Helgard P Meyer

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi ReN-1869 [(R)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperidine carboxylic acid], a novel histamine H1 receptor antagonist, produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and
    R Suzuki
    Department of Pharmacology, University College London, WC1E 6BT London, UK
    J Pharmacol Exp Ther 309:1230-8. 2004
  2. ncbi Evidence for spinal dorsal horn hyperexcitability in rats following sustained morphine exposure
    Rie Suzuki
    Department of Pharmacology, Medical Sciences Building, University College London, Gower Street, London WC1E 6BT, UK
    Neurosci Lett 407:156-61. 2006
  3. ncbi Pain treatment with acupuncture for patients with fibromyalgia
    Rosa A Targino
    Division of Physical Medicine, Department of Orthopedics and Traumatology, University of Sao Paulo School of Medicine, Ave Giovanni Gronchi, 1106 San Paulo, Brazil
    Curr Pain Headache Rep 6:379-83. 2002
  4. ncbi Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways
    Rie Suzuki
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 5:1319-26. 2002
  5. ncbi The coding of noxious mechanical and thermal stimuli of deep dorsal horn neurones is attenuated in NK1 knockout mice
    Rie Suzuki
    Department of Pharmacology, Medical Sciences Building, University College London, Gower Street, London WC1E 6BT, UK
    Neuropharmacology 45:1093-100. 2003
  6. ncbi Bad news from the brain: descending 5-HT pathways that control spinal pain processing
    Rie Suzuki
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Trends Pharmacol Sci 25:613-7. 2004
  7. ncbi Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin
    Rie Suzuki
    Department of Pharmacology Medical Sciences Building, University College London, Gower Street, London WC1E 6BT, UK
    Pain 117:292-303. 2005
  8. ncbi Spinal and supraspinal contributions to central sensitization in peripheral neuropathy
    Rie Suzuki
    Department of Pharmacology, Medical Sciences Building, University College London, UK
    Neurosignals 14:175-81. 2005
  9. ncbi Differential pharmacological modulation of the spontaneous stimulus-independent activity in the rat spinal cord following peripheral nerve injury
    Rie Suzuki
    Department of Pharmacology, Medical Sciences Building, University College London, Gower Street, London WC1E 6BT, UK
    Exp Neurol 198:72-80. 2006
  10. ncbi Myofascial pain syndrome and its suggested role in the pathogenesis and treatment of fibromyalgia syndrome
    Helgard P Meyer
    University of Pretoria, Private Bag X 396, Pretoria 0001, South Africa
    Curr Pain Headache Rep 6:274-83. 2002

Collaborators

Detail Information

Publications20

  1. ncbi ReN-1869 [(R)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperidine carboxylic acid], a novel histamine H1 receptor antagonist, produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and
    R Suzuki
    Department of Pharmacology, University College London, WC1E 6BT London, UK
    J Pharmacol Exp Ther 309:1230-8. 2004
    ..We propose that ReN-1869 may represent a novel agent for the treatment of certain modalities of persistent pain states, in particular for the treatment of mechanical allodynia...
  2. ncbi Evidence for spinal dorsal horn hyperexcitability in rats following sustained morphine exposure
    Rie Suzuki
    Department of Pharmacology, Medical Sciences Building, University College London, Gower Street, London WC1E 6BT, UK
    Neurosci Lett 407:156-61. 2006
    ....
  3. ncbi Pain treatment with acupuncture for patients with fibromyalgia
    Rosa A Targino
    Division of Physical Medicine, Department of Orthopedics and Traumatology, University of Sao Paulo School of Medicine, Ave Giovanni Gronchi, 1106 San Paulo, Brazil
    Curr Pain Headache Rep 6:379-83. 2002
    ..The results were found by applying traditional acupuncture, which demonstrated positive rates in the Visual Analogue Scale, myalgic index, number of tender points, and improvement in quality of life based on the SF-36 questionnaire...
  4. ncbi Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways
    Rie Suzuki
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 5:1319-26. 2002
    ....
  5. ncbi The coding of noxious mechanical and thermal stimuli of deep dorsal horn neurones is attenuated in NK1 knockout mice
    Rie Suzuki
    Department of Pharmacology, Medical Sciences Building, University College London, Gower Street, London WC1E 6BT, UK
    Neuropharmacology 45:1093-100. 2003
    ..We conclude that NK1-Rs are important in the high intensity noxious signalling of acute peripheral (mechanical/thermal) stimuli and this may result from the lack of wind-up and/or the disruption of spinal-bulbo-spinal loops...
  6. ncbi Bad news from the brain: descending 5-HT pathways that control spinal pain processing
    Rie Suzuki
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Trends Pharmacol Sci 25:613-7. 2004
    ....
  7. ncbi Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin
    Rie Suzuki
    Department of Pharmacology Medical Sciences Building, University College London, Gower Street, London WC1E 6BT, UK
    Pain 117:292-303. 2005
    ..These hypotheses are testable in patients...
  8. ncbi Spinal and supraspinal contributions to central sensitization in peripheral neuropathy
    Rie Suzuki
    Department of Pharmacology, Medical Sciences Building, University College London, UK
    Neurosignals 14:175-81. 2005
    ..Understanding these pain pathways is a first step toward elucidating the complex links between pain and emotions...
  9. ncbi Differential pharmacological modulation of the spontaneous stimulus-independent activity in the rat spinal cord following peripheral nerve injury
    Rie Suzuki
    Department of Pharmacology, Medical Sciences Building, University College London, Gower Street, London WC1E 6BT, UK
    Exp Neurol 198:72-80. 2006
    ..This may form an electrophysiological basis for the efficacy of gabapentin and spinal morphine on ongoing pain in patients with peripheral neuropathy...
  10. ncbi Myofascial pain syndrome and its suggested role in the pathogenesis and treatment of fibromyalgia syndrome
    Helgard P Meyer
    University of Pretoria, Private Bag X 396, Pretoria 0001, South Africa
    Curr Pain Headache Rep 6:274-83. 2002
    ..The purpose of this review is to present clinically relevant data regarding myofascial pain syndrome and to discuss its possible role in the pathophysiology and optimal treatment of fibromyalgia syndrome...
  11. ncbi Neuropharmacologic targets and agents in fibromyalgia
    Rie Suzuki
    Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Curr Pain Headache Rep 6:267-73. 2002
    ..It is likely that drugs with central actions will prove to be effective against a number of symptoms. This article aims to outline some of the potential spinal pharmacologic targets that may be used to treat this condition...
  12. ncbi Nerve injury-induced changes in opioid modulation of wide dynamic range dorsal column nuclei neurones
    R Suzuki
    Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK
    Neuroscience 111:215-28. 2002
    ....
  13. pmc The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury
    R Suzuki
    Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT
    Br J Pharmacol 132:1615-23. 2001
    ..Our results demonstrate a plasticity in the endogenous adenosine-mediated inhibitory system following SNL and provide a possible basis for the use of this compound for the treatment of neuropathic and other persistent pain states...
  14. ncbi Comparison of the effects of MK-801, ketamine and memantine on responses of spinal dorsal horn neurones in a rat model of mononeuropathy
    R Suzuki
    Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK
    Pain 91:101-9. 2001
    ..The favourable side effect profile of memantine supports its potential use for the treatment of neuropathic pain...
  15. ncbi The effectiveness of spinal and systemic morphine on rat dorsal horn neuronal responses in the spinal nerve ligation model of neuropathic pain
    R Suzuki
    Department of Pharmacology, University College London, UK
    Pain 80:215-28. 1999
    ..Spinal opioids may be a useful approach to pain control in neuropathic pain states where systemic routes produce inadequate analgesia...
  16. ncbi Different increase in C-fibre evoked responses after nociceptive conditioning stimulation in sham-operated and neuropathic rats
    L J Rygh
    Neuropharmacology of Pain Group, Department of Pharmacology, University College London, Gower Street, WC1 6BT, London, UK
    Neurosci Lett 288:99-102. 2000
    ..Thus, it is suggested that the nerve injury itself is likely to induce an LTP-like state in the neurones studied. Further studies using the LTP-inducing model can provide new information on the mechanisms of neuropathic pain...
  17. ncbi Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats
    V Chapman
    Department of Pharmacology, University College London, UK
    Pain 75:261-72. 1998
    ..Further studies at the spinal level may shed light on the physiology and pharmacology of the aberrant processes associated with neuropathic pain...
  18. pmc Electrophysiological characterization of spinal neuronal response properties in anaesthetized rats after ligation of spinal nerves L5-L6
    V Chapman
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 507:881-94. 1998
    ..We suggest that an interplay between pathological peripheral and central mechanisms may account for some of the changes that could contribute to allodynia and hyperalgesia...
  19. ncbi Proliferation and differentiation in the human breast during pregnancy
    R Suzuki
    Ludwig Institute for Cancer Research, University College London, School of Medicine, Department of Surgery, UK
    Differentiation 66:106-15. 2000
    ....
  20. ncbi Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors
    V Souslova
    Department of Biology, University College London, UK
    Nature 407:1015-7. 2000
    ..Notably, although dorsal-horn neuronal responses to mechanical and noxious heat application are normal, P2X3-null mice are unable to code the intensity of non-noxious 'warming' stimuli...