Michel Michaelides

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc The PROM1 mutation p.R373C causes an autosomal dominant bull's eye maculopathy associated with rod, rod-cone, and macular dystrophy
    Michel Michaelides
    UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 51:4771-80. 2010
  2. pmc Integrity of the cone photoreceptor mosaic in oligocone trichromacy
    Michel Michaelides
    UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:4757-64. 2011
  3. doi request reprint Developmental macular disorders: phenotypes and underlying molecular genetic basis
    Michel Michaelides
    UCL Institute of Ophthalmology, University College London, London, UK
    Br J Ophthalmol 96:917-24. 2012
  4. ncbi request reprint Evidence of genetic heterogeneity in MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome
    Michel Michaelides
    Moorfields Eye Hospital, and Institute of Ophthalmology, University College London, London, United Kingdom
    Am J Ophthalmol 141:418-20. 2006
  5. ncbi request reprint A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2
    Michel Michaelides
    Department of Medical Retina, Moorfields Eye Hospital, London, United Kingdom
    Ophthalmology 117:1078-1086.e2. 2010
  6. doi request reprint Macular dystrophy associated with the A3243G mitochondrial DNA mutation. Distinct retinal and associated features, disease variability, and characterization of asymptomatic family members
    Michel Michaelides
    Moorfields Eye Hospital, London, England
    Arch Ophthalmol 126:320-8. 2008
  7. pmc Glaucoma following congenital cataract surgery--the role of early surgery and posterior capsulotomy
    Michel Michaelides
    Department of Paediatric Ophthalmology and Strabismus, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK
    BMC Ophthalmol 7:13. 2007
  8. ncbi request reprint RP1L1 variants are associated with a spectrum of inherited retinal diseases including retinitis pigmentosa and occult macular dystrophy
    Alice E Davidson
    University College London Institute of Ophthalmology, London, UK
    Hum Mutat 34:506-14. 2013
  9. doi request reprint Unilateral vitelliform maculopathy: a comprehensive phenotype study with molecular screening of BEST1 and PRPH2
    Mala Subash
    UCL Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Br J Ophthalmol 96:719-22. 2012
  10. doi request reprint A longitudinal study of Stargardt disease: quantitative assessment of fundus autofluorescence, progression, and genotype correlations
    Kaoru Fujinami
    University College London Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:8181-90. 2013

Detail Information

Publications58

  1. pmc The PROM1 mutation p.R373C causes an autosomal dominant bull's eye maculopathy associated with rod, rod-cone, and macular dystrophy
    Michel Michaelides
    UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 51:4771-80. 2010
    ..To characterize in detail the phenotype of five unrelated families with autosomal dominant bull's eye maculopathy (BEM) due to the R373C mutation in the PROM1 gene...
  2. pmc Integrity of the cone photoreceptor mosaic in oligocone trichromacy
    Michel Michaelides
    UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:4757-64. 2011
    ..It has been proposed that these patients have a reduced number of normal functioning cones (oligocone). This paper has sought to evaluate the integrity of the cone photoreceptor mosaic in four patients previously described as having OT...
  3. doi request reprint Developmental macular disorders: phenotypes and underlying molecular genetic basis
    Michel Michaelides
    UCL Institute of Ophthalmology, University College London, London, UK
    Br J Ophthalmol 96:917-24. 2012
    ..Improved knowledge of the underlying molecular genetics and disease mechanisms will raise the possibility of future treatments for these disorders, for which there are no specific therapies available at the present time...
  4. ncbi request reprint Evidence of genetic heterogeneity in MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome
    Michel Michaelides
    Moorfields Eye Hospital, and Institute of Ophthalmology, University College London, London, United Kingdom
    Am J Ophthalmol 141:418-20. 2006
    ..To present the detailed phenotype of a subject with MRCS (microcornea, retinal dystrophy, cataract, and posterior staphyloma) syndrome and to investigate the underlying molecular genetic basis...
  5. ncbi request reprint A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2
    Michel Michaelides
    Department of Medical Retina, Moorfields Eye Hospital, London, United Kingdom
    Ophthalmology 117:1078-1086.e2. 2010
    ....
  6. doi request reprint Macular dystrophy associated with the A3243G mitochondrial DNA mutation. Distinct retinal and associated features, disease variability, and characterization of asymptomatic family members
    Michel Michaelides
    Moorfields Eye Hospital, London, England
    Arch Ophthalmol 126:320-8. 2008
    ..3243A>G) and their asymptomatic maternal relatives, (2) intrafamilial and interfamilial phenotypic variability, and (3) the presence of other systemic features...
  7. pmc Glaucoma following congenital cataract surgery--the role of early surgery and posterior capsulotomy
    Michel Michaelides
    Department of Paediatric Ophthalmology and Strabismus, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK
    BMC Ophthalmol 7:13. 2007
    ..To determine the rate of glaucoma following congenital cataract surgery at Moorfields Eye Hospital (MEH), and to investigate potential risk factors for glaucoma in our case series...
  8. ncbi request reprint RP1L1 variants are associated with a spectrum of inherited retinal diseases including retinitis pigmentosa and occult macular dystrophy
    Alice E Davidson
    University College London Institute of Ophthalmology, London, UK
    Hum Mutat 34:506-14. 2013
    ..These findings imply an important and diverse role for RP1L1 in human retinal physiology and disease...
  9. doi request reprint Unilateral vitelliform maculopathy: a comprehensive phenotype study with molecular screening of BEST1 and PRPH2
    Mala Subash
    UCL Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Br J Ophthalmol 96:719-22. 2012
    ..To describe the clinical features of a case series of patients with unilateral vitelliform maculopathy and the results of screening BEST1 and PRPH2 for disease-causing mutations...
  10. doi request reprint A longitudinal study of Stargardt disease: quantitative assessment of fundus autofluorescence, progression, and genotype correlations
    Kaoru Fujinami
    University College London Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:8181-90. 2013
    ..We characterized subtypes of fundus autofluorescence (AF) and the progression of retinal atrophy, and correlated these findings with genotype in Stargardt disease...
  11. doi request reprint The clinical effect of homozygous ABCA4 alleles in 18 patients
    Kaoru Fujinami
    UCL Institute of Ophthalmology, London, United Kingdom Moorfields Eye Hospital, London, United Kingdom National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Ophthalmology 120:2324-31. 2013
    ..To describe the phenotypic presentation of a cohort of individuals with homozygous disease-associated ABCA4 variants...
  12. doi request reprint Clinical and molecular analysis of Stargardt disease with preserved foveal structure and function
    Kaoru Fujinami
    University College London, Institute of Ophthalmology, London, United Kingdom
    Am J Ophthalmol 156:487-501.e1. 2013
    ..To describe a cohort of patients with Stargardt disease who show a foveal-sparing phenotype...
  13. doi request reprint "Cone dystrophy with supernormal rod electroretinogram": a comprehensive genotype/phenotype study including fundus autofluorescence and extensive electrophysiology
    Anthony G Robson
    Department of Electrophysiology, Moorfields Eye Hospital, London, UK
    Retina 30:51-62. 2010
    ..The purpose of this study was to characterize the clinical, electrophysiologic, and genetic features in "cone dystrophy with supernormal rod electroretinogram (ERG)."..
  14. ncbi request reprint Macular perfusion determined by fundus fluorescein angiography at the 4-month time point in a prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (Bolt Study): Report 1
    Michel Michaelides
    Department of Medical Retina, Moorfields Eye Hospital, London, UK
    Retina 30:781-6. 2010
    ....
  15. doi request reprint Vision in observers with enhanced S-cone syndrome: an excess of s-cones but connected mainly to conventional s-cone pathways
    Caterina Ripamonti
    UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 55:963-76. 2014
    ..The effect of increased numbers of S-cone photoreceptors in enhanced S-cone syndrome (ESCS) was investigated psychophysically in six ESCS observers to understand more about relative cone sensitivities and postreceptoral organization...
  16. ncbi request reprint Mutation in the gene GUCA1A, encoding guanylate cyclase-activating protein 1, causes cone, cone-rod, and macular dystrophy
    Michel Michaelides
    Institute of Ophthalmology, University College London, London, United Kingdom
    Ophthalmology 112:1442-7. 2005
    ..To determine the underlying molecular genetic basis of a retinal dystrophy identified in a 4-generation family and to examine the phenotype and the degree of intrafamilial variability...
  17. ncbi request reprint A 2-year prospective randomized controlled trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic macular edema: 24-month data: report 3
    Ranjan Rajendram
    Department of Medical Retina, Moorfields Eye Hospital, 162 City Rd, London EC1V 2PD, England, UK
    Arch Ophthalmol 130:972-9. 2012
    ....
  18. pmc Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans
    Zheng Li
    University College London UCL Institute of Ophthalmology, London EC1V 9EL, UK
    Am J Hum Genet 85:711-9. 2009
    ..These findings suggest an important role of this specific cation channel for the normal function of ON bipolar cells in the human retina...
  19. doi request reprint Phenotypic variation in enhanced S-cone syndrome
    Isabelle Audo
    Department of Electrophysiology, Moorfields Eye Hospital, 162 City Road, London, United Kingdom
    Invest Ophthalmol Vis Sci 49:2082-93. 2008
    ..To characterize the clinical, psychophysical, and electrophysiological phenotype of 19 patients with enhanced S-cone syndrome (ESCS) and relate the phenotype to the underlying genetic mutation...
  20. pmc Variations in opsin coding sequences cause x-linked cone dysfunction syndrome with myopia and dichromacy
    Michelle McClements
    University College London Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:1361-9. 2013
    ..To determine the role of variant L opsin haplotypes in seven families with Bornholm Eye Disease (BED), a cone dysfunction syndrome with dichromacy and myopia...
  21. pmc Functional characteristics of patients with retinal dystrophy that manifest abnormal parafoveal annuli of high density fundus autofluorescence; a review and update
    Anthony G Robson
    Department of Electrophysiology, Moorfields Eye Hospital, 162 City Road, London EC1 2PD, UK
    Doc Ophthalmol 116:79-89. 2008
    ..To examine the presence and functional significance of annular fundus autofluorescence abnormalities in patients with different retinal dystrophies...
  22. ncbi request reprint X-linked cone dysfunction syndrome with myopia and protanopia
    Michel Michaelides
    Institute of Ophthalmology, University College London, London, United Kingdom
    Ophthalmology 112:1448-54. 2005
    ..To perform a detailed clinical, psychophysical, and molecular assessment of members of 4 families with an unusual X-linked cone dysfunction syndrome associated with myopia...
  23. doi request reprint Phenotypic findings in C1QTNF5 retinopathy (late-onset retinal degeneration)
    Vasileios Soumplis
    Moorfields Eye Hospital, London, UK
    Acta Ophthalmol 91:e191-5. 2013
    ..To describe the ocular and electrophysiological phenotype of four patients with late-onset retinal degeneration (LORD)...
  24. doi request reprint A longitudinal study of stargardt disease: clinical and electrophysiologic assessment, progression, and genotype correlations
    Kaoru Fujinami
    University College London, Institute of Ophthalmology, London, United Kingdom
    Am J Ophthalmol 155:1075-1088.e13. 2013
    ..To investigate the clinical and electrophysiologic natural history of Stargardt disease and correlate with the genotype...
  25. ncbi request reprint Cone-rod dystrophy, intrafamilial variability, and incomplete penetrance associated with the R172W mutation in the peripherin/RDS gene
    Michel Michaelides
    Institute of Ophthalmology, University College London, London, United Kingdom
    Ophthalmology 112:1592-8. 2005
    ..To determine the underlying molecular genetic basis of a retinal dystrophy identified in a 5-generation family, and to examine the phenotype and degree of intrafamilial variability...
  26. pmc Clinical characteristics of early retinal disease due to CDHR1 mutation
    Rola Ba-Abbad
    UCL Institute of Ophthalmology, University College London, London, UK Moorfields Eye Hospital, London, UK Ophthalmology Department, King Abdulaziz University Hospital, Riyadh, Saudi Arabia
    Mol Vis 19:2250-9. 2013
    ..To describe the early clinical and electrophysiological features of cone-rod dystrophy due to a mutation of cadherin-related family member 1 (CDHR1)...
  27. pmc X-linked cone dystrophy and colour vision deficiency arising from a missense mutation in a hybrid L/M cone opsin gene
    Michelle McClements
    UCL Institute of Ophthalmology, London, UK
    Vision Res 80:41-50. 2013
    ....
  28. pmc X-linked cone dystrophy caused by mutation of the red and green cone opsins
    Jessica C Gardner
    UCL Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Am J Hum Genet 87:26-39. 2010
    ..Mutations in the LW/MW cone opsin gene array can, therefore, lead to a spectrum of disease, ranging from color blindness to progressive cone dystrophy (XLCOD5)...
  29. pmc Blue cone monochromacy: causative mutations and associated phenotypes
    Jessica C Gardner
    Institute of Ophthalmology, University College London, London, UK
    Mol Vis 15:876-84. 2009
    ..To perform a phenotypic assessment of members of three British families with blue cone monochromatism (BCM), and to determine the underlying molecular genetic basis of disease...
  30. ncbi request reprint Maculopathy due to the R345W substitution in fibulin-3: distinct clinical features, disease variability, and extent of retinal dysfunction
    Michel Michaelides
    Moorfields Eye Hospital, City Road, and Instiute of Ophthalmology, University College London, United Kingdom
    Invest Ophthalmol Vis Sci 47:3085-97. 2006
    ....
  31. ncbi request reprint An early-onset autosomal dominant macular dystrophy (MCDR3) resembling North Carolina macular dystrophy maps to chromosome 5
    Michel Michaelides
    Institute of Ophthalmology, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 44:2178-83. 2003
    ..To characterize the phenotype of an autosomal dominant macular dystrophy and identify the chromosomal locus...
  32. ncbi request reprint Visual consequences of molecular changes in the guanylate cyclase-activating protein
    Andrew Stockman
    UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 55:1930-40. 2014
    ..The mutation causes an excess of cGMP in the dark and results in progressive photoreceptor loss...
  33. pmc X-linked megalocornea caused by mutations in CHRDL1 identifies an essential role for ventroptin in anterior segment development
    Tom R Webb
    Institute of Ophthalmology, University College London, UK
    Am J Hum Genet 90:247-59. 2012
    ..Our findings reveal an unexpected requirement for ventroptin during anterior segment development and the consequences of a lack of function in the retina and brain...
  34. doi request reprint Cone dystrophy with "supernormal" rod ERG: psychophysical testing shows comparable rod and cone temporal sensitivity losses with no gain in rod function
    Andrew Stockman
    UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 55:832-40. 2014
    ..We compared losses for rod- and for cone-mediated vision to further investigate the disorder and to assess whether the supernormal ERG is associated with any visual benefit...
  35. ncbi request reprint Identification of novel RPGR ORF15 mutations in X-linked progressive cone-rod dystrophy (XLCORD) families
    Neil D Ebenezer
    Division of Molecular Genetics, University College London, UK
    Invest Ophthalmol Vis Sci 46:1891-8. 2005
    ....
  36. doi request reprint High-resolution optical coherence tomography imaging in KCNV2 retinopathy
    Panagiotis I Sergouniotis
    Moorfields Eye Hospital, 162 City Road, London EC1V 2PD, UK
    Br J Ophthalmol 96:213-7. 2012
    ....
  37. pmc Mutations in the gene KCNV2 encoding a voltage-gated potassium channel subunit cause "cone dystrophy with supernormal rod electroretinogram" in humans
    Huimin Wu
    University College London, Institute of Ophthalmology, London, United Kingdom
    Am J Hum Genet 79:574-9. 2006
    ....
  38. doi request reprint Novel mutations and electrophysiologic findings in RGS9- and R9AP-associated retinal dysfunction (Bradyopsia)
    Michel Michaelides
    Institute of Ophthalmology, University College London, London, United Kingdom Moorfields Eye Hospital, London, United Kingdom
    Ophthalmology 117:120-127.e1. 2010
    ....
  39. ncbi request reprint An autosomal dominant bull's-eye macular dystrophy (MCDR2) that maps to the short arm of chromosome 4
    Michel Michaelides
    Institute of Ophthalmology, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 44:1657-62. 2003
    ..To describe the phenotype of an autosomal dominant macular dystrophy and identify the chromosomal locus...
  40. pmc Extended extraocular phenotype of PROM1 mutation in kindreds with known autosomal dominant macular dystrophy
    Francesca I Arrigoni
    Department of Vascular Physiology, UCL Institute of Child Health, London, UK
    Eur J Hum Genet 19:131-7. 2011
    ..We also noted renal infections, haematuria and recurrent miscarriages possibly reflecting consequences of abnormal tubular modelling. Further studies are needed to confirm these findings...
  41. ncbi request reprint Bilateral epiretinal membranes in Gorlin syndrome associated with a novel PTCH mutation
    Andrew Scott
    Moorfields Eye Hospital, City Road, London, United Kingdom
    Am J Ophthalmol 143:346-8. 2007
    ..To present the detailed ocular phenotype of a subject with Gorlin syndrome (GS) (basal cell nevus syndrome; OMIM 109400) and to undertake mutation screening of the gene Patched (PTCH)...
  42. doi request reprint Retinal structure and function in achromatopsia: implications for gene therapy
    Venki Sundaram
    UCL Institute of Ophthalmology, University College London, London, UK Moorfields Eye Hospital, London, UK
    Ophthalmology 121:234-45. 2014
    ..To characterize retinal structure and function in achromatopsia (ACHM) in preparation for clinical trials of gene therapy...
  43. ncbi request reprint Progressive cone and cone-rod dystrophies: phenotypes and underlying molecular genetic basis
    Michel Michaelides
    Institute of Ophthalmology, University College London, UK
    Surv Ophthalmol 51:232-58. 2006
    ..This improved knowledge of disease mechanisms has raised the possibility of future treatments for these disorders, for which there are no specific therapies available at the present time...
  44. pmc Structural and functional measures of efficacy in response to bevacizumab monotherapy in diabetic macular oedema: exploratory analyses of the BOLT study (report 4)
    Sobha Sivaprasad
    NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital, London, United Kingdom
    PLoS ONE 8:e72755. 2013
    ..To describe structural and functional changes associated with diabetic macular oedema (DMO) treated with intravitreal bevacizumab over 24 months...
  45. pmc Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation
    Sanjay M Sisodiya
    Department of Clinical and Experimental Epilepsy, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Med Genet 44:373-80. 2007
    ..RIMS1 encodes a synapse active-zone protein with important roles in the maintenance of normal synaptic function: mice lacking this protein have greatly reduced learning ability and memory function...
  46. ncbi request reprint Progressive cone dystrophy associated with mutation in CNGB3
    Michel Michaelides
    Institute of Ophthalmology, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 45:1975-82. 2004
    ..To determine the molecular basis for phenotypic variability in a three-generation consanguineous family containing a single individual with complete achromatopsia and three individuals with progressive cone dystrophy...
  47. ncbi request reprint Residual cone vision without alpha-transducin
    Andrew Stockman
    Institute of Ophthalmology, University College London, London, UK
    J Vis 7:8. 2007
    ....
  48. doi request reprint Injection frequency and response to bevacizumab monotherapy for diabetic macular oedema (BOLT Report 5)
    Sobha Sivaprasad
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London, UK
    Br J Ophthalmol 97:1177-80. 2013
    ..To explore the parameters that influence injection frequency in patients treated with intravitreal bevacizumab (ivB) for diabetic macular oedema. Injection frequency was considered as a surrogate marker of persistent or recurrent oedema...
  49. pmc Deep intronic mutation in OFD1, identified by targeted genomic next-generation sequencing, causes a severe form of X-linked retinitis pigmentosa (RP23)
    Tom R Webb
    UCL Institute of Ophthalmology, London EC1V 9EL, UK
    Hum Mol Genet 21:3647-54. 2012
    ....
  50. pmc Optical coherence tomography: an assessment of current training across all levels of seniority in 8 ophthalmic units in the United Kingdom
    Wai H Chan
    Department of Ophthalmology, St Thomas Hospital, London, SE1 7EH, UK
    BMC Ophthalmol 6:33. 2006
    ..The aim of this study was to determine the clinical competence in OCT image interpretation of ophthalmologists in different subspecialties and grades...
  51. pmc Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/Guca1a gene
    Prateek K Buch
    University College London Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 6:e18089. 2011
    ..Importantly, this knock-in mutant mouse has many features in common with the human disease, thereby making it an excellent model to further probe disease pathogenesis and investigate therapeutic interventions...
  52. ncbi request reprint The extended clinical phenotype of dome-shaped macula
    Marie Hélène Errera
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
    Graefes Arch Clin Exp Ophthalmol 252:499-508. 2014
    ..This retroprospective cohort study aims to gain further pathophysiological understanding in eyes with DSM...
  53. doi request reprint Guanylate cyclases and associated activator proteins in retinal disease
    David M Hunt
    UCL Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Mol Cell Biochem 334:157-68. 2010
    ..In a similar fashion to the disease mechanism for the dominant GUCY2D mutations, these mutations generally alter the sensitivity of the cyclase to inhibition as Ca(2+) levels rise following a light flash...
  54. doi request reprint Skills acquisition and assessment after a microsurgical skills course for ophthalmology residents
    Daniel G Ezra
    Department of Education Moorfields Eye Hospital, London, United Kingdom
    Ophthalmology 116:257-62. 2009
    ....
  55. doi request reprint A randomized controlled trial comparing everting sutures with everting sutures and a lateral tarsal strip for involutional entropion
    Marius A Scheepers
    Charing Cross and Western Eye Hospitals, London, United Kingdom
    Ophthalmology 117:352-5. 2010
    ..To determine whether there is a statistically significant difference in the surgical outcome of everting sutures (ES) alone versus everting sutures with a lateral tarsal strip (ES+LTS) in the treatment of involutional entropion...
  56. pmc Leber congenital amaurosis associated with AIPL1: challenges in ascribing disease causation, clinical findings, and implications for gene therapy
    Mei Hong Tan
    Department of Genetics, Institute of Ophthalmology, University College London, London, United Kingdom
    PLoS ONE 7:e32330. 2012
    ..This data suggests that there are patients who have a reasonable window of opportunity for gene therapy in childhood...
  57. doi request reprint Retinal vein occlusion and angle closure: a retrospective case series
    Michel Michaelides
    UCL Institute of Ophthalmology, London, UK
    J Glaucoma 19:643-9. 2010
    ..To describe a series of patients who have sustained a retinal vein occlusion (RVO) and also have primary angle-closure (PAC)...
  58. pmc Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice
    Zhenglin Yang
    Department of Ophthalmology and Visual Science, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah, USA
    J Clin Invest 118:2908-16. 2008
    ..Collectively, our results identify what we believe to be a novel complex involved in photoreceptor disk morphogenesis and indicate a possible role for PROM1 and PCDH21 in macular degeneration...