Research Topics
| Elizabeth A MilesSummaryAffiliation: University of Southampton Country: UK Publications
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Detail Information
Publications
Dietary fish oil reduces intercellular adhesion molecule 1 and scavenger receptor expression on murine macrophagesE A Miles
Institute of Human Nutrition, University of Southampton, Bassett Crescent East, SO16 7PX, Southampton, UK
Atherosclerosis 152:43-50. 2000....- Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood culturesElizabeth A Miles
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
Nutrition 21:389-94. 2005..This study investigated the effects of phenolic compounds found in extra virgin olive oil on inflammatory mediator production by human mononuclear cells... - The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjectsElizabeth A Miles
Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 91:893-903. 2004..At this dose EPA increases IgG2 concentrations. STA can increase immune cell EPA status, but at 1.0 g/d does not affect human immune function... - The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteersElizabeth A Miles
Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Prostaglandins Leukot Essent Fatty Acids 70:529-38. 2004..Such effects may offer new strategies for manipulation of cell composition in order to influence cellular responses and functions in desirable ways... - Limited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers and functions in healthy young malesElizabeth A Miles
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
Nutrition 22:512-9. 2006.... - Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrationsElizabeth A Miles
Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom
Atherosclerosis 196:298-305. 2008..To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these... - Production of lymphocyte-derived cytokines by whole umbilical cord blood cultures stimulated with mitogens and allergensElizabeth A Miles
Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Cytokine 21:74-83. 2003..IL-10 was induced with mitogen and allergen stimulation. Thus, this study has established conditions for assessing production of lymphocyte-derived cytokines in a simple whole umbilical cord blood culture system... - In vitro effects of eicosanoids derived from different 20-carbon Fatty acids on production of monocyte-derived cytokines in human whole blood culturesE A Miles
Institute of Human Nutrition, University of Southampton, Southampton, UK
Cytokine 20:215-23. 2002..Methods Human whole blood was diluted 1:5 and incubated for 48h with lipopolysaccharide. PGE and LT were added and the concentrations of inflammatory cytokines in the cell culture supernatants determined... - An olive oil-rich diet reduces scavenger receptor mRNA in murine macrophagesE A Miles
Institute of Human Nutrition, University of Southampton, UK
Br J Nutr 85:185-91. 2001.... - Effects of polyphenols on human Th1 and Th2 cytokine productionElizabeth A Miles
Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Clin Nutr 24:780-4. 2005..Numerous phenolic compounds are consumed in the diet in a range of foods. There are very few studies of the effects of these compounds on the production of lymphocyte-derived cytokines... - Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementationTimothy M Trebble
Institute of Human Nutrition, School of Medicine, University of Southampton, United Kingdom
Am J Clin Nutr 78:376-82. 2003..The effects of fish oil on lymphocyte proliferation and production of IFN-gamma and IL-4 are unclear and may be influenced by the availability of antioxidants... 
Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 moPaul S Noakes
Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, United Kingdom
Am J Clin Nutr 95:395-404. 2012..Long-chain n-3 PUFAs found in oily fish may have a role in lowering the risk of allergic disease...- Salmon consumption by pregnant women reduces ex vivo umbilical cord endothelial cell activationLieke W J van den Elsen
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Netherlands
Am J Clin Nutr 94:1418-25. 2011..However, to our knowledge, no previous human studies have examined the influence of an altered diet on CAM expression... - Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjectsFiona A Wallace
Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Br J Nutr 89:679-89. 2003..The threshold of EPA+DHA intake that results in decreased IL-6 production is between 0.44 and 0.94 g/d... - Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementationTimothy Trebble
The Institute of Human Nutrition, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
Br J Nutr 90:405-12. 2003..Thus, increased dietary n-3 PUFA consumption resulted in defined but contrasting patterns of modulation of phospholipid fatty acid composition and PBMC function, which were further influenced by antioxidant intake... - The Salmon in Pregnancy Study: study design, subject characteristics, maternal fish and marine n-3 fatty acid intake, and marine n-3 fatty acid status in maternal and umbilical cord bloodElizabeth A Miles
Institute of Human Nutrition and Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, United Kingdom
Am J Clin Nutr 94:1986S-1992S. 2011..Oily fish provides marine n-3 (omega-3) fatty acids that are considered to be important in the growth, development, and health of the fetus and newborn infant... - Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritisElizabeth A Miles
Institute of Human Nutrition and Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Br J Nutr 107:S171-84. 2012.... - Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic reviewLefkothea Stella Kremmyda
Institute of Human Nutrition and Institute of Developmental Sciences, School of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
Clin Rev Allergy Immunol 41:36-66. 2011.... - Influence of very long-chain n-3 fatty acids on plasma markers of inflammation in middle-aged menHayati M Yusof
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
Prostaglandins Leukot Essent Fatty Acids 78:219-28. 2008..Thus, one reason why only limited effects were seen here may be that the dose of DHA provided was insufficient... - Self-reported health problems in young male subjects supplementing their diet with oils rich in eicosapentaenoic, gamma-linolenic and stearidonic acidsElizabeth A Miles
Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Prostaglandins Leukot Essent Fatty Acids 75:57-60. 2006 
Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trialVera M Barbosa
Institute of Human Nutrition, School of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
Crit Care 14:R5. 2010..The effect of parenteral fish oil in septic patients is not widely studied. This study investigated the effects of parenteral fish oil on plasma phospholipid fatty acids, inflammatory mediators, and clinical outcomes...- Fatty acid composition abnormalities in atopic disease: evidence explored and role in the disease process examinedA Sala-Vila
Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
Clin Exp Allergy 38:1432-50. 2008.... - Dietary fatty acids influence the production of Th1- but not Th2-type cytokinesF A Wallace
Institute of Human Nutrition, University of Southampton, United Kingdom
J Leukoc Biol 69:449-57. 2001..The effects of fatty acids on cytokine production appear to be exerted at the level of gene expression... - Fatty acids and lymphocyte functionsP C Calder
Institute of Human Nutrition, University of Southampton, UK
Br J Nutr 87:S31-48. 2002..Recent evidence indicates that fish oil may be of benefit in some asthmatics but not others... - Is there a role for fatty acids in early life programming of the immune system?Philip C Calder
Institute of Human Nutrition and Institute of Developmental Sciences, School of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Proc Nutr Soc 69:373-80. 2010..Fish oil supplementation in infancy may decrease the risk of developing some manifestations of allergic disease, but whether this benefit persists as other factors come into play remains to be determined... - β2-1 Fructans have a bifidogenic effect in healthy middle-aged human subjects but do not alter immune responses examined in the absence of an in vivo immune challenge: results from a randomised controlled trialAmy R Lomax
Institute of Human Nutrition and Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
Br J Nutr 108:1818-28. 2012..It is concluded that, compared with maltodextrin, Orafti® Synergy1 has a bifidogenic effect in healthy middle-aged human subjects but does not alter immune responses examined in the absence of an in vivo immune challenge... - In vitro effects of eicosanoids derived from different 20-carbon fatty acids on T helper type 1 and T helper type 2 cytokine production in human whole-blood culturesE A Miles
Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton, UK
Clin Exp Allergy 33:624-32. 2003..It may, however, be mediated through a change in the total amount of PGE produced at the site of antigen presentation... - Influence of age and dietary fish oil on plasma soluble adhesion molecule concentrationsE A Miles
Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
Clin Sci (Lond) 100:91-100. 2001..043), with a median decrease of 20% (range 16-60%). These observations suggest that fish oil decreases endothelial activation in elderly subjects... - Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytesClaudia R Cavaglieri
Biomedical Sciences Group, Health Sciences Faculty, Methodist University of Piracicaba, SP, Brazil
Life Sci 73:1683-90. 2003..A combination of the three SCFA causes a shift in the T helper lymphocyte phenotype towards a more anti-inflammatory phenotype and this might explain the protective effects of fiber... - Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN StudyMuriel J Caslake
Department of Vascular Biochemistry, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom
Am J Clin Nutr 88:618-29. 2008..The lipid-modulatory effects of high intakes of the fish-oil fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are well established and likely to contribute to cardioprotective benefits... - Membrane fatty acids, oxidative burst and phagocytosis after enrichment of P388D1 monocyte/macrophages with essential 18-carbon fatty acidsHerbert Fuhrmann
Institute of Biochemistry, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany
Ann Nutr Metab 51:155-62. 2007..NF-kappaB activation at 1 h post-stimulation was not affected by adding LA or LNA to the culture medium. We conclude that the fatty acid composition of macrophages influences their ability to phagocytose and mount oxidative burst... - Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjectsRoberta Cazzola
Department of Preclinical Sciences LITA Vialba, University of Milan, 74 Via G B Grassi, Milan 20157, Italy
Atherosclerosis 193:159-67. 2007..Young males are unlikely to suffer adverse consequences from high EPA intake, whereas older males may have an increased risk of lipoprotein peroxidation... - Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older menDinka Rees
The Rowett Research Institute, Aberdeen, United Kingdom
Am J Clin Nutr 83:331-42. 2006..05 g/d. Older subjects are more sensitive to the immunologic effects of EPA, and the neutrophil respiratory burst is lower at higher EPA intakes...