Research Topics
| Irmtraud M MeyerSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Statistical evidence for conserved, local secondary structure in the coding regions of eukaryotic mRNAs and pre-mRNAsIrmtraud M Meyer
European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
Nucleic Acids Res 33:6338-48. 2005....
Gene structure conservation aids similarity based gene predictionIrmtraud M Meyer
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Nucleic Acids Res 32:776-83. 2004..It is more accurate than Genewise for genes whose proteins are <80% identical, and is suitable for use in a combined gene prediction system where other methods identify well conserved and non-conserved genes, and pseudogenes...
Co-transcriptional folding is encoded within RNA genesIrmtraud M Meyer
University of Oxford, Oxford OX1 3QB, UK
BMC Mol Biol 5:10. 2004..Dedicated experiments with individual RNA molecules have shown that RNA folds while it is being transcribed and that its correct folding can also depend on the proper speed of transcription...
Comparative ab initio prediction of gene structures using pair HMMsIrmtraud M Meyer
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Bioinformatics 18:1309-18. 2002..More information can be found at: http://www.sanger.ac.uk/Software/analysis/doublescan/..
Moments of the Boltzmann distribution for RNA secondary structuresIstván Miklós
MTA ELTE Theoretical Biology and Ecology Modelling Group, H 1117 Budapest, Pazmany Peter setany 1 C, Hungary
Bull Math Biol 67:1031-47. 2005..These results suggest that biologically functional RNA sequences not only require a thermodynamically stable minimum free energy structure, but also an ensemble of structures whose free energies are close to the minimum free energy...
SimulFold: simultaneously inferring RNA structures including pseudoknots, alignments, and trees using a Bayesian MCMC frameworkIrmtraud M Meyer
UBC Bioinformatics Centre, University of British Columbia, Vancouver, British Columbia, Canada
PLoS Comput Biol 3:e149. 2007..It is thus likely to have a strong impact, both on the field of RNA structure prediction and on a wide range of data analyses...
A linear memory algorithm for Baum-Welch trainingIstván Miklós
MTA ELTE Theoretical Biology and Ecology Group, Pázmány Péter sétány 1 c 1117 Budapest, Hungary
BMC Bioinformatics 6:231. 2005..This has so far effectively prevented the automatic parameter training of hidden Markov models that are currently used for biological sequence analyses...
A practical guide to the art of RNA gene predictionIrmtraud M Meyer
Bioinformatics Centre and Department of Computer Science, University of British Columbia, 2366 Main Mall, Vancouver, BC, Canada V6T 1Z4
Brief Bioinform 8:396-414. 2007..It discusses our current view of RNA genes as well as recent computational analyses of RNA genes and concludes with an outlook to future directions in algorithm development and data analyses...
A cross-species comparison of X-chromosome inactivation in EutheriaZiny C Yen
Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
Genomics 90:453-63. 2007....
Predicting novel RNA-RNA interactionsIrmtraud M Meyer
UBC Bioinformatics Centre and Department of Medical Genetics, University of British Columbia, 2185 East Mall, Vancouver, BC, Canada V6T 1Z4
Curr Opin Struct Biol 18:387-93. 2008..We conclude by discussing the merits of the different approaches and provide an outlook on probably and desirable future developments in the field...
