Research Topics
| Robert H MichellSummaryAffiliation: University of Birmingham Country: UK Publications
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Publications
Inositol phosphates: a remarkably versatile enzymeRobert H Michell
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
Curr Biol 12:R313-5. 2002..It now transpires that one protein with ATP-dependent kinase and phosphatase activities interconverts Ins(3,4,5,6)P(4) and Ins(1,3,4,5,6)P(5), as well as several other inositol polyphosphates...
A protein complex that regulates PtdIns(3,5)P2 levelsRobert H Michell
School of Biosciences, University of Birmingham, Edgbaton, Birmingham, UK
EMBO J 28:86-7. 2009....
First came the link between phosphoinositides and Ca2+ signalling, and then a deluge of other phosphoinositide functionsRobert H Michell
School of Biosciences, University of Birmingham, Birmingham, UK
Cell Calcium 45:521-6. 2009..This article briefly outlines how the roles of these minority membrane lipids in Ca(2+) signalling and then in multifarious other biological processes were recognised during the latter half of the 20th century...- Inositol and its derivatives: their evolution and functionsRobert H Michell
School of Biosciences, University of Birmingham, Birmingham, United Kingdom
Adv Enzyme Regul 51:84-90. 2011..So are PtdIns3P and PtdIns(3,5)P2, which have ubiquitous roles in the regulation of membrane trafficking events. However, synthesis of and signalling by PtdIns(3,4,5) P 3 appears to be confined to a later-evolved group of eukaryotes... - Inositol derivatives: evolution and functionsRobert H Michell
School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK
Nat Rev Mol Cell Biol 9:151-61. 2008..and how might inositol, inositol lipids and inositol phosphates have become ubiquitous constituents of eukaryotes? And how, later, might the multifarious functions of inositol derivatives have emerged during eukaryote diversification?.. - Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functionsRobert H Michell
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
Trends Biochem Sci 31:52-63. 2006.... - Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectorsStephen K Dove
School of Biosciences, University of Birmingham, Birmingham, UK
EMBO J 23:1922-33. 2004..Svp1p is not involved in the contributions of FAB1/PtdIns(3,5)P2 to MVB sorting or to vacuole acidification and so additional PtdIns(3,5)P2 effectors must exist... - Versatility and nuances of the architecture of haematopoiesis - Implications for the nature of leukaemiaGeoffrey Brown
School of Immunity and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK
Leuk Res 36:14-22. 2012..This leads one to ask whether leukaemia stem cells are equally or less versatile than their normal counterparts?.. - Complex changes in cellular inositol phosphate complement accompany transit through the cell cycleChristopher J Barker
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
Biochem J 380:465-73. 2004..These results establish that several fairly abundant intracellular inositol polyphosphates, for which important biological roles are emerging, display dynamic behaviour that is synchronized with cell-cycle progression... - Cell differentiation and proliferation--simultaneous but independent?Geoffrey Brown
Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK
Exp Cell Res 291:282-8. 2003.... - The versatility of haematopoietic stem cells: implications for leukaemiaGeoffrey Brown
School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Crit Rev Clin Lab Sci 47:171-80. 2010..Here we examine this decision-making process and ask whether, developmentally, leukaemia stem cells are equally or less versatile than their normal counterparts... - Hypo-osmotic stress activates Plc1p-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol Hexakisphosphate accumulation in yeastNevin M Perera
School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
J Biol Chem 279:5216-26. 2004..This ability routinely to activate Plc1p-catalyzed PtdIns(4,5)P2 hydrolysis in vivo opens up new opportunities for molecular and genetic scrutiny of the regulation and functions of phosphoinositidases C of the delta-subfamily... - Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular bodyStephen K Dove
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
Curr Biol 12:885-93. 2002..No regulators of Fab1 were identified until recently... - The sequential determination model of hematopoiesisGeoffrey Brown
Division of Immunity and Infection, The Medical School, Edgbaston, Birmingham B15 2TT, UK
Trends Immunol 28:442-8. 2007..An updated SD model complemented by several recently recognized processes--spatiotemporal fluctuations in transcription factor concentrations, asymmetric cell division, and Notch signalling--still offers a sound summary of hematopoiesis... - Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome functionStephen K Dove
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
Biochem J 419:1-13. 2009..We also discuss new evidence linking PtdIns(3,5)P(2) and PtdIns5P to the regulation of exocytosis... - Inositol lipid-dependent functions in Saccharomyces cerevisiae: analysis of phosphatidylinositol phosphatesStephen K Dove
Phosphoinositide Lab, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
Methods Mol Biol 462:59-74. 2009..This chapter describes how to extract and quantify the inositol lipids of S. cerevisiae cells that have been radiolabeled to isotopic equilibrium with [3H]myo-inositol... - HL60 cells halted in G1 or S phase differentiate normallyGeoffrey Brown
Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
Exp Cell Res 281:28-38. 2002.... - Phosphoinositide signalling links O-GlcNAc transferase to insulin resistanceXiaoyong Yang
Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Nature 451:964-9. 2008..These findings identify a molecular mechanism by which nutritional cues regulate insulin signalling through O-GlcNAc, and underscore the contribution of this modification to the aetiology of insulin resistance and type 2 diabetes... - PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49Tim R Jeffries
Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3PX, United Kingdom
Mol Biol Cell 15:2652-63. 2004..We conclude that WIPI49 is a novel regulatory component of the endosomal and MPR pathway and that this role is dependent upon the PI-binding properties of its WD40 domain...