reprint From promises to practical strategies in epigenetic epidemiology
    Jonathan Mill
    University of Exeter Medical School, Exeter University, St Luke s Campus, Magdalen Street, Exeter EX1 2LU, UK
    Nat Rev Genet 14:585-94. 2013
  2. pmc DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice
    Ruth Pidsley
    Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Mol Brain 5:42. 2012
  3. pmc Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future
    Emma Dempster
    Exeter University Medical School, University of Exeter, UK
    Schizophr Bull 39:11-6. 2013
  4. pmc Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
    Matthew N Davies
    Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Genome Biol 13:R43. 2012
  5. pmc Allelic skewing of DNA methylation is widespread across the genome
    Leonard C Schalkwyk
    MRC SGDP Research Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Hum Genet 86:196-212. 2010
  6. pmc Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    Emma L Dempster
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Hum Mol Genet 20:4786-96. 2011
  7. pmc Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight
    Ruth Pidsley
    Institute of Psychiatry, King s College London, London, UK
    Epigenetics 7:155-63. 2012
  8. doi request reprint Stochastic choice of allelic expression in human neural stem cells
    Aaron R Jeffries
    King s College London, Institute of Psychiatry, Centre for the Cellular Basis of Behaviour, Department of Neuroscience, London, United Kingdom
    Stem Cells 30:1938-47. 2012
  9. doi request reprint Drugs and addiction: an introduction to epigenetics
    Chloe C Y Wong
    Institute of Psychiatry, SGDP Research Centre, King s College London, De Crespigny Park, Denmark Hill, UK
    Addiction 106:480-9. 2011
  10. pmc Allele-specific methylation in the human genome: implications for genetic studies of complex disease
    Emma L Meaburn
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    Epigenetics 5:578-82. 2010

Collaborators

Detail Information

Publications23

  1. doi request reprint From promises to practical strategies in epigenetic epidemiology
    Jonathan Mill
    University of Exeter Medical School, Exeter University, St Luke s Campus, Magdalen Street, Exeter EX1 2LU, UK
    Nat Rev Genet 14:585-94. 2013
    ..We propose that improved understanding of the molecular mechanisms underlying human health and disease are best achieved through carrying out studies of epigenetics in populations as a part of an integrated functional genomics strategy. ..
  2. pmc DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice
    Ruth Pidsley
    Institute of Psychiatry, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Mol Brain 5:42. 2012
    ..Previously we reported evidence of a negative correlation between DNA methylation in this region and cerebellum weight in humans...
  3. pmc Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future
    Emma Dempster
    Exeter University Medical School, University of Exeter, UK
    Schizophr Bull 39:11-6. 2013
    ..Rather than investigating genetic and epigenetic factors independently, an integrative etiological research paradigm based on the combination of genomic, transcriptomic, and epigenomic analyses is required...
  4. pmc Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
    Matthew N Davies
    Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Genome Biol 13:R43. 2012
    ..We characterized intra- and inter-individual methylomic variation across whole blood and multiple regions of the brain from multiple donors...
  5. pmc Allelic skewing of DNA methylation is widespread across the genome
    Leonard C Schalkwyk
    MRC SGDP Research Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Hum Genet 86:196-212. 2010
    ..These findings impact our understanding about the origin of individual phenotypic differences and have implications for genetic studies of complex disease...
  6. pmc Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    Emma L Dempster
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Hum Mol Genet 20:4786-96. 2011
    ..Overall, our data provide further evidence to support a role for DNA methylation differences in mediating phenotypic differences between MZ twins and in the etiology of both SZ and BD...
  7. pmc Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight
    Ruth Pidsley
    Institute of Psychiatry, King s College London, London, UK
    Epigenetics 7:155-63. 2012
    ....
  8. doi request reprint Stochastic choice of allelic expression in human neural stem cells
    Aaron R Jeffries
    King s College London, Institute of Psychiatry, Centre for the Cellular Basis of Behaviour, Department of Neuroscience, London, United Kingdom
    Stem Cells 30:1938-47. 2012
    ..We conclude that stochastic allelic expression is prevalent in neural stem cells, providing clonal diversity to developing tissues such as the human brain...
  9. doi request reprint Drugs and addiction: an introduction to epigenetics
    Chloe C Y Wong
    Institute of Psychiatry, SGDP Research Centre, King s College London, De Crespigny Park, Denmark Hill, UK
    Addiction 106:480-9. 2011
    ..The implications of these findings for molecular studies of addiction and the future development of novel therapeutic interventions are also discussed...
  10. pmc Allele-specific methylation in the human genome: implications for genetic studies of complex disease
    Emma L Meaburn
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London, UK
    Epigenetics 5:578-82. 2010
    ....
  11. pmc Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    BMC Psychiatry 9:3. 2009
    ..Only few studies have reported association between promoter polymorphisms of the gene and ADHD...
  12. pmc A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Behav Brain Funct 8:31. 2012
    ..Recent evidence suggests DNA methylation can be influenced by cis-acting DNA sequence variation, that is, DNA sequence variation located nearby on the same chromosome...
  13. pmc A longitudinal twin study of skewed X chromosome-inactivation
    Chloe Chung Yi Wong
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 6:e17873. 2011
    ..These data have implications for our understanding about sex differences in complex disease, and the potential causes of phenotypic discordance between MZ female twins...
  14. doi request reprint Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem research
    Ruth Pidsley
    Institute of Psychiatry, King s College London, United Kingdom
    Biol Psychiatry 69:146-56. 2011
    ..In this article, we discuss methodologic and logistic issues related to epigenomic studies using postmortem brain tissue, before discussing the future implications of such research for our understanding of psychosis...
  15. pmc A data-driven approach to preprocessing Illumina 450K methylation array data
    Ruth Pidsley
    Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    BMC Genomics 14:293. 2013
    ..These metrics also have potential utility as quality scores for datasets...
  16. doi request reprint Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility
    Jonathan Mill
    Institute of Psychiatry, SGDP Research Centre, London, UK
    J Child Psychol Psychiatry 49:1020-30. 2008
    ..We propose that understanding the epigenetic processes involved in linking specific environmental pathogens to an increased risk for ADHD may offer new possibilities for preventative and therapeutic intervention...
  17. doi request reprint Anxiety sensitivity in adolescence and young adulthood: the role of stressful life events, 5HTTLPR and their interaction
    Helena M S Zavos
    Institute of Psychiatry, King s College London, United Kingdom
    Depress Anxiety 29:400-8. 2012
    ..In light of this, we looked at the association between stressful life events, the serotonin transporter gene polymorphism (5HTTLPR), and anxiety sensitivity in a longitudinal sample of adolescents...
  18. ncbi request reprint Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples
    Xiaohui Xu
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 144:83-6. 2007
    ..57, P = 0.032) and the pooled sample set (TDT: chi(2) = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD...
  19. doi request reprint DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA
    Sophia J Docherty
    King s College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Methods 52:255-8. 2010
    ..This method generates accurate quantitative assessments of group DNA methylation averages, reducing the time, cost and amount of DNA starting material required for large-scale epigenetic investigation of disease phenotypes...
  20. pmc A longitudinal study of epigenetic variation in twins
    Chloe Chung Yi Wong
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Epigenetics 5:516-26. 2010
    ..The observation of dynamic changes in DNA methylation over time highlights the importance of longitudinal research designs for epigenetic research...
  21. pmc Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model
    Rebecca G Smith
    Medical Research Council Social Genetic and Developmental Psychiatry Centre, King s College London, London, United Kingdom
    PLoS ONE 4:e8456. 2009
    ..In order to establish causality, this study used an animal model to investigate the effects of advanced paternal age on behavioural deficits in the offspring...
  22. doi request reprint Epigenetics, genomic mutations and cognitive function
    Abraham Reichenberg
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Cogn Neuropsychiatry 14:377-90. 2009
    ..However, there is accumulating evidence that dynamic genomic and epigenetic alterations can modulate complex cognitive processes, and influence susceptibility to disorders associated with impaired cognitive functioning...
  23. pmc The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression
    Emma L Dempster
    Molecular Genetics, Psychological Medicine, Institute of Psychiatry, London, UK
    BMC Med Genet 7:10. 2006
    ..Previous research has suggested that activity and expression of COMT is altered in schizophrenia, and is mediated by one or more polymorphisms within the gene, including the functional Val158Met polymorphism...