Robert H Michell

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint Inositol phosphates: a remarkably versatile enzyme
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Curr Biol 12:R313-5. 2002
  2. pmc A protein complex that regulates PtdIns(3,5)P2 levels
    Robert H Michell
    School of Biosciences, University of Birmingham, Edgbaton, Birmingham, UK
    EMBO J 28:86-7. 2009
  3. doi request reprint First came the link between phosphoinositides and Ca2+ signalling, and then a deluge of other phosphoinositide functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham, UK
    Cell Calcium 45:521-6. 2009
  4. doi request reprint Inositol and its derivatives: their evolution and functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    Adv Enzyme Regul 51:84-90. 2011
  5. doi request reprint Inositol derivatives: evolution and functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK
    Nat Rev Mol Cell Biol 9:151-61. 2008
  6. ncbi request reprint Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Trends Biochem Sci 31:52-63. 2006
  7. pmc Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors
    Stephen K Dove
    School of Biosciences, University of Birmingham, Birmingham, UK
    EMBO J 23:1922-33. 2004
  8. doi request reprint Versatility and nuances of the architecture of haematopoiesis - Implications for the nature of leukaemia
    Geoffrey Brown
    School of Immunity and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK
    Leuk Res 36:14-22. 2012
  9. doi request reprint Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human disease
    Robert H Michell
    School of Biosciences, University of Birmingham, UK
    FEBS J 280:6281-94. 2013
  10. pmc Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle
    Christopher J Barker
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Biochem J 380:465-73. 2004

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Inositol phosphates: a remarkably versatile enzyme
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Curr Biol 12:R313-5. 2002
    ..It now transpires that one protein with ATP-dependent kinase and phosphatase activities interconverts Ins(3,4,5,6)P(4) and Ins(1,3,4,5,6)P(5), as well as several other inositol polyphosphates...
  2. pmc A protein complex that regulates PtdIns(3,5)P2 levels
    Robert H Michell
    School of Biosciences, University of Birmingham, Edgbaton, Birmingham, UK
    EMBO J 28:86-7. 2009
    ....
  3. doi request reprint First came the link between phosphoinositides and Ca2+ signalling, and then a deluge of other phosphoinositide functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham, UK
    Cell Calcium 45:521-6. 2009
    ..This article briefly outlines how the roles of these minority membrane lipids in Ca(2+) signalling and then in multifarious other biological processes were recognised during the latter half of the 20th century...
  4. doi request reprint Inositol and its derivatives: their evolution and functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    Adv Enzyme Regul 51:84-90. 2011
    ..So are PtdIns3P and PtdIns(3,5)P2, which have ubiquitous roles in the regulation of membrane trafficking events. However, synthesis of and signalling by PtdIns(3,4,5) P 3 appears to be confined to a later-evolved group of eukaryotes...
  5. doi request reprint Inositol derivatives: evolution and functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK
    Nat Rev Mol Cell Biol 9:151-61. 2008
    ..and how might inositol, inositol lipids and inositol phosphates have become ubiquitous constituents of eukaryotes? And how, later, might the multifarious functions of inositol derivatives have emerged during eukaryote diversification?..
  6. ncbi request reprint Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Trends Biochem Sci 31:52-63. 2006
    ....
  7. pmc Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors
    Stephen K Dove
    School of Biosciences, University of Birmingham, Birmingham, UK
    EMBO J 23:1922-33. 2004
    ..Svp1p is not involved in the contributions of FAB1/PtdIns(3,5)P2 to MVB sorting or to vacuole acidification and so additional PtdIns(3,5)P2 effectors must exist...
  8. doi request reprint Versatility and nuances of the architecture of haematopoiesis - Implications for the nature of leukaemia
    Geoffrey Brown
    School of Immunity and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK
    Leuk Res 36:14-22. 2012
    ..This leads one to ask whether leukaemia stem cells are equally or less versatile than their normal counterparts?..
  9. doi request reprint Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human disease
    Robert H Michell
    School of Biosciences, University of Birmingham, UK
    FEBS J 280:6281-94. 2013
    ....
  10. pmc Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle
    Christopher J Barker
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Biochem J 380:465-73. 2004
    ..These results establish that several fairly abundant intracellular inositol polyphosphates, for which important biological roles are emerging, display dynamic behaviour that is synchronized with cell-cycle progression...
  11. ncbi request reprint Cell differentiation and proliferation--simultaneous but independent?
    Geoffrey Brown
    Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK
    Exp Cell Res 291:282-8. 2003
    ....
  12. doi request reprint The versatility of haematopoietic stem cells: implications for leukaemia
    Geoffrey Brown
    School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Crit Rev Clin Lab Sci 47:171-80. 2010
    ..Here we examine this decision-making process and ask whether, developmentally, leukaemia stem cells are equally or less versatile than their normal counterparts...
  13. ncbi request reprint Hypo-osmotic stress activates Plc1p-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol Hexakisphosphate accumulation in yeast
    Nevin M Perera
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Biol Chem 279:5216-26. 2004
    ..This ability routinely to activate Plc1p-catalyzed PtdIns(4,5)P2 hydrolysis in vivo opens up new opportunities for molecular and genetic scrutiny of the regulation and functions of phosphoinositidases C of the delta-subfamily...
  14. ncbi request reprint Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body
    Stephen K Dove
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Curr Biol 12:885-93. 2002
    ..No regulators of Fab1 were identified until recently...
  15. doi request reprint Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function
    Stephen K Dove
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Biochem J 419:1-13. 2009
    ..We also discuss new evidence linking PtdIns(3,5)P(2) and PtdIns5P to the regulation of exocytosis...
  16. doi request reprint Inositol lipid-dependent functions in Saccharomyces cerevisiae: analysis of phosphatidylinositol phosphates
    Stephen K Dove
    Phosphoinositide Lab, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    Methods Mol Biol 462:59-74. 2009
    ..This chapter describes how to extract and quantify the inositol lipids of S. cerevisiae cells that have been radiolabeled to isotopic equilibrium with [3H]myo-inositol...
  17. ncbi request reprint The sequential determination model of hematopoiesis
    Geoffrey Brown
    Division of Immunity and Infection, The Medical School, Edgbaston, Birmingham B15 2TT, UK
    Trends Immunol 28:442-8. 2007
    ..An updated SD model complemented by several recently recognized processes--spatiotemporal fluctuations in transcription factor concentrations, asymmetric cell division, and Notch signalling--still offers a sound summary of hematopoiesis...
  18. ncbi request reprint HL60 cells halted in G1 or S phase differentiate normally
    Geoffrey Brown
    Division of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Exp Cell Res 281:28-38. 2002
    ....
  19. doi request reprint Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance
    Xiaoyong Yang
    Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 451:964-9. 2008
    ..These findings identify a molecular mechanism by which nutritional cues regulate insulin signalling through O-GlcNAc, and underscore the contribution of this modification to the aetiology of insulin resistance and type 2 diabetes...
  20. pmc PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49
    Tim R Jeffries
    Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3PX, United Kingdom
    Mol Biol Cell 15:2652-63. 2004
    ..We conclude that WIPI49 is a novel regulatory component of the endosomal and MPR pathway and that this role is dependent upon the PI-binding properties of its WD40 domain...