Elizabeth A Miles

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Dietary fish oil reduces intercellular adhesion molecule 1 and scavenger receptor expression on murine macrophages
    E A Miles
    Institute of Human Nutrition, University of Southampton, Bassett Crescent East, SO16 7PX, Southampton, UK
    Atherosclerosis 152:43-50. 2000
  2. ncbi request reprint Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom
    Atherosclerosis 196:298-305. 2008
  3. ncbi request reprint Limited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers and functions in healthy young males
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
    Nutrition 22:512-9. 2006
  4. ncbi request reprint Effects of polyphenols on human Th1 and Th2 cytokine production
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Clin Nutr 24:780-4. 2005
  5. ncbi request reprint Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
    Nutrition 21:389-94. 2005
  6. ncbi request reprint The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 91:893-903. 2004
  7. ncbi request reprint The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Prostaglandins Leukot Essent Fatty Acids 70:529-38. 2004
  8. ncbi request reprint Production of lymphocyte-derived cytokines by whole umbilical cord blood cultures stimulated with mitogens and allergens
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Cytokine 21:74-83. 2003
  9. ncbi request reprint In vitro effects of eicosanoids derived from different 20-carbon Fatty acids on production of monocyte-derived cytokines in human whole blood cultures
    E A Miles
    Institute of Human Nutrition, University of Southampton, Southampton, UK
    Cytokine 20:215-23. 2002
  10. ncbi request reprint An olive oil-rich diet reduces scavenger receptor mRNA in murine macrophages
    E A Miles
    Institute of Human Nutrition, University of Southampton, UK
    Br J Nutr 85:185-91. 2001

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Dietary fish oil reduces intercellular adhesion molecule 1 and scavenger receptor expression on murine macrophages
    E A Miles
    Institute of Human Nutrition, University of Southampton, Bassett Crescent East, SO16 7PX, Southampton, UK
    Atherosclerosis 152:43-50. 2000
    ....
  2. ncbi request reprint Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom
    Atherosclerosis 196:298-305. 2008
    ..To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these...
  3. ncbi request reprint Limited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers and functions in healthy young males
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
    Nutrition 22:512-9. 2006
    ....
  4. ncbi request reprint Effects of polyphenols on human Th1 and Th2 cytokine production
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Clin Nutr 24:780-4. 2005
    ..Numerous phenolic compounds are consumed in the diet in a range of foods. There are very few studies of the effects of these compounds on the production of lymphocyte-derived cytokines...
  5. ncbi request reprint Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
    Nutrition 21:389-94. 2005
    ..This study investigated the effects of phenolic compounds found in extra virgin olive oil on inflammatory mediator production by human mononuclear cells...
  6. ncbi request reprint The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 91:893-903. 2004
    ..At this dose EPA increases IgG2 concentrations. STA can increase immune cell EPA status, but at 1.0 g/d does not affect human immune function...
  7. ncbi request reprint The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Prostaglandins Leukot Essent Fatty Acids 70:529-38. 2004
    ..Such effects may offer new strategies for manipulation of cell composition in order to influence cellular responses and functions in desirable ways...
  8. ncbi request reprint Production of lymphocyte-derived cytokines by whole umbilical cord blood cultures stimulated with mitogens and allergens
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Cytokine 21:74-83. 2003
    ..IL-10 was induced with mitogen and allergen stimulation. Thus, this study has established conditions for assessing production of lymphocyte-derived cytokines in a simple whole umbilical cord blood culture system...
  9. ncbi request reprint In vitro effects of eicosanoids derived from different 20-carbon Fatty acids on production of monocyte-derived cytokines in human whole blood cultures
    E A Miles
    Institute of Human Nutrition, University of Southampton, Southampton, UK
    Cytokine 20:215-23. 2002
    ..Methods Human whole blood was diluted 1:5 and incubated for 48h with lipopolysaccharide. PGE and LT were added and the concentrations of inflammatory cytokines in the cell culture supernatants determined...
  10. ncbi request reprint An olive oil-rich diet reduces scavenger receptor mRNA in murine macrophages
    E A Miles
    Institute of Human Nutrition, University of Southampton, UK
    Br J Nutr 85:185-91. 2001
    ....
  11. ncbi request reprint Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation
    Timothy M Trebble
    Institute of Human Nutrition, School of Medicine, University of Southampton, United Kingdom
    Am J Clin Nutr 78:376-82. 2003
    ..The effects of fish oil on lymphocyte proliferation and production of IFN-gamma and IL-4 are unclear and may be influenced by the availability of antioxidants...
  12. doi request reprint Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo
    Paul S Noakes
    Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, United Kingdom
    Am J Clin Nutr 95:395-404. 2012
    ..Long-chain n-3 PUFAs found in oily fish may have a role in lowering the risk of allergic disease...
  13. doi request reprint Salmon consumption by pregnant women reduces ex vivo umbilical cord endothelial cell activation
    Lieke W J van den Elsen
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Netherlands
    Am J Clin Nutr 94:1418-25. 2011
    ..However, to our knowledge, no previous human studies have examined the influence of an altered diet on CAM expression...
  14. ncbi request reprint Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects
    Fiona A Wallace
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Br J Nutr 89:679-89. 2003
    ..The threshold of EPA+DHA intake that results in decreased IL-6 production is between 0.44 and 0.94 g/d...
  15. ncbi request reprint Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation
    Timothy Trebble
    The Institute of Human Nutrition, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Br J Nutr 90:405-12. 2003
    ..Thus, increased dietary n-3 PUFA consumption resulted in defined but contrasting patterns of modulation of phospholipid fatty acid composition and PBMC function, which were further influenced by antioxidant intake...
  16. doi request reprint The Salmon in Pregnancy Study: study design, subject characteristics, maternal fish and marine n-3 fatty acid intake, and marine n-3 fatty acid status in maternal and umbilical cord blood
    Elizabeth A Miles
    Institute of Human Nutrition and Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 94:1986S-1992S. 2011
    ..Oily fish provides marine n-3 (omega-3) fatty acids that are considered to be important in the growth, development, and health of the fetus and newborn infant...
  17. doi request reprint β2-1 Fructans have a bifidogenic effect in healthy middle-aged human subjects but do not alter immune responses examined in the absence of an in vivo immune challenge: results from a randomised controlled trial
    Amy R Lomax
    Institute of Human Nutrition and Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Br J Nutr 108:1818-28. 2012
    ..It is concluded that, compared with maltodextrin, Orafti® Synergy1 has a bifidogenic effect in healthy middle-aged human subjects but does not alter immune responses examined in the absence of an in vivo immune challenge...
  18. doi request reprint Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis
    Elizabeth A Miles
    Institute of Human Nutrition and Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Br J Nutr 107:S171-84. 2012
    ....
  19. doi request reprint Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review
    Lefkothea Stella Kremmyda
    Institute of Human Nutrition and Institute of Developmental Sciences, School of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Clin Rev Allergy Immunol 41:36-66. 2011
    ....
  20. doi request reprint Influence of very long-chain n-3 fatty acids on plasma markers of inflammation in middle-aged men
    Hayati M Yusof
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Prostaglandins Leukot Essent Fatty Acids 78:219-28. 2008
    ..Thus, one reason why only limited effects were seen here may be that the dose of DHA provided was insufficient...
  21. ncbi request reprint Self-reported health problems in young male subjects supplementing their diet with oils rich in eicosapentaenoic, gamma-linolenic and stearidonic acids
    Elizabeth A Miles
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Prostaglandins Leukot Essent Fatty Acids 75:57-60. 2006
  22. pmc Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial
    Vera M Barbosa
    Institute of Human Nutrition, School of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Crit Care 14:R5. 2010
    ..The effect of parenteral fish oil in septic patients is not widely studied. This study investigated the effects of parenteral fish oil on plasma phospholipid fatty acids, inflammatory mediators, and clinical outcomes...
  23. ncbi request reprint Fatty acids and lymphocyte functions
    P C Calder
    Institute of Human Nutrition, University of Southampton, UK
    Br J Nutr 87:S31-48. 2002
    ..Recent evidence indicates that fish oil may be of benefit in some asthmatics but not others...
  24. doi request reprint Fatty acid composition abnormalities in atopic disease: evidence explored and role in the disease process examined
    A Sala-Vila
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    Clin Exp Allergy 38:1432-50. 2008
    ....
  25. ncbi request reprint Dietary fatty acids influence the production of Th1- but not Th2-type cytokines
    F A Wallace
    Institute of Human Nutrition, University of Southampton, United Kingdom
    J Leukoc Biol 69:449-57. 2001
    ..The effects of fatty acids on cytokine production appear to be exerted at the level of gene expression...
  26. doi request reprint Is there a role for fatty acids in early life programming of the immune system?
    Philip C Calder
    Institute of Human Nutrition and Institute of Developmental Sciences, School of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Proc Nutr Soc 69:373-80. 2010
    ..Fish oil supplementation in infancy may decrease the risk of developing some manifestations of allergic disease, but whether this benefit persists as other factors come into play remains to be determined...
  27. doi request reprint Supplemental intravenous n-3 fatty acids and n-3 fatty acid status and outcome in critically ill elderly patients in the ICU receiving enteral nutrition
    Karina V Barros
    Departamento de Fisiologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Clin Nutr 32:599-605. 2013
    ..The aims were to identify whether FA status is altered in critical illness and to evaluate the effect of supplemental intravenous n-3 FA on plasma FA status and clinical outcome in ICU patients receiving enteral nutrition...
  28. ncbi request reprint Influence of age and dietary fish oil on plasma soluble adhesion molecule concentrations
    E A Miles
    Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Clin Sci (Lond) 100:91-100. 2001
    ..043), with a median decrease of 20% (range 16-60%). These observations suggest that fish oil decreases endothelial activation in elderly subjects...
  29. ncbi request reprint In vitro effects of eicosanoids derived from different 20-carbon fatty acids on T helper type 1 and T helper type 2 cytokine production in human whole-blood cultures
    E A Miles
    Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton, UK
    Clin Exp Allergy 33:624-32. 2003
    ..The effects of the different series of PGs and LTs on production of T helper type 1 (Th1) and Th2 cytokines by human cells are not well established...
  30. doi request reprint Fatty acids in plasma, white and red blood cells, and tissues after oral or intravenous administration of fish oil in rats
    Karina V Barros
    Departamento de Fisiologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom Electronic address
    Clin Nutr 32:993-8. 2013
    ....
  31. ncbi request reprint Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study
    Muriel J Caslake
    Department of Vascular Biochemistry, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom
    Am J Clin Nutr 88:618-29. 2008
    ..The lipid-modulatory effects of high intakes of the fish-oil fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are well established and likely to contribute to cardioprotective benefits...
  32. ncbi request reprint Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects
    Roberta Cazzola
    Department of Preclinical Sciences LITA Vialba, University of Milan, 74 Via G B Grassi, Milan 20157, Italy
    Atherosclerosis 193:159-67. 2007
    ..Young males are unlikely to suffer adverse consequences from high EPA intake, whereas older males may have an increased risk of lipoprotein peroxidation...
  33. ncbi request reprint Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men
    Dinka Rees
    The Rowett Research Institute, Aberdeen, United Kingdom
    Am J Clin Nutr 83:331-42. 2006
    ..Increasing intakes of long-chain n-3 polyunsaturated fatty acids (PUFAs) can decrease markers of immunity. However, dose- and age-related responses have not been identified...
  34. ncbi request reprint Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes
    Claudia R Cavaglieri
    Biomedical Sciences Group, Health Sciences Faculty, Methodist University of Piracicaba, SP, Brazil
    Life Sci 73:1683-90. 2003
    ..A combination of the three SCFA causes a shift in the T helper lymphocyte phenotype towards a more anti-inflammatory phenotype and this might explain the protective effects of fiber...
  35. ncbi request reprint Membrane fatty acids, oxidative burst and phagocytosis after enrichment of P388D1 monocyte/macrophages with essential 18-carbon fatty acids
    Herbert Fuhrmann
    Institute of Biochemistry, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    Ann Nutr Metab 51:155-62. 2007
    ..NF-kappaB activation at 1 h post-stimulation was not affected by adding LA or LNA to the culture medium. We conclude that the fatty acid composition of macrophages influences their ability to phagocytose and mount oxidative burst...